WorldCat Identities

Clark, William R. 1938-

Works: 27 works in 245 publications in 9 languages and 15,269 library holdings
Genres: Popular works  History  Conference papers and proceedings  Nature films  Children's films 
Roles: Author, Editor
Publication Timeline
Most widely held works by William R Clark
A means to an end : the biological basis of aging and death by William R Clark( )

22 editions published between 1999 and 2003 in English and Japanese and held by 2,500 WorldCat member libraries worldwide

"Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control." "With such discoveries in mind, noted cell biologist William R. Clark describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders - such as Werner's syndrome - that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning."--Jacket
At war within : the double-edged sword of immunity by William R Clark( )

18 editions published between 1995 and 2000 in English and Undetermined and held by 2,078 WorldCat member libraries worldwide

A look at the immune system and its potential to help and hurt
Sex and the origins of death by William R Clark( )

30 editions published between 1996 and 2001 in 6 languages and held by 2,052 WorldCat member libraries worldwide

Why death? Is death an inextricable consequence of life? If not, where did death come from? In Sex and the Origins of Death, William R. Clark looks at life and death at the level of individual cells to address questions such as why we age, why cells die, and why sex and death seem to go hand in hand. Why must we die? To shed light on this question, Clark reaches far back in evolutionary history, to the moment when "inevitable death" (death from aging) first appeared. For cells during the first billion years, death, when it occurred, was accidental; there was nothing programmed into them that said they must die. But fierce competition gradually led to multicellular animals - size being an advantage against predators - and with this change came cell specialization and, most important, germ cells in which reproductive DNA was segregated from the DNA used to operate individual cells. When sexual reproduction evolved, it became the dominant form of reproduction on the planet, in part because mixing DNA from two individuals generates altogether new germline DNA. During this process, most mutations that have crept into the germline are corrected. But this does not happen in the other (somatic) cells of the body; the mutations are not corrected, and continue to accumulate. The somatic cells become, from a genetic point of view, both superfluous and dangerous. Nature's solution to this dilemma, Clark concludes, was programmed death - the somatic cells must die. Unfortunately, we are the somatic cells. Death is necessary to exploit to the fullest the advantages of sexual reproduction
Are we hardwired? : the role of genes in human behavior by William R Clark( Book )

23 editions published between 2000 and 2006 in English and held by 1,895 WorldCat member libraries worldwide

"The power and fascination of Are We Hardwired? lie in their explanation of that deceptively simple answer. Using eye-opening examples of genetically identical twins who, though raised in different families, have had remarkably parallel lives, the authors show that indeed roughly half of human behavior can be accounted for by DNA. But the picture is quite complicated. Clark and Grunstein take us on a tour of modern genetics and behavioral science, revealing that few elements of behavior depend upon a single gene; complexes of genes, often across chromosomes, driven most of our heredity-based actions. To illustrate this point, they examine the genetic basis, and quirks, of individual behavioral traits - including aggression, sexuality, mental function, eating disorders, alcoholism, and drug abuse. They show that genes and environment are not opposing forces; heredity shapes how we interpret our surroundings, which in turn changes the very structure of our brain. Clearly we are not simply puppets of either influence. Perhaps most interesting, the book suggests that the source of our ability to choose, to act unexpectedly, may lie in the chaos principle: the most minute differences during activation of a single neuron may lead to utterly unpredictable actions." "This account of the nature-nurture controversy answers some of our oldest questions in unexpected new ways."--Jacket
The new healers : the promise and problems of molecular medicine in the twenty-first century by William R Clark( )

14 editions published between 1997 and 1999 in English and held by 1,831 WorldCat member libraries worldwide

Science and medicine have provided us with clues to the treatment of a few genetic diseases, although by their very nature they have never been considered curable. But, as William R. Clark shows, that is about to change through one of the most profound revolutions in modern medicine: gene therapy, a branch of the new field of molecular medicine. Clark takes us to the laboratories which have been able to isolate human genes, to make billions of copies of them, and to reintroduce healthy genes into unfortunate individuals who have inherited damaged or functionless genes. The New Healers outlines
In defense of self : how the immune system really works by William R Clark( )

18 editions published between 2007 and 2008 in English and held by 1,720 WorldCat member libraries worldwide

We live in a sea of seething microbial predators, an infinity of invisible and invasive microorganisms capable of setting up shop inside us and sending us to an early grave. The only thing keeping them out? The immune system. William Clark's In Defense of Self offers a refreshingly accessible tour of the immune system, putting in layman's terms essential information that has been for too long the exclusive province of trained specialists. Clark explains how the immune system works by using powerful genetic, chemical, and cellular weapons to protect us from the vast majority of disease-causing microbes-bacteria, viruses, molds, and parasites. Only those microbes our bodies need to help us digest food and process vitamins are admitted. But this same system can endanger us by rejecting potentially life-saving organ transplants, or by overreacting and turning too much force against foreign invaders, causing serious-occasionally lethal-collateral damage to our tissues and resulting in autoimmune disease. In Defense of Self covers everything from how antibodies work and the strategies the body uses to distinguish self from not self to the nature of immunological memory, the latest approaches to vaccination, and how the immune system will react should we ever be subjected to a bioterrorist attack. Clark also offers important insights on the vital role that the immune system plays in cancer, AIDS, autoimmunity, rheumatoid arthritis, allergies and asthma, and other diseases. Of special interest to all those suffering from diseases related to the immune system, as well as their families, In Defense of Self lucidly explains a system none of us could live without.--From the publisher
The experimental foundations of modern immunology by William R Clark( Book )

32 editions published between 1980 and 1991 in 3 languages and held by 1,070 WorldCat member libraries worldwide

Bracing for armageddon? : the science and politics of bioterrorism in America by William R Clark( Book )

12 editions published in 2008 in English and held by 864 WorldCat member libraries worldwide

This primer for the general reader discusses the science behind potential bioterrorist attacks, revealing what could happen, what is likely to happen, and what almost certainly will not happen. He reviews likely threats (from agroterrorism to a poisoning of the water supply), plus the lethal agents on the CDC's bioterrorism list
Killer lymphocytes by Gideon Berke( )

13 editions published between 2005 and 2007 in English and Undetermined and held by 792 WorldCat member libraries worldwide

The authors summarize the extensive literature based on the study of CMC in vitro. Several important questions about killer cells have now been answered, for example, how they go about destroying other cells. Research ultimately revealed at least three lytic mechanisms available to killer lymphocytes. But do killer cells actually use these mechanisms in vivo? The possible involvement of CMC in transplant rejection, control of intracellular parasites, cancer, autoimmunity, and immune homeostatic regulation is analyzed in detail, yielding some surprising findings, and outlining important questions that remain unanswered. This extensively documented, comprehensive survey of cell-mediated cytotoxicity traces the history of killer lymphocytes from 1960 to the present, providing a definitive resource for specialists and non-specialists alike
Mechanisms of cell-mediated cytotoxicity by William R Clark( Book )

15 editions published in 1982 in English and held by 330 WorldCat member libraries worldwide

The First International Workshop was held at Carry-le-Rouet, France, September 14-16, 1981. The Workshop brought together for the first time leading investigators in each of the principal areas of cell-mediated cytotoxicity, as well as experts in the area of complement-mediated cytoxicity. Formal research presentations were held to a minimum, the emphasis being on open discussion of current knowledge about mechanisms of cytoxicity in each of the systems under consideration. The major objectives of the Workshop were 1) to compare and integrate what is known about the mechanism(s) of cytoxicity in each system; 2) to determine whether, on the basis of information in hand, it seems likely that the mechanisms of cytotoxicity in the various systems are the same or are unique; and 3) to stimulate thinking about new approaches to elucidating the fundamental mechanisms by which certain cells are able to kill other cells. This volume is intended as something more than a simple report or record of the Workshop. Various participants were asked to write either a review on a given topic, or a more detailed specific account of relevant current research. The mass of formal presentation in this volume thus far exceeds the amount of formal presentation that actually occurred. Each author has been encouraged to engage in a bit more speculation about possible mechanisms than might be appropriate for a standard research journal. Moreover, because most of the time in the various sessions was spent in open discussion we have tried to capture some of that flavor by appending portions of these discussions after papers, where appropriate. This may convey some impression of how at least some of us defend our present-day uncertainties
Emergency education; a social study of the W.P.A. education project in Rhode Island by William R Clark( Book )

15 editions published between 1940 and 1971 in English and held by 73 WorldCat member libraries worldwide

Explorers of the world by William R Clark( Book )

10 editions published between 1964 and 1968 in English and held by 19 WorldCat member libraries worldwide

Geni e comportamento by William R Clark( Book )

1 edition published in 2001 in Italian and held by 8 WorldCat member libraries worldwide

Shuai lao wen ti tan mi : Shuai lao yu si wang de sheng wu xue ji chu by William R Clark( Book )

3 editions published in 2001 in Chinese and held by 5 WorldCat member libraries worldwide

Ben shu miao shu le zai ge ti xi bao shui ping shang shuai lao ru he kai shi,Xi bao fu zhi you ru he yu sheng wu zheng ti de shuai lao xiang lian xi,Zuo zhe tan tao le shuai lao de jin hua qi yuan yu gong neng,Shuai lao yu ai zheng jian de xi bao lian xi,Shuai lao yu zao lao xing chi dai jian de xiang si xing yi ji tong guo yan jiu zhu ru wo shi zong he zheng deng ti xian shuai lao zheng zhuang de yi chuan xing ji bing suo huo de de jian jie
Antarctic wildlife adventure ; Antarctic challenge( Visual )

1 edition published in 2005 in English and held by 5 WorldCat member libraries worldwide

Shows the wide variety of wildlife--including humpback whales, penguins, and elephant seals--seen from a fifty-foot schooner on a voyage through the islands of the Antarctic peninsula
Idenshi iryō no jidai : 21seikijin no kitai to fuan by William R Clark( Book )

3 editions published in 1999 in Japanese and held by 4 WorldCat member libraries worldwide

Ji yin zhi liao : 21 shi ji fen zi yi xue de xi wang he wen ti by William R Clark( Book )

2 editions published in 2001 in Chinese and held by 4 WorldCat member libraries worldwide

Idenshi wa watakushitachi o dokomade shihaishiteiruka : DNA kara kokoro no nazo o toku( Book )

2 editions published in 2003 in Japanese and held by 4 WorldCat member libraries worldwide

Men'eki no hangyaku( Book )

2 editions published in 1997 in Japanese and held by 3 WorldCat member libraries worldwide

Płeć i śmierć by William R Clark( Book )

1 edition published in 2000 in Polish and held by 2 WorldCat member libraries worldwide

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Audience level: 0.17 (from 0.08 for A means to ... to 0.98 for Płeć i ś ...)

A means to an end : the biological basis of aging and death
At war within : the double-edged sword of immunitySex and the origins of deathAre we hardwired? : the role of genes in human behaviorThe new healers : the promise and problems of molecular medicine in the twenty-first centuryIn defense of self : how the immune system really worksThe experimental foundations of modern immunologyBracing for armageddon? : the science and politics of bioterrorism in AmericaKiller lymphocytes
Alternative Names
クラーク, ウィリアム・R