WorldCat Identities

Eisenhofer, Graeme

Overview
Works: 19 works in 49 publications in 2 languages and 860 library holdings
Genres: Conference papers and proceedings 
Roles: Editor, Author
Publication Timeline
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Most widely held works by Graeme Eisenhofer
Pheochromocytoma : diagnosis, localization, and treatment by Karel Pacak( )

9 editions published between 2007 and 2008 in English and held by 220 WorldCat member libraries worldwide

"Pheochromocytos are rare but treacherous catecholamine-producing tumors, which if missed or not properly treated, will almost invariably prove fatal. Prompt diagnosis is, therefore, essential for effective treatment, usually by surgical resection. The manifestations are diverse and the tumor can mimic a variety of conditions, often resulting in either erroneous diagnoses or a delayed diagnosis." "Reflecting the recent leaps in understanding this condition, Pheochromocytoma: Diagnosis, Localization, and Treatment provides a comprehensive update on the improvements in the diagnosis, localization, management and treatment of pheochromocytomas - providing you with the latest cutting edge science alongside best clinical practice. Written by the leading names in the field, the text details the significant developments in understanding the genetics and biology of the tumors, coupled with technological advances in the fields of analytical chemistry, genomics, molecular biology and nuclear medicine."--BOOK JACKET
Endocrine hypertension by International Workshop on Endocrine Hypertension( Book )

7 editions published in 2002 in English and held by 211 WorldCat member libraries worldwide

Catecholamines : bridging basic science with clinical medicine( )

8 editions published between 1997 and 1998 in English and held by 205 WorldCat member libraries worldwide

This volume in Advances in Pharmacology focuses on all aspects of catecholamine research, from very basic to medical. It is broad based and covers many areas within physiology and medicine
Pheochromocytoma : first international symposium( Book )

8 editions published in 2006 in English and held by 199 WorldCat member libraries worldwide

"Pheochromocytoma is a rare neuroendocrine tumor with a highly variable presentation. There is lack of agreement about the most efficient and cost-effective methods for diagnosis and localization of the tumor, which can be lethal if not identified and treated promptly. Autopsy studies indicate that up to 50% of all cases remain undiagnosed until death. Between 30 and 35% of the tumors have a hereditary basis. Development of malignancy is highly variable -- from less than 5% to more than 50% depending on the mutation; there is currently no effective cure. This volume encompasses a number of themes in several sections: genetics and clinical decision-making; genetics, molecular pathways of tumorigenesis, and divergent phenotypes; kaleidoscopic presentations and a minefield for differential diagnosis of pheochromocytoma; biochemical diagnosis: can we reach consensus?; tumor localization and the evolving importance of functional imaging; and new molecular markers and targets for diagnosis and treatment of malignant pheochromcytoma."--Publisher's website
Catecholamines : Bridging Basic Science with Clinical Medicine: Advances in Pharmacology, Volume 42( )

1 edition published in 1998 in English and held by 4 WorldCat member libraries worldwide

The Eighth International Catecholamine Symposium, Pacific Grove, California, October 13-18, 1996 by International Catecholamine Symposium( Book )

2 editions published in 1997 in English and held by 3 WorldCat member libraries worldwide

Advances in Pharmacology, 42 : Catecholamines - Bridging Basic Science with Clinical Medicine by David S Goldstein( )

1 edition published in 1997 in English and held by 3 WorldCat member libraries worldwide

This volume in the series andquot;Advances in Pharmacologyandquot; focuses on all aspects of catecholamine research, from very basic to medical. It is broad-based and covers many areas within physiology and medicine
The acute and chronic effects of ethanol on water metabolism and the sympathetic nervous system in man by Graeme Eisenhofer( Book )

2 editions published in 1982 in English and held by 2 WorldCat member libraries worldwide

Biokemična diagnoza feokromocitoma : kateri test je najboljši? = (Biochemical diagnosis of pheochromocytoma : which test is best?)( )

1 edition published in 2002 in Slovenian and held by 2 WorldCat member libraries worldwide

Izhodišče: Diagnozo feokromocitoma postavimo z biokemičnim dokazom tumorskega izločanja kateholaminov. Vendar še ni znano, kateri test je za postavitev diagnoze najboljši. Cllj: Določiti biokemični test ali kombinacijo testov, ki predstavlja najboljšo metodo za diagnosticiranje feokromocitoma. Oblika, mestoraziskave in bolniki: Multicentrična, kohortna raziskava bolnikov, testiranih za feokromocitom v 4 raziskovalnih centrih med letoma 1994 in 2001. Analiza je vključevala 214 bolnikov, pri katerih je bila potrjena diagnoza feokromocitoma, in 644 bolnikov, ki tumorja niso imeli. Vodilna merila izida: Občutljivost in specifičnost testa, krivulje ROC (receiver operating characteristic) ter pozitivne in negativne napovedne vrednosti pri različnih prevalencah pred testiranjem, z uporabo prostih metanefrinov v plazmi, plazemskih kateholaminov, kateholaminov v urinu, cefotnih in frakcioniranih metanefrinov v urinu in vanililmandljeve kisline v urinu. (Izvleček skrajšan pri 2000 znakih)
Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract: The adrenal gland is a highly plastic organ with the capacity to adapt the body homeostasis to different physiological needs. The existence of stem-like cells in the adrenal cortex has been revealed in many studies. Recently, we identified and characterized in mice a pool of glia-like multipotent Nestin-expressing progenitor cells, which contributes to the plasticity of the adrenal medulla. In addition, we found that these Nestin progenitors are actively involved in the stress response by giving rise to chromaffin cells. Interestingly, we also observed a Nestin-GFP-positive cell population located under the adrenal capsule and scattered through the cortex. In this article, we discuss the possibility of a common progenitor giving rise to subpopulations of cells both in the adrenal cortex and medulla, the isolation and characterization of this progenitor as well as its clinical potential in transplantation therapies and in pathophysiology. Highlights: Nestin-positive progenitors persist in both the adrenal medulla and cortex. Sympathoadrenal progenitors differentiate to chromaffin cells under stress. Nestin is expressed in adrenal tumors and associated with tumor malignancy. Chromospheres might be used for transplantation therapies of neurodegenerative diseases
Advances in Pharmacology and Chemotherapy - Volume 42 by Richard McCarty( Book )

1 edition published in 1997 in English and held by 1 WorldCat member library worldwide

Advances in pharmacology( Book )

1 edition published in 1997 in English and held by 1 WorldCat member library worldwide

Immunohistopathology and steroid profiles associated with biochemical outcomes after adrenalectomy for unilateral primary aldosteronism( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Unilateral primary aldosteronism (PA) is the most common surgically curable form of hypertension that must be accurately differentiated from bilateral PA for therapeutic management (surgical versus medical). Adrenalectomy results in biochemical cure (complete biochemical success) in almost all patients diagnosed with unilateral PA; the remaining patients with partial or absent biochemical success comprise those with persisting aldosteronism who were misdiagnosed as unilateral PA preoperatively. To identify determinants of postsurgical biochemical outcomes, we compared the adrenal histopathology and the peripheral venous steroid profiles of patients with partial and absent or complete biochemical success after adrenalectomy for unilateral PA. A large multicenter cohort of adrenals from patients with absent and partial biochemical success (n=43) displayed a higher prevalence of hyperplasia (49% versus 21%; P=0.004) and a lower prevalence of solitary functional adenoma (44% versus 79%; P<0.001) compared with adrenals from age- and sex-matched patients with PA with complete biochemical success (n=52). We measured the peripheral plasma steroid concentrations in a subgroup of these patients (n=43) and in a group of patients with bilateral PA (n=27). Steroid profiling was associated with histopathologic phenotypes (solitary functional adenoma, hyperplasia, and aldosterone-producing cell clusters) and classified patients according to biochemical outcome or diagnosis of bilateral PA. If validated, peripheral venous steroid profiling may be a useful tool to guide the decision to perform surgery based on expectations of biochemical outcome after the procedure
Proceedings of the 3rd International Symposium on Pherochromacytoma and Paraganglioma by International Symposium on Pherochromacytoma and Paraganglioma( Book )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Proceedings of the 3rd International Symposium on Pheochromocytoma and Paraganglioma by International Symposium on Pheochromocytoma and Paraganglioma( Book )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Genotype-Specific Steroid Profiles Associated With Aldosterone-Producing Adenomas( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract : Primary aldosteronism comprises 2 main subtypes: unilateral aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia. Somatic KCNJ5 mutations are found in APA at a prevalence of around 40% that drive and sustain aldosterone excess. Somatic APA mutations have been described in other genes (CACNA1D, ATP1A1, and ATP2B3) albeit at a lower frequency. Our objective was to identify genotype-specific steroid profiles in adrenal venous (AV) and peripheral venous (PV) plasma in patients with APAs. We measured the concentrations of 15 steroids in AV and PV plasma samples by liquid chromatography-tandem mass spectrometry from 79 patients with confirmed unilateral primary aldosteronism. AV sampling lateralization ratios of steroids normalized either to cortisol or to DHEA+androstenedione were also calculated. The hybrid steroid 18-oxocortisol exhibited 18- and 16-fold higher concentrations in lateralized AV and PV plasma, respectively, from APA with KCNJ5 mutations compared with all other APA combined together (P <0.001). Lateralization ratios for the KCNJ5 group were also generally higher. Strikingly, we demonstrate that a distinct steroid signature can differentiate APA genotype in AV and PV plasma. Notably, a 7-steroid fingerprint in PV plasma correctly classified 92% of the APA according to genotype. Prospective studies are necessary to translate these findings into clinical practice and determine if steroid fingerprinting could be of value to select patients with primary aldosteronism who are particularly suitable candidates for adrenal venous sampling because of a high probability of having an APA. Abstract : Supplemental Digital Content is available in the text
Computational analysis of liquid chromatography-tandem mass spectrometric steroid profiling in NCI H295R cells following angiotensin II, forskolin and abiraterone treatment( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Highlights: An LC–MS/MS based computational analysis of steroidogenesis is proposed. Multiple time point measurements reveal dynamics of induced perturbations. The computational analysis successfully describes steroid production. Calculated reaction rate constants appropriately reflect effects of agents. Abstract: Adrenal steroid hormones, which regulate a plethora of physiological functions, are produced via tightly controlled pathways. Investigations of these pathways, based on experimental data, can be facilitated by computational modeling for calculations of metabolic rate alterations. We therefore used a model system, based on mass balance and mass reaction equations, to kinetically evaluate adrenal steroidogenesis in human adrenal cortex-derived NCI H295R cells. For this purpose a panel of 10 steroids was measured by liquid chromatographic-tandem mass spectrometry. Time-dependent changes in cell incubate concentrations of steroids – including cortisol, aldosterone, dehydroepiandrosterone and their precursors – were measured after incubation with angiotensin II, forskolin and abiraterone. Model parameters were estimated based on experimental data using weighted least square fitting. Time-dependent angiotensin II- and forskolin-induced changes were observed for incubate concentrations of precursor steroids with peaks that preceded maximal increases in aldosterone and cortisol. Inhibition of 17-alpha-hydroxylase/17, 20-lyase with abiraterone resulted in increases in upstream precursor steroids and decreases in downstream products. Derived model parameters, including rate constants of enzymatic processes, appropriately quantified observed and expected changes in metabolic pathways at multiple conversion steps. Our data demonstrate limitations of single time point measurements and the importance of assessing pathway dynamics in studies of adrenal cortical cell line steroidogenesis. Our analysis provides a framework for evaluation of steroidogenesis in adrenal cortical cell culture systems and demonstrates that computational modeling-derived estimates of kinetic parameters are an effective tool for describing perturbations in associated metabolic pathways
Catecholamines : Bridging Basic Science with Clinical Medicine by J. Thomas August( )

1 edition published in 1997 in English and held by 0 WorldCat member libraries worldwide

This volume in Advances in Pharmacology focuses on all aspects of catecholamine research, from very basic to medical. It is broad based and covers many areas within physiology and medicine
 
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Endocrine hypertension Endocrine hypertension ; [... result of the First International Workshop on Endocrine Hypertension presented by the Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development and the Office of Rare Diseases, National Institutes of Health held on November 16, 2001 in Bethesda, Maryland]
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Endocrine hypertensionCatecholamines : bridging basic science with clinical medicinePheochromocytoma : first international symposiumEndocrine hypertension ; [... result of the First International Workshop on Endocrine Hypertension presented by the Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development and the Office of Rare Diseases, National Institutes of Health held on November 16, 2001 in Bethesda, Maryland]Advances in Pharmacology, 42 : Catecholamines - Bridging Basic Science with Clinical MedicineAdvances in pharmacologyCatecholamines : Bridging Basic Science with Clinical Medicine
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