WorldCat Identities

Jaulhac, Benoît

Overview
Works: 20 works in 29 publications in 2 languages and 132 library holdings
Roles: Thesis advisor, Author, Editor, Opponent
Classifications: RC155.5, 616.9246
Publication Timeline
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Most widely held works by Benoît Jaulhac
Lyme borreliosis : biological and clinical aspects( Book )

8 editions published in 2009 in English and held by 48 WorldCat member libraries worldwide

A comprehensive and up-to-date review by leading experts in the field
SEROLOGIE DE LA BORRELIOSE DE LYME PAR IMMUNO-EMPREINTE : INFLUENCE DE LA SOUCHE UTILISEE COMME ANTIGENE (DES BIOLOGIE MEDICALE) by SYLVIE DE MARTINO( Book )

1 edition published in 2000 in French and held by 3 WorldCat member libraries worldwide

EVALUATION DE 14 COFFRETS COMMERCIAUX DE DEPISTAGE DE LA BORRELIOSE DE LYME EN FRANCE (DES BIOL. MED.) by Pierre Zachary( Book )

1 edition published in 2000 in French and held by 2 WorldCat member libraries worldwide

Etude de la survie en air ambiant de bactéries anaérobies d'intérêt médical by Pierre-Adrien BIHL( Book )

1 edition published in 2013 in French and held by 2 WorldCat member libraries worldwide

MISE AU POINT D'UNE TECHNIQUE DE REVELATION NON RADIOACTIVE DE PRODUITS D'AMPLIFICATION GENIQUE IN VITRO : APPLICATION A LA DETECTION DES LEGIONELLA by BRUNO SUDAN( Book )

1 edition published in 1997 in French and held by 2 WorldCat member libraries worldwide

Détection de la résistance à la méticilline et identification d'espèces de staphylocoques sur des hémocultures par PCR en temps réel by Céline Menard( Book )

1 edition published in 2006 in French and held by 2 WorldCat member libraries worldwide

Toxine du syndrome de choc toxique et entérotoxines de staphylococcus aureus nouveaux moyens de diagnostic by Benoît Jaulhac( Book )

1 edition published in 1990 in French and held by 2 WorldCat member libraries worldwide

Détermination des espèces de borrelia burgdorferi responsables d'érythème migrant en Alsace par une technique de typage moléculaire par PCR en temps réel by Mahsa Mohseni Zadeh( Book )

1 edition published in 2005 in French and held by 2 WorldCat member libraries worldwide

Inflammation cutanée et borréliose de Lyme rôle de l'immunité innée et de la tique dans la transmission à l'homme de Borrelia burgdorferi by Claire Marchal( )

2 editions published between 2009 and 2010 in French and held by 2 WorldCat member libraries worldwide

Lyme disease is an arthropod borne disease transmitted by a hard tick, Ixodes spp., and caused by a spirochetal bacteria Borrelia burgdorferi. It is a zoonotic organism that occurs between an arthropod, the tick and a vertebrate host. The disease prevails mainly in the Northern hemisphere. Infection by this organism induces multiple and varied symptoms : articular, neurologic, cutaneous and cardiatis attacks. The tick Ixodes is a hemotaphagous arthropod that had to attach during 4 to 8 days on the vertebrate host in order to feed to repletion. To secure the attachment and susceptibility of reservoir hosts for future tick infestations, the vector inject saliva which possesses not only pharmacologic properties but immunomodulatory too. Among these tick saliva proteins, Salp15 is a major immunomodulatory protein of I. scapularis. It inhibits T lymphocyte activation by biding to the CD4 co-receptor, and inhibits adaptive immune responses by suppressing human dendritic cell functions. In addition, Salp15 binds to B. burgdorferi outer surface protein (Osp) C and protect the bacteria against host antibodies. In vector-borne diseases, the interface skin has a very important role. We therefore analyzed the role of resident cells of the skin: the keratinocytes (KCs) and fibroblasts (FBs) in inflammation. Innate immunity induced skin antimicrobial peptides (PAMs) that kill a wide range of pathogens which have chemotactic and angiogenic activities. We have demonstrated that KCs incubated in vitro with B. burgdorferi induce an inflammatory response (chemokine and PAMs). We then studied the effect of immunosuppressive potential of extracts of salivary glands and protein tick, Salp15 of I. ricinus. We found that they inhibit the inflammatory response with effect anti-alarmin. This immunosuppressive effect could facilitate the transmission and propagation of Borrelia. Then, we studied the role of FBs, skin cells in Lyme borreliosis. We have shown that Borrelia induces the expression of some metalloproteinases (MMPs), during the cooperation between KCs and FBs. The bacteria may then migrate through the ECM of the skin and spread. Finally we studied the interaction of KCs with different species of B. burgdorferi : B. garinii, B. burgdorferi ss and B. afzelii or different strains to study the possible role of the skin in organ specimens of Borrelia
Inflammation cutanée lors de la transmission vectorielle de la borreliose de Lyme étude sur modèle murin by Aurélie Kern( Book )

2 editions published between 2011 and 2012 in French and held by 2 WorldCat member libraries worldwide

Lyme disease, is an infectious disorder caused by a tick-transmitted bacteria : Borrelia burgdorferi. The skin constitutes an essential interface in this arthropod borne disease. Indeed, the primary manifestation is a cutaneous inflammation, the erythema migrans. Dissemination of spirochetes from the site of inoculation can lead to other manifestations typically involving the skin, heart, joints or central nervous system. Mechanisms responsible of this specific dissemination are not known. In this project we focused on the cutaneous innate immune response during Lyme disease transmission. Part of skin innate immunity is constituted by the secretion of antimicrobial peptides (AMPs), cytokines and chemokines. We developed two experimental strategies. In vitro to measure the specific response from skin resident cells: keratinocytes. In vivo we challenged C3H/HeN mice with spirochetes from B. burgdoferi sensu stricto strains initially isolated from human clinical manifestation. In conclusion, we propose that tick saliva has a property not previously described : an anti-alarmin effect. Tick saliva is an essential actor in the pathogenesis of skin inflammation. Furthermore, we showed a clear difference in the skin innate immunity according to the strain tested. The skin by its immunity and the specificity of its different resident cells likely plays a major role in the development of Borrelia infection in the vertebrate host. There, an intense bacterial multiplication occurs. Some specific factors of both, the bacteria (like OspC and BBK32) and the host (like AMPs and MCP-1), display a sophisticated interaction that likely further orientate the bacterium in the rest of the body
Mise au point d'une technique de confirmation par PCR en temps réel pour la détection de borrelia burgdorferi sensu lato by Anne Kiesler( Book )

1 edition published in 2006 in French and held by 2 WorldCat member libraries worldwide

OUTILS MOLECULAIRES DE DETECTION ET DE TYPAGE DE BORRELIA BURGDORFERI SENSU LATO DANS L'ARTHRITE DE LYME by Benoît Jaulhac( Book )

1 edition published in 1998 in French and held by 1 WorldCat member library worldwide

BORRELIA BURGDORFERI SENSU LATO (B. BURGDORFERI SL) EST RESPONSABLE DES DIFFERENTES MANIFESTATIONS DE LA BORRELIOSE DE LYME. LA MISE EN EVIDENCE DE CETTE BACTERIE DANS LES PRELEVEMENTS HUMAINS PAR DES METHODES CLASSIQUES (CULTURE, COLORATION) EST RAREMENT COURONNEE DE SUCCES. LE PREMIER BUT DE CE TRAVAIL A ETE DE METTRE AU POINT UNE METHODE DE DETECTION DE L'ADN DE B. BURGDORFERI SL PAR AMPLIFICATION GENIQUE IN VITRO DANS LES PRELEVEMENTS SYNOVIAUX (LIQUIDES ARTICULAIRES ET BIOPSIES). NOUS AVONS ENSUITE REALISE UNE ETUDE PROSPECTIVE CHEZ DES PATIENTS ATTEINTS D'ARTHRITE DE LYME ET MONTRE QU'EN UTILISANT UNE CIBLE CHROMOSOMIQUE, LA SENSIBILITE DE CETTE METHODE ETAIT DE 42% SUR LIQUIDE ARTICULAIRE ET DE 91% SUR BIOPSIE SYNOVIALE. CECI EST EN FAVEUR D'UNE LOCALISATION PREFERENTIELLE DE CETTE BACTERIE DANS LE TISSU SYNOVIAL. CHEZ UN PATIENT, NOUS AVONS MONTRE PAR MICROSCOPIE ELECTRONIQUE QUE BORRELIA BURGDORFERI ETAIT PRESENTE DANS LE CYTOPLASME DES SYNOVIOCYTES. NOUS AVONS ENSUITE APPLIQUE CETTE METHODE A DES PRELEVEMENTS MUSCULAIRES EFFECTUES CHEZ DES PATIENTS ATTEINTS DE MYALGIES CHRONIQUES APRES UNE NEUROBORRELIOSE OU UNE ARTHRITE DE LYME. NOUS AVONS DETECTE LA PRESENCE D'ADN DE BORRELIA BURGDORFERI POUR CERTAINS D'ENTRE EUX, PROUVANT LA DISSEMINATION DE CE SPIROCHETE DANS LE TISSU MUSCULAIRE. NOUS AVONS MIS AU POINT SUR MODELE MURIN D'ARTHRITE DE LYME UNE METHODE SENSIBLE DE DETECTION DES ARNM DE B. BURGDORFERI SL PAR RT-PCR EN UNE ETAPE AFIN D'ETUDIER LA VIABILITE DE CES SPIROCHETES DANS LES TISSUS HUMAINS. PARMI LES NOMBREUSES ESPECES DE BORRELIA, 4 ESPECES AU MOINS SONT RESPONSABLES EN EUROPE DE LA BORRELIOSE DE LYME. L'IDENTIFICATION DE CES DIFFERENTES ESPECES N'EST PAS POSSIBLE PAR DES METHODES PHENOTYPIQUES. NOUS AVONS DEVELOPPE UNE METHODE DIRECTE DE TYPAGE DE CES ESPECES PAR PCR ET HYBRIDATION PAR DES OLIGONUCLEOTIDES SPECIFIQUES. CETTE METHODE A ETE APPLIQUEE A DIX PATIENTS ATTEINTS D'ARTHRITE DE LYME : B. BURGDORFERI SENSU STRICTO EN ETAIT RESPONSABLE DANS 9 CAS ET B. GARINII N'A ETE DETECTEE QUE CHEZ UN SEUL PATIENT
Lyme borreliosis : biological and clinical aspects : Current problems in dermatology by D Lipsker( Book )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

EVALUATION PROSPECTIVE DU SERODIAGNOSTIC DE LA MALADIE DES GRIFFES DU CHAT CHEZ 311 PATIENTS : ANALYSE CRITIQUE by MARC PIERRE STREIFF( Book )

1 edition published in 1998 in French and held by 1 WorldCat member library worldwide

Borrelia burgdorferi sensu lato by Benoît Jaulhac( )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Enhanced culture of Borrelia garinii and Borrelia afzelii strains on a solid BSK-based medium in anaerobic conditions( )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

The growth of 29 human strains from the three main pathogenic species of Borrelia burgdorferi sensu lato on a solid BSK-based medium was compared in two culture atmospheres: 3% CO(2) air and anaerobiosis. All strains grew underanaerobic conditions, whereas only 13 strains were able to grow in aerobiosis with 3% CO(2) (P<0.001). In the latter condition, 75% of the B. burgdorferi sensu stricto strains grew versus 33% of the B. garinii and B. afzelii strains. These data suggest that, especially for B. garinii and B. afzelii species, anaerobic conditions enhance growth yield and speed of low-passage Borrelia strains
Etude des facteurs cellulaires responsables de l'initiation et de la dissémination du virus de l'hépatite C by Marine Turek( )

1 edition published in 2013 in French and held by 1 WorldCat member library worldwide

HCV infection is the leading cause of chronic liver disease. The current SOC is still limited by high costs, toxicity and emergence of viral resistance. In the first part of my thesis we focused our workon viral entry. Viral entry is required for initiation, spread, and maintenance of infection, and thus is a promising target for the development of new antiviral therapies. CD81 and SR-BI are the first entry factors identified as important for HCV entry. In our work we confirmed their crucial role in entry, especially at the post-binding step. In addition we proved their key role in viral dissemination through the cell-cell transmission. As HCV mainly infects hepatocytes, we studied in the second part of my thesis, the restricted cellular tropism of HCV to hepatocytes and we defined the minimal host factors rendering non hepatic cell lines susceptible to HCV infection by the establishment of a powerful tool to identify new assembly and replication factors
Inflammation cutanée et borréliose de Lyme : étude in vitro des interactions entre les cellules résidentes de la peau et Borrelia by Frédéric Schramm( )

1 edition published in 2012 in French and held by 1 WorldCat member library worldwide

We studied the role of the skin innate immunity during the transmission of Borrelia (the infectious agent of Lyme borreliosis) by its vector, a hard tick belonging to the genus Ixodes. We showed that tick saliva and its protein Salp15 both inhibate Borrelia-induced inflammatory reaction of keratinocytes. The antialarmin effect of tick saliva ensure a favorable environment for Borrelia. We also showed that Borrelia induce a strong inflammatory response in dermal fibroblasts. We also demonstrate a dose-dependent lytic effect of tick salivary gland extracts on dermal fibroblasts and that this cytotoxic effect was of proteinaceous nature and not related to Salp15. These results indicate that dermal fibroblasts could be considered as central mediators in immune cell recruitment to the skin site of Borrelia invasion
 
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Audience level: 0.81 (from 0.71 for Lyme borre ... to 0.98 for Lyme borre ...)

Associated Subjects
Lyme borreliosis : biological and clinical aspects
Languages
French (18)

English (11)

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