WorldCat Identities

Aarestrup, Frank M. 1966-

Overview
Works: 3 works in 16 publications in 1 language and 276 library holdings
Genres: Science films  Documentary films  Nonfiction films  Internet videos 
Roles: Editor
Publication Timeline
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Most widely held works by Frank M Aarestrup
Antimicrobial resistance in bacteria of animal origin( Book )

13 editions published between 1463 and 2006 in English and held by 213 WorldCat member libraries worldwide

Comprehensively examines the current research on antimicrobial resistance in the main veterinary and zoonotic pathogens, including resistance to disinfectants and metals used in agriculture. the early chapters provide information on modes of action of antibiotics and mechanisms of bacterial resistance, in addition to exploring the history of antimicrobial use in agriculture. Several chapters are devoted to examination of antimicrobial resistance in specific bacteria, including: the family Pasteurellaceae, species of Campylobacter, pathogenic Escherichia coli, staphylococci, streptococci, and Enterococcus. Also detailed are phenotypic and molecular methods for susceptibility testing, regulatory mechanisms for usage of antibiotics, and methods for monitoring drug usage and resistance
Resistance( Visual )

2 editions published in 2014 in English and held by 41 WorldCat member libraries worldwide

"Seventy years ago antibiotics revolutionized medicine. Only now are we realizing the potentially catastrophic consequences of these miracle drugs. The question is: have we reached a point where we must save antibiotics to save ourselves? Resistance sets out to answer that question and more. Microscopic footage, harrowing personal stories, and expert insights propel this eye-opening and sometimes infuriating look at antibiotic resistance, starting from the first mass production of antibiotics to the rise of superbugs in the 21st century."--Container
Nucleoside analogues are activated by bacterial deoxyribonucleoside kinases ina species-specific manner( )

1 edition published in 2007 in English and held by 1 WorldCat member library worldwide

Objectives: To investigate the bactericidal activity of antiviral and anticancer nucleoside analogues against a variety of pathogenic bacteria and characterize the activating enzymes, deoxyribonucleoside kinases (dNKs). Methods: Several FDA-approved nucleoside analogue drugs were screened for their potential bactericidal activity against several clinical bacterial isolates and type strains. We identified and subcloned the genes coding for putative deoxyribonucleoside kinases in Escherichia coli, Pasteurella multocida, Salmonella enterica, Yersinia enterocolitica, Bacillus cereus, Clostridium perfringens and Listeria monocytogenes. These genes were tested for their ability to increase the susceptibility of a dNK-deficient E. coli strain to various analogues. We overexpressed, purified and characterized the substrate specificity and kinetic properties of the recombinant enzymes from S. enterica and B. cereus. Results: The tested Gram-negative bacteria were susceptible to 3'-azido-3'-deoxythymidine (AZT) in the concentration range 0.032-31.6 microM except for a single E. coli isolate and two Pseudomonas aeruginosa isolates which were resistant to the tested AZT concentrations. Purified recombinant S. enterica thymidine kinase phosphorylated AZT efficiently with a Km of 73.3 microM and k(cat)/Km of 6.6 x 10(4) s( -1) M( -1) and is the activator of this drug in vivo. 2',2'-Difluoro-2'-deoxycytidine (gemcitabine) was a potent antibiotic against Gram-positive bacteria in the concentration range between 0.001 and 1.0 microM. The B. cereus deoxyadenosinekinase had a Km for gemcitabine of 33.5 microM and k(cat)/Km of 5.1 x 10(3) s( -1) M( -1) and activates gemcitabine in vivo. S. enterica and B. cereus are now amongst the first bacteria with a completely characterized set of dNK enzymes. CONCLUSIONS: Bacterial dNKs efficiently activate nucleoside analogues in a species-specific manner. (Abs. trunc. at 2000 ch.)
 
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Audience Level
1
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Audience level: 0.59 (from 0.43 for Resistance ... to 0.97 for Nucleoside ...)

Antimicrobial resistance in bacteria of animal origin
Languages
English (16)

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