WorldCat Identities

Ma, Peter X.

Overview
Works: 14 works in 58 publications in 2 languages and 1,465 library holdings
Genres: Academic theses 
Roles: Editor, Author, Contributor
Publication Timeline
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Most widely held works by Peter X Ma
Biomimetics : advancing nanobiomaterials and tissue engineering by Murugan Ramalingam( )

10 editions published in 2013 in English and held by 612 WorldCat member libraries worldwide

This book compiles all aspects of biomimetics from fundamental principles to current technological advances and their future trends in the development of nanoscale biomaterials and tissue engineering. The scope of this book is principally confined to biologically-inspired design of materials and systems for the development of next generation nanobiomaterials and tissue engineering. The book addresses the state-of-the-art of research progress in the applications of the principles, processes, and techniques of biomimetics. The prospective outcomes of current advancements and challenges in bio
Tissue engineering using ceramics and polymers by A. R Boccaccini( )

9 editions published between 2014 and 2016 in English and held by 314 WorldCat member libraries worldwide

Tissue engineering using ceramics and polymers continues to be an area of strong growth within the scientific community. This second edition comprehensively reviews the latest advances in this area with regard to chapters from the first volume. Chapters in part one provides readers with general information on the materials. Part two looks at the processing, characterisation and modeling of polymers and ceramics. The final set of chapters review the latest research and advances in tissue and organ regeneration using ceramics and polymers. This second edition comprehensively exami
Scaffolding in tissue engineering by P. X Ma( Book )

18 editions published between 2005 and 2006 in English and Undetermined and held by 269 WorldCat member libraries worldwide

"While certain books and journal articles address various aspects in the field, this is the first current, comprehensive text focusing on scaffolding for tissue engineering. Scaffolding in Tissue Engineering reviews the general tenets of tissue engineering and concentrates on the principles, methods, and applications for a broad range of tissue engineering scaffolds. It presents an in-depth exploration of traditional and novel materials, fabrication technologies, including three-dimensional scaffold design, structural and functional scaffold modification, and various tissue engineering applications."--Jacket
Biomaterials and regenerative medicine by Peter Ma( )

10 editions published between 2014 and 2015 in English and held by 246 WorldCat member libraries worldwide

"Written by world-leading experts, this book focusses on the role of biomaterials in stem cell research and regenerative medicine. Emphasising basic principles and methodology, it covers stem cell interactions, fabrication technologies, design principles, physical characterisation and biological evaluation, across a broad variety of systems and biomaterials. Topics include: stem cell biology, including embryonic stem cells, IPS, HSC and progenitor cells; modern scaffold structures, including biopolymer, bioceramic, micro- and nanofiber, ECM and biohydrogel; advanced fabrication technologies, including computer-aided tissue engineering and organ printing; cutting-edge drug delivery systems and gene therapy techniques; medical applications spanning hard and soft tissues, the cardiovascular system and organ regeneration. With a contribution by Nobel laureate Shinya Yamanaka, this is a must-have reference for anyone in the field of biomaterials, stem cell biology and engineering, tissue engineering and regenerative medicine"--Provided by publisher
Tissue engineering using ceramics and polymers( Book )

1 edition published in 2014 in English and held by 13 WorldCat member libraries worldwide

Time-domain simulation of vortex-induced vibration for deepwater marine risers by Peter Ma( Book )

2 editions published between 2012 and 2013 in English and held by 3 WorldCat member libraries worldwide

Taiwan Tian zhu jiao shou ce by Peter Ma( Book )

1 edition published in 1972 in Chinese and held by 2 WorldCat member libraries worldwide

Methacrylate-ended polypeptides and polypeptoids for antimicrobial and antifouling coatings1( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract : Methacrylate-terminated polypept(o)ides were directly synthesized via NCA-ROP, and then surface-grafted to form a polymer brush coating with infection-resistant efficacy. Abstract : Methacrylate-ended polypeptides/polypeptoids were successfully synthesized via ring-opening polymerization (ROP) of N -carboxyanhydrides (NCA). These oligomers were further initiated under ultraviolet (UV) irradiation by a polydopamine (pDA) layer which is attachable to the surface of virtually all materials to generate a polymer brush coating. This brush-like polymer coating comprising cationic antimicrobial polypeptides (MePpep) and antifouling polysarcosine (MePsar) exhibited effective antimicrobial activity against four pathogens (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans), as well as antifouling activity in the resistance to protein and platelet adhesion, and thus prevented biofilm formation for up to 7 days. An in vitro cytotoxicity study showed that this coating is biocompatible with mouse fibroblast (L929) cells. More importantly, this coating exhibited significant anti-infectivity in vivo . This dual-functional polymer brush coating can be immobilized on the surface of multiple categories of materials through the mussel-inspired pDA coating, and thus should be widely applicable for combating infection in many classes of bio-medical materials
A highly bioactive and biodegradable poly(glycerol sebacate)-silica glass hybrid elastomer with tailored mechanical properties for bone tissue regeneration1( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

<Title><x>Abstract</x></title><graphic></graphic>A highly bioactive and biodegradable PGS-Silica bioactive glass hybrid elastomer with tailored mechanical properties was developed for bone tissue regeneration application.<title><x>Abstract</x></title>Biodegradable poly(glycerol sebacate) (PGS) elastomers have received much attention as promising materials for potential applications in soft tissue repair and regeneration, due to their biomimetic viscoelastic properties. However, the low strength and the absence of bioactivity have limited their potential applications in hard (bone, tooth, tendon and ligament) tissue regeneration. Here, we introduced the molecular-level silica bioactive glass into the matrix of polymer elastomers to prepare bioactive hybrid elastomers (PGSSC) for bone tissue regeneration applications. We have shown here that our PGSSC provide some advantages over conventional bioactive materials and elastomers due to their controlled biomineralization (apatite-forming bioactivity), tunable elastic properties and biodegradation, and enhanced osteoblast proliferation. The tensile strength and the initial modulus of PGSSC hybrid elastomers ranged from 1 to 5 MPa and 2 to 32 MPa respectively by controlling silica phase contents, which are several times higher than pure PGS elastomers. PGSSC elastomers also showed enhanced hydrophilicity with contact angle ranging from 75 to 25 degree. The biological apatite was formed on the surfaces of PGSSC when soaked in simulated body fluid (SBF) for 1 day. The osteoblast (MC3T3) demonstrated significantly enhanced proliferation on PGSSC compared with PGS. The development of bioactive PGSSC hybrid elastomers may offer a new choice for bone tissue repair and regeneration
Monodispersed Bioactive Glass Nanoclusters with Ultralarge Pores and Intrinsic Exceptionally High miRNA Loading for Efficiently Enhancing Bone Regeneration( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract: Bioactive glass nanoparticles (BGNs) have attracted much attention in drug delivery and bone tissue regeneration, due to the advantages including biodegradation, high bone-bonding bioactivity, and facile large-scale fabrication. However, the wide biomedical applications of BGNs such as efficient gene delivery are limited due to their poor pore structure and easy aggregation. Herein, for the first time, this study reports novel monodispersed bioactive glass nanoclusters (BGNCs) with ultralarge mesopores (10-30 nm) and excellent miRNA delivery for accelerating critical-sized bone regeneration. BGNCs with different size (100-500 nm) are fabricated by using a branched polyethylenimine as the structure director and catalyst. BGNCs show an excellent apatite-forming ability and high biocompatibility. Importantly, BGNCs demonstrate an almost 19 times higher miRNA loading than those of conventional BGNs. Additionally, BGNCs-miRNA nanocomplexes exhibit a significantly high antienzymolysis, enhance cellular uptake and miRNA transfection efficiency, overpassing BGNs and commercial Lipofectamine 3000. BGNCs-mediated miRNA delivery significantly improves the osteogenic differentiation of bone marrow stromal stem cells in vitro and efficiently enhances bone formation in vivo. BGNCs can be a highly efficient nonviral vector for various gene therapy applications. The study may provide a novel strategy to develop highly gene-activated bioactive nanomaterials for simultaneous tissue regeneration and disease therapy. Abstract : Monodispersed bioactive glass nanoclusters (BGNCs) with ultra-large mesopores (10-30 nm) are developed for miRNA delivery to enhance bone regeneration. BGNCs demonstrated an ultrahigh miRNA loading and transfection efficiency, overpassing commercial lipofectamine. BGNCs-mediated miRNA delivery significantly improved osteogenic differentiation of bone marrow stromal stem cells in vitro and enhanced bone formation in vivo
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1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract: Roughly one third of all human cancers are attributable to the functional inhibition of the tumor suppressor protein p53 by its two negative regulators MDM2 and MDMX, making dual-specificity peptide antagonists of MDM2 and MDMX highly attractive drug candidates for anticancer therapy. Two pharmacological barriers, however, remain a major obstacle to the development of peptide therapeutics: susceptibility to proteolytic degradation invivo and inability to traverse the cell membrane. Here we report the design of a fluorescent lanthanide oxyfluoride nanoparticle (LONp)-based multifunctional peptide drug delivery system for potential treatment of acute myeloid leukemia (AML) that commonly harbors wild type p53, high levels of MDM2 and/or MDMX, and an overexpressed cell surface receptor, CD33. We conjugated to LONp via metal-thiolate bonds a dodecameric peptide antagonist of both MDM2 and MDMX, termed PMI, and a CD33-targeted, humanized monoclonal antibody to allow for AML-specific intracellular delivery of a stabilized PMI. The resultant nanoparticle antiCD33-LONp-PMI, while nontoxic to normal cells, induced apoptosis of AML cell lines and primary leukemic cells isolated from AML patients by antagonizing MDM2 and/or MDMX to activate the p53 pathway. Fluorescent antiCD33-LONp-PMI also enabled real-time visualization of a series of apoptotic events in AML cells, proving a useful tool for possible disease tracking and treatment response monitoring. Our studies shed light on the development of antiCD33-LONp-PMI as a novel class of antitumor agents, which, if further validated, may help targeted molecular therapy of AML
Development of silica grafted poly(1,8-octanediol-co-citrates) hybrid elastomers with highly tunable mechanical properties and biocompatibility( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

<Title><x>Abstract</x></title><graphic></graphic>By a facile polymerization, we synthesized a series of silica grafted poly (1,8-octanediol-<italic>co</italic>-citrate) (SPOC) hybrid elastomers with highly tunable physicochemical properties and bioactivities.<title><x>Abstract</x></title>Biodegradable elastomers are attractive in soft tissue regeneration due to their biomimetic viscoelastic properties and biocompatibility. However, conventional elastomers are inherently weak and lack the bioactivity required for highly efficient tissue regeneration. Silica-based biomaterials have shown high mechanical stiffness and special bioactivities including stimulating osteogenesis and angiogenesis by enhancing corresponding gene expressions. Here, by a facile polymerization, we synthesized a series of silica grafted poly (1,8-octanediol-<italic>co</italic>-citrate) (SPOC) hybrid elastomers with highly tunable physicochemical properties and bioactivities. The silica phase was successfully grafted to the side chain of POC. The silica phase incorporation significantly endowed POC elastomers with highly controlled thermal stability, mechanical properties, hydrophilicity, biodegradation and biocompatibility. The tensile strength, initial modulus and elongation of SPOC hybrid elastomers were highly tunable and range from 2-15 MPa, 4-25 MPa and 50-140% respectively, which is almost a four-fold enhancement compared with pure POC elastomers. In addition, SPOC elastomers significantly enhanced the proliferation and metabolic activities of multiple cell lines including the adipose-derived stem cells, fibroblasts, myoblasts and osteoblasts, indicating their high biocompatibility. These optimized structures and properties of the silica-grafted hybrid elastomers make them promising for soft and hard tissue regeneration applications
Taiwan Tian zhu jiao shou ce by Peter Ma( Book )

1 edition published in 1972 in Chinese and held by 0 WorldCat member libraries worldwide

 
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Audience level: 0.49 (from 0.31 for Biomimetic ... to 1.00 for Taiwan Tia ...)

Scaffolding in tissue engineering
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Alternative Names
Ma, P. X.

Ma, Peter

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