WorldCat Identities

Fayer, Michael D.

Works: 57 works in 121 publications in 2 languages and 3,447 library holdings
Genres: Popular works 
Roles: Author, Editor, Compiler, Thesis advisor, Other, Honoree
Publication Timeline
Most widely held works by Michael D Fayer
Absolutely small : how quantum theory explains our everyday world by Michael D Fayer( )

13 editions published between 2010 and 2011 in English and Undetermined and held by 2,420 WorldCat member libraries worldwide

This book makes the field of quantum theory understandable to nonscientists, without oversimplifying and without bogging down in complicated math. It uses clear explanations, real-world examples, and diagrams instead of dense equations to help you understand
Elements of quantum mechanics by Michael D Fayer( Book )

12 editions published between 2001 and 2018 in English and Japanese and held by 310 WorldCat member libraries worldwide

Ultrafast infrared and Raman spectroscopy( Book )

13 editions published in 2001 in English and held by 303 WorldCat member libraries worldwide

A discussion of ultrafast infrared and Raman measurements. It covers procedures for probing bond activation, H-bonded systems, molecular dynamical mechanisms, vibrational dephasing, simple liquids, and proteins and energy flow effects using ultrafast vibrational spectroscopy experiments
Ultrafast infrared vibrational spectroscopy by Michael D Fayer( )

13 editions published in 2013 in English and held by 252 WorldCat member libraries worldwide

La 4e de couv. indique : "The advent of laser-based sources of ultrafast infrared pulses has extended the study of very fast molecular dynamics to the observation of processes manifested through their effects on the vibrations of molecules. In addition, non-linear infrared spectroscopic techniques make it possible to examine intra- and intermolecular interactions and how such interactions evolve on very fast time scales, but also in some instances on very slow time scales. Ultrafast Infrared Vibrational Spectroscopy is an advanced overview of the field of ultrafast infrared vibrational spectroscopy based on the scientific research of the leading figures in the field. The book discusses experimental and theoretical topics reflecting the latest accomplishments and understanding of ultrafast infrared vibrational spectroscopy. Each chapter provides background, details of methods, and explication of a topic of current research interest. Experimental and theoretical studies cover topics as diverse as the dynamics of water and the dynamics and structure of biological molecules. Methods covered include vibrational echo chemical exchange spectroscopy, IR-Raman spectroscopy, time resolved sum frequency generation, and 2D IR spectroscopy. Edited by a recognized leader in the field and with contributions from top researchers, including experimentalists and theoreticians, this book presents the latest research methods and results. It will serve as an excellent resource for those new to the field, experts in the field, and individuals who want to gain an understanding of particular methods and research topics."
Watching ultrafast molecular motions with 2d ir chemical exchange spectroscopy : selected works of M.D. Fayer by Michael D Fayer( Book )

5 editions published in 2011 in English and held by 44 WorldCat member libraries worldwide

Absolutely small : how quantum theory explains our everyday world by Michael D Fayer( )

4 editions published between 2010 and 2013 in English and held by 26 WorldCat member libraries worldwide

Absolutely small makes the field of quantum theory understandable to nonscientists, without oversimplifying and without bogging down in complicated math. It uses clear explanations, real-world examples, and diagrams instead of dense equations to help you understand
Absolutely Small How Quantum Theory Explains Our Everyday World by Michael D Fayer( )

in English and held by 20 WorldCat member libraries worldwide

Relaxation and transport of excitations in solids( Book )

3 editions published in 1988 in English and held by 11 WorldCat member libraries worldwide

Ultrafast Nonlinear Optical Investigations of Supercritical Fluids( Book )

4 editions published between 1997 and 2001 in English and held by 4 WorldCat member libraries worldwide

During the course of this grant, substantial progress in the investigation of dynamics and intermolecular interactions in supercritical fluids (SCFs) has been made. The project also included studies of liquids to provide understanding of the relationship between SCFs and normal liquids. The research utilized fast (ps) dynamical measurements of solutes in SCFs. The focus has been on experiments that can probe dynamics and interactions on the ground state potential surface. The first measurements of vibrational relaxation of polyatomic solutes in polyatomic SCFs have been made. These measurements are the first to examine dynamics near the SCF critical temperature. Previous bibrational dynamics measurements on systems, such as a diatomic in a rare gas, have been made far from the critical temperature. Measurements, such as fluorescence of large molecules, have also been conducted far from the critical temperature. Our vibrational relaxation experiments are performed using the ps infrared (IR) pump-probe method. As a precursor to future work, we have also made orientational relaxation polarization selective IR measurements in liquids and performed vibrational echo experiments in liquids
Protein dynamics of myoglobin : ultrafast infrared vibrational echo experiments by Michael D Fayer( Visual )

2 editions published in 1999 in English and held by 4 WorldCat member libraries worldwide

Biological fluorescence imaging on the nanoscale : STED super-resolution microscopy of cells and tissues by Lana Lau( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

A majority of biological microscopy investigations involve the focusing of visible light with conventional lenses. Fluorescence microscopy is one of the most widely used tools in biology but its resolution has historically suffered from the diffraction limit to about 200 nm laterally and 800 nm axially. In the past decade, this resolution problem has been overcome by the rapidly emerging field of super-resolution microscopy. The first demonstrated super-resolution technique, STimulated Emission Depletion (STED) Microscopy, is the topic of this Dissertation. This Dissertation has two primary areas of focus: the design optimization of a STED microscope, covered in Chapters 2-4, and its application to super-resolution imaging in cells and tissues, covered in Chapters 4-6. Chapter 2 describes the STED apparatus and experimental methods used. This chapter covers the guiding principles behind the design of a STED microscope, which forms a basis for understanding the logic underlying the homebuilt STED microscope which was constructed for this research. This STED microscope has a typical resolution of approximately 60 nm (full-width-at-half-maximum) or 25 nm (sigma) and has the sensitivity to image single fluorophores. In Chapter 3, a framework for evaluating and optimizing STED performance in the presence of several key tradeoffs is presented. Chapter 4 describes both developments in STED Microscopy required to utilize far-red-emitting dyes and the challenges associated with performing super-resolution imaging in intact Drosophila tissue. In Chapter 5, the optimization of labeling density revealed the 9-fold symmetry of a centriole protein structure, an important organelle in cell development. In Chapter 6, Huntingtin protein aggregates are resolved beyond the diffraction limit in a cell model of the neurodegenerative Huntington's disease
The development of techniques for three-dimensional super-resolution fluorescence microscopy and their application to biological systems by Michael Anthony Thompson( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Fluorescence microscopy is one of the most widely used tools in cell biology due its intrinsically high detection sensitivity coupled with the ability to genetically label proteins and other cellular structures with fluorescent tags. However, the resolution of fluorescence microscopy has historically been limited to about 200 nm laterally and 800 nm axially because of the diffraction limit of visible light. In the past five years, imaging below the diffraction limit ("super-resolution imaging") by localizing single fluorophores, one at a time (1-3), has opened a wide a variety of new biological systems for study. This Dissertation is a collection of both techniques for two and three dimensional super-resolution imaging as well as applications in bacterial and yeast imaging. References 1. Betzig E, et al (2006) Imaging intracellular fluorescent proteins at nanometer resolution. Science 313: 1642-1645. 2. Hess ST, Girirajan TPK & Mason MD (2006) Ultra-high resolution imaging by fluorescence photoactivation localization microscopy. Biophys J 91: 4258-4272. 3. Rust MJ, Bates M & Zhuang X (2006) Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Nat Methods 3: 793-795
Multi-Dimensional Ultrafast Infrared Vibrational Coherence Spectrometer( Book )

2 editions published in 2002 in English and held by 2 WorldCat member libraries worldwide

The Multi-Dimensional Ultrafast Infrared Vibrational Coherence Spectrometer has been constructed. The instrument divided into four subsections: 1. generation of ultrashort visible pulses, 2. generation of infrared (IR) pulses, 3. multiple beam propagation and sample excitation, 4. signal detection and processing. The figure shows a schematic of the instrument
Enhanced Vibrational Echo Correlation Spectrometer for the Study of Molecular Dynamics, Structures, and Analytical Applications( Book )

2 editions published in 2006 in English and held by 2 WorldCat member libraries worldwide

Funds from a DURIP equipment grant were used to augment the ultrafast IR 2D vibrational echo spectrometer. The major improvement involved a new dual MOT array detector composed of two 32 x 1 element MCT IR detector arrays. The dual array makes it possible to improve signal-to-noise ratio in the heterodyne detection of the vibrational echo signal. To implement the revamping of the system, new optics to implement the two beam geometry were put in place and precision translation stages required to control the path lengths to fractions of a wavelength of light obtained. The instrument has been used make the first measurements of ultrafast chemical exchange, making in possible to study fast solute solvent complex dynamics and isomerization in room temperature solutions under thermal equilibrium conditions
Ultrafast Multi-Dimensional Infrared Spectroscopy of Gases at Low and High Pressures( Book )

2 editions published in 2005 in English and held by 2 WorldCat member libraries worldwide

Infrared pump-probe experiments were used to study vibrational relaxation of polyatomic molecules in supercritical fluids and the gas phase. IR pump-probe experiments and theory were used to investigate hydrogen bond dynamics in oligomers of alcohols. Vibrational echo correlation spectroscopy (VECS) was developed and experiments were performed on molecules in liquids and gases. VECS is an ultrafast multidimensional approach that is in many respects the vibrational equivalent of multidimensional NMR. VECS experiments have been performed on molecules in liquids and gases. The OD hydroxyl stretch of HOD in water was studied and the results were compared to theoretical simulation models of water. The time evolution of the vibrational echo correlation spectrum reflects the structural evolution of the hydrogen bond networks in water. The experiments and theory provide detailed tests of water models. A gas cell for performing ultrafast infrared experiments was developed and the first vibrational echo correlation spectroscopy experiments were performed in the gas phase. VECS was also been demonstrated as a new type of analytical tool that can aid in sorting out congested vibrational spectra
Ultrafast Multidimensional Infrared Vibrational Echo Spectroscopy of Gases and Liquids( Book )

2 editions published in 2008 in English and held by 2 WorldCat member libraries worldwide

Ultrafast infrared 2D-IR vibrational echo experiments were extended experimentally and theoretically. Detailed studies of water dynamics were performed and compared to MD simulations. 2D-IR vibrational echo chemical exchange experiments were used to study the formation and dissociation kinetics of eight solute-solvent complexes, and the results were related to the enthalpies of formation. MD simulations of the chemical exchange were performed for the phenol-benzene complex and found to be in good agreement with the data. Chemical exchange experiments were used to measure the rate of gauche-trans orientational isomerization about a carbon-carbon single bond. The dynamics of molecules in the first solvation shell of solutes in mixed solvents were studied, and the time dependent solvent compositional fluctuations about solutes were elucidated. A detailed time dependent diagrammatic perturbation theory of the 2D-IR vibrational echo chemical exchange experiment including spectral diffusion, orientational relaxation, and vibrational relaxation was developed. An important new theoretical method for determining the dynamics from 2D-IR vibrational echo experiments was developed and demonstrated
Single-molecule and super-resolution in living cells by Hsiao-lu Lee( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Since the first successful detection single molecules over two decades ago, single-molecule spectroscopy has developed into a burgeoning field with a wealth of experiments at room temperature and inside living cells. Probing asynchronous and heterogeneous populations in situ, one molecule at a time, is not only desirable, but critical for many biological questions. Further, super-resolution imaging based on sequential imaging of sparse subsets of single molecules, has seen explosive growth within the last five years. This dissertation describes both the application of live-cell single-molecule imaging as an answer to important biological questions, and development and validation of fluorescent probes for targeted super-resolution imaging
Bayesian approaches to building models for biological systems by Jiakun Shi( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Understanding the structure and dynamics of biological macromolecules is a central focus of biological research. To be able to study and gain insights into these systems, it is first necessary to have an accurate and informative model for the system of interest. However, such a model is often difficult to build. For example, during protein folding, many proteins collapse into transient kinetic intermediates on timescales too fast for high-resolution experimental techniques to detect, preventing structural characterization of these species. Alternatively, current algorithms for RNA design (i.e. predicting a sequence that folds into a desired target structure) cannot accurately model structure-sequence relationships and rely primarily on brute force stochastic search, leading to poor performance on complex targets. Here, we show that it is possible to improve the quality of models for biological systems by applying a common Bayesian approach to building them, i.e. incorporating prior information to impose informative constraints on the model parameters. Through this approach, it is possible to build high-resolution models of protein dynamics given limited experimental data, as well as a state-of-the-art computational RNA design agent that outperforms all currently existing algorithms
Application and characterization of optogenetic systems based on cryptochrome 2/CIB1 by Liting Duan( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Various cellular processes are dependent on the regulation of protein activities. In particular, some cellular processes, including migration, division and differentiation, require sophisticated coordination of protein activities in space and time. Therefore, a method capable of perturbing protein activities with precise spatial and temporal control is indispensable for understanding cellular behaviors. However, conventional means, such as genetic or pharmacological perturbation, are either relatively slow to implement, difficult to design, or spatiotemporally uncontrollable. Approaches using inducible chemical genetic enable the control of protein activities by using chemical inducers to trigger engineered proteins. However, these approaches suffer from irreversibility and cannot achieve spatial control. The emerging area of optogenetic actuators provides opportunities to temporally and spatially regulate protein activities. Several pairs of light-induced dimerization proteins have been developed, including the light-oxygen-voltage domain, phytochrome B and cryptochrome 2 (CRY2). CRY2 and its binding partner CIB1 are the optogenetic dimerizers utilized in my research due to their rapidness, reversibility and no need for exogenous cofactor. In my thesis, I develop the optogenetic strategies to optically manipulate two processes: signaling pathway and organelle activity, both of which are determined by protein activities. The light-induced CRY2/CIB1 interaction is complicated by the light-induced CRY2 homo-oligomerization. Therefore, in this thesis, I also study the dual characteristics of CRY2 homo-oligomerization and hetero-dimerization. This thesis consists of three chapters. In the first chapter, I demonstrate the strategies designed to optically activate the RAF/ERK and AKT/FOXO signaling pathways with temporal control, which can help to dissect and resolve the signaling pathways in a quantitative manner. Next, I construct an optogenetic method that exploits light to manipulate organelle distribution and reshaping with reversibility and subcellular spatial precision. This method will be useful to establish a direct linkage between organelle distribution/shaping and cellular functions. Finally, I characterize the CRY2 homo-oligomerization and its interplay with CRY2/CIB1 hetero-dimerization. The results can serve as a guide to the usage of CRY2/CIB1 system
Long-lived probes to study the dynamics of liquid crystals by ultrafast infrared vibrational spectroscopy by Kathleen P Sokolowsky( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Nematic liquid crystals have been widely studied in the context of practical applications and the nature of phase transitions. Above the nematic-isotropic phase transition temperature (TNI), orientational fluctuations are correlated; the existence of these pseudonematic domains in the isotropic phase dominate the dynamic properties of the bulk liquid. To examine the influence of pseudonematic ordering on the local dynamics, ultrafast infrared (IR) spectroscopies were employed. Two dimensional (2D) vibrational echo spectroscopy supplies information on the spectral diffusion of a vibrational probe molecule. Spectral diffusion is the process by which the frequency of an oscillator changes as the liquid structure about it evolves; it is characterized by the frequency-frequency correlation function (FFCF). The FFCF directly relates the frequency fluctuations of the probe molecule to the dynamics of the liquid structure surrounding it. The model nematic liquid crystal system selected is 4-cyano-4'-pentylbiphenyl (5CB); 5CB contains a nitrile group which can act as the vibrational probe. Examination of the natural abundance carbon-13 nitrile stretch allows for thicker samples, mitigating heating effects. Unfortunately, the vibrational lifetime of the carbon-13 stretch is short, and spectral diffusion is not nearly complete in the experimental window. Two novel extended lifetime vibrational probes similar in structure to 5CB were synthesized. A small amount of either molecule can be added to 5CB to probe the local structure dynamics. OHD-OKE experiments were performed on the doped solutions confirm that the addition of vibrational probe molecule does not significantly perturb the pseudonematic domains of 5CB. Temperature dependent 2D IR experiments were conducted on 5CB and 4-pentylbiphenyl (5B). 5B is molecularly very similar to 5CB, but is not a liquid crystal. The spectral diffusion dynamics in the two liquid are remarkably similar far removed from the liquid crystal phase transition. Close to TNI, the dynamics in 5CB slow down dramatically. The time constants for spectral diffusion are shown to diverge as a[T*/(T-T*)]^1/2. The temperature dependence of the time constants matches that of the size of the pseudonematic domains, not the orientational relaxation time for the domains. Two more liquid crystals are shown to have the same behavior approaching their respective phase transitions, suggesting the divergence may be universal for rod-shaped nematogens. Even at temperatures very close to TNI, spectral diffusion in liquid crystals is complete on the order of a few nanoseconds. This is drastically different than the time for total orientational relaxation which is multiple orders of magnitude slower. The complete randomization of pseudonematic domains is not required for the vibrational probe to sample all structures that contribute to the inhomogeneous line shape. A mode coupling model is constructed for the FFCF to describe spectral diffusion in terms of coupling to large wave vector density fluctuations and orientational fluctuations. The source of spectral diffusion is proposed to be small wave vector density fluctuations, which critically slow as TNI is approached
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Absolutely small : how quantum theory explains our everyday world
Elements of quantum mechanicsUltrafast infrared and Raman spectroscopyWatching ultrafast molecular motions with 2d ir chemical exchange spectroscopy : selected works of M.D. Fayer
Alternative Names
Fayer, M. D.

Fayer, M. D. 1947-

Michael D. Fayer American chemist

Michael D. Fayer Amerikaans scheikundige

Michael D. Fayer US-amerikanischer Chemiker