WorldCat Identities

Wagner, Jeffrey

Overview
Works: 9 works in 15 publications in 1 language and 241 library holdings
Genres: Photographs  Exhibition, pictorial works  Pictorial works 
Roles: Author
Publication Timeline
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Most widely held works by Jeffrey Wagner
Lamas, princes, and brigands : Joseph Rock's photographs of the Tibetan borderlands of China by Joseph F Rock( Book )

6 editions published in 1992 in English and held by 217 WorldCat member libraries worldwide

Guidelines for the quality assessment of transfusion( Book )

2 editions published in 2006 in English and held by 17 WorldCat member libraries worldwide

Design, Commissioning and Operational Results of Wide Dynamic Range BPM Switched Electrode Electronics( )

1 edition published in 1997 in English and held by 2 WorldCat member libraries worldwide

Uncertainty and species recovery program desing by Julie A Dyar( )

1 edition published in 2003 in English and held by 1 WorldCat member library worldwide

333 Obtaining the Genetic Fingerprint of Resistance to Glioblastoma Through a Novel Multigenerational Xenograft Model( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract : INTRODUCTION: Despite positive preclinical/clinical trials, a major hurdle in the clinical application of bevacizumab, an antiangiogenic therapy, in glioblastoma is the development of resistance and progression following a transient response period. METHODS: We established a multigenerational glioblastoma xenograft model of acquired bevacizumab resistance through subcutaneous implantation of U87 cells, bevacizumab treatment, and selection and reimplantation of the fastest growing tumor in each generation to new mice. Whole human genome microarray (Illumina) was performed on 3 tumor samples from generations 1, 4, and 9, and bioinformatic analysis of gene expression data was performed in Matlab2014a. RESULTS: Using published statistical methods, we identified a set of genes exhibiting significant intergenerational variance. Protein-protein interaction (PPI) scores were extracted of String database (v10); subsequent spectral clustering revealed 13 gene subnetworks of closely interrelated genes. Gene set overrepresentation (GSO) analysis via ConsensusPathDB suggested biologically meaningful subnetworks mediating distinct functions, including inflammation, extracellular matrix remodeling, cell cycle, metabolism, and cytoskeletal dynamics. Gene set enrichment analysis revealed significant overexpression across generations of previously identified gene expression signatures of the mesenchymal subtype. Important markers, including putative tumor-stemness marker CD44 and critical epithelial-mesenchymal-transition transcription factors SNAI2 and ZEB2 were upregulated across generations. These results suggest tumor progression under bevacizumab to be accompanied by a gene expression shift toward the mesenchymal subtype, associated with enhanced invasiveness, resistance, and worse outcomes. Our analysis revealed expression changes in angiogenesis-related pathways. Genes identified via GSO suggested a tumor proangiogenic response to bevacizumab, composed of converging pathways involving inflammation, hypoxia, extracellular matrix remodeling, upregulation of alternative proangiogenic pathways, and downregulation of antiangiogenic factors. CONCLUSION: Using microarray analysis of a model of bevacizumab resistance in glioblastoma, we found development of resistance to be accompanied by a gene expression shift toward the mesenchymal subtype, as well as activation of alternative proangiogenic pathways. These findings shed light on the mechanisms of resistance to antiangiogenic therapy in glioblastoma
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1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled Bile acid receptor 1 (GP-BAR1, TGR5) agonists( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Graphical abstract: Abstract: GP-BAR1 (also known as TGR5), a novel G-protein coupled receptor regulating various non-genomic functions via bile acid signaling, has emerged as a promising target for metabolic disorders, including obesity and type II diabetes. However, given that many bile acids (BAs) are poorly tolerated for systemic therapeutic use, there is significant need to develop GP-BAR1 agonists with improved potency and specificity and there also is significant impetus to develop a stereoselective synthetic methodology for GP-BAR1 agonists. Here, we report the development of highly stereo-controlled strategies to investigate a series of naturally occurring bile acid derivatives with markedly enhanced GP-BAR1 activity. These novel GP-BAR1 agonists are evaluated in vitro using luciferase-based reporter and cAMP assays to elucidate their biological properties. In vivo studies revealed that the GP-BAR1 agonist 23( S )-m-LCA increased intestinal GLP-1 transcripts by 26-fold. Additionally, computational modeling studies of selected ligands that exhibit enhanced potency and specificity for GP-BAR1 provide information on potential binding sites for these ligands in GP-BAR1
The continuing struggle for Indian sovereignty by Jeffrey Wagner( )

1 edition published in 1984 in English and held by 0 WorldCat member libraries worldwide

Design, commissioning and operational results of wide dynamic range BPM switched electrode electronics, May 1996 by Tom Powers( )

1 edition published in 1996 in English and held by 0 WorldCat member libraries worldwide

 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.58 (from 0.56 for Lamas, pri ... to 1.00 for Design, co ...)

Lamas, princes, and brigands : Joseph Rock's photographs of the Tibetan borderlands of China
Alternative Names
Wagner, Jeffery

Languages
English (15)

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