WorldCat Identities

University of Texas at Houston

Overview
Works: 54 works in 72 publications in 2 languages and 93 library holdings
Genres: Popular works  Educational films  Nonfiction films 
Roles: Researcher
Classifications: RG580.D5, 618.3
Publication Timeline
.
Most widely held works about University of Texas at Houston
 
Most widely held works by University of Texas at Houston
Radiation-induced micrencephaly in guinea pigs( )

1 edition published in 1992 in English and held by 5 WorldCat member libraries worldwide

The effect of x rays on brain weight of guinea pig pups at birth was studied for 21-day old embroys exposed in utero to doses of 75 and 100 mGy. When compared to controls and when corrected for body weight, gestation time, litter size, sex, and examiner differences the brains of irradiated pups weighed approximately 46 mg less than those of controls (p<0.001) for the 75-mGy group and about 55 mg less for the 100-mGy group. Brains of females weighed 51 mg less than those of males of the same body weight. Dam weight and caging conditions had no observed effect on brain weight
Radiation-induced micrencephaly in guinea pigs( )

1 edition published in 1992 in English and held by 5 WorldCat member libraries worldwide

The effect of x rays on brain weight of guinea pig pups at birth was studied for 21-day old embroys exposed in utero to doses of 75 and 100 mGy. When compared to controls and when corrected for body weight, gestation time, litter size, sex, and examiner differences the brains of irradiated pups weighed approximately 46 mg less than those of controls (p<0.001) for the 75-mGy group and about 55 mg less for the 100-mGy group. Brains of females weighed 51 mg less than those of males of the same body weight. Dam weight and caging conditions had no observed effect on brain weight
Radiation induced micrencephaly in guinea pigs( )

1 edition published in 1991 in English and held by 5 WorldCat member libraries worldwide

A brain weight deficit of about 70 mg was induced at doses of approximately 75-mGy and a deficit of 60 mg was induced at 100 mGy. This confirms the effects projected and observed by Wanner and Edwards. Although the data do not demonstrate a clear dose-response relationship between the 75-mGy and 100-mGy groups, the data are statistically consistent with a dose-response effect because of the overlapping confidence intervals. The lack of a statistically significant observation is most likely related to the small difference in doses and the limited numbers of animals examined. There are several factors that can influence the brain weight of guinea pig pups, such as caging and housing conditions, the sex of the animal, and litter size. These should be taken into account for accurate analysis. Dam weight did not appear to have a significant effect. The confirmation of a micrencephalic effect induced x rays at doses of 75-mGy during this late embryonic stage of development is consistent with the findings of small head size induced in those exposed prior to the eight week of conception at Hiroshima. This implies a mechanism for micrencephaly different from those previously suggested and lends credence to a causal relation between radiation and small head size in humans at low doses as reported by Miller and Mulvihill. 16 refs., 13 tabs
The Texas Constitution : an annotated and comparative analysis by George D Braden( Book )

1 edition published in 1974 in English and held by 4 WorldCat member libraries worldwide

Characterization of CTL Recognized Epitopes on Human Breast Tumors( )

4 editions published between 1995 and 1999 in English and held by 4 WorldCat member libraries worldwide

Studies during the last granting period were focused on the activating ability of tumor Ag identified from HER-2 and FBP for T cells from breast cancer patients. Ongoing studies focuses on improvement of Ag presentation and enhanced activation of CTL functions concludes that: (1) IL-l2 is required for early and rapid IFN- induction in response to tumor Ag. This was established using both randomly selected breast cancer patients, and patients vaccinated with HER-2 tumor Ag, E75 using GM-CSF as adjuvant; (2) Tumor Ag such as E75 induce the angiostatic/anti-angiogenic chemokine IP-lO from responder lymphocytes (3). Enhanced Ag presentation and immunogenicity can be achieved by inducing Ser/Thr phosphorylation of HER-2
Cuidese : comprendiendo la labor de parto prematura( Visual )

1 edition published in 1991 in Spanish and held by 4 WorldCat member libraries worldwide

Discussion of preterm labor signs & synptoms and how to deal with the problem
Take care : understanding preterm labor( Visual )

1 edition published in 1987 in English and held by 3 WorldCat member libraries worldwide

Describes the warning signs, precautions and treatment that can help prevent a premature birth
Genomic Instability at Premalignant and Early Stages of Breast Cancer Development( )

3 editions published between 1995 and 1997 in English and held by 3 WorldCat member libraries worldwide

We have developed techniques that allow the analysis of multiple chromosomal loci from single paraffin sections from breast cancer lesions. This approach is being used to allelotype small preinvasive breast cancer lesions. We identified the chromosome arms most frequently affected by allelic losses and imbalances at preinvasive stages of breast carcinogenesis and those allelic losses involved in more advanced stages of progression. We have now performed a high resolution allelotype of chromosome 16q. This allowed us to refine the location of specific subchromosome regions containing putative tumor suppressor genes of relevance on early breast carcinogenesis. We also performed a chromosome 16 high resolution allelotype of a panel of human breast cancer lines in order to identify areas of hemizygosity and homozygous loss. As a natural and important extension of these studies we have built a contig of yeast artificial chromosome (YAC) and bacterial artificial chromosome (BAC) clones spanning the chromosome 16q region in which frequent allelic losses were detected. In studies in progress we have isolated numerous cDNA clones from a human breast epithelial library that map to the region of interest
Bacterially induced precipitation of CaCO₃ : an example from studies of cyanobacterial mats. Final report( )

1 edition published in 1990 in English and held by 3 WorldCat member libraries worldwide

Bacteria induce the precipitation of calcium carbonate in the laboratory and in nature by altering their chemical environment. Geologists are recognizing the possibility that bacterially induced precipitates may form significant mineral deposits, unfortunately, there are currently no sound criteria by which they can be recognized in recent sediments, or in the rock record. Cultures of aerobic and facultative bacteria from cyanobacterial mats on Andros Island, Bahamas, and Baffin Bay, Texas, induced the precipitation of calcium carbonate under controlled conditions. Crusts, the largest features formed, are composed of 5--200[mu]m diameter bundles which are, in turn, composed of numerous individual crystals. The smallest observed features are 0.1--0.4[mu]m spheres and rods which comprise some individual crystals and crystal bundles. Crystal bundles resembling rhombohedra, tetragonal disphenoids, tetragonal dipyramids, and calcite dumbbells appear to be uniquely bacterial in origin, and they have all been observed in recent sediments. Swollen rods, discs, curved dumbbells, and 50--200[mu]m optically continuous crystals resembling brushes may be uniquely bacterial in origin, however, they have not been reported by other laboratories nor observed in natural settings. Presence of any of these forms in recent sediments should be taken as strong evidence for bacterial influence. Spheres and aragonite dumbbells have also been observed in natural environments, however, they are not always bacterial in origin. Precipitation of calcium carbonate occurs preferentially on dead cyanobacteria in the presence of bacteria. Lithification of algal mats to form stromatolites may take place in the zone of decaying organic matter due to bacterial activity
Role of the Mammary Adenocarcinoma Cell Transferrin Response in Breast Cancer Metastasis( )

3 editions published between 1996 and 1998 in English and held by 3 WorldCat member libraries worldwide

Rior to the grant, we had found that breast cancer expression of the transferrin receptor (TfR) and concomitant response to transferrin correlated with the metastatic capabilities of the cells. The purpose of the grant was to test this by purposefully altering breast cancer cell TfR expression, and to determine the effects of this on their metastatic behavior. In addition, the creation of and assessment of self-Tf producing cells was proposed as well as the testing of some known TfR modulators on breast cancer cell TfR level. In a rat breast cancer cell model, lab-induced elevation of cellular TfR by selection or transfection techniques caused an increase in metastatic capability, proving the major aims of the grant. Attempts to decrease TfR expression by antisense TfR transfection were met with major roadblocks, however, successful accomplishment of this was performed in vitro. A plasmid containing the human Tf cDNA was unable to confer Tf production in transfected cells. Interleukins which have major TfR level modulating effects on certain immune and other cells were found not to fluctuate breast cancer cell TfR levels
The Role of Integrins in Breast Cancer Metastasis( Book )

2 editions published in 1998 in English and held by 2 WorldCat member libraries worldwide

Our objective is to investigate the role of cell surface integrins in metastasis of human breast cancer. Integrins play an important role in cell adhesions and interactions with extracellular matrix proteins and the maintenance of differentiation. Variants of the human breast cancer cell line MDA-MB-435 were selected for different levels of alpha6 integrin expression. High alpha6-expressing clones showed enhanced binding to laminin in vitro. These cells were also more metastatic to the lungs of nude mice than the clones with low expression of the integrin. The alpha6 integrin dimerizes with beta1 in this cell line, while in the majority of human breast cancer cell lines studied a6 preferentially dimerizes with the beta4 subunit. MDA-MB-435 cells lack beta4 protein, possibly due to alternate splicing of beta4 RNA transcript. The alternate form was sequenced and found to be novel. Both wild-type and alternate forms were seen in RT-PCR products, yet no protein was detected in FACS analyses for surface expression. Study of a panel of human breast cancer cell lines revealed a relationship between high alpha6 expression and malignant growth and metastasis in nude mice. The results support the hypothesis that a6 integrin expression on breast cancer cells promotes invasion and metastasis
P/CAF Function in Transcriptional Activation by Steroid Hormone Receptors and Mammary Cell Proliferation( Book )

2 editions published in 1998 in English and held by 2 WorldCat member libraries worldwide

Inappropriate gene expression and abnormal progression of the cell cycle are intimately linked to oncogenesis and tumor formation. The purpose of this proposal is to examine the role of the PCAF histone acetyltransferase as a co-factor for steroid hormone receptors in the regulation of gene expression. Five specific aims define the scope of our project: 1) to complete the isolation and cloning of mouse PCAF cDNA and genomic sequences 2) to characterize PCAF as a histone acetyltransferase 3) to examine PCAF interactions with specific steroid receptors 4) To examine whether acetyltransferase activity is required for transcriptional activation by steroid hormone receptors 5) to create mice deficient for PCAF and mice that overexpress this factor to assess the role of PCAF in mouse development, differentiation, or tumorigenesis. In the past year we have largely completed the first and second aims of our project and have made good progress towards experiments described in the fifth specific aim as well. We have also discovered that another protein, GCN5 is highly similar to PCAF in both structure and acetyltransferase functions. We conclude that both proteins are important transcriptional regulators and will expand our aims to include studies of GCN5 as well as PCAF in steroid hormone responses
Studies on the Biologies of Mosquito Species Incriminated as Vectors of Keystone Virus in Houston, Texas( Book )

1 edition published in 1973 in English and held by 2 WorldCat member libraries worldwide

This investigation was undertaken to obtain data on the woodland mosquitoes in sufficient detail to characterize, ecologically and behaviorally, the most common species. The specific goals were: (1) to find taxonomic characters for separating all life stages of the woodland mosquitoes; (2) to provide detailed biological information on A. atlanticus, A. tormentor, and associated species relevant to their distribution in time and space; and (3) to analyze the findings in the context of the epidemiology of KEY virus. The attainment of these objectives was accomplished through an integrated program of field and laboratory studies. Quantitative samples of all life stages were taken at a woodland area, with an adjoining field, located at the University of Houston Gulf Coast Research Station. The laboratory studies were conducted at The University of Texas School of Public Health. This investigation was part of an over-all effort to elucidate certain aspects of the ecology of the CEV group in the Houston, Texas area and all adult mosquitoes collected during these studies were processed for virus isolation. This effort resulted in a number of isolation of members of the CEV group from mosquitoes, in addition to those obtained from a concurrently operated sentinel rabbit program. The sentinel rabbit program was particularly rewarding during the spring period of peak mosquito abundance
Treatment of Metastatic Breast Carcinoma Refractory to Doxorubicin With Liposomal-Annamycin( Book )

2 editions published in 1997 in English and held by 2 WorldCat member libraries worldwide

Annamycin is a non-cross resistant doxorubicin analog that is formulated in a liposomal carrier. We have completed a phase I study and initiated a phase II study of liposomal Annamycin in patients with metastatic breast carcinoma. The maximum tolerated dose was 210/mg/m2. The limiting toxicity was myelosuppression. Other toxicities were limited to allergic reactions. No significant cardiotoxicity, alopecia, mucositis, nor gastrointestinal toxicity have been observed. No antitumor responses were observed in the Phase I study. Three patients have been accrued in the Phase II study. Tumor tissue is being stored for determination of MDR-1 and MRP status at baseline and after therapy
The p16 Pathway in Breast Cancer and Senescence Control( Book )

2 editions published in 1998 in English and held by 2 WorldCat member libraries worldwide

The p16INK4a protein, hereafter referred to as pl6, is a known negative regulator of cell cycle progression through its cyclin dependent kinase (CDK) inhibiting function (1). pl6 competes with the activating D type cyclins for association with CDK4 or CDK6, thereby preventing phosphorylation of proteins controlling Ol exit such as the retinoblastoma (Rb) protein (2). Inactivation of p16 has been observed in numerous tumor types (3-8), and lack or reduced expression of p16 has also been shown through a variety of technical approaches to occur in at least 50% of the breast cancer samples examined (9, 10). While these findings suggest that p16 may play an important role in breast tumorigenesis, the consequence of such abberrations of p16 are not yet clear
Gestational diabetes by Judy Grisell( Visual )

1 edition published in 1989 in English and held by 2 WorldCat member libraries worldwide

Discussion of how to deal with gestational diabetes
Importance of USF in Breast Cancer( Book )

2 editions published in 1998 in English and held by 2 WorldCat member libraries worldwide

USF is a family of transcription factors that can antagonize the activity of the Myc oncoproteins in cellular proliferation and transformation. The abundance and activity of the USF proteins in normal and tumorigenic breast epithelial cells were analyzed. All cell lines tested contained similar USF DNA-binding activity and similar expression levels of the ubiquitous USFl and USF2 polypeptides. In MCF-lOA, a normal breast epithelial cell line, the USF proteins acted as strong transcriptional activators at promoters containing USF-specific binding sites. In contrast, the transcriptional activity of USF was either decreased or absent in several breast cancer cell lines. This partial or complete loss of USF function is likely to contribute to the uncontrolled proliferation and tumorigenicity of breast cancer cells
Mdm2 Function in Tumorigenesis( Book )

2 editions published in 1997 in English and held by 2 WorldCat member libraries worldwide

To examine mdm2 function in vivo, we have performed experiments in two mouse models. The mdm2 null mouse is an embryo lethal whose phenotype is completely rescued in the absence of p53. Analysis if the embryos indicate that they are dying by apoptosis. Analysis of mice null for p53 and the presence or absence of the mdm2 gene indicate a longer tumor latency in p53-/-mdm2+/- mice. In addition, these mice exhibit an increase in sarcomas with a concomitant decrease in lymphomas. We have also analyzed transgenic mice that overexpress mdm2 in the breast epithelium and find that the mammary epithelial cells undergo multiple rounds of DNA synthesis without cell division. Importantly, this phenomenon is independent of p53 suggesting novel functions for MDM2. Th mammary epithelial cells are overexpressing cyclin A, but not cyclin B suggesting that the cells never exit S-phase. The S-phase transcription factor that binds MDM2, E2F1, appears to have no role in this defect
Practice variations in pain control at the end of life : abstract, executive summary, and final report by Charles S Cleeland( Book )

1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide

Disaster Relief and Emergency Medical Services Project (DREAMS TM) : clinical and basic science projects( Book )

2 editions published in 1999 in English and held by 2 WorldCat member libraries worldwide

DREAMS clinical and basic science projects complement the digital EMS effort by investigating the mechanisms of tissue injury in order to minimize the mortality and mortality of trauma and "natural" injuries such as heart attacks. We have a broad effort aimed at the major problems: oxidation (common to resuscitation/reperfusion injuries of heart, brain, liver and kidney), toxins, apoptosis, inflammation, cell proliferation and angiogenesis. We have made progress in understanding the genes controlling anthrax, and those of the human P450 defense system; we have developed new probes to help interventionalists and surgeons diagnose tissue types and distinguish inflammation and necrosis in real time; a field implantable pump has been developed to boost cardiac output in order to prevent the viscous cycle of low cardiac output causing ischemia; we have increased our understanding of the denitration of NO (the gas that regulated blood pressure, clotting, oxidant defense against microbes, nerve Cell communication, cell proliferation and death); we have learned more about the roles played by PPAR gamma, ICAM1, E-selectin and VCAM1 in inflammation, finally, we have learned new ways to introduce genes into cells and have demonstrated new possibilities in gene therapy while uncovering new problems with a current technique of gene therapy
 
moreShow More Titles
fewerShow Fewer Titles
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.74 (from 0.21 for Cuidese : ... to 0.97 for Studies on ...)

Alternative Names
Texas Univ. at Houston

University of Texas, Houston

Languages