WorldCat Identities

Cardoso, Silvia

Works: 3 works in 5 publications in 2 languages and 6 library holdings
Genres: Juvenile works  Biographies 
Roles: Author, Editor
Classifications: BF1815.M47, 616.079
Publication Timeline
Most widely held works by Silvia Cardoso
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier by Judith Hauptmann( )

2 editions published in 2020 in English and held by 5 WorldCat member libraries worldwide

Abstract: The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood-brain barrier (BBB) endothelial cells (ECs), astrocytes and microglia for EAE development, using mice with the conditional deletion of its signaling receptor IL-1R1. We found that IL-1 signaling in microglia and astrocytes is redundant for the development of EAE, whereas the IL-1R1 deletion in BBB-ECs markedly ameliorated disease severity. IL-1 signaling in BBB-ECs upregulated the expression of the adhesion molecules Vcam-1, Icam-1 and the chemokine receptor Darc, all of which have been previously shown to promote CNS-specific inflammation. In contrast, IL-1R1 signaling suppressed the expression of the stress-responsive heme catabolizing enzyme heme oxygenase-1 (HO-1) in BBB-ECs, promoting disease progression via a mechanism associated with deregulated expression of the IL-1-responsive genes Vcam1, Icam1 and Ackr1 (Darc). Mechanistically, our data emphasize a functional crosstalk of BBB-EC IL-1 signaling and HO-1, controlling the transcription of downstream proinflammatory genes promoting the pathogenesis of autoimmune neuroinflammation
Contribuição para o estudo dos custos unitários das análises laboratóriais e sua comparação com preços estabelecidos pelo Sistema Único de Saúde - SUS em um laboratório hospitalar em 2001 by Silvia Cardoso( Book )

1 edition published in 2003 in Portuguese and held by 1 WorldCat member library worldwide

(Continuação)o tempo gasto na realização foi cronometrado. Na comparação entre os custos unitários das análises apuradas e a Tabela de Procedimentos do SUS verificou-se que, dos 67 procedimentos comparados, O estudo também revelou que os custos indiretos eram, na maioria das análises, os de maior valor, assim como nas análises realizadas por processo manual. Nos processos automatizados regidos por contrato de comodato, o estudo revelou que o custo direto dos reagentes é inversamente proporcional ao número de análises realizadas. Por fim, verificou-se que as análises apuradas mais onerosas são as de microbiologia, área onde os custos chegam a ser 4,9 vezes maiores que o valor pago pelo SUS para as hemoculturas positivas, e 2,9 vezes para as culturas gerais positivas
Mucho mucho amor : the story of Walter Mercado by Sabrina Vourvoulias( Book )

2 editions published in 2022 in English and held by 0 WorldCat member libraries worldwide

"A nonfiction picture book biography chronicling the life of TV star Walter Mercado. A bilingual picture book"--
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