WorldCat Identities

Klein, Sabra L.

Works: 7 works in 33 publications in 1 language and 713 library holdings
Roles: Editor, Author, Other
Publication Timeline
Most widely held works by Sabra L Klein
Sex hormones and immunity to infection by Sabra L Klein( )

15 editions published between 2009 and 2014 in English and held by 439 WorldCat member libraries worldwide

This book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes. The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology. The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research
Sex and gender differences in infection and treatments for infectious diseases( )

10 editions published in 2015 in English and held by 264 WorldCat member libraries worldwide

This book provides an overview of the underlying sex-based and hormone-based differences in immunity, wound healing and pharmacokinetics, while also exploring how pregnancy affects immunity. The second part of the book shows, for the first time in a single volume, the growing number of infectious diseases for which sex and gender differences are noted, identifies common as well as distinct mechanisms mediating these differences and illustrates how responses to treatments might differ between the sexes. The awareness that males and females differ in their response to specific pathogens as well as to treatments for infectious diseases may yield sex-specific personalized treatments. This book will be of interest to basic scientists and clinicians in the fields of microbiology, immunology and pharmacology. Individuals working in academia, government and industry will also benefit from the information presented
Seasonal patterns of stress, immune function, and disease by Randy Joe Nelson( )

4 editions published in 2002 in English and held by 6 WorldCat member libraries worldwide

This book presents evidence that infection is cyclical with the seasons, and that this phenomenon is mirrored in cycles of immune function. The book identifies the mechanisms by which immune systems are bolstered to counteract seasonally-recurrent stressors, such as extreme temperature reductions and food shortages. Stress, infectious diseases, autoimmune diseases, and human cancers are examined, and the role of hormones such as melatonin and glucocorticoids is considered. The book begins with an overview of seasonality, biological rhythms and photoperiodism, and basic immunology, and then dis
Evaluation of the innate immune responses to influenza and live-attenuated influenza vaccine infection in primary differentiated human nasal epithelial cells( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Graphical abstract: Abstract: The host innate immune response to influenza virus is a key determinant of pathogenic outcomes and long-term protective immune responses against subsequent exposures. Here, we present a direct contrast of the host responses in primary differentiated human nasal epithelial cell (hNEC) cultures following infection with either a seasonal H3N2 influenza virus (WT) or the antigenically-matched live-attenuated vaccine (LAIV) strain. Comparison of the transcriptional profiles obtained 24 and 36 h post-infection showed that the magnitude of gene expression was greater in LAIV infected relative to that observed in WT infected hNEC cultures. Functional enrichment analysis revealed that the antiviral and inflammatory responses were largely driven by type III IFN induction in both WT and LAIV infected cells. However, the enrichment of biological pathways involved in the recruitment of mononuclear leukocytes, antigen-presenting cells, and T lymphocytes was uniquely observed in LAIV infected cells. These observations were reflective of the host innate immune responses observed in individuals acutely infected with influenza viruses. These findings indicate that cell-intrinsic type III IFN-mediated innate immune responses in the nasal epithelium are not only crucial for viral clearance and attenuation, but may also play an important role in the induction of protective immune responses with live-attenuated vaccines
Changing oral vaccine to inactivated polio vaccine might increase mortality( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Behavioral, physiological and evolutionary factors mediating sex and species differences in immune function among rodents by Sabra L Klein( )

1 edition published in 1998 in English and held by 1 WorldCat member library worldwide

Sex differences in vaccine efficacy( Visual )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

(CIT): ORWH Women's Health Seminar Series. This lecture will focus on sex differences in immunology in relation to vaccines. Dr. Klein is an Associate Professor in the Department of Molecular Microbiology and Immunology at Johns Hopkins University. She is also affiliated with the Johns Hopkins Center for Women's Health, Sex, and Gender Differences. Dr. Klein earned her M.S. from the University of Georgia and her Ph.D. from Johns Hopkins University. Her work aims to uncover the mechanisms mediating how males and females differ in their immune responses to viral infection and vaccination. Her research has shown that females typically mount more robust immune responses than males, which can be beneficial for clearance of viruses but also can be detrimental by causing immunopathology
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.50 (from 0.04 for Seasonal p ... to 0.96 for Sex differ ...)

Sex hormones and immunity to infection
Seasonal patterns of stress, immune function, and disease
English (33)