WorldCat Identities

Ambrose, Paul G.

Overview
Works: 8 works in 36 publications in 1 language and 454 library holdings
Roles: Editor
Classifications: RM267, 615.329
Publication Timeline
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Most widely held works by Paul G Ambrose
Antimicrobial pharmacodynamics in theory and clinical practice by C. H Nightingale( Book )

8 editions published between 2001 and 2004 in English and held by 112 WorldCat member libraries worldwide

This work explores the pharmacodynamics of antimicrobials, as well as the absorption, distribution, metabolism, and elimination of the major classes of antimicrobials, including penicillins, cephalosporins, cephamycins, carbapenems, monobactans, macrolides and antivirals
Antibiotic optimization : concepts and strategies in clinical practice by Robert A Owens( Book )

13 editions published between 2004 and 2005 in English and held by 112 WorldCat member libraries worldwide

"Antimicrobial stewardship," a term coined by Dr. Dale Gerding, applies to the selection of an antimicrobial agent and its appropriate dosage and duration of therapy. In principle, this results in the best clinical outcome in the treatment or prevention of infection, with the least toxicity and, most important, a minimal effect on the development of resistance in the patient and in larger populations, whether in the hospital or the community. The goal of this book is to provide the practicing clinician and the interested administrator with the background, scientific foundation, and practical knowledge required to develop institutional programs that foster good antimicrobial stewardship. The book draws on many recommendations by professional societies and national and international organizations that have recognized the importance of antimicrobial stewardship as a mechanism to prevent antimicrobial resistance. The editors are to be congratulated for assembling an expert group of authors to write the 19 chapters that make up this treatise. The book has two main parts. The initial chapters provide an overview of topics that serve as the foundation of a successful program of antimicrobial stewardship, such as the importance of a pharmacy and therapeutics committee, a program for infection control and hospital epidemiology, and a basic understanding of pharmacoeconomics, pharmacokinetics, and pharmacodynamics. The remainder of the book deals with examples of the application of antimicrobial stewardship. These chapters provide insight into the importance of pharmacodynamic principles, transitional-therapy programs, and the development and implementation of an antimicrobial formulary. The chapters are very well referenced and understandable for readers without expert knowledge of the subject. In general, the references are to articles published up to 2003, with a few from 2004
Community-acquired respiratory infections : antimicrobial management by C. H Nightingale( Book )

10 editions published in 2003 in English and held by 78 WorldCat member libraries worldwide

This book includes proven clinical approaches that will aid practitioners to successfully manage patients with community-associated respiratory tract infections. Reviews current issues involved in the treatment and the use of antibiotics to manage rhinosinusitis, otitis media, pharyngitis, and chronic bronchitis
Community-acquired respiratory infections : antimicrobial infections( Book )

1 edition published in 2003 in English and held by 1 WorldCat member library worldwide

Antimicrobial Pharmacodynamics in Theory and Clinical Practice, Second Edition by H. Nightingale Charles( )

1 edition published in 2013 in English and held by 0 WorldCat member libraries worldwide

Taking readers from the research laboratory to the bedside, this Second Edition compiles essential information on the pharmacodynamics of all major classes of the antimicrobial armamentarium including penicillins, cephalosposorins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, antifungals, antivirals, and emerging agents currently in development. Written by experienced professionals in the field, this guide uses an abundance of examples to depict methods to apply pharmacodynamic concepts to everyday clinical practice
Pharmacokinetics-Pharmacodynamics of Gatifloxacin in a Lethal Murine Bacillus Anthracis Inhalation Infection Model( )

1 edition published in 2007 in English and held by 0 WorldCat member libraries worldwide

We determined the pharmacokinetic-pharmacodynamic (PK-PD) measure most predictive of gatifloxacin efficacy and the magnitude of this measure necessary for survival in a murine Bacillus anthracis inhalation infection model. We then used population pharmacokinetic models for gatifloxacin and simulation to identify dosing regimens with high probabilities of attaining exposures likely to be efficacious in adults and children. In this work, 6- to 8-week-old nonneutropenic female BALB/c mice received aerosol challenges of 50 to 75 50% lethal doses of B. anthracis (Ames strain, for which the gatifloxacin MIC is 0.125 mg/liter). Gatifloxacin was administered at 6- or 8-h intervals beginning 24 h postchallenge for 21 days, and dosing was designed to produce profiles mimicking fractionated concentration-time profiles for humans. Mice were evaluated daily for survival. Hill-type models were fitted to survival data. To identify potentially effective dosing regimens, adult and pediatric population pharmacokinetic models for gatifloxacin and Monte Carlo simulation were used to generate 5,000 individual patient exposure estimates. The ratio of the area under the concentration-time curve from 0 to 24 h (AUC(0-24)) to the MIC of the drug for the organism (AUC(0-24)/MIC ratio) was the PK-PD measure most predictive of survival (R(2) = 0.96). The 50% effective dose (ED(50)) and the ED(90) and ED(99) corresponded to AUC(0-24)/MIC ratios of 11.5, 15.8, and 30, respectively, where the maximum effect was 97% survival. Simulation results indicate that a daily gatifloxacin dose of 400 mg for adults and 10 mg/kg of body weight for children gives a 100% probability of attaining the PK-PD target (ED(99)). Sensitivity analyses suggest that the probability of PK-PD target attainment in adults and children is not affected by increases in MICs for strains of B. anthracis to levels as high as
Antibiotic Optimization Concepts And Strategies I by Robert C. Owens Jr( )

1 edition published in 2004 in English and held by 0 WorldCat member libraries worldwide

Presenting essential principles and strategies to optimize the utility of antiomicrobial agents in modern inpatient healthcare settings, this reference also discusses practical means to track intervention outcomes through benchmarking
Antimicrobial Pharmacodynamics in Theory and Clinical Practice. Infectious Disease and Therapy, Volume 44( )

1 edition published in 2007 in English and held by 0 WorldCat member libraries worldwide

Taking readers from the research laboratory to the bedside, this Second Edition compiles essential information on the pharmacodynamics of all major classes of the antimicrobial armamentarium including penicillins, cephalosposorins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, antifungals, antivirals, and emerging agents currently in development. Written by experienced professionals in the field, this guide uses an abundance of examples to depict methods to apply pharmacodynamic concepts to everyday clinical practices
 
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Audience Level
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Audience level: 0.61 (from 0.53 for Antibiotic ... to 1.00 for Pharmacoki ...)

Antibiotic optimization : concepts and strategies in clinical practice
Languages
English (36)

Covers
Antibiotic optimization : concepts and strategies in clinical practiceCommunity-acquired respiratory infections : antimicrobial managementCommunity-acquired respiratory infections : antimicrobial infections