Kołodziejczyk, Krzysztof

Electrical responses of oligodendrocytes to pathological stimuli by Krzysztof Kołodziejczyk( Book )

2 editions published in 2011 in English and held by 2 WorldCat member libraries worldwide

The white matter is crucial for rapid transmission of information between different parts of the brain and spinal cord, and is damaged in diseases including the genetic leukodystrophies, stroke, spinal cord injury and multiple sclerosis. While damage in the grey matter of the CNS is well known to often involve over-activation of glutamate receptors, our understanding of white matter pathology is less advanced. The experiments in this thesis used patch-clamping and [Ca2+]i imaging to examine the cerebellar white matter oligodendrocyte response to pathological insults mimicking those occurring in the leukodystrophies and in the ischaemia that occurs in stroke or after spinal cord injury. Oligodendrocytes responded to simulated ischaemia with an inward current, which was triggered by glutamate release mediated by reversal of glutamate transporters, and not by exocytosis, NKCC1 or cystine/glutamate exchange. Surprisingly, this inward current was not mediated by glutamate receptors, nor by ASICs, gap junctional hemichannels, P2X receptors or GABAA receptors, but reflected the closing of potassium channels. In current clamp mode this initial closing of K+ channels produced a depolarisation of the cells, followed by a repolarisation as other K+ channels activated. These data indicate, for the first time, a significant role for K+ channels in the response of oligodendrocytes to ischaemia. In Canavan and Pelizaeus-Merzbacher-like leukodystrophies, elevated levels of Nacetylaspartylglutamate (NAAG) and N-acetylaspartate (NAA) occur. These compounds can activate or block neuronal NMDA receptors. Since oligodendrocytes are reported to express NMDA receptors, I tested their response to NAAG and NAA. NAAG, but not NAA, evoked a small inward NMDA receptor-mediated current in oligodendrocytes, but no [Ca2+]i rise. Much of the inward current was a secondary effect of NAAG acting on neurons. Thus, actions of NAAG and NAA on oligodendrocyte NMDARs are unlikely to be a major contributor to white matter damage in the leukodystrophies

Projektowanie wielostrumieniowych urządzeń sedymentacyjnych z wykorzystaniem metod numerycznych = Design of lamella sedimentation devices using numerical methods by Krzysztof Kołodziejczyk( Book )

1 edition published in 2017 in Polish and held by 2 WorldCat member libraries worldwide

Hadwiger--Wills-Type Higher-Dimensional Generalizations of Pick's Theorem by Krzysztof Kołodziejczyk( )

in English and held by 2 WorldCat member libraries worldwide

Projektowanie wielostrumieniowych urządzeń sedymentacyjnych z wykorzystaniem metod numerycznych by Krzysztof Kołodziejczyk( Book )

1 edition published in 2017 in Polish and held by 2 WorldCat member libraries worldwide

Roxindole, a Dopamine Autoreceptor Agonist with a Potential Antidepressant Activity II. Effects on the 5-Hydroxytryptamine System( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

Dealer : samochodowy magazyn informacyjno-reklamowy( )

in Polish and held by 1 WorldCat member library worldwide

Turystyczny szlak patriotyczny "Polski Walczącej" : na terenie powiatu legionowskiego : mapa turystyczna 1:40 000 : opis miejsc historycznych( )

1 edition published in 2017 in Polish and held by 1 WorldCat member library worldwide

Pracownicy naukowo-dydaktyczni [Wydziału Inżynierii Mechanicznej i Robotyki AGH] by Marian Banaś( Book )

1 edition published in 2002 in Polish and held by 1 WorldCat member library worldwide