Schlichting, I. (Ilme) 1960-
Overview
| Works: | 24 works in 37 publications in 4 languages and 257 library holdings |
|---|---|
| Genres: | Conference papers and proceedings |
| Roles: | Author, dgs, Other, Editor |
Publication Timeline
.
Most widely held works by
I Schlichting
Data mining in structure biology : signal transduction and beyond : with 37 figures and 14 tables by
I Schlichting(
Book
)
10 editions published between 2001 and 2014 in English and held by 228 WorldCat member libraries worldwide
This book combines in a comprehensive manner the results of biochemical studies, structural biology investigations and small molecule design within some of the protein classes that play major roles in signal transduction: the protein kinases, the growth factor family and the transcription factors. It is described how these proteins communicate with each other via different signalling pathways. Three-dimensional structures of these proteins are presented, and their interaction with small molecules and co-factors are described. The use of these proteins for pharmaceutical research and the design of small molecules and their selectivity towards such proteins are discussed
10 editions published between 2001 and 2014 in English and held by 228 WorldCat member libraries worldwide
This book combines in a comprehensive manner the results of biochemical studies, structural biology investigations and small molecule design within some of the protein classes that play major roles in signal transduction: the protein kinases, the growth factor family and the transcription factors. It is described how these proteins communicate with each other via different signalling pathways. Three-dimensional structures of these proteins are presented, and their interaction with small molecules and co-factors are described. The use of these proteins for pharmaceutical research and the design of small molecules and their selectivity towards such proteins are discussed
Zeitaufgelöste mechanistische Röntgenstrukturanalysen zur Dynamik der Ligandenbindung an Myoglobin und des Substrate Channeling
in Tryptophan Synthase : Förderzeitraum: 01.04.1995-31.03.1998(
)
2 editions published between 1998 and 1999 in German and held by 3 WorldCat member libraries worldwide
2 editions published between 1998 and 1999 in German and held by 3 WorldCat member libraries worldwide
Zeitaufgelöste mechanistische Röntgenstrukturanalysen zum Mechanismus des Substrate channeling in Tryptophan Synthase BMBF-Förderschwerpunkt:
Erforschung der kondensierten Materie ; Großgeräte der physikalischen Grundlagenforschung ; [Schlussbericht] ; Förderzeitraum:
01.04.98 - 31.03.01(
)
2 editions published in 2001 in German and held by 3 WorldCat member libraries worldwide
2 editions published in 2001 in German and held by 3 WorldCat member libraries worldwide
Biophysikalische Studien am ras-Onkogenprodukt p21H [pH] by
I Schlichting(
Book
)
1 edition published in 1989 in German and held by 2 WorldCat member libraries worldwide
1 edition published in 1989 in German and held by 2 WorldCat member libraries worldwide
Consolidation des berges des canaux : rapport(
Book
)
1 edition published in 1892 in French and held by 2 WorldCat member libraries worldwide
1 edition published in 1892 in French and held by 2 WorldCat member libraries worldwide
Time-resolved imaging of macromolecular processes and interactions(
Book
)
3 editions published in 2004 in English and held by 2 WorldCat member libraries worldwide
3 editions published in 2004 in English and held by 2 WorldCat member libraries worldwide
Untersuchungen über die physiologische Spezialisierung des Weizenmehltaus, Erysiphe graminis tritici (D.C.), in Deutschland by
I Schlichting(
Book
)
1 edition published in 1938 in German and held by 1 WorldCat member library worldwide
1 edition published in 1938 in German and held by 1 WorldCat member library worldwide
Simple and efficient system for photoconverting light-sensitive proteins in serial crystallography experiments(
)
1 edition published in 2017 in English and held by 1 WorldCat member library worldwide
Abstract : The design and application of an enclosed micro-device for generating laser-induced semi-stationary states in light-sensitive microcrystals are described. The setup is suitable for time-resolved serial crystallography at synchrotrons and X-ray free-electron lasers. Abstract : Proteins that change their structure in response to light absorption regulate many functional processes in living cells. Moreover, biotechnological approaches like optogenetics and super-resolution fluorescence microscopy recently triggered the generation of new genetically modified photosensitive proteins. Light-induced structural changes in photosensitive proteins can be studied by time-resolved serial femtosecond crystallography (SFX), an X-ray diffraction technique that allows the determination of macromolecular structures at X-ray free-electron lasers from a large number of nano- to micro-sized crystals. This article describes a simple and efficient system for converting photosensitive proteins into light-induced semi-stationary states by inline laser illumination prior to sample injection with a gas-focused liquid jet and subsequent optical pump-X-ray probe exposure. The simple setup of this device makes it suitable for integration into other liquid injectors (like electro-spinning and electro-kinetic injectors) and potentially also in high-viscosity extruders, provided that embedding microcrystals in viscous media does not alter protein photophysical properties. The functioning of the device is demonstrated with an example of a photoswitchable fluorescent protein pre-illuminated (photoactivated) for time-resolved SFX experiments. The device can be easily adapted for the conversion in time-resolved SFX experiments of other microcrystalline proteins, such as photosystems, phytochromes and rhodopsins
1 edition published in 2017 in English and held by 1 WorldCat member library worldwide
Abstract : The design and application of an enclosed micro-device for generating laser-induced semi-stationary states in light-sensitive microcrystals are described. The setup is suitable for time-resolved serial crystallography at synchrotrons and X-ray free-electron lasers. Abstract : Proteins that change their structure in response to light absorption regulate many functional processes in living cells. Moreover, biotechnological approaches like optogenetics and super-resolution fluorescence microscopy recently triggered the generation of new genetically modified photosensitive proteins. Light-induced structural changes in photosensitive proteins can be studied by time-resolved serial femtosecond crystallography (SFX), an X-ray diffraction technique that allows the determination of macromolecular structures at X-ray free-electron lasers from a large number of nano- to micro-sized crystals. This article describes a simple and efficient system for converting photosensitive proteins into light-induced semi-stationary states by inline laser illumination prior to sample injection with a gas-focused liquid jet and subsequent optical pump-X-ray probe exposure. The simple setup of this device makes it suitable for integration into other liquid injectors (like electro-spinning and electro-kinetic injectors) and potentially also in high-viscosity extruders, provided that embedding microcrystals in viscous media does not alter protein photophysical properties. The functioning of the device is demonstrated with an example of a photoswitchable fluorescent protein pre-illuminated (photoactivated) for time-resolved SFX experiments. The device can be easily adapted for the conversion in time-resolved SFX experiments of other microcrystalline proteins, such as photosystems, phytochromes and rhodopsins
Consolidation des berges des canaux. av. 1 pl by
I Schlichting(
Book
)
1 edition published in 1892 in French and held by 1 WorldCat member library worldwide
1 edition published in 1892 in French and held by 1 WorldCat member library worldwide
Light induced charge and energy transport in nucleic acids and proteins: general discussion(
)
1 edition published in 2018 in English and held by 1 WorldCat member library worldwide
1 edition published in 2018 in English and held by 1 WorldCat member library worldwide
Structure of a photosynthetic reaction centre determined by serial femtosecond crystallography by
Linda C Johansson(
)
1 edition published in 2013 in English and held by 1 WorldCat member library worldwide
Serial femtosecond crystallography is an X-ray free-electron-laser-based method with considerable potential to have an impact on challenging problems in structural biology. Here we present X-ray diffraction data recorded from microcrystals of the Blastochloris viridis photosynthetic reaction centre to 2.8 angstrom resolution and determine its serial femtosecond crystallography structure to 3.5 angstrom resolution. Although every microcrystal is exposed to a dose of 33MGy, no signs of X-ray-induced radiation damage are visible in this integral membrane protein structure
1 edition published in 2013 in English and held by 1 WorldCat member library worldwide
Serial femtosecond crystallography is an X-ray free-electron-laser-based method with considerable potential to have an impact on challenging problems in structural biology. Here we present X-ray diffraction data recorded from microcrystals of the Blastochloris viridis photosynthetic reaction centre to 2.8 angstrom resolution and determine its serial femtosecond crystallography structure to 3.5 angstrom resolution. Although every microcrystal is exposed to a dose of 33MGy, no signs of X-ray-induced radiation damage are visible in this integral membrane protein structure
Bionanophotonics: general discussion(
)
1 edition published in 2018 in English and held by 1 WorldCat member library worldwide
1 edition published in 2018 in English and held by 1 WorldCat member library worldwide
Light induced damage and repair in nucleic acids and proteins: general discussion(
)
1 edition published in 2018 in English and held by 1 WorldCat member library worldwide
1 edition published in 2018 in English and held by 1 WorldCat member library worldwide
Catechesis ecclesiarum polonicarum : primo anno 1609 in lucem emissa by
Johann Crell(
)
1 edition published in 1659 in Latin and held by 1 WorldCat member library worldwide
1 edition published in 1659 in Latin and held by 1 WorldCat member library worldwide
Biophysikalische Studien am ras-Onkogenprodukt p21_1hnH [pH] by
I Schlichting(
)
1 edition published in 1989 in German and held by 1 WorldCat member library worldwide
1 edition published in 1989 in German and held by 1 WorldCat member library worldwide
Data mining in structural biology : signal transduction and beyond(
Book
)
1 edition published in 2001 in English and held by 1 WorldCat member library worldwide
1 edition published in 2001 in English and held by 1 WorldCat member library worldwide
Structural characterization of cell surface receptors involved in axon guidance by
Magda Chegkazi(
)
1 edition published in 2017 in English and held by 1 WorldCat member library worldwide
1 edition published in 2017 in English and held by 1 WorldCat member library worldwide
Spiers Memorial Lecture. Introductory lecture: the impact of structure on photoinduced processes in nucleic acids and proteins(
)
1 edition published in 2018 in English and held by 1 WorldCat member library worldwide
Abstract : This review gives an overview of the impact of structure on the understanding of photoinduced processes in macromolecules, focusing on systems presented at this Faraday Discussion meeting. Abstract : Light is an important environmental variable and most organisms have evolved means to sense, exploit or avoid it and to repair detrimental effects on their genome. In general, light absorption is the task of specific chromophores, however other biomolecules such as oligonucleotides also do so which can result in undesired outcomes such as mutations and cancer. Given the biological importance of light-induced processes and applications for imaging, optogenetics, photodynamic therapy or photovoltaics, there is a great interest in understanding the detailed molecular mechanisms of photoinduced processes in proteins and nucleic acids. The processes are typically characterized by time-resolved spectroscopic approaches or computation, inferring structural information on transient species from stable ground state structures. Recently, however, structure determination of excited states or other short-lived species has become possible with the advent of X-ray free-electron lasers. This review gives an overview of the impact of structure on the understanding of photoinduced processes in macromolecules, focusing on systems presented at this Faraday Discussion meeting
1 edition published in 2018 in English and held by 1 WorldCat member library worldwide
Abstract : This review gives an overview of the impact of structure on the understanding of photoinduced processes in macromolecules, focusing on systems presented at this Faraday Discussion meeting. Abstract : Light is an important environmental variable and most organisms have evolved means to sense, exploit or avoid it and to repair detrimental effects on their genome. In general, light absorption is the task of specific chromophores, however other biomolecules such as oligonucleotides also do so which can result in undesired outcomes such as mutations and cancer. Given the biological importance of light-induced processes and applications for imaging, optogenetics, photodynamic therapy or photovoltaics, there is a great interest in understanding the detailed molecular mechanisms of photoinduced processes in proteins and nucleic acids. The processes are typically characterized by time-resolved spectroscopic approaches or computation, inferring structural information on transient species from stable ground state structures. Recently, however, structure determination of excited states or other short-lived species has become possible with the advent of X-ray free-electron lasers. This review gives an overview of the impact of structure on the understanding of photoinduced processes in macromolecules, focusing on systems presented at this Faraday Discussion meeting
Epsilon/zeta toxin-antioxin systems in gram-negative bacteria by
Andrea Rocker(
)
1 edition published in 2016 in English and held by 1 WorldCat member library worldwide
1 edition published in 2016 in English and held by 1 WorldCat member library worldwide
I.1ère question à 4ème question : les berges des canaux : rapports : Vème congrès international de navigation intérieure
: Consolidation des beregs des canaux : rapport : consolidation des berges des canaux dans la région du Nord de la France
: consolidation des berges des canaux des Pays-Bas : sur quelques travaux de consolidation des berges des canaux exécutés
en Russie : alimentation des canaux de la Belgique : alimentation des canaux principalement dans l'est de la France : moyens
employés en Italie pour l'étanchement des canaux : les réservoirs dans les Indes anglaises : réservoirs établis en Espagne
: les réservoirs dans le Midi de la France : les réservoirs du département de la Haute-Marne : les réservoirs d'alimentation
: canal du Centre et canal de Bourgogne : considérations sur les grands barrages en maçonnerie by
I Schlichting(
Book
)
1 edition published in 1892 in French and held by 1 WorldCat member library worldwide
1 edition published in 1892 in French and held by 1 WorldCat member library worldwide
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