WorldCat Identities

Jaulhac, Benoît

Overview
Works: 22 works in 32 publications in 2 languages and 142 library holdings
Roles: Thesis advisor, Author, Editor, Opponent
Publication Timeline
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Most widely held works by Benoît Jaulhac
Lyme borreliosis : biological and clinical aspects( Book )

9 editions published in 2009 in English and held by 47 WorldCat member libraries worldwide

A comprehensive and up-to-date review by leading experts in the field
Inflammation cutanée lors de la transmission vectorielle de la borreliose de Lyme étude sur modèle murin by Aurélie Kern( Book )

2 editions published between 2011 and 2012 in French and held by 2 WorldCat member libraries worldwide

Lyme disease, is an infectious disorder caused by a tick-transmitted bacteria : Borrelia burgdorferi. The skin constitutes an essential interface in this arthropod borne disease. Indeed, the primary manifestation is a cutaneous inflammation, the erythema migrans. Dissemination of spirochetes from the site of inoculation can lead to other manifestations typically involving the skin, heart, joints or central nervous system. Mechanisms responsible of this specific dissemination are not known. In this project we focused on the cutaneous innate immune response during Lyme disease transmission. Part of skin innate immunity is constituted by the secretion of antimicrobial peptides (AMPs), cytokines and chemokines. We developed two experimental strategies. In vitro to measure the specific response from skin resident cells: keratinocytes. In vivo we challenged C3H/HeN mice with spirochetes from B. burgdoferi sensu stricto strains initially isolated from human clinical manifestation. In conclusion, we propose that tick saliva has a property not previously described : an anti-alarmin effect. Tick saliva is an essential actor in the pathogenesis of skin inflammation. Furthermore, we showed a clear difference in the skin innate immunity according to the strain tested. The skin by its immunity and the specificity of its different resident cells likely plays a major role in the development of Borrelia infection in the vertebrate host. There, an intense bacterial multiplication occurs. Some specific factors of both, the bacteria (like OspC and BBK32) and the host (like AMPs and MCP-1), display a sophisticated interaction that likely further orientate the bacterium in the rest of the body
Mise au point d'une technique de revelation non radioactive de produits d'amplification genique in vitro : application a la detection des legionella by BRUNO SUDAN( Book )

1 edition published in 1997 in French and held by 2 WorldCat member libraries worldwide

Etude de la survie en air ambiant de bactéries anaérobies d'intérêt médical by Pierre-Adrien BIHL( Book )

1 edition published in 2013 in French and held by 2 WorldCat member libraries worldwide

Détermination des espèces de borrelia burgdorferi responsables d'érythème migrant en Alsace par une technique de typage moléculaire par PCR en temps réel by Mahsa Mohseni Zadeh( Book )

1 edition published in 2005 in French and held by 2 WorldCat member libraries worldwide

Evaluation de 14 coffrets commerciaux de depistage de la borreliose de lyme en france (des biol. med.) by Pierre Zachary( Book )

1 edition published in 2000 in French and held by 2 WorldCat member libraries worldwide

Toxine du syndrome de choc toxique et entérotoxines de staphylococcus aureus : nouveaux moyens de diagnostic by Benoît Jaulhac( )

1 edition published in 1990 in French and held by 2 WorldCat member libraries worldwide

Mise au point d'une technique de confirmation par PCR en temps réel pour la détection de borrelia burgdorferi sensu lato by Anne Kiesler( Book )

1 edition published in 2006 in French and held by 2 WorldCat member libraries worldwide

Détection de la résistance à la méticilline et identification d'espèces de staphylocoques sur des hémocultures par PCR en temps réel by Céline Menard( Book )

1 edition published in 2006 in French and held by 2 WorldCat member libraries worldwide

Inflammation cutanée et borréliose de Lyme rôle de l'immunité innée et de la tique dans la transmission à l'homme de Borrelia burgdorferi by Claire Marchal( Book )

2 editions published between 2009 and 2010 in French and held by 2 WorldCat member libraries worldwide

Lyme disease is an arthropod borne disease transmitted by a hard tick, Ixodes spp., and caused by a spirochetal bacteria Borrelia burgdorferi. It is a zoonotic organism that occurs between an arthropod, the tick and a vertebrate host. The disease prevails mainly in the Northern hemisphere. Infection by this organism induces multiple and varied symptoms : articular, neurologic, cutaneous and cardiatis attacks. The tick Ixodes is a hemotaphagous arthropod that had to attach during 4 to 8 days on the vertebrate host in order to feed to repletion. To secure the attachment and susceptibility of reservoir hosts for future tick infestations, the vector inject saliva which possesses not only pharmacologic properties but immunomodulatory too. Among these tick saliva proteins, Salp15 is a major immunomodulatory protein of I. scapularis. It inhibits T lymphocyte activation by biding to the CD4 co-receptor, and inhibits adaptive immune responses by suppressing human dendritic cell functions. In addition, Salp15 binds to B. burgdorferi outer surface protein (Osp) C and protect the bacteria against host antibodies. In vector-borne diseases, the interface skin has a very important role. We therefore analyzed the role of resident cells of the skin: the keratinocytes (KCs) and fibroblasts (FBs) in inflammation. Innate immunity induced skin antimicrobial peptides (PAMs) that kill a wide range of pathogens which have chemotactic and angiogenic activities. We have demonstrated that KCs incubated in vitro with B. burgdorferi induce an inflammatory response (chemokine and PAMs). We then studied the effect of immunosuppressive potential of extracts of salivary glands and protein tick, Salp15 of I. ricinus. We found that they inhibit the inflammatory response with effect anti-alarmin. This immunosuppressive effect could facilitate the transmission and propagation of Borrelia. Then, we studied the role of FBs, skin cells in Lyme borreliosis. We have shown that Borrelia induces the expression of some metalloproteinases (MMPs), during the cooperation between KCs and FBs. The bacteria may then migrate through the ECM of the skin and spread. Finally we studied the interaction of KCs with different species of B. burgdorferi : B. garinii, B. burgdorferi ss and B. afzelii or different strains to study the possible role of the skin in organ specimens of Borrelia
Serologie de la borreliose de lyme par immuno-empreinte : influence de la souche utilisee comme antigene (des biologie medicale) by SYLVIE DE MARTINO( Book )

1 edition published in 2000 in French and held by 2 WorldCat member libraries worldwide

Inflammation cutanée et borréliose de Lyme : étude in vitro des interactions entre les cellules résidentes de la peau et Borrelia by Frédéric Schramm( )

1 edition published in 2012 in French and held by 1 WorldCat member library worldwide

Nous avons étudié le rôle de l'immunité innée de la peau lors de la transmission des Borrelia (agent infectieux de la borréliose de Lyme) par son vecteur, une tique dure du genre Ixodes. Nous avons montré que la salive de tique et la protéine salivaire Salp15 inhibent la réaction inflammatoire (production de chimiokines et de peptides antimicrobiens) des kératinocytes induite par Borrelia. Cet effet anti- « alarmine » de la salive de tique contribue probablement à créer un environnement cutané local favorable à la transmission de Borrelia. Nous avons montré que Borrelia induit également au niveau des fibroblastes cutanés la transcription de nombreux gènes proinflammatoires. Nous avons observé un effet toxique direct de la salive de tique sur les fibroblastes cutanés : cet effet dose-dépendant est de nature protéique mais non lié à la protéine Salp15. Ces résultats indiquent que les fibroblastes jouent un rôle important dans l'inflammation cutanée induite par Borrelia
There is inadequate evidence to support the division of the genus Borrelia( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Enhanced culture of Borrelia garinii and Borrelia afzelii strains on a solid BSK-based medium in anaerobic conditions( )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

The growth of 29 human strains from the three main pathogenic species of Borrelia burgdorferi sensu lato on a solid BSK-based medium was compared in two culture atmospheres: 3% CO(2) air and anaerobiosis. All strains grew underanaerobic conditions, whereas only 13 strains were able to grow in aerobiosis with 3% CO(2) (P<0.001). In the latter condition, 75% of the B. burgdorferi sensu stricto strains grew versus 33% of the B. garinii and B. afzelii strains. These data suggest that, especially for B. garinii and B. afzelii species, anaerobic conditions enhance growth yield and speed of low-passage Borrelia strains
Borrelia burgdorferi sensu lato by Benoît Jaulhac( )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Etude des facteurs cellulaires responsables de l'initiation et de la dissémination du virus de l'hépatite C by Marine Turek( )

1 edition published in 2013 in French and held by 1 WorldCat member library worldwide

HCV infection is the leading cause of chronic liver disease. The current SOC is still limited by high costs, toxicity and emergence of viral resistance. In the first part of my thesis we focused our workon viral entry. Viral entry is required for initiation, spread, and maintenance of infection, and thus is a promising target for the development of new antiviral therapies. CD81 and SR-BI are the first entry factors identified as important for HCV entry. In our work we confirmed their crucial role in entry, especially at the post-binding step. In addition we proved their key role in viral dissemination through the cell-cell transmission. As HCV mainly infects hepatocytes, we studied in the second part of my thesis, the restricted cellular tropism of HCV to hepatocytes and we defined the minimal host factors rendering non hepatic cell lines susceptible to HCV infection by the establishment of a powerful tool to identify new assembly and replication factors
Analyse cellulaire et moléculaire de la transmission précoce de la borréliose de Lyme : rôle de l'interface cutanée by Quentin Bernard( )

1 edition published in 2015 in French and held by 1 WorldCat member library worldwide

Vector-borne diseases account for seventeen percent of world-wide infectious diseases. They are amajor threat to public health. Lyme borreliosis is the first vector-borne disease of the northernhemisphere. It is caused by a bacteria, Borrelia burgdorferi sensu lato, inoculated by a hard tickbelonging to the Ixodes genus. The first contact between the vertebrate host and the tick, and sobetween the vertebrate host and the bacteria, occurs at the skin interface. The skin is then of majorimportance for the early development of the immune response against Borrelia.The tick bite induces a skin injury owing to its biting pieces, the hypostome and two chelicerae. The ticksaliva also creates a feeding pool allowing the tick to feed efficiently. This process also facilitates Borreliatransmission. We have characterized a tick saliva protein which might participate to the formation ofthe feeding pool: histone H4. This protein lyses fibroblasts and harbors bactericidal properties againstcommensal bacteria. These two activities might help Borrelia to infect the vertebrate host by sustainingits development in the skin. Once bacteria have been injected into the skin, they interact with residentskin cells, keratinocytes and fibroblasts, and immune cells. We have shown that the inflammationinduced by the tick bite increases the keratinocyte inflammatory response against Borrelia. However,the saliva inhibits this cross-talk which depends on TLR3/TRIFF and TLR2/MyD88 pathways. Once thetick has detached and the saliva has disappeared, the cross-talk might explained the inflammationobserved during the erythema migrans.Other skin cells than keratinocytes and fibroblasts are involved in the early inflammatory responseagainst Borrelia such as dendritic cells, macrophages and neutrophils. We have explored theinvolvement of another poorly-studied cell-type: mast cells. We have shown that these cells can secreteIL-6 and degranulate in response to Borrelia. Bacteria antigens responsible of the activation mightdepends on the living state of Borrelia. The tick saliva is able to negatively control the secretion of IL-6,but not to completely inhibit it. At this point, we cannot conclude in a WSH mouse model deficient inmast cells, to a major role of these cells in the inflammatory response against Borrelia.While in the skin, Borrelia expresses many genes which will facilitate the dissemination across thevertebrate host, to reach different target organs (brain, joint, distant skin). We have characterized twogenes potentially involved in the dissemination of a virulent clone of B. burgdorferi sensu stricto: bb0347and bb0213. bb0347 encodes for an adhesion which can specifically interact with the extracellularmatrix of the skin while the role of bb0213 is unknown. bb0347 might help the bacteria to migratethrough skin tissues and then increases the infection rate
Lyme borreliosis : biological and clinical aspects : Current problems in dermatology by Dan Lipsker( Book )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

OUTILS MOLECULAIRES DE DETECTION ET DE TYPAGE DE BORRELIA BURGDORFERI SENSU LATO DANS L'ARTHRITE DE LYME by Benoît Jaulhac( Book )

1 edition published in 1998 in French and held by 1 WorldCat member library worldwide

BORRELIA BURGDORFERI SENSU LATO (B. BURGDORFERI SL) EST RESPONSABLE DES DIFFERENTES MANIFESTATIONS DE LA BORRELIOSE DE LYME. LA MISE EN EVIDENCE DE CETTE BACTERIE DANS LES PRELEVEMENTS HUMAINS PAR DES METHODES CLASSIQUES (CULTURE, COLORATION) EST RAREMENT COURONNEE DE SUCCES. LE PREMIER BUT DE CE TRAVAIL A ETE DE METTRE AU POINT UNE METHODE DE DETECTION DE L'ADN DE B. BURGDORFERI SL PAR AMPLIFICATION GENIQUE IN VITRO DANS LES PRELEVEMENTS SYNOVIAUX (LIQUIDES ARTICULAIRES ET BIOPSIES). NOUS AVONS ENSUITE REALISE UNE ETUDE PROSPECTIVE CHEZ DES PATIENTS ATTEINTS D'ARTHRITE DE LYME ET MONTRE QU'EN UTILISANT UNE CIBLE CHROMOSOMIQUE, LA SENSIBILITE DE CETTE METHODE ETAIT DE 42% SUR LIQUIDE ARTICULAIRE ET DE 91% SUR BIOPSIE SYNOVIALE. CECI EST EN FAVEUR D'UNE LOCALISATION PREFERENTIELLE DE CETTE BACTERIE DANS LE TISSU SYNOVIAL. CHEZ UN PATIENT, NOUS AVONS MONTRE PAR MICROSCOPIE ELECTRONIQUE QUE BORRELIA BURGDORFERI ETAIT PRESENTE DANS LE CYTOPLASME DES SYNOVIOCYTES. NOUS AVONS ENSUITE APPLIQUE CETTE METHODE A DES PRELEVEMENTS MUSCULAIRES EFFECTUES CHEZ DES PATIENTS ATTEINTS DE MYALGIES CHRONIQUES APRES UNE NEUROBORRELIOSE OU UNE ARTHRITE DE LYME. NOUS AVONS DETECTE LA PRESENCE D'ADN DE BORRELIA BURGDORFERI POUR CERTAINS D'ENTRE EUX, PROUVANT LA DISSEMINATION DE CE SPIROCHETE DANS LE TISSU MUSCULAIRE. NOUS AVONS MIS AU POINT SUR MODELE MURIN D'ARTHRITE DE LYME UNE METHODE SENSIBLE DE DETECTION DES ARNM DE B. BURGDORFERI SL PAR RT-PCR EN UNE ETAPE AFIN D'ETUDIER LA VIABILITE DE CES SPIROCHETES DANS LES TISSUS HUMAINS. PARMI LES NOMBREUSES ESPECES DE BORRELIA, 4 ESPECES AU MOINS SONT RESPONSABLES EN EUROPE DE LA BORRELIOSE DE LYME. L'IDENTIFICATION DE CES DIFFERENTES ESPECES N'EST PAS POSSIBLE PAR DES METHODES PHENOTYPIQUES. NOUS AVONS DEVELOPPE UNE METHODE DIRECTE DE TYPAGE DE CES ESPECES PAR PCR ET HYBRIDATION PAR DES OLIGONUCLEOTIDES SPECIFIQUES. CETTE METHODE A ETE APPLIQUEE A DIX PATIENTS ATTEINTS D'ARTHRITE DE LYME : B. BURGDORFERI SENSU STRICTO EN ETAIT RESPONSABLE DANS 9 CAS ET B. GARINII N'A ETE DETECTEE QUE CHEZ UN SEUL PATIENT
 
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Associated Subjects
Lyme borreliosis : biological and clinical aspects
Languages
French (17)

English (13)

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