WorldCat Identities

Kho, Alvin T.

Overview
Works: 11 works in 38 publications in 2 languages and 1,605 library holdings
Roles: Author, Contributor
Publication Timeline
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Most widely held works by Alvin T Kho
Microarrays for an integrative genomics by Isaac S Kohane( )

26 editions published between 2001 and 2005 in English and held by 1,586 WorldCat member libraries worldwide

Functional genomics--the deconstruction of the genome to determine the biological function of genes and gene interactions--is one of the most fruitful new areas of biology. The growing use of DNA microarrays allows researchers to assess the expression of tens of thousands of genes at a time. This quantitative change has led to qualitative progress in our ability to understand regulatory processes at the cellular level.This book provides a systematic introduction to the use of DNA microarrays as an investigative tool for functional genomics. The presentation is appropriate for readers from biology or bioinformatics. After presenting a framework for the design of microarray-driven functional genomics experiments, the book discusses the foundations for analyzing microarray data sets, genomic data-mining, the creation of standardized nomenclature and data models, clinical applications of functional genomics research, and the future of functional genomics
Tōgō genomikusu no tameno maikuroarei dēta anarishisu( Book )

3 editions published between 2004 and 2012 in Japanese and held by 3 WorldCat member libraries worldwide

Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy by Michael J McGeachie( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Platform dependence of inference on gene-wise and gene-set involvement in human lung development by Rose Du( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

Circulating microRNAs and prediction of asthma exacerbation in childhood asthma by Alvin T Kho( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age by Simon Kebede Merid( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Vitamin D related genes in lung development and asthma pathogenesis by Alvin T Kho( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes by Alvin T Kho( )

1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

Expression analysis of asthma candidate genes during human and murine lung development by Erik Melén( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Microarrays for an Integrative Genomics (Computational molecular biology) by Isaac S Kohane( Book )

1 edition published in 2003 in English and held by 1 WorldCat member library worldwide

CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract: Chronic lung disease of prematurity/bronchopulmonary dysplasia (BPD) is the leading cause of perinatal morbidity in developed countries. Inflammation is a prominent finding. Currently available interventions have associated toxicities and limited efficacy. While BPD often resolves in childhood, survivors of preterm birth are at risk for acquired respiratory disease in early life and are more likely to develop chronic obstructive pulmonary disease (COPD) in adulthood. We previously cloned Crispld2 (Lgl1), a glucocorticoid-regulated mesenchymal secretory protein that modulates lung branching and alveogenesis through mesenchymal-epithelial interactions. Absence of Crispld2 is embryonic lethal. Heterozygous Crispld2+/− mice display features of BPD, including distal airspace enlargement, disruption of elastin, and neonatal lung inflammation. CRISPLD2 also plays a role in human fetal lung fibroblast cell expansion, migration, and mesenchymal-epithelial signaling. This study assessed the effects of endogenous and exogenous CRISPLD2 on expression of proinflammatory mediators in human fetal and adult (normal and COPD) lung fibroblasts and epithelial cells. CRISPLD2 expression was upregulated in a lipopolysaccharide (LPS)-induced human fetal lung fibroblast line (MRC5). LPS-induced upregulation of the proinflammatory cytokines IL-8 and CCL2 was exacerbated in MRC5- CRISPLD2 knockdown cells. siRNA suppression of endogenous CRISPLD2 in adult lung fibroblasts (HLFs) led to augmented expression of IL-8, IL-6, CCL2. LPS-stimulated expression of proinflammatory mediators by human lung epithelial HAEo- cells was attenuated by purified secretory CRISPLD2. RNA sequencing results from HLF- CRISPLD2 knockdown suggest roles for CRISPLD2 in extracellular matrix and in inflammation. Our data suggest that suppression of CRISPLD2 increases the risk of lung inflammation in early life and adulthood. Abstract : This study assessed the effects of CRISPLD2 on expression of proinflammatory mediators in human fetal and adult (normal and chronic obstructive pulmonary disease) lung fibroblast and epithelial cells. Our data show that suppression of CRISPLD2 increases the risk of lung inflammation in both early life and in adulthood. Lipopolysaccharide-stimulated expression of proinflammatory mediators by human lung epithelial cells was attenuated by purified secretory CRISPLD2. Given the paucity of available and effective prevention and treatment for the profound burden of neonatal lung injury, investigating the role of CRISPLD2 in lung inflammation is of enduring interest
 
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Microarrays for an integrative genomics
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Kho, Alvin T.

コー, A. T

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