WorldCat Identities

Nakazawa, Toru 1970-

Overview
Works: 22 works in 35 publications in 2 languages and 327 library holdings
Roles: Editor, Author, Other
Publication Timeline
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Most widely held works by Toru Nakazawa
Neuroprotection and neuroregeneration for retinal diseases by Toru Nakazawa( )

13 editions published in 2014 in English and held by 307 WorldCat member libraries worldwide

This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. All these conditions are characterized by degeneration of specific retinal cell types, making it essential to establish treatments to protect retinal neurons and the optic nerve. With that aim in mind, this book explains the mechanisms underlying aforementioned diseases and their experimental models. The novel strategy proposals for the treatment of retinal diseases based on the concept of neuroprotection are also discussed in the main body of the text, while the section on regenerative research discusses optic nerve regeneration, endothelial progenitor cells, and iPS cells. This book is recommended as a professional reference work for all doctors and trainees in the field of ophthalmology who are interested in neuroprotective and neuroregenerative treatments
Optic nerve head microcirculation in autosomal dominant optic atrophy and normal‐tension glaucoma( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Shochi to shujutsu shugi( Book )

1 edition published in 2017 in Japanese and held by 1 WorldCat member library worldwide

Mitokondoria. [Mitochondria by Toru Nakazawa( Book )

1 edition published in 1975 in Japanese and held by 1 WorldCat member library worldwide

The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Gendai seibutsu kagaku( Book )

1 edition published in 2000 in Japanese and held by 1 WorldCat member library worldwide

Chikujō kaisetsu, 2014-nen Kin'yū shōhin torihikihō kaisei( Book )

1 edition published in 2015 in Japanese and held by 1 WorldCat member library worldwide

Seimei to busshitsu( Book )

1 edition published in 1997 in Japanese and held by 1 WorldCat member library worldwide

Gendai no seibutsugaku. [Modern biology, edited by Ryuichi Yasugi and Toru Nakazawa by Ryūichi Yasugi( Book )

1 edition published in 1967 in Japanese and held by 1 WorldCat member library worldwide

Shinsatsu to kensa( Book )

1 edition published in 2016 in Japanese and held by 1 WorldCat member library worldwide

Anterior chamber aqueous flare and optic nerve microcirculation in eyes with rhegmatogenous retinal detachment( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Shindan to chiryō( Book )

1 edition published in 2017 in Japanese and held by 1 WorldCat member library worldwide

Kiso seibutsugaku( Book )

1 edition published in 1998 in Japanese and held by 1 WorldCat member library worldwide

Furusato ga butai : Ōita kenmin engeki no nijūgonen( Book )

2 editions published in 1997 in Japanese and held by 1 WorldCat member library worldwide

Calcium and calpain activation by Morin Ryu( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Efficacy of Chandelier Illumination for Combined Cataract Operation and Penetrating Keratoplasty( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract : Purpose: The aim of this study was to describe a method for non–open-sky continuous curvilinear capsulorhexis (CCC) with chandelier retroillumination for penetrating keratoplasty triple procedure and report its effectiveness in decreasing intraoperative complications and enabling successful primary intraocular lens (IOL) insertion in patients with moderate or dense central corneal opacities. Methods: Seventeen eyes of 17 patients were enrolled in this study, divided into a chandelier group, including 7 eyes of 7 patients, and a nonchandelier group, including 10 eyes of 10 patients. In each group, time to achieve CCC (in seconds), open-sky time (in seconds), and operation time (in minutes) were measured, and the rates of successful CCC completion, rupture of the posterior capsule or zonule of Zinn, and successful IOL insertion were recorded. Results: CCC time was not significantly different in both groups. In the chandelier group, however, open-sky time and operation time were significantly shorter than in the nonchandelier group (1429 ± 67 vs. 2016 ± 354 seconds, and 90.4 ± 3.5 vs. 108.9 ± 10.3 minutes, respectively). In the chandelier group, the rate of successful CCC completion was significantly higher than in the nonchandelier group (86% vs. 30%). The rates of posterior capsule or zonule of Zinn rupture and successful IOL insertion were not significantly different (14% vs. 40%, 14% vs. 10%, and 86% vs. 70%, respectively). Conclusions: Non–open-sky CCC with chandelier illumination has many advantages for penetrating keratoplasty triple procedure compared with open-sky CCC without chandelier illumination. Abstract : Supplemental Digital Content is Available in the Text
Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Abstract NF-E2 related factor 2 (Nrf2) is a key transcription factor that plays a pivotal role in endogenous protection against oxidative stress. However, the role of Nrf2 in visual disorders remains unclear. It has been reported that oxidative stress is thought of as one of the causes of glaucoma. Here, we investigate whether the function of Nrf2 in oxidative stress-induced retinal ganglion cell (RGC) death. This study used adult male Nrf2 deficient mice (Nrf2 KO) and age- and sex-matched wild-type (WT) mice. We dissociated and purified N-4-[4-didecylaminostryryl]-N-methyl-pyridinium iodide-labeled RGCs with fluorescence-activated cell sorting, and tried to detect the Nrf2 and Keap1 genes. In the absence of nerve crush (NC), the number of RGCs in Nrf2 KO mice was almost same as that in WT mice. 1-(2-cyano-3-, 12-dioxooleana-1, 9 (11)-dien-28-oyl) imidazole (CDDO-Im), an Nrf2 activator, prevented NC-induced loss of RGCs in WT mice. Seven days after NC, without treatment, the number of RGCs in Nrf2 KO mice was significantly lower than in WT mice. In addition, after CDDO-Im treatment, quantitative RT-PCR showed increased expression of antioxidant and phase II detoxifying enzymes. These results suggest that up-regulation of Nrf2 signaling after CDDO-Im treatment may be a novel therapeutic strategy for the protection of RGCs, especially in glaucoma. This study suggests that NF-E2 related factor 2 (Nrf2), a transcription factor, plays a pivotal role in counteracting oxidative stress. Most importantly, a neuroprotective effect against oxidative stress-induced retinal ganglion cell (RGC) death was achieved with the pharmacological Nrf2 activator CDDO-Im. This suggests that pharmacological treatment to up-regulate Nrf2 signaling may be a new therapeutic technique to protect RGCs
Usa yamataikoku jōu himiko : gikyoku genpon hazama hisashi usa bunka no nazo( Book )

in Japanese and held by 1 WorldCat member library worldwide

Vitreous lavage fluid and bronchoalveolar lavage fluid have equal diagnostic value in sarcoidosis( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract : Abstract: Here, we elucidate the immunological features of both bronchoalveolar lavage fluid (BALF) and vitreous lavage fluid (VLF) samples from patients with histopathologically verified sarcoidosis. In addition, we assess the safety of vitrectomy in sarcoidosis patients by investigating the occurrence of complications and the recovery of visual acuity. Twenty-two eyes of 22 patients with tissue-proven sarcoidosis were enrolled in this study. BALF and VLF samples were obtained and compared in each patient, and the clinical course (including visual acuity) was followed. The presence of sarcoidosis was assessed with a flow cytometric analysis of T-lymphocytes in the BALF and VLF samples. Our results indicated that the CD4 T-cell population and the CD4/CD8 ratio were significantly higher in the VLF T-lymphocytes than the BALF T-lymphocytes. On the other hand, the CD8+ T-cell population was significantly lower in the VLF T-lymphocytes. Therefore, our findings suggest that VLF samples have a high diagnostic value (equal to that of BALF samples) for sarcoidosis. Moreover, we found that the sample collection did not affect visual acuity and that there were no adverse events after surgery. A flow cytometric analysis of a VLF sample may therefore be a useful adjunct in the diagnosis of sarcoidosis
 
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Audience level: 0.50 (from 0.48 for Neuroprote ... to 0.99 for Shinsatsu ...)

Languages
English (21)

Japanese (12)