WorldCat Identities

Jaulhac, Benoît

Overview
Works: 21 works in 31 publications in 2 languages and 135 library holdings
Roles: Thesis advisor, Author, Editor, Opponent
Classifications: RC155.5, 616.9246
Publication Timeline
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Most widely held works by Benoît Jaulhac
Lyme borreliosis : biological and clinical aspects( Book )

9 editions published in 2009 in English and held by 47 WorldCat member libraries worldwide

A comprehensive and up-to-date review by leading experts in the field
Inflammation cutanée lors de la transmission vectorielle de la borreliose de Lyme Etude sur modèle murin by Aurélie Kern( Book )

2 editions published between 2011 and 2012 in French and held by 2 WorldCat member libraries worldwide

La borréliose de Lyme est une infection bactérienne due à Borrelia burgdorferi sensu lato et transmise à l'Homme par piqûre de tique du genre Ixodes. Cette affection est caractérisée par des manifestations cliniques variées. La transmission de l'agent pathogène induit dans un premier temps une inflammation cutanée : l'érythème migrant. Après dissémination, les manifestations cliniques peuvent être de nature neurologique, articulaire ou cutanée. La peau est une interface essentielle dans la transmission du pathogène par le vecteur. Le rôle central de l'interface cutanée est abordé au cours de ce travail de thèse. D'une part, nous nous sommes intéressés à la modulation de l'immunité cutanée par la salive de la tique, plus précisément à l'effet de la salive sur l'expression de peptides anti-microbiens (PAM), de cytokines pro-inflammatoires et de chimiokines. D'autre part, les mécanismes responsables du tropisme préférentiel des bactéries vers les organes cibles ne sont pas connus à ce jour. Afin de répondre à ces questions, nous avons établi différents modèles expérimentaux. D'une part, un modèle in vitro permettant d'analyser spécifiquement la réponse des cellules résidantes de la peau. D'autre part, une approche in vivo d'infection chez des souris C3H/HeN. Au cours de ce travail, nous avons mis en évidence une immuno-modulation cutanée par la salive de tique durant la transmission de la borréliose de Lyme. Nous avons proposé un effet anti-alarmine de la salive sur la peau. Nous montrons également que la peau est un site de multiplication massive de la bactérie avant sa dissémination vers les organes cibles. De plus, la mise en évidence d'une réponse immunitaire différente selon le pathotype souligne le rôle potentiel de l'interface cutanée pour l'évolution de B. burgdorferi dans l'hôte vertébré
Mise au point d'une technique de confirmation par PCR en temps réel pour la détection de borrelia burgdorferi sensu lato by Anne Kiesler( Book )

1 edition published in 2006 in French and held by 2 WorldCat member libraries worldwide

Serologie de la borreliose de lyme par immuno-empreinte : influence de la souche utilisee comme antigene (des biologie medicale) by SYLVIE DE MARTINO( Book )

1 edition published in 2000 in French and held by 2 WorldCat member libraries worldwide

Evaluation de 14 coffrets commerciaux de depistage de la borreliose de lyme en france (des biol. med.) by Pierre Zachary( Book )

1 edition published in 2000 in French and held by 2 WorldCat member libraries worldwide

Détection de la résistance à la méticilline et identification d'espèces de staphylocoques sur des hémocultures par PCR en temps réel by Céline Menard( Book )

1 edition published in 2006 in French and held by 2 WorldCat member libraries worldwide

Inflammation cutanée et borréliose de Lyme rôle de l'immunité innée et de la tique dans la transmission à l'homme de Borrelia burgdorferi by Claire Marchal( Book )

2 editions published between 2009 and 2010 in French and held by 2 WorldCat member libraries worldwide

Lyme disease is an arthropod borne disease transmitted by a hard tick, Ixodes spp., and caused by a spirochetal bacteria Borrelia burgdorferi. It is a zoonotic organism that occurs between an arthropod, the tick and a vertebrate host. The disease prevails mainly in the Northern hemisphere. Infection by this organism induces multiple and varied symptoms : articular, neurologic, cutaneous and cardiatis attacks. The tick Ixodes is a hemotaphagous arthropod that had to attach during 4 to 8 days on the vertebrate host in order to feed to repletion. To secure the attachment and susceptibility of reservoir hosts for future tick infestations, the vector inject saliva which possesses not only pharmacologic properties but immunomodulatory too. Among these tick saliva proteins, Salp15 is a major immunomodulatory protein of I. scapularis. It inhibits T lymphocyte activation by biding to the CD4 co-receptor, and inhibits adaptive immune responses by suppressing human dendritic cell functions. In addition, Salp15 binds to B. burgdorferi outer surface protein (Osp) C and protect the bacteria against host antibodies. In vector-borne diseases, the interface skin has a very important role. We therefore analyzed the role of resident cells of the skin: the keratinocytes (KCs) and fibroblasts (FBs) in inflammation. Innate immunity induced skin antimicrobial peptides (PAMs) that kill a wide range of pathogens which have chemotactic and angiogenic activities. We have demonstrated that KCs incubated in vitro with B. burgdorferi induce an inflammatory response (chemokine and PAMs). We then studied the effect of immunosuppressive potential of extracts of salivary glands and protein tick, Salp15 of I. ricinus. We found that they inhibit the inflammatory response with effect anti-alarmin. This immunosuppressive effect could facilitate the transmission and propagation of Borrelia. Then, we studied the role of FBs, skin cells in Lyme borreliosis. We have shown that Borrelia induces the expression of some metalloproteinases (MMPs), during the cooperation between KCs and FBs. The bacteria may then migrate through the ECM of the skin and spread. Finally we studied the interaction of KCs with different species of B. burgdorferi : B. garinii, B. burgdorferi ss and B. afzelii or different strains to study the possible role of the skin in organ specimens of Borrelia
Etude de la survie en air ambiant de bactéries anaérobies d'intérêt médical by Pierre-Adrien BIHL( Book )

1 edition published in 2013 in French and held by 2 WorldCat member libraries worldwide

Détermination des espèces de borrelia burgdorferi responsables d'érythème migrant en Alsace par une technique de typage moléculaire par PCR en temps réel by Mahsa Mohseni Zadeh( Book )

1 edition published in 2005 in French and held by 2 WorldCat member libraries worldwide

Toxine du syndrome de choc toxique et entérotoxines de staphylococcus aureus : nouveaux moyens de diagnostic by Benoît Jaulhac( )

1 edition published in 1990 in French and held by 2 WorldCat member libraries worldwide

Mise au point d'une technique de revelation non radioactive de produits d'amplification genique in vitro : application a la detection des legionella by BRUNO SUDAN( Book )

1 edition published in 1997 in French and held by 2 WorldCat member libraries worldwide

Outils moleculaires de detection et de typage de borrelia burgdorferi sensu lato dans l'arthrite de lyme by Benoît Jaulhac( Book )

1 edition published in 1998 in French and held by 1 WorldCat member library worldwide

BORRELIA BURGDORFERI SENSU LATO (B. BURGDORFERI SL) EST RESPONSABLE DES DIFFERENTES MANIFESTATIONS DE LA BORRELIOSE DE LYME. LA MISE EN EVIDENCE DE CETTE BACTERIE DANS LES PRELEVEMENTS HUMAINS PAR DES METHODES CLASSIQUES (CULTURE, COLORATION) EST RAREMENT COURONNEE DE SUCCES. LE PREMIER BUT DE CE TRAVAIL A ETE DE METTRE AU POINT UNE METHODE DE DETECTION DE L'ADN DE B. BURGDORFERI SL PAR AMPLIFICATION GENIQUE IN VITRO DANS LES PRELEVEMENTS SYNOVIAUX (LIQUIDES ARTICULAIRES ET BIOPSIES). NOUS AVONS ENSUITE REALISE UNE ETUDE PROSPECTIVE CHEZ DES PATIENTS ATTEINTS D'ARTHRITE DE LYME ET MONTRE QU'EN UTILISANT UNE CIBLE CHROMOSOMIQUE, LA SENSIBILITE DE CETTE METHODE ETAIT DE 42% SUR LIQUIDE ARTICULAIRE ET DE 91% SUR BIOPSIE SYNOVIALE. CECI EST EN FAVEUR D'UNE LOCALISATION PREFERENTIELLE DE CETTE BACTERIE DANS LE TISSU SYNOVIAL. CHEZ UN PATIENT, NOUS AVONS MONTRE PAR MICROSCOPIE ELECTRONIQUE QUE BORRELIA BURGDORFERI ETAIT PRESENTE DANS LE CYTOPLASME DES SYNOVIOCYTES. NOUS AVONS ENSUITE APPLIQUE CETTE METHODE A DES PRELEVEMENTS MUSCULAIRES EFFECTUES CHEZ DES PATIENTS ATTEINTS DE MYALGIES CHRONIQUES APRES UNE NEUROBORRELIOSE OU UNE ARTHRITE DE LYME. NOUS AVONS DETECTE LA PRESENCE D'ADN DE BORRELIA BURGDORFERI POUR CERTAINS D'ENTRE EUX, PROUVANT LA DISSEMINATION DE CE SPIROCHETE DANS LE TISSU MUSCULAIRE. NOUS AVONS MIS AU POINT SUR MODELE MURIN D'ARTHRITE DE LYME UNE METHODE SENSIBLE DE DETECTION DES ARNM DE B. BURGDORFERI SL PAR RT-PCR EN UNE ETAPE AFIN D'ETUDIER LA VIABILITE DE CES SPIROCHETES DANS LES TISSUS HUMAINS. PARMI LES NOMBREUSES ESPECES DE BORRELIA, 4 ESPECES AU MOINS SONT RESPONSABLES EN EUROPE DE LA BORRELIOSE DE LYME. L'IDENTIFICATION DE CES DIFFERENTES ESPECES N'EST PAS POSSIBLE PAR DES METHODES PHENOTYPIQUES. NOUS AVONS DEVELOPPE UNE METHODE DIRECTE DE TYPAGE DE CES ESPECES PAR PCR ET HYBRIDATION PAR DES OLIGONUCLEOTIDES SPECIFIQUES. CETTE METHODE A ETE APPLIQUEE A DIX PATIENTS ATTEINTS D'ARTHRITE DE LYME : B. BURGDORFERI SENSU STRICTO EN ETAIT RESPONSABLE DANS 9 CAS ET B. GARINII N'A ETE DETECTEE QUE CHEZ UN SEUL PATIENT
Analyse cellulaire et moléculaire de la transmission précoce de la borréliose de Lyme : rôle de l'interface cutanée by Quentin Bernard( )

1 edition published in 2015 in French and held by 1 WorldCat member library worldwide

Vector-borne diseases account for seventeen percent of world-wide infectious diseases. They are amajor threat to public health. Lyme borreliosis is the first vector-borne disease of the northernhemisphere. It is caused by a bacteria, Borrelia burgdorferi sensu lato, inoculated by a hard tickbelonging to the Ixodes genus. The first contact between the vertebrate host and the tick, and sobetween the vertebrate host and the bacteria, occurs at the skin interface. The skin is then of majorimportance for the early development of the immune response against Borrelia.The tick bite induces a skin injury owing to its biting pieces, the hypostome and two chelicerae. The ticksaliva also creates a feeding pool allowing the tick to feed efficiently. This process also facilitates Borreliatransmission. We have characterized a tick saliva protein which might participate to the formation ofthe feeding pool: histone H4. This protein lyses fibroblasts and harbors bactericidal properties againstcommensal bacteria. These two activities might help Borrelia to infect the vertebrate host by sustainingits development in the skin. Once bacteria have been injected into the skin, they interact with residentskin cells, keratinocytes and fibroblasts, and immune cells. We have shown that the inflammationinduced by the tick bite increases the keratinocyte inflammatory response against Borrelia. However,the saliva inhibits this cross-talk which depends on TLR3/TRIFF and TLR2/MyD88 pathways. Once thetick has detached and the saliva has disappeared, the cross-talk might explained the inflammationobserved during the erythema migrans.Other skin cells than keratinocytes and fibroblasts are involved in the early inflammatory responseagainst Borrelia such as dendritic cells, macrophages and neutrophils. We have explored theinvolvement of another poorly-studied cell-type: mast cells. We have shown that these cells can secreteIL-6 and degranulate in response to Borrelia. Bacteria antigens responsible of the activation mightdepends on the living state of Borrelia. The tick saliva is able to negatively control the secretion of IL-6,but not to completely inhibit it. At this point, we cannot conclude in a WSH mouse model deficient inmast cells, to a major role of these cells in the inflammatory response against Borrelia.While in the skin, Borrelia expresses many genes which will facilitate the dissemination across thevertebrate host, to reach different target organs (brain, joint, distant skin). We have characterized twogenes potentially involved in the dissemination of a virulent clone of B. burgdorferi sensu stricto: bb0347and bb0213. bb0347 encodes for an adhesion which can specifically interact with the extracellularmatrix of the skin while the role of bb0213 is unknown. bb0347 might help the bacteria to migratethrough skin tissues and then increases the infection rate
Borrelia burgdorferi sensu lato by Benoît Jaulhac( )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Etude des facteurs cellulaires responsables de l'initiation et de la dissémination du virus de l'hépatite C by Marine Turek( )

1 edition published in 2013 in French and held by 1 WorldCat member library worldwide

Le VHC est une cause majeure de cancer du foie. Le traitement actuel est caractérisé par à un cout élevé, la présence de toxicité et l'émergence de résistance virale. Dans la 1ère partie de ma thèse, je me suis intéressé à l'entrée virale. L'entrée est nécessaire pour l'initiation ; la dissémination et le maintien de l'infection et représente ainsi une cible intéressante dans le développement de thérapies antivirales : CD81 et SRBI sont les 1ers facteurs décrits comme importants pour l'entrée : Nous avons confirmé leur rôle clé dans l'entrée et les étapes suivant l'entrée. De plus, nous avons montré leur rôle crucial dans la transmission cellule/cellule. Le VHC infecte principalement les hépatocytes, nous avons étudié en seconde partie de ma thèse le tropisme restreint du VHC aux hépatocytes. En définissant les facteurs essentiels à l'infection de cellules non hépatiques et en développant un modèle cellulaire afin d'identifier de nouveaux facteurs d'assemblage et de réplication du VHC
Evaluation prospective du serodiagnostic de la maladie des griffes du chat chez 311 patients : analyse critique by MARC PIERRE STREIFF( Book )

1 edition published in 1998 in French and held by 1 WorldCat member library worldwide

Enhanced culture of Borrelia garinii and Borrelia afzelii strains on a solid BSK-based medium in anaerobic conditions( )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

The growth of 29 human strains from the three main pathogenic species of Borrelia burgdorferi sensu lato on a solid BSK-based medium was compared in two culture atmospheres: 3% CO(2) air and anaerobiosis. All strains grew underanaerobic conditions, whereas only 13 strains were able to grow in aerobiosis with 3% CO(2) (P<0.001). In the latter condition, 75% of the B. burgdorferi sensu stricto strains grew versus 33% of the B. garinii and B. afzelii strains. These data suggest that, especially for B. garinii and B. afzelii species, anaerobic conditions enhance growth yield and speed of low-passage Borrelia strains
Inflammation cutanée et borréliose de Lyme : étude in vitro des interactions entre les cellules résidentes de la peau et Borrelia by Frédéric Schramm( )

1 edition published in 2012 in French and held by 1 WorldCat member library worldwide

We studied the role of the skin innate immunity during the transmission of Borrelia (the infectious agent of Lyme borreliosis) by its vector, a hard tick belonging to the genus Ixodes. We showed that tick saliva and its protein Salp15 both inhibate Borrelia-induced inflammatory reaction of keratinocytes. The antialarmin effect of tick saliva ensure a favorable environment for Borrelia. We also showed that Borrelia induce a strong inflammatory response in dermal fibroblasts. We also demonstrate a dose-dependent lytic effect of tick salivary gland extracts on dermal fibroblasts and that this cytotoxic effect was of proteinaceous nature and not related to Salp15. These results indicate that dermal fibroblasts could be considered as central mediators in immune cell recruitment to the skin site of Borrelia invasion
 
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Associated Subjects
Lyme borreliosis : biological and clinical aspects
Languages
French (19)

English (11)

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