WorldCat Identities

Sigel, Astrid

Overview
Works: 133 works in 683 publications in 1 language and 12,198 library holdings
Genres: Periodicals 
Roles: Editor, Author, Contributor, Other
Publication Timeline
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Most widely held works by Astrid Sigel
Manganese and its role in biological processes( )

11 editions published between 1999 and 2000 in English and held by 495 WorldCat member libraries worldwide

Mercury and its effects on environment and biology by Astrid Sigel( )

14 editions published in 1997 in English and held by 455 WorldCat member libraries worldwide

Interplay between metal ions and nucleic acids by Astrid Sigel( )

15 editions published between 2011 and 2014 in English and held by 437 WorldCat member libraries worldwide

Annotation
Structural and catalytic roles of metal ions in RNA by Astrid Sigel( )

13 editions published between 2011 and 2015 in English and held by 417 WorldCat member libraries worldwide

The discovery of ribozymes triggered a huge interest in the chemistry and biology of RNAs. Much of the recently made progress focusing on metal ions is addressed in Volume 9. This book, written by 28 internationally recognized experts, provides a most up-to-date view and it is thus of special relevance for colleagues teaching courses in biological inorganic chemistry and for researchers dealing, e.g., with nucleic acids, gene expression, and enzymology, but also for those in analytical and bioinorganic chemistry or biophysics. Structural and Catalytic Roles of Metal Ions in RNA describes metal ion-binding motives, methods to detect and characterize metal ion binding sites, and the role of metal ions in folding and catalysis. It deals with diffuse metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial ribozymes. The ribosome, ribozymes and redox cofactors, as well as the binding of kinetically inert metal ions to RNA are also considered
Cadmium : from toxicity to essentiality by Astrid Sigel( )

12 editions published between 2012 and 2013 in English and held by 363 WorldCat member libraries worldwide

Cadmium: From Toxicity to Essentiality, MILS-11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted. The book terminates with a fascinating report on the use of Cd(II) in carbonic anhydrase of certain marine phytoplankton species. Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems
Interrelations between essential metal ions and human diseases by Astrid Sigel( )

10 editions published in 2013 in English and held by 352 WorldCat member libraries worldwide

"MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between essential metal ions and human diseases"--Publisher's description
Neurodegenerative diseases and metal ions( Book )

12 editions published in 2006 in English and held by 349 WorldCat member libraries worldwide

About the Series...Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine
Handbook on toxicity of inorganic compounds by Hans G Seiler( Book )

8 editions published between 1987 and 1988 in English and held by 330 WorldCat member libraries worldwide

Nickel and its surprising impact in nature( )

11 editions published between 2006 and 2007 in English and held by 330 WorldCat member libraries worldwide

The primary colonization and long-term survival of Helicobacter pylori in the hostile gastric niche and the role of nickel in this environmental adaptation is covered in detail in Chapter 15. Nickel is widely employed in modern industry in conjunction with other metals for the production of alloys for coins, jewellery, and stainless steel; it is also used for plating, battery production, as a catalyst, etc. Workers are exposed to nickel at all stages of the processing of nickel-containing products through air, water or skin contacts. For example, the exposure to airborne nickel-containing particles has long been known to cause acute respiratory symptoms ranging from mild irritation and inflammation of the respiratory system to bronchitis, asthma, and pulmonary fibrosis and edema. Another well known adverse effect is allergic contact dermatitis. The indicated health problems caused by nickel exposure are mediated by an active change in the expression of genes that control inflammation, the response to stress, cell proliferation or cell death. All this and more is covered in Chapter 16. However, the most serious health effects beyond nickel toxicity relate to carcinogenesis; these concerns represent an area of considerable research activity today as is evident from the terminating chapter of Nickel and Its Surprising Impact in Nature
Metal-carbon bonds in enzymes and cofactors by Astrid Sigel( )

21 editions published between 2009 and 2015 in English and held by 321 WorldCat member libraries worldwide

This book covers the occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans
The ubiquitous roles of cytochrome P450 proteins( )

11 editions published in 2007 in English and held by 316 WorldCat member libraries worldwide

Looking across the tree of life, it is amazing to find cytochrome P450 proteins represented in all life forms. Volume 3, devoted solely to the vital and still expanding research area concerning P450s, offers in 17 stimulating chapters written by 36 internationally recognized experts an authoritative and timely account of this fascinating subject. The Ubiquitous Roles of Cytochrome P450 Proteins highlights, supported by nearly 2700 references, more than 20 tables and 190 illustrations, the function of these versatile catalysts which act as monooxygenases and insert an oxygen atom from dioxygen into a substrate molecule oxidizing it. P450s are important in the biosynthesis of hormones and signaling molecules as well as in xenobiotic metabolism and detoxification ranging from pharmaceuticals in humans to toxic substances in insects and plants. Mechanistic aspects and the design and engineering of P450 systems for biotechnological applications are also covered. MILS-3 is essential for scientists working in the wide range from bioinorganic chemistry all the way through to medicine including the clinic. This volume encompasses the breadth of research efforts focused on P450s from structure to function including an appreciation of the diversity and complexity of the biotransformations they catalyze. The introductory Chapter 1, setting the scene, explores the many different levels at which these P450 enzymes (and their respective genes) have diverged in the process of evolution to yield the plethora of enzymes that are now termed "P450 monooxygenases". This broad and unprecedented reactivity of P450 enzymes which contain a heme iron center (most commonly iron(III)protoporphyrin IX) with a deprotonated cysteine side chain providing the fifth ligand to iron, has challenged the "biomimetic community". Indeed, much has been accomplished over the past five decades, e.g., regarding the understanding of the unusual activation of paramagnetic dioxygen by reductive oxygen clea
Biomineralization : from nature to application by Astrid Sigel( )

17 editions published between 2008 and 2010 in English and held by 315 WorldCat member libraries worldwide

Biomineralization is a hot topic in the area of materials, and this volume in the Metals Ions in Life Sciences series takes a systematic approach, dealing with all aspects from the fundamentals to applications. Key biological features of biomineralization, such as gene directed growth and the role of enzymes are covered, as are new areas, including copper/zinc in the jaws of invertebrates or magnetic biomaterials that help birds with navigation
Metallothioneins and related chelators by Astrid Sigel( )

21 editions published between 2009 and 2015 in English and held by 308 WorldCat member libraries worldwide

An essential resource for scientists working in a wide range of disciplines from environmental toxicology and inorganic biochemistry all the way through to physiology and medicine
Organometallics in environment and toxicology by Astrid Sigel( )

18 editions published between 2010 and 2015 in English and held by 274 WorldCat member libraries worldwide

"Organometallic compounds contain per definition a metal-carbon bond. Therefore, the present Volume 7 is related to the preceding Volume 6, Metal- Carbon Bonds in Enzymes and Cofactors, which, as follows from its title, focused on living organisms. Now the focus is on the role that organometal(loid)s play in the environment and in toxicology; naturally, here again living systems are involved in the synthesis, transformation, remediation, detoxification, etc."--Preface
Metal ions in toxicology : effects, interactions, interdependencies by Roland K. O Sigel( )

20 editions published between 2010 and 2015 in English and Undetermined and held by 255 WorldCat member libraries worldwide

It is an old wisdom that metals are indispensable for life. Indeed, severalof them, like sodium, potassium, and calcium, are easily discovered in livingmatter. However, the role of metals and their impact on life remainedlargely hidden until inorganic chemistry and coordination chemistryexperienced a pronounced revival in the 1950s. The experimental and theoreticaltools created in this period and their application to biochemicalproblems led to the development of the field or discipline now known asBioinorganic Chemistry, Inorganic Biochemistry, or more recently alsooften addressed as Biological Inorganic Chemistry. By 1970 Bioinorganic Chemistry was established and further promoted bythe book series Metal Ions in Biological Systems founded in 1973 (edited byH. S., who was soon joined by A.S.) and published by Marcel Dekker, Inc., New York, for more than 30 years. After this company ceased to be a familyendeavor and its acquisition by another company, we decided, after havingedited 44 volumes of the MIBS series (the last two together with R.K.O.S.)to launch a new and broader minded series to cover today's needs in the LifeSciences. Therefore, the Sigels new series is entitledMetal Ions in Life Sciences. After publication of the first four volumes (2006-2008) with John Wiley & Sons, Ltd., Chichester, UK, we are happy to join forces now in this still newendeavor with the Royal Society of Chemistry, Cambridge, UK; a mostexperienced Publisher in the Sciences
Metal ions in biological systems( )

in English and held by 251 WorldCat member libraries worldwide

Calcium and its role in biology( Book )

6 editions published in 1984 in English and held by 250 WorldCat member libraries worldwide

The alkali metal ions : their role for life by Astrid Sigel( )

7 editions published in 2016 in English and Undetermined and held by 250 WorldCat member libraries worldwide

"MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The alkali metal ions: their role for life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel have long-standing interests in biological inorganic chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal ions in biological systems."--Back cover
Biogeochemical cycles of elements( Book )

11 editions published in 2005 in English and held by 230 WorldCat member libraries worldwide

(Publisher-supplied data) In 10 stimulating chapters, Volume 43 of Metal Ions in Biological Systems focuses on the vibrant research area related to the cycling of elements, metals, and nonmetals in biology and geology. It critically highlights the biogeochemistry of hydrogen, oxygen, nitrogen, sulfur, and phosphorus, examines the interrelations between the availability of iron, phytoplankton growth, and the carbon cycle, considers the biogeochemical cycling of mercury and lead, and includes a chapter devoted to cadmium, a highly toxic element that is also a micronutrient for phytoplankton. This volume contains more than 50 illustrations along with more than 1300 references for further research on the subject
Circulation of metals in the environment( Book )

12 editions published between 1984 and 1986 in English and held by 221 WorldCat member libraries worldwide

 
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Neurodegenerative diseases and metal ions
Languages
English (264)

Covers
Mercury and its effects on environment and biologyStructural and catalytic roles of metal ions in RNANeurodegenerative diseases and metal ionsNickel and its surprising impact in natureMetal-carbon bonds in enzymes and cofactorsThe ubiquitous roles of cytochrome P450 proteinsBiomineralization : from nature to applicationMetallothioneins and related chelators