WorldCat Identities

Dickens, Michael

Overview
Works: 8 works in 19 publications in 1 language and 1,152 library holdings
Genres: Identification guides  Exhibition catalogs  Catalogs 
Roles: Author
Publication Timeline
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Most widely held works by Michael Dickens
The world of butterflies by Michael Dickens( Book )

7 editions published in 1972 in English and held by 676 WorldCat member libraries worldwide

Full-color pictures of 108 butterflies are accompanied by information on common and scientific name, wingspan, range and habitat, food, sexual and identifying characteristics, family, subspecies, and similar species
The world of moths : text by Michael Dickens( Book )

6 editions published between 1973 and 1974 in English and held by 466 WorldCat member libraries worldwide

Mark Gertler and his circle( Book )

1 edition published in 1994 in English and held by 2 WorldCat member libraries worldwide

Butterflies by Michael Dickens( Book )

1 edition published in 1972 in Undetermined and held by 1 WorldCat member library worldwide

More about the "masquerade" at the Bloomsbury Workshop ... 27th July-25th August 2000 by England) Bloomsbury Workshop (London( Book )

1 edition published in 2000 in English and held by 1 WorldCat member library worldwide

Small molecule inhibitors of Mdm2 E3 ubiquitin ligase activity by Michael Dickens( )

1 edition published in 2011 in English and held by 1 WorldCat member library worldwide

Half of cancers retain wild type p53 but have alterations in the pathways involved in p53 regulation. Murine double minute 2 (Mdm2) regulates p53 by acting as an E3 ubiquitin ligase, which tags p53 for degradation through the proteasome. A small molecule inhibitor, a 5-deazaflavin analogue, has previously been identified by high throughput screening to inhibit Mdm2 E3 ubiquitin ligase activity, thereby reactivating apoptotic function of p53 selectively in cancer cells. Ninety 5-deazaflavin analogues have been synthesised by an optimized existing method and a novel method of synthesis, using the required 6-anilinouracil and 2-p-toluenesulfonyloxybenzaldehyde. The biological ability of the 5-deazaflavin analogues to act as inhibitors of Mdm2 E3 ubiquitin ligase activity to reactivate p53 has been ascertained. A new quantitative biological assay was developed, by scientists based at the Beatson Institute, for 5-deazaflavin compounds, showing excellent inhibition of Mdm2 E3 ubiquitin ligase activity on the previous qualitative biological assay, to yield IC50 data. The biological results have established a clear and logical structure-activity relationship comprising of an electron-withdrawing hydrophobic substituent at the nine position and the N10 phenyl being a prerequisite for activity as a Mdm2 inhibitor. Also meta substitution of the N10 phenyl improves activity against Mdm2 E3 ubiquitin ligase activity. Hit optimization has occurred with 10-(3-chlorophenyl)-9-trifluoromethyl-5-deazaflavin being thirty times more active than the previous identified hit compound, 10-(4-chlorophenyl)-7-nitro-5-deazaflavin. Using the X-ray crystal structure of the Mdm2/MdmX heterodimer, an improved understanding of how Mdm2 acts as an E3 ubiquitin ligase is described and used to form a hypothesis of how 5-deazaflavin analogues function as inhibitors of Mdm2. The work suggests the principle that small molecular weight compounds can inhibit E3 ubiquitin ligases as a possible anti-cancer therapy, and provide the foundation and framework for additional studies and investigation in a new and developing field of medicinal chemistry
Stanley Spencer and his circle at The Bloomsbury Workshop in association with Michael Dickens : 13th October-12th November 1992( Book )

1 edition published in 1992 in English and held by 1 WorldCat member library worldwide

The secret life of "Patricia Preece" at the Bloomsbury Workship ... 28th July-10th September 1998 by England) Bloomsbury Workshop (London( Book )

1 edition published in 1998 in English and held by 1 WorldCat member library worldwide

 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.24 (from 0.19 for Butterflie ... to 0.86 for More about ...)

Languages
English (18)