Küppers, Ralf

Overview

Works:	49 works in 80 publications in 2 languages and 818 library holdings
Genres:	Laboratory manuals
Roles:	Editor, dgs, Contributor, Author, Other, htt
Classifications:	RC280.L9, 616.994

Publication Timeline

Most widely held works by Ralf Küppers

Lymphoma : methods and protocols by Ralf Küppers( )

21 editions published between 2012 and 2019 in English and held by 308 WorldCat member libraries worldwide

This second edition volume expands on the previous edition with descriptions of recent developments in the field. The new and updated chapters discuss the latest approaches for studying single cell RNA sequencing, whole genome sequencing data, CRISPR/Cas9-mediated gene knockout, protein interactions by a proximity ligation assay, and detection of circulating cell-free tumor DNA in lymphomas. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Innovative and thorough, Lymphoma: Methods and Protocols, Second Edition is a valuable resource for hematologists, hematopathologists, and any scientists interested in cancer research, human genetics, and immunology

Precision molecular pathology of Hodgkin lymphoma( )

10 editions published between 2017 and 2018 in English and held by 185 WorldCat member libraries worldwide

This text provides a comprehensive and up-to-date overview of Hodgkin lymphoma. The volume reviews every facet of the cancer in great detail, including pathology, pathobiology, molecular genetics, microenvironment, epidemiology, treatment, and new therapeutic advances. The specific role of the lymphoma microenvironment is addressed, and the relationship of Hodgkin lymphoma to related non-Hodgkin lymphomas is covered as well. Written by experts in the field, Precision Molecular Pathology of Hodgkin Lymphoma is a valuable resource for oncologists, surgeons, pathologists, clinical trainees, and investigators engaged in the diagnosis, treatment, and research studies of this lymphoid neoplasm.

Different EML4-ALK fusion variants and novel ALK resistance mutations induce differential sensitivity to ALK kinase inhibitors by Johannes Heuckmann( )

1 edition published in 2013 in English and held by 26 WorldCat member libraries worldwide

Untersuchung molekularer Grundlagen der Pathogenese des klassischen Hodgkin Lymphoms by Frank Nonnenmacher( )

1 edition published in 2011 in German and held by 22 WorldCat member libraries worldwide

Das klassische Hodgkin Lymphom (cHL) ist eines der häufigsten Lymphome der westlichen Welt. Repräsentativ für das cHL sind seine Tumorzellen, die Hodgkin- und Reed-Sternberg (HRS)-Zellen. Charakteristisch für diese Zellen ist unter anderem die konstitutive Aktivierung verschiedener Signalwege zu denen auch der Janus Kinasen / Signal Transducer and Activator of Transcription (JAK/STAT)-Signalweg gehört. In unserer Arbeitsgruppe wurde bereits STAT6 als wichtiger Überlebensfaktor für HRS-Zellen nachgewiesen und mittels Genexpressionsanalysen konnten neue potentielle STAT6-Zielgene identifiziert werden Im Rahmen dieser Arbeit wurden einige dieser Gene als direkte STAT6-Zielgene identifiziert. Über deren Regulation STAT6 an der gestörten Entwicklung der HRS-Zellen bzw. an der Inhibition der Apoptose beteiligt ist. Des Weiteren wurden STAT6 und STAT1 als antagonistische Regulatoren der Apoptose in HRS-Zellen identifiziert. N eben der konstitutiven Aktivierung verschiedener Signaltransduktionswege ist das cHL durch die geringe oder gar nicht vorhandene Expression B-Zell-spezifischer Gene gekennzeichnet. In dieser Arbeit konnte gezeigt werden, dass die nicht exprimierten Gene mit trimethyliertem H3K27, einer Histon-Modifikation für stillgelegtes Chromatin, assoziiert sind. Die Inhibierung dieser Modifikation bzw. der für sie verantwortlichen Proteine des Polycomb Repressive Complex 2 (PRC2) durch verschiedene Ansätze führte zu einer erhöhten Expression der B-Zell-spezifischen Gene und der Induktion von Apoptose in cHL-Zelllinien

Malignant lymphomas : biology and molecular pathogenesis( )

1 edition published in 2016 in English and held by 21 WorldCat member libraries worldwide

This book is an up to date compendium on the biology and molecular pathogenesis of lymphomas, which represent malignant cancers of the lymphoid system. With its focus on the biology and genetic basis of these diseases, the book is of interest to basic scientists, biologists, clinical hematologists and pathologists as well as medical students

Vergleichende Analyse der anti-Bcl-2 Antisense-Oligonukleotide SPC2996 und Oblimersen in präklinischen Modellen der chronischen lymphatischen Leukämie by Carola Gigel( )

1 edition published in 2013 in German and held by 21 WorldCat member libraries worldwide

Die Rolle des WNT Signalwegs und des Transskriptionsfaktors LEF1 bei der Entwicklung von B-Zellen und in der Leukämie by Simon Jonas Poll-Wolbeck( )

1 edition published in 2014 in German and held by 18 WorldCat member libraries worldwide

Plasmazytoide dendritische Zellen (PDC) Suche nach einem Liganden des humanen PDC-spezifischen Oberflächenrezeptors CD303 und funktionelle Charakterisierung von murinen Sca-1+ und Sca-1- PDC-Subpopulationen by Marina Niederquell( )

1 edition published in 2013 in German and held by 18 WorldCat member libraries worldwide

Analyse der B-Zell-Differenzierung in menschlichen Keimzentren und der Hodgkin- und Reed-Sternberg-Zellen des Morbus Hodgkin mittels Mikromanipulation und Einzelzell-PCR by Ralf Küppers( Book )

2 editions published in 1995 in German and held by 16 WorldCat member libraries worldwide

Funktionelle Analyse von Numb und Redefinition der humanen hämatopoetischen Hierarchie by André Görgens( )

1 edition published in 2013 in German and held by 16 WorldCat member libraries worldwide

Deregulation von microRNA und Mutationen des Tumorsuppressorgens CYLD im Hodgkin Lymphom by Annette Schmidt( )

1 edition published in 2011 in German and held by 15 WorldCat member libraries worldwide

Die Rolle von Tumorsuppressorgenmutationen in B-Zell-Non-Hodgkin-Lymphomen by René Scholtysik( )

1 edition published in 2012 in German and held by 15 WorldCat member libraries worldwide

Einfluss der Überexpression von CD83 und miR183 in CD4+ T-Zellen by Christina Alter( )

1 edition published in 2014 in German and held by 15 WorldCat member libraries worldwide

Molekulare Mechanismen in der Pathogenese des klassischen Hodgkin-Lymphoms by Markus Schneider( )

1 edition published in 2015 in German and held by 12 WorldCat member libraries worldwide

Analyse genetischer Läsionen im Hodgkin-Lymphom und einem Kombinationslymphom sowie Charakterisierung humaner CD30-positiver B-Zellen by Stefanie Schneider( )

1 edition published in 2015 in German and held by 12 WorldCat member libraries worldwide

Regulation of immunoglobulin diversification by checkpoint signalling by Kathrin Davari( )

1 edition published in 2015 in English and held by 11 WorldCat member libraries worldwide

The primary immunoglobulin (Ig) repertoire is further diversified during secondary Ig diversification in germinal centre B cells. The secondary Ig diversification via somatic hypermutation and class switch recombination in humans and mice or by Ig gene conversion in some farm animals like chickens is based on the induction of DNA damage by activation-induced cytidine deaminase (AID), an enzyme that deaminates cytidine to uracil. These DNA lesions can either be repaired in an error-prone mode in the Ig loci or in an error-free manner, which is favoured in other cellular genes. However, the molecular mechanism of this differential repair fidelity is unknown to date. Maintenance of the integrity of the entire genome is essential for cancer prevention and activation of two different checkpoint signalling axes plays an important role in triggering cell cycle arrest and improved DNA repair. In case of long single stranded regions as a result of stalled replication forks or single strand breaks, ATR is activated, which phosphorylates the checkpoint kinase 1 (Chk1). On the other hand, DNA double strand breaks activate ATM, which phosphorylates the checkpoint kinase 2 (Chk2). Given the extensive DNA damage caused by AID during Ig diversification, activation of checkpoint control is likely, but not much is known about the effects of checkpoint signalling on secondary Ig diversification processes. In this work, we could show that the two checkpoint kinases are involved and oppose each other in the regulation of somatic hypermutation, Ig gene conversion and class switch recombination. Our results suggest that Ig diversification depends on a highly regulated interplay of the two checkpoint kinases, as Chk2 is required for efficient somatic hypermutation and class switch recombination, while Chk1 activity may contribute to the prevention of B cell lymphomas

Die Rolle des Transkriptionsfaktors BATF3 in CD30+-Lymphomen und die genetische Charakterisierung von Kombinationslymphomen by Anna Lollies( )

1 edition published in 2017 in German and held by 10 WorldCat member libraries worldwide

MedSys Verbundprojekt: Haematosys - Systembiologie der Hämatopoese und hämatopoetischer Neoplasien Haematosys Abschlußbericht 2012 ; Berichtszeitraum: 01.03.2009-31.08.2012( )

2 editions published in 2013 in German and held by 9 WorldCat member libraries worldwide

Bedeutung von B-Zell-spezifischen Transkriptionsfaktoren, insbesondere EBF1, für die Tumorzellen des Hodgkin-Lymphoms by Verena Bohle( )

1 edition published in 2012 in German and held by 8 WorldCat member libraries worldwide

Schlussbericht für den Standort Essen des ICGC MMML-Seq-Verbundes (Prof. Dr. Ralf Küppers) by Ralf Küppers( )

1 edition published in 2016 in German and held by 7 WorldCat member libraries worldwide