WorldCat Identities

Christen, Yves

Overview
Works: 187 works in 885 publications in 3 languages and 20,169 library holdings
Genres: Conference papers and proceedings 
Roles: Editor, Author, htt, Publishing director, Other, Author of introduction
Classifications: BF692.2, 155.33
Publication Timeline
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Most widely held works about Yves Christen
 
Most widely held works by Yves Christen
Hormones and the brain by Claude Kordon( )

14 editions published between 2004 and 2005 in English and held by 599 WorldCat member libraries worldwide

Annotation
Sex differences : modern biology and the unisex fallacy by Yves Christen( Book )

20 editions published between 1990 and 2017 in English and held by 579 WorldCat member libraries worldwide

Few people realize just how much modern science can tell us about the differences between men and women. Christen, a biologist and prolific science writer, provides the first comprehensive overview of new research in this area in many years. While some of these new findings are themselves stunning, Christen goes beyond simplistic "biology is destiny" arguments. He constructs a convincing case for linking social and biological approaches in order to understand complex differences in human behavior. Biologists now agree, says Christen, that the sexes differ in brain structure as they do in body structure. He persuasively links these differences in cerebral anatomy to differences in behavioral and intellectual propensity. Taking his readers on a wide-ranging journey through psychology, endocrinology, demography, and a host of other fields, Christen shows that the biological and the social are not antagonistic. To the contrary, social factors tend to exaggerate the biological rather than neutralize it
Micro-, meso- and macro-connectomics of the brain by Henry Kennedy( )

16 editions published between 2016 and 2018 in 3 languages and held by 532 WorldCat member libraries worldwide

This book has brought together leading investigators who work in the new arena of brain connectomics. This includes {u2018}macro-connectome{u2019} efforts to comprehensively chart long-distance pathways and functional networks; {u2018}micro-connectome{u2019} efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and {u2018}meso-connectome{u2019} efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static {u2018}hard-wired{u2019} circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease
Retrotransposition, diversity, and the brain by F Gage( )

14 editions published between 2007 and 2010 in English and held by 500 WorldCat member libraries worldwide

This Fondation IPSEN Colloque M??decine et Recherche was devoted to the interface between the complexity of brain organization and function, the mechanisms for generating diversity and genetic mobility. The goal was to expand the current limits of research in neurobiology not only to the benefit of those interested in the cellular and molecular processes but also for the understanding of high-level cognitive functions and the understanding of complex mental diseases
Memories : molecules and circuits by B Bontempi( )

13 editions published in 2007 in English and held by 490 WorldCat member libraries worldwide

Provides an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. This book also discusses the state-of-the-art and future avenues, along with an overview of the underlying neurobiology of cognitive processes from a basic science standpoint
Insights into receptor function and new drug development targets by Michael Conn( )

14 editions published in 2006 in English and held by 480 WorldCat member libraries worldwide

G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function. The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed their role in health and disease and provided insight to new therapeutic approaches, based on control of protein trafficking. Understanding receptor-receptor interactions has provided one mechanism for receptor cross-talk and revealed unexpected interactions. The completion of the human genome has identified a new source of therapeutic targets: "orphan receptors" with unknown functions and yet-to-be discovered ligands. Some orphans have now been identified as ghrelin, nociceptin, apelin, and urocortin. This finding, along with important technologies to develop ligands with desirable characteristics, including peptidomimetics is likely to further accelerate interest in this area
Neurobiology of "Umwelt" : how living beings perceive the world by A Berthoz( )

14 editions published between 2008 and 2010 in English and held by 479 WorldCat member libraries worldwide

At the beginning of the 20th century, German biologist Jakob von Uexkull created the concept of 'Umwelt' to denote the environment as experienced by a subject. This concept of environment differs from the idea of passive surroundings and is defined not just by physical surroundings, but is rather a 'subjective universe', a space weighted with meaning. Today, neuroscience provides a new way to look at the brain's capability to create a representation of the world. At the same time behavioural specialists are demonstrating that animals have a richer mental universe than previously known. Philosophical reflection thus finds itself with more experimental and objective data as well. Nearly a century after the publication of von Uexkull's founding work ("Umwelt und Innenwelt der Tiere" was published in 1909), neurobiologists, psychologists, sociologists, anthropologists, ethologists, and philosophers revisit his mail concept at the light of modern science
Micro-, meso- and macro-dynamics of the brain by Yves Christen( )

17 editions published between 2016 and 2018 in English and Undetermined and held by 476 WorldCat member libraries worldwide

How does the brain orchestrate perceptions, thoughts, and actions from the activity of its neurons? Addressing these challenging issues requires methods with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks as well as theories to advance understanding how different levels of brain dynamics interact. This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The topics cover the most fascinating facets of neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory and mental illness, brain controlled robots, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Overall, this volume offers an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease
Deciphering growth by J.-C Carel( )

15 editions published in 2005 in English and Undetermined and held by 470 WorldCat member libraries worldwide

Growth is a complex process that is essential to life. Not only does size play an important role in the process of cellular proliferation, but body size is also a critical factor in determining which organisms live longer. Evolution has been characterised by an increase in an organism's body size, which is not limited to the size of the brain
Synaptic plasticity and the mechanism of Alzheimer's disease by Dennis J Selkoe( )

21 editions published in 2008 in English and held by 467 WorldCat member libraries worldwide

"Remarkable progress has been made in Alzheimer's research over the last decade. Our understanding of which molecular mechanisms are involved in the cascade of events characteristic of the disease is growing. However, the mechanisms by which they induce deleterious effect are still not clear. Many recent studies have confirmed that the synapse is a key target in the pathogenesis of Alzheimer's disease. Not only does synaptic loss occur at an early stage of the disease, but it seems that [Beta]-amyloid peptide deposits or microtubular disorders affect synaptic function. This may explain the memory deficits that are so characteristic of the disease. It is therefore logical to investigate therapeutic approaches targeting the deleterious mechanisms that affect the synapse. This area of research promises to be all the more productive because synaptic dysfunction is involved in various other neurodegenerative diseases or, more generally speaking, central nervous system disorders."--Jacket
IGFs : local repair and survival factors throughout life span by D. R Clemmons( )

8 editions published in 2010 in English and held by 458 WorldCat member libraries worldwide

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer
Characterizing consciousness : from cognition to the clinic? by Stanislas Dehaene( )

18 editions published in 2011 in English and German and held by 455 WorldCat member libraries worldwide

'Characterizing Consciousness' presents testable theoretical models of consciousness, and discusses how our understanding of the role consciousness plays in our cognitive processes
Intracellular traffic and neurodegenerative disorders by Peter St. George-Hyslop( )

14 editions published between 2008 and 2009 in English and held by 442 WorldCat member libraries worldwide

Explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them
Macro roles for microRNAs in the life and death of neurons by Bart de Strooper( )

9 editions published in 2010 in English and held by 441 WorldCat member libraries worldwide

The discovery of microRNAs has revealed an unexpected and spectacular additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. Since the initial studies performed in C.elegans, we have gone a far way to begin to understand how microRNA pathways can have an impact on health and disease in human. Although microRNAs are abundantly expressed in the brain, relatively little is known about the multiple functions of these RNA molecules in the nervous system. Nevertheless, we know already that microRNA pathways play major roles in the proliferation, differentiation, function and maintenance of neuronal cells. Several intriguing studies have linked microRNAs as major regulators of the neuronal phenotype, and have implicated specific microRNAs in the regulation of synapse formation and plasticity. Dysfunction of microRNA pathways is also slowly emerging as a potential important contributor to the pathogenesis of major neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. These novel insights appear to be particular promising for the understanding of the very frequent and badly understood sporadic forms of these diseases as compared to the genetic forms. Thus, the better understanding of the implications of this novel field of molecular biology is crucial for the broad area of neurosciences, from the fundamental aspects to the clinic, and from novel diagnostic to potentially therapeutic applications for severe neurological and maybe psychiatric diseases
Two faces of evil : cancer and neurodegeneration by Tom Curran( )

20 editions published between 2010 and 2013 in English and German and held by 440 WorldCat member libraries worldwide

Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profo
A time for metabolism and hormones by Paolo Sassone-Corsi( )

18 editions published between 2016 and 2018 in English and Undetermined and held by 437 WorldCat member libraries worldwide

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies
Stem cells in neuroendocrinology by Donald W Pfaff( )

10 editions published between 2016 and 2018 in English and Undetermined and held by 436 WorldCat member libraries worldwide

This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers. The last chapter provides an overview of this particular field of research and presents a vision for its future directions.
Protein quality control in neurodegenerative diseases by Richard I Morimoto( )

13 editions published between 2012 and 2015 in English and German and held by 433 WorldCat member libraries worldwide

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation
Programmed cells from basic neuroscience to therapy by F Gage( )

16 editions published between 2013 and 2016 in English and German and held by 430 WorldCat member libraries worldwide

The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed the experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson's Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. In addition, because PSC technology allows for the study of human neurons during development, disease-specific pathways can be investigated prior to and during disease onset. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, it is now feasible to obtain gene expression profiles from neurons that capture the genetic uniqueness of each patient. Importantly, once the neurological neural phenotype is detected in vitro, the so-called "disease-in-a-dish" approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases
Hormones and social behavior by Donald W Pfaff( )

8 editions published in 2008 in English and held by 428 WorldCat member libraries worldwide

Advances in 21st Century neuroscience and endocrinology will permit complex problems of medicine and public health to be elucidated. Among these problems are failures of normal social and sexual behaviors. As it turns out, these behaviors are influenced by hormone actions in the human brain using mechanisms that we have inherited from lower animals. This book concentrates on two major topics: First, the molecular and neural biology of hormone actions relevant to normal social behaviors; and Second, the clinical treatment of human patients in whom these behaviors have gone wrong
 
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WorldCat IdentitiesRelated Identities
Hormones and the brain
Covers
Retrotransposition, diversity, and the brainMemories : molecules and circuitsInsights into receptor function and new drug development targetsNeurobiology of "Umwelt" : how living beings perceive the worldDeciphering growthSynaptic plasticity and the mechanism of Alzheimer's diseaseIGFs : local repair and survival factors throughout life spanCharacterizing consciousness : from cognition to the clinic?
Alternative Names
Christen, Y.

Christen, Y. 1948-

Christen, Y. (Yves)

Yves Christen Frans journalist

Yves Christen French journalist

Yves Christen periodista francés

Languages
English (280)

German (5)

Spanish (4)