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University of Alberta School of Public Health Health Technology & Policy Unit

Works: 39 works in 45 publications in 1 language and 446 library holdings
Genres: Educational films  Internet videos  Documentary films 
Publication Timeline
Most widely held works by University of Alberta
Photodynamic therapy for the treatment of Barrett's esophagus : a systematic review and economic evaluation : final report( )

2 editions published in 2012 in English and held by 200 WorldCat member libraries worldwide

"This review assesses the evidence on the safety and effectiveness of photodynamic therapy for the treatment of Barrett's esophagus with high grade dysplasia in comparison to esophagectomy and other endoscopic treatments for this condition. It also examines the social and economic considerations for the provision of PDT in comparison to alternate treatments"--Page 3
Photodynamic therapy for skin cancer & pre-cancerous skin conditions( )

2 editions published in 2012 in English and held by 49 WorldCat member libraries worldwide

"This assessment is a systematic review of the evidence on photodynamic therapy (PDT) for the treatment of pre-cancerous skin conditions (i.e. actinic keratosis), and non-melanoma skin cancers (i.e. Bowen's disease, basal cell carcinoma, and mammary and extra-mammary Paget's disease). The objectives of this review were to determine the safety, effectiveness and cost- effectiveness and budget impact of PDT in comparison to other treatments for these conditions; to identify particular sub-groups of patients who might benefit most from PDT; and to summarize current criteria for the use of PDT and alternative treatments for these skin conditions."--Page iii
An assessment of sleep disordered breathing diagnosis using level I versus level III sleep studies : final report( )

2 editions published in 2012 in English and held by 47 WorldCat member libraries worldwide

"Sleep disordered breathing (SDB) includes various conditions, all of which involve abnormal respiration during sleep. Obstructive sleep apnea is the most common of these disorders, but other types of SDB include central sleep apnea (caused by cardiac or neurological malfunction that affects breathing), and disorders caused by other medical conditions, for example, Cheyne-Stokes respiration, which affects many patients with heart failure"--Page 12
Photodynamic therapy for the treatment of early esophageal cancer : a systematic review and economic evaluation : final report( )

2 editions published in 2012 in English and held by 47 WorldCat member libraries worldwide

"This assessment examines the safety and effectiveness of PDT for early stage esophageal cancer, compared to surgery (esophagectomy), chemotherapy, radiotherapy, combined chemoradiotherapy, and a number of more recently introduced endoscopic techniques (endoscopic mucosal resection, radiofrequency ablation, argon plasma coagulation and cryoablation). (Photodynamic therapy is also used as a palliative treatment in advanced esophageal cancer, but its role in advanced cancer treatment is not included in this review.)"--Page 3
Level I and level III sleep studies for the diagnosis of sleep disordered breathing (SDB) in adults : final report( )

1 edition published in 2014 in English and held by 37 WorldCat member libraries worldwide

"Sleep disordered breathing (SDB) includes various conditions caused by problems with respiration during sleep. The most common type of SDB, obstructive sleep apnea (OSA) affects many Albertans. The number of Albertans with SDB is increasing - mainly due to population aging, rising rates of obesity, and growing numbers of patients with chronic obstructive pulmonary disease. Improved public and physician awareness of the health risks associated with sleep disorders is also contributing to the growing demand for sleep studies. Level I sleep studies, or polysomnography, involve overnight testing in a sleep laboratory with a trained health care professional in attendance. Polysomnography is the reference standard for the diagnosis of SDB because it captures many different types of physiological data and can distinguish both OSA and other sleep disorders. Unfortunately, level I polysomnography is an imperfect gold standard and an expensive test to perform. Level III sleep studies, using portable devices intended for patients to use at-home may provide an alternative diagnostic tool for some patients with SDB. These devices are less expensive than level I inlab polysomnography, and are widely available. However, most of the studies of level III devices have included only patients with simple OSA (i.e., without other major comorbidities). It is not clear whether level III sleep studies are appropriate for patients with other types of SDB, or in patients with other serious health conditions. To assess the safety and effectiveness of SDB diagnosis, and to delineate which sub-populations of patients might benefit from level III at-home sleep studies versus level I in-lab sleep studies, two reviews were prepared - one of the published evidence on level III studies and another on level I studies. An additional review was prepared for the economic evaluation."--Executive summary
Individualized health related quality of life measures : their use in children and their psychometric properties by Sana Ishaque( )

2 editions published in 2012 in English and held by 5 WorldCat member libraries worldwide

Lunchbox breakdown( Visual )

1 edition published in 2010 in English and held by 5 WorldCat member libraries worldwide

"Walk down the aisles of any supermarket, and you'll notice an explosion of prepared foods for kids' lunches. This collection of three National mini-documentaries takes a closer look at these convenient snacks and meals to find out how they stack up nutritionally. Reporter Reg Sherren profiles Alberta's APPLE Project promoting active living and healthy eating in schools. Ian Hanomansing assesses the nutritional content of some common lunch items, including the additives, dyes and other questionable ingredients they contain. He then visits one elementary school to see what lunch choices students make when they have healthy options."--Container
Identification of shared and distinct gene-disease associations among multiple related diseases and multiple subtypes of a disease by Conrado Franco-Villalobos( )

1 edition published in 2013 in English and held by 4 WorldCat member libraries worldwide

Genome-wide association study (GWAS) is an approach with high-throughput genotyping to uncover genetic susceptibilities of complex diseases. However, the genetic susceptibilities discovered usually carry very small risk increments. Additionally, the current approach to assess whether these genetic associations are shared among a group of diseases relies mainly on statistical significance alone, ignoring biologically relevant information such as magnitude and direction of the associations. The methodology proposed takes into account not only strength and direction of the associations but also the resemblance of the biological mechanism by using logic regression to generate a graphical representation of the similarity of the associations. We found evidence that 149 genetic associations have certain degree of uniqueness with Crohn's Disease, Rheumatoid Arthritis, and Type I Diabetes while 11 were shared between at least 2 diseases. Additionally, the gene-level analysis of TB cases stratified by age, strain, and lineage identified 3 new susceptibility genes (ZFHX1B, FER, and FAM77) associated with different TB subgroups
Work, injury, and depression : the influence of work status on depressive symptoms for those recovering from musculoskeletal injury by David Charles Jones( )

1 edition published in 2013 in English and held by 4 WorldCat member libraries worldwide

Many individuals obtain a sense of personal identity from work as well as the resources necessary for basic living. Musculoskeletal injury is a common barrier to continued employment in developed countries and despite numerous compensation programs, work absences can significantly disrupt an individual's sense of self, potentially predisposing the injured individual to significant symptoms of depression. The goal of this dissertation was to investigate the relationship between work status and subsequent depression following injury. Chapter two provided an introductory, theoretical framework from which to view the contribution of work to the possible prevention or resolution of depressive symptoms following injury. In chapter 3, a cohort of whiplash patients were followed forward in time to investigate the temporal relationship between work status and depressive symptoms following injury. From this investigation it was found that work status significantly influence subsequent depression shortly after injury, but not in the longer term. In Chapter 4, a cohort of worker's compensation claimants were categorized by work status shortly after their injury and followed forward in time for depression outcomes. The relationships observed in chapter 3 were not replicated in chapter 4; however, the worker's compensation cohort suffered from loss to follow-up and the timing of assessments differed significantly from those used in chapter 3. Chapter five provided a methodological comparison of differing methods with which to control for confounding in studies using continuous baseline health outcome measures which are also used to categorize disease status further on in follow-up. Through this investigation it became apparent that there is no one right answer for using related continuous and categorical outcomes in the same regression models; however, for our research, it was apparent that prior depressive symptom scores were best characterized as a confounding variable in the 'work-status and subsequent depression' relationship. In conclusion this dissertation provided three important contributions to the study of depression following injury: 1. There is a plausible and visually explainable mechanism by which alterations in work status can influence subsequent depression following injury; 2. Work status is significantly associated with subsequent depression status shortly after whiplash injury; and 3. The alteration of a single modeling variable can substantially alter the conclusions drawn in follow-up studies of depression and depressive symptomatology; careful consideration must be made when including and excluding seemingly associated variables in a predictive regression model
Building management capacity for evidence use in health care organizations by Serena Lynn Humphries( )

2 editions published in 2013 in English and held by 3 WorldCat member libraries worldwide

Social determinants of alcohol, drug and gambling problems among urban Aboriginal adults in Canada by Cheryl Currie( )

1 edition published in 2012 in English and held by 3 WorldCat member libraries worldwide

Objective: Little is known about the determinants of addictive disorders within the rapidly growing urban Aboriginal population in Canada. The objectives of this dissertation were to examine whether Aboriginal enculturation, Canadian acculturation, and racial discrimination were associated with addictive problems among urban Aboriginal Canadians, and to test potential mediators of these associations. Methods: Data were collected via in-person surveys and interviews with two community-based samples of Aboriginal adults living in a mid-sized city in western Canada. Sample 1 was recruited in 2008-09 and included Aboriginal university students (N = 60). Sample 2 was recruited in 2010 and included urban Aboriginal adults more generally (N = 381). Results: Both samples evidenced high levels of Aboriginal enculturation and Canadian acculturation. In Sample 1, Aboriginal enculturation served as a protective factor for alcohol use problems. In Sample 2, Aboriginal enculturation served as a protective factor for illicit and prescription drug problems, as well as a resilience factor that buffered the effects of low educational attainment on illicit drug problems in this population. The protective impacts of enculturation on illicit and prescription drug problems were partially explained by elevated self-esteem among urban Aboriginal participants who were more highly enculturated. Canadian acculturation was not statistically associated with alcohol or illicit drug problems and served as a risk factor for prescription drug problems among urban Aboriginal participants. Racial discrimination served as a risk factor for prescription drug problems and gambling problems. Mediational analyses indicate the impacts of racial discrimination on addictive outcomes were explained by elevated PTSD symptomology among those experiencing high levels of discrimination. These associations could not be explained by statistical adjustment for factors such as separation from birth parents in childhood, abuse in childhood, and exposure to poverty over the life course. Conclusions: Findings support the growth of programs and services that encourage Aboriginal peoples to maintain their culture within the urban setting. Results also support policies and programs to reduce racism directed at Aboriginal peoples in urban areas, and services to help Aboriginal peoples cope with these experiences
The relationship between health related quality of life and non-small cell lung cancer surgery by Sayf Gazala( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Cumulative total incidence for estimating the burden of recurrent events and risk vs. rate concepts and regression models in epidemiology by Huiru Dong( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

In the first part of this thesis, a straightforward intuitive method for descriptive survival analysis, termed "cumulative total incidence", is proposed to measure the total burden of recurrent events in a population by a given time. Using data from the Childhood Cancer Survivor Study, demonstrate the utility of this method contrasting this method to cumulative incidence. In the second part of this thesis, the concepts of risk and rate, and their relationship are discussed in the framework of survival analysis. Regression approaches for estimating the association between factors on event risk and event rate are discussed. Using data from the Childhood Cancer Survivor Study on two competing outcomes, we further demonstrate how competing-risk event affects the estimated association of covariates of interest with event risk and rate
Mental health and chronic medical conditions : schizophrenia, its treatment, risk of metabolic complications, and health care utilization by Lauren Christine Bresee( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Factors associated with severe and fatal cycling injuries in North America by Lindsay A Gaudet( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Background: Cycling is an increasingly popular recreational activity and mode of transportation, and many North American municipalities are implementing policies and infrastructure to encourage cycling participation for all ages. Crashes while cycling, however, can have devastating consequences including debilitating injury and death. The factors relating to the occurrence of severe injury events are not well studied, making it difficult to refine and implement successful injury prevention strategies. This thesis aims to compile the current evidence on cycling fatalities, examine the role of age in their occurrence compared to severe injury, and describe their occurrence in a sparsely populated area with a northern climate. Methods: Three studies were completed to investigate severe and fatal cycling injuries in North America. First, a scoping review was conducted to explore the current literature on fatal cycling injuries in North America. Second, a systematic review was conducted to examine the burden of injury due to cycling fatalities in adults compared with children. Finally, a descriptive observational study was conducted using chart review methods to extract data from fatality case files of the Office of the Chief Medical Examiner of Alberta, and population-based fatality rates by age category and by region were calculated using census data. Results: The scoping review identified 25 studies documenting cycling fatalities in North America, of which 21 used data from US populations, four used data from Canadian populations, 19 included both child and adult cyclists, four included only children, and two reported only on adults. Studies most commonly reported on: sex (n=16), motor vehicle involvement (n=12), lighting condition (n=12), alcohol use (n=10), and occurrence of head injury (n=9). Of the 46 eligible studies of severe and fatal cycling injuries in North America identified in the systematic review, data were available from 27. Overall, children had a lower weighted proportion of fatalities (3.0%; 95% CI: 2.3-3.8%) than adults (7.2%; 95% CI: 5.6 - 8.7%). Heterogeneity was very high, except for pediatric studies conducted in Canada (I2=27) and pediatric studies in regions where mandatory helmet legislation existed (I2=0). One-hundred and one cycling-related deaths over 14 years in Alberta were identified. Most (87%) deceased cyclists were male, median age was 47 years (inter-quartile range: 25, 58), and 25% wore helmets. Collisions with motor vehicles and cyclist-only crashes accounted for 67% and 22% of fatalities, respectively; 12 (12%) crashes had "other" mechanisms, such as a collision with a train, light rail transit, pedestrian, or other cyclist. The population-based fatality rate was highest for the ≥65 age group. Conclusions: There are few high-quality studies examining the factors associated with cycling fatalities, especially compared with nonfatal injuries. Overall, studies of severe and fatal cycling injury events provide only weak evidence, have inconsistent reporting of results and efforts to standardize them are warranted. In cases of severe injury, adults appear to have a higher burden of fatality than children, and older adults (≥60 years old) had the highest fatality burden. Injury prevention strategies should target male cyclists, helmet use and avoidance of substance use while cycling. Future studies should focus on improved methods, including use of comparison groups and prospective study designs, and more detailed reporting of known or suspected risk factors
To measure the cost of collaborative partnership for the healthy Alberta communities project by Jane Leung-Ching Woo( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Abnormal small intestinal permeability in asymptomatic first-degree relatives of patients with Crohn's disease is not caused by subclinical Crohn's disease by Christopher Wayne Teshima( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Impact of introduction of safety-engineered devices on the incidence of sharp object injury among health care workers in the capital region of Alberta by Yun Lu( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Urinary metabolomics of gastric cancer by Angela W Chan( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Gastric cancer is an aggressive malignancy. Much of the mortality is attributable to delayed diagnosis from non-specific symptoms, and lack of early and accurate screening modalities. Metabolomics, the most downstream of the "omics" sciences (genomics, transcriptomics, proteomics) is the latest tool to join the diagnostic armamentarium. The transformation from normalcy to malignancy is accompanied by a series of aberrant biochemical and metabolic alterations. Through detection of metabolites from such pathways, metabolomics may offer potential for early and non-invasive detection of gastric cancer. Hydrogen nuclear magnetic resonance spectroscopy was used as the analytical platform to explore the urinary metabolomic profile of patients with gastric cancer, in comparison to patients with benign gastric disease and healthy controls who were age, sex and body mass index matched. On multivariate statistical analysis, gastric cancer individuals had a discrete urinary metabolomic signature that was clearly distinguishable from healthy patients, and a subset of benign gastric disease individuals, namely those with chronic gastritis and ulcers. LASSO logistic regression generated a parsimonious model with three metabolites (alanine, 2-hydroxyisobutyrate, 3-indoxylsulfate) that discriminated gastric cancer from healthy controls with high accuracy, sensitivity and specificity. These preliminary results suggest that there is clinical potential for metabolic profiling for gastric cancer detection; however, future studies will be required to validate these findings
Identifying prognostic factors for adverse outcomes in adults with bacteremic pneumococcal pneumonia by Jessica A Beatty( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Bacteremic pneumococcal pneumonia (BPP) is a severe form of invasive pneumonia that continues to cause significant morbidity and mortality worldwide, yet large-scale studies identifying prognostic factors for adverse outcomes in patients with BPP is significantly lacking. Furthermore, considerable knowledge gaps and conflicting results exist for even widely known prognostic factors for mortality such as smoking. Therefore, the first objective of this program of research was to identify prognostic factors associated with mortality and in-hospital complications in adult patients with BPP. This objective was achieved using a population-based cohort study composed of 1636 adults (≥18 years) with BPP hospitalized between 2000-2010 in Northern Alberta, Canada. The results indicated that both acid-suppressing drugs and guideline discordant antibiotic treatments are potentially modifiable prognostic factors. Furthermore, frailty (i.e. elderly, nursing home residents, or dementia patients), pneumonia severity, and high case fatality rate (CFR) serotypes were associated with an increased risk of morbidity and mortality, while prior pneumococcal vaccination was associated with a reduced risk. Paradoxically, current smoking was associated with reduce mortality in patients with BPP. Building on this result, the second objective of this research program was to examine whether differential acquisition of pneumococcal serotypes in smokers could potentially explain the influence on mortality. The results indicated that current smokers were more likely to be infected with low CFR pneumococcal serotypes compared to non-smokers, which may fully, or partially, explain the reduced mortality previously reported in studies involving patients with CAP. Collectively this research suggests that several modifiable prognostic factors exist in patients with BPP. Moreover, additional follow-up in patients who are frail following BPP may also be warranted. As this research is the first to suggest that differential acquisition of low CFR serotypes may explain the reduced mortality in smokers with pneumonia, further research is needed to confirm these findings and determine the usefulness of providing CFR data rapidly at the point of care
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English (26)