WorldCat Identities

California Institute of Technology Division of Biology

Works: 839 works in 947 publications in 1 language and 1,309 library holdings
Genres: Conference papers and proceedings  Periodicals  Academic theses 
Roles: Researcher
Classifications: QK882, 581.13342
Publication Timeline
Most widely held works about California Institute of Technology
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Most widely held works by California Institute of Technology
Genes, cells, and behavior : a view of biology fifty years later : 50th anniversary symposium, Division of Biology, California Institute of Technology, November 1-3, 1978 by Cells and Behavior Genes( Book )

4 editions published in 1980 in English and held by 228 WorldCat member libraries worldwide

Biology annual report( )

in English and held by 9 WorldCat member libraries worldwide

Water relations of plants by California Institute of Technology( Book )

1 edition published in 1949 in English and held by 6 WorldCat member libraries worldwide

Permeability and salt accumulation by California Institute of Technology( Book )

1 edition published in 1948 in English and held by 5 WorldCat member libraries worldwide

The physiology of cell division and cell growth( Book )

1 edition published in 1954 in English and held by 4 WorldCat member libraries worldwide

Photosynthesis by D. O Hall( Book )

1 edition published in 1952 in English and held by 4 WorldCat member libraries worldwide

A clear, concise and vivid account of the process of photosynthesis is presented in this enlarged and fully revised 6th ed. The details of photosynthetic processes at the macro and molecular level are discussed
Soil conditions for plant growth( Book )

1 edition published in 1955 in English and held by 4 WorldCat member libraries worldwide

Biology : a report on the research and other activities of the division by California Institute of Technology( Book )

in English and held by 4 WorldCat member libraries worldwide

Signal transduction, regulation, and developmental logic of EGFR signalling in C. elegans by Chieh Chang( )

2 editions published in 2001 in English and held by 3 WorldCat member libraries worldwide

RTKs-mediated signaling systems and the pathways with which they interact (e.g., those initiated by G protein-mediated signaling) involve a highly cooperative network that sense a large number of cellular inputs and then integrate, amplify, and process this information to orchestrate an appropriate set of cellular responses. The responses include virtually all aspects of cell function, from the most fundamental (proliferation, differentiation) to the most specialized (movement, metabolism, chemosensation). The basic tenets of RTK signaling system seem rather well established. Yet, new pathways and even new molecular players continue to be discovered. Although we believe that many of the essential modules of RTK signaling system are rather well understood, we have relatively little knowledge of the extent of interaction among these modules and their overall quantitative importance. My research has encompassed the study of both positive and negative signaling by RTKs in C. elegans. I identified the C. elegans S0S-1 gene and showed that it is necessary for multiple RAS-mediated developmental signals. In addition, I demonstrated that there is a SOS-1-independent signaling during RAS-mediated vulval differentiation. By assessing signal outputs from various triple mutants, I have concluded that this SOS-1-independent signaling is not mediated by PTP-2/SHP-2 or the removal of inhibition by GAP-1/ RasGAP and it is not under regulation by SLI-1/Cb1. I speculate that there is either another exchange factor for RASor an as yet unidentified signaling pathway operating during RAS-mediated vulval induction in C. elegans. In an attempt to uncover the molecular mechanisms of negative regulation of EGFR signaling by SLI-1/Cb1, I and two other colleagues codiscovered that RING finger domain of SLI-1 is partially dispensable for activity. This structure-function analysis shows that there is an ubiquitin protein ligase-independent activity for SLI-1 in regulating EGFR signaling. Further, we identified an inhibitory tyrosine of LET-23/ EGFR requiring sli-1(+)for its effects: removal of this tyrosine closely mimics loss of sli-1 but not loss of other negative regulator function. By comparative analysis of two RTK pathways with similar signaling mechanisms, I have found that clr-1, a previously identified negative regulator of egl-15 mediated FGFR signaling, is also involved in let-23 EGFR signaling. The success of this approach promises a similar reciprocal test and could potentially extend to the study of other signaling pathways with similar signaling logic. Finally, by correlating the developmental expression of lin-3 EGF to let-23 EGFR signaling activity, I demonstrated the existence of reciprocal EGF signaling in coordinating the morphogenesis of epithelia. This developmental logic of EGF signaling could provide a basis to understand a universal mechanism for organogenesis
VLSI analogs of neuronal visual processing : a synthesis of form and function by Misha Mahowald( )

2 editions published in 1992 in English and held by 3 WorldCat member libraries worldwide

Since circuits are essentially physical structures, I advocate the use of analog VLSI as powerful medium of abstraction, suitable for understanding and expressing the function of real neural systems. The working chip elevates the circuit description to a kind of synthetic formalism. The behaving physical circuit provides a formal test of theories of function that can be expressed in the language of circuits."
Genetic and neural regulation of aggressive behavior in Drosophila melanogaster by Liming Wang( )

2 editions published in 2011 in English and held by 3 WorldCat member libraries worldwide

"Aggression is an evolutionarily conserved behavior across the animal kingdom. Aggressive behavior among conspecifics is critical for the acquisition and defense of important resources including food, mates, and shelter, hence contributing to the survival and reproduction of animals. Therefore, it is of particular interest to understand how this behavior is regulated. We use the fruit fly Drosophila melanogaster as a model system to understand the regulation of aggression. We identify Cyp6a20, a cytochrome P450, as a gene mediating the suppressive effect of social experience on the intensity of male-male aggression. Notably, Cyp6a20 has been previously identified by profiling Drosophila strains subjected to genetic selection for differences in aggressiveness. Therefore our findings reveal a common genetic target for environmental and heritable influences on aggressiveness. Interestingly, Cyp6a20 is expressed in a subset of non-neuronal support cells associated with pheromone-sensing olfactory sensilla, suggesting that olfactory pheromone(s) may contribute to the regulation of aggression. Consistent with this idea, we find that cis-11-vaccenyl acetate (cVA), a previously identified olfactory pheromone, promotes male-male aggression via a group of olfactory receptor neurons expressing Or67d. Despite its robust behavioral effect, cVA is not required for baseline male-male aggression, and exogenous cVA does not induce male-female aggression, suggesting that sex specificity of male aggression is independent of cVA. Our subsequent studies show that the sex specificity of male social behaviors is determined by a different class of pheromones, named male cuticular hydrocarbons. Male flies perform significantly less aggression and more courtship towards male flies lacking male CHs, both of which can be rescued by synthetic (Z)-7-tricosene (7-T), the most abundant male cuticular hydrocarbon. The opposite influences of 7-T on aggression and courtship are independent, but both require the gustatory receptor Gr32a. Surprisingly, sensitivity to 7-T is required for the aggression-promoting effect of cVA, but not vice versa. Furthermore, the increased courtship in the absence of male cuticular hydrocarbons is induced by pheromone(s) detected by an olfactory receptor Or47b. Thus, male social behaviors are controlled by gustatory pheromones that promote and suppress aggression and courtship, respectively, and whose influences are dominant to olfactory pheromones that enhance these behaviors."
Expression of eph-family receptor tyrosine kinases and ephrins in the tadpole of the frog Xenopus laevis, and possible roles in the development of retinotectal topography by Anita Gould( )

2 editions published in 2001 in English and held by 3 WorldCat member libraries worldwide

Assembling a nervous system requires exquisite specificity in the construction of neuronal connectivity. One method by which such specificity is implemented is the presence of chemical cues within the tissues, differentiating one region from another, and the presence of receptors for those cues on the surface of neurons and their axons that are navigating within this cellular environment. Connections from one part of the nervous system to another often take the form of a topographic mapping. One widely studied model system that involves such a mapping is the vertebrate retinotectal projection-the set of connections between the eye and the optic tectum of the midbrain, which is the primary visual center in non-mammals and is homologous to the superior colliculus in mammals. In this projection the two-dimensional surface of the retina is mapped smoothly onto the two-dimensional surface of the tectum, such that light from neighboring points in visual space excites neighboring cells in the brain. This mapping is implemented at least in part via differential chemical cues in different regions of the tectum. The Eph family of receptor tyrosine kinases and their cell-surface ligands, the ephrins, have been implicated in a wide variety of processes, generally involving cellular movement in response to extracellular cues. In particular, they possess expression patterns-i.e., complementary gradients of receptor in retina and ligand in tectum- and in vitro and in vivo activities and phenotypes-i.e., repulsive guidance of axons and defective mapping in mutants, respectively-consistent with the long-sought retinotectal chemical mapping cues. The tadpole of Xenopus laevis, the South African clawed frog, is advantageous for in vivo retinotectal studies because of its transparency and manipulability. However, neither the expression patterns nor the retinotectal roles of these proteins have been well characterized in this system. We report here comprehensive descriptions in swimming stage tadpoles of the messenger RNA expression patterns of eleven known Xenopus Eph and ephrin genes, including xephrin-A3, which is novel, and xEphB2, whose expression pattern has not previously been published in detail. We also report the results of in vivo protein injection perturbation studies on Xenopus retinotectal topography, which were negative, and of in vitro axonal guidance assays, which suggest a previously unrecognized attractive activity of ephrins at low concentrations on retinal ganglion cell axons. This raises the possibility that these axons find their correct targets in part by seeking out a preferred concentration of ligands appropriate to their individual receptor expression levels, rather than by being repelled to greater or lesser degrees by the ephrins but attracted by some as-yet-unknown cue(s)
Hlh-1 and the C. elegans body wall muscle transcriptional differentiation by Steven Gregory Kuntz( )

2 editions published in 2011 in English and held by 3 WorldCat member libraries worldwide

To understand the structure and function of gene regulatory networks, it is important to first catalogue the components. Measurable constituents of networks include cis-regulatory elements, identified by their conservation and ability to drive expression; transcription factor binding motifs, identified by protein binding; transcription factors, identified by their necessity in network function; and target genes, identified by their conditional expression. The heart of a regulatory network is the transcription factor, which is dedicated to its role in the network. Transcription factors must be activated and regulate downstream targets in a discrete and reproducible fashion. Any deviation in network function may result in the collapse of the network and death of the animal. Thus, a network must be robust enough to function under a variety of biological conditions. However, network redundancies are inefficient in terms of fitness and lost during the course of evolution. The network structure and function reflects these evolutionary realities: strong sequence conservation of cis-regulatory elements coupled with widespread stochastic transcription factor binding, and ancient transcription factor conservation coupled with overlapping activation of targets. The evolution of functional transcription factor networks therefore must be a balance between conservation and flexibility
Molecular mechanism of sulfated carbohydrate recognition : structural and biochemical studies of the cysteine-rich domain of mannose receptor by Yang Liu( )

2 editions published in 2001 in English and held by 3 WorldCat member libraries worldwide

Genetic correlates of neural crest evolution by Daniel Keith Meulemans( Book )

1 edition published in 2004 in English and held by 3 WorldCat member libraries worldwide

Neural crest cells are unique to vertebrates and generate most of the adult structures that distinguish them from their closest invertebrate relatives, the cephalochordates. To elucidate the molecular bases of neural crest evolution, I analyzed the expression, function, and cis-regulation of amphioxus genes with vertebrate homologs having established roles in neural crest development. By comparing these amphioxus genes with their agnathan and gnathostome homologs, I have uncovered genetic changes coincident with, and potentially causal to, the origins of neural crest. I demonstrate that three transcriptional regulators involved with neural crest development, AP-2, Id, and SoxE, were recruited to the neural plate border early in vertebrate evolution--implying that genetic cooption of high-order transcription factors was a major driving force in neural crest evolution. I also show that the function of the Snail protein in establishing the neural plate border was not significantly altered during vertebrate evolution, although vertebrate Snail genes may have evolved novel domains necessary for later functions in neural crest cells. Finally, I began characterizing the cis-regulation of vertebrate and amphioxus Slug/Snail orthologs to determine if divergent aspects of Snail gene expression (i.e., expression in neural crest cells) are reflected in structural differences in Snail cis-regulatory DNA. Using this 3-tiered approach I have begun to define the novel genetic regulatory interactions that drove the evolution of neural crest cells in the vertebrate lineage
Negative regulation of transcription factors by Srb10 cyclin-dependent kinase by Yŏng Chi( )

2 editions published in 2001 in English and held by 3 WorldCat member libraries worldwide

The ubiquitin-dependent proteolytic pathway plays an important role in a broad array of cellular processes, inducting cell cycle control and transcription. Biochemical analysis of the ubiquitination of Sic1, the B-type cyclin-dependent kinase (CDK) inhibitor in budding yeast helped to define a ubiquitin ligase complex named SCFcdc⁴ (for Skp1, Cdc53/cullin, F-box protein). We found that besides Sic1, the CDK inhibitor Far1 and the replication initiation protein Cdc6 are also substrates of SCFcdc⁴ in vitro. A common feature in the ubiquitination of the cell cycle SCFcdc⁴ substrates is that they must be phosphorylated by the major cell cycle CDK, Cdc28. Gcn4, a transcription activator involved in the general control of amino acid biosynthesis, is rapidly degraded in an SCFcdc⁴-dependent manner in vivo. We have focused on this substrate to investigate the generality of the SCFcdc⁴ pathway. Through biochemical fractionations, we found that the Srb10 CDK phosphorylates Gcn4 and thereby marks it for recognition by SCFcdc⁴ ubiquitin ligase. Srb10 is a physiological regulator of Gcn4 stability because both phosphorylation and turnover of Gcn4 are diminished in srb10 mutants. Furthermore, we found that at least two different CDKs, Pho85 and Srb10, conspire to promote the rapid degradation of Gcn4 in vivo. The multistress response transcriptional regulator Msn2 is also a substrate for Srb10 and is hyperphosphorylated in an Srb10-dependent manner upon heat stress-induced translocation into the nucleus. Whereas Msn2 is cytoplasmic in resting wild type cells, its nuclear exclusion is partially compromised in srb10 mutant cells. Srb10 has been shown to repress a subset of genes in vivo, and has been proposed to inhibit transcription via phosphorylation of the C-terminal domain of RNA polymerase II. Our results suggest a general theme that Srb10 represses the transcription of specific genes by directly antagonizing the transcriptional activators
Annual report by California Institute of Technology( )

in English and held by 1 WorldCat member library worldwide

(Developing a physical map of human chromosome 22)( )

1 edition published in 1991 in English and held by 0 WorldCat member libraries worldwide

We have developed bacterial F-factor based systems for cloning large fragments of human DNA in E. coli. In addition to large size, these systems are capable of maintaining human DNA with a high degree of stability. The cosmid size clones are called Fosmids and the clones containing larger inserts (100--200 kb) are called bacterial artificial chromosomes (BACs). The ultimate test of the effectiveness of cloning and mapping technology is the degree to which it can be efficiently applied to solve complex mapping problems. We, therefore, plan to use the large fragment cloning procedure as well as a variety of other approaches to generate a complete map of overlapping clones corresponding to human chromosome 22. We have thus far prepared two human chromosome 22 specific Fosmid libraries and we are in the process of constructing a chromosome 22 specific BAC library composed of fragments larger than 100 kb. We will further optimize the technology so that libraries of fragments larger than 200 kb can be readily prepared
Molecular analysis of ethylene-insensitive mutants in arabidopsis( )

1 edition published in 1991 in English and held by 0 WorldCat member libraries worldwide

The subject of this study is the biochemical basis of ethylene reception. The Arabidopsis thaliana ETR gene codes for the ethylene receptor or is involved in transduction of the ethylene-generated signal. We have cloned an etr mutation which results in a decrease in the ethylene response of the plant, with a decrease in ethylene binding of about five-fold. Two genes have been found in the cloned region which confer resistance. By sequence analysis, the first protein contains three distinct regions: a transmembrane region, a serine/threonine protein kinase region, and a control region similar to the RAS-binding region of yeast adenylate cyclase. The second protein contains a zinc-finger; since sequence of the first protein shows no mutant-dependent changes, and transition metals have been implicated in ethylene binding, this protein could be the ETR gene product. However, no mutant dependent differences have been found in this protein, either. The mutation could be upstream of the coding region of either gene and involve regulatory elements, so we are continuing to sequence. (MHB)
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California Institute of Technology, Pasadena. Division of Biology.

English (44)