WorldCat Identities

Sigel, Astrid

Overview
Works: 141 works in 634 publications in 1 language and 11,917 library holdings
Roles: Editor, Author, Contributor, Other
Classifications: QP532, 574.19214 S
Publication Timeline
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Most widely held works by Astrid Sigel
Handbook on toxicity of inorganic compounds by Hans G Seiler( Book )

8 editions published between 1987 and 1988 in English and held by 335 WorldCat member libraries worldwide

Metal ions in biological systems( )

in English and held by 261 WorldCat member libraries worldwide

Calcium and its role in biology( Book )

7 editions published in 1984 in English and held by 253 WorldCat member libraries worldwide

Circulation of metals in the environment( Book )

10 editions published in 1984 in English and held by 219 WorldCat member libraries worldwide

Zinc and its role in biology and nutrition( Book )

7 editions published in 1983 in English and held by 219 WorldCat member libraries worldwide

Neurodegenerative diseases and metal ions by Astrid Sigel( Book )

14 editions published in 2006 in English and held by 181 WorldCat member libraries worldwide

Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized. With more than 2000 references to assist further research, Neurodegenerative Diseases and Metal Ions is an essential resource for scientists and students in many disciplines, including biological inorganic chemistry, molecular biology, enzymology, pharmacology, physiology, medicine, and toxicology
Nickel and its surprising impact in nature( Book )

12 editions published between 2006 and 2007 in English and held by 156 WorldCat member libraries worldwide

Volume 2 focuses on the vibrant research area concerning nickel as well as its complexes and their role in Nature. With more than 2800 references and over 130 illustrations, it is an essential resource for scientists working in the wide range from inorganic biochemistry all the way through to medicine. In 17 stimulating chapters, written by 47 internationally recognized experts, Nickel and Its Surprising Impact in Nature highlights critically the biogeochemistry of nickel, its role in the environment, in plants and cyanobacteria, as well as for the gastric pathogen Helicobacter pylori, for gene expression and carcinogenensis. In addition, it covers the complex-forming properties of nickel with amino acids, peptides, phosphates, nucleotides, and nucleic acids. The volume also provides sophisticated insights in the recent progress made in understanding the role of nickel in enzymes such as ureases, hydrogenases, superoxide dismutases, acireductone dioxygenases, acetyl-coenzyme A synthases, carbon monoxide dehydrogenases, methyl-coenzyme M reductases ... and it reveals the chaperones of nickel metabolism. The book opens with the biogeochemistry of this element and its release into the environment, which occurs from both natural and anthropogenic sources, whereby atmospheric distribution plays an important role. In the second chapter the impact of nickel on the metabolism of cyanobacteria and eukaryotic plants including deficiency and toxicity is considered, as is the application of nickel hyperaccumulator plants for phytomining and phytoremediation. Complex formation of nickel(II/III) with amino acids and peptides as well as of nickel(II) with sugar residues, nucleobases, phosphates, nucleosides, and nucleic acids is summarized in Chapters 3 and 4, respectively, by also taking into account intramolecular equilibria and comparisons with related metal ions
The ubiquitous roles of cytochrome P450 proteins( Book )

12 editions published in 2007 in English and held by 146 WorldCat member libraries worldwide

Looking across the tree of life, it is amazing to find cytochrome P450 proteins represented in all life forms. Volume 3, devoted solely to the vital and still expanding research area concerning P450s, offers in 17 stimulating chapters written by 36 internationally recognized experts an authoritative and timely account of this fascinating subject. The Ubiquitous Roles of Cytochrome P450 Proteins highlights, supported by nearly 2700 references, more than 20 tables and 190 illustrations, the function of these versatile catalysts which act as monooxygenases and insert an oxygen atom from dioxygen into a substrate molecule oxidizing it. P450s are important in the biosynthesis of hormones and signaling molecules as well as in xenobiotic metabolism and detoxification ranging from pharmaceuticals in humans to toxic substances in insects and plants. Mechanistic aspects and the design and engineering of P450 systems for biotechnological applications are also covered. MILS-3 is essential for scientists working in the wide range from bioinorganic chemistry all the way through to medicine including the clinic. This volume encompasses the breadth of research efforts focused on P450s from structure to function including an appreciation of the diversity and complexity of the biotransformations they catalyze. The introductory Chapter 1, setting the scene, explores the many different levels at which these P450 enzymes (and their respective genes) have diverged in the process of evolution to yield the plethora of enzymes that are now termed "P450 monooxygenases". This broad and unprecedented reactivity of P450 enzymes which contain a heme iron center (most commonly iron(III)protoporphyrin IX) with a deprotonated cysteine side chain providing the fifth ligand to iron, has challenged the "biomimetic community". Indeed, much has been accomplished over the past five decades, e.g., regarding the understanding of the unusual activation of paramagnetic dioxygen by reductive oxygen clea
Manganese and its role in biological processes( Book )

10 editions published between 1999 and 2000 in English and held by 145 WorldCat member libraries worldwide

Biogeochemical cycles of elements( Book )

11 editions published in 2005 in English and held by 141 WorldCat member libraries worldwide

(Publisher-supplied data) In 10 stimulating chapters, Volume 43 of Metal Ions in Biological Systems focuses on the vibrant research area related to the cycling of elements, metals, and nonmetals in biology and geology. It critically highlights the biogeochemistry of hydrogen, oxygen, nitrogen, sulfur, and phosphorus, examines the interrelations between the availability of iron, phytoplankton growth, and the carbon cycle, considers the biogeochemical cycling of mercury and lead, and includes a chapter devoted to cadmium, a highly toxic element that is also a micronutrient for phytoplankton. This volume contains more than 50 illustrations along with more than 1300 references for further research on the subject
Metal-carbon bonds in enzymes and cofactors by Astrid Sigel( Book )

15 editions published in 2009 in English and held by 131 WorldCat member libraries worldwide

Related to Co-corrin, the Ni-porphinoid unit (F430) is the prosthetic group of methyl-coenzyme M reductase. This enzyme, the topic of Chapter 3, catalyzes the methane-forming step in methanogenic archaea and most probably also the methane-oxidizing step in methanotrophic archaea. Chapter 4 deals with acetyl-coenzyme A synthases/carbon monoxide dehydrogenases, i.e., bifunctional nickel-containing enzymes, which catalyze the synthesis of acetyl-CoA and the reversible reduction of CO2 to CO in anaerobic, mostly thermophilic, organisms, able to grow chemiautotrophically on simple inorganic compounds like CO2. Ni-C bonds with methyl, acetyl, carbonyl, and carboxylate groups are evidenced. [NiFe]-, [FeFe]-, and [Fe]-hydrogenases are detailed in the next three chapters. These enzymes, present in many microorganisms, catalyze the oxidation of molecular hydrogen or the reduction of protons. All of them have a Fe(CO)x unit in their active site. Iron-cyanide units occur in [NiFe]- and [FeFe]-hydrogenases. However, despite the indicated similarities they clearly have independent evolutionary origins. The participation of the commonly considered toxic ligands CO and CN- in the active sites of hydrogenases is still a surprise to many; yet, exactly their occurrence incites a great interest in physical chemists as well as evolutionary biologists
Biomineralization : from nature to application( Book )

14 editions published in 2008 in English and held by 129 WorldCat member libraries worldwide

Biomineralization is a hot topic in the area of materials, and this volume in the Metals Ions in Life Sciences series takes a systematic approach, dealing with all aspects from the fundamentals to applications. Key biological features of biomineralization, such as gene directed growth and the role of enzymes are covered, as are new areas, including copper/zinc in the jaws of invertebrates or magnetic biomaterials that help birds with navigation
Organometallics in environment and toxicology( Book )

13 editions published between 2010 and 2015 in English and held by 114 WorldCat member libraries worldwide

"Organometallic compounds contain per definition a metal-carbon bond. Therefore, the present Volume 7 is related to the preceding Volume 6, Metal-Carbon Bonds in Enzymes and Cofactors, which, as follows from its title, focused on living organisms. Now the focus is on the role that organometal(loid)s play in the environment and in toxicology; naturally, here again living systems are involved in the synthesis, transformation, remediation, detoxification, etc."--Preface
Metallothioneins and related chelators by Astrid Sigel( Book )

16 editions published in 2009 in English and held by 105 WorldCat member libraries worldwide

Volume 5 focuses on the vibrant research area centering around Metallothioneins and related sulfur-containing chelators and their role in nature. In 15 stimulating chapters, written by 30 internationally recognized experts, Metallothioneins and Related Chelators highlghts critically the interrelations between metallothioneins, the homeostasis of essential metal ions and heavy metal toxicology. With close to 2000 references, about 20 tables, and over 80 illustrations, one third of these in color, this book is an essential resource for scientists working in the wide range from ebviornmental toxicology and inorganic biochemistry all the way through to physiology amd medicine. Metallothioneins are cysteine-rich low molecular mass (5 to 10 kDa) proteins, with commonly 7 metal ions, occurring from bacteria to humans. This fact alone already emphasizes the importance of these proteins which are in the focus of this book. Relevant research is going on now for more than 50 years and its historical development, concentrating on mammalian metallothioneins (MTs) and their role in cadmium toxicology is summarized in Chapter 1. Chapter 2 provides an overview of our current knowledge on the expression and regulation of MT genes: The intracellular concentration of MTs is adjusted to cellular demand. Especially upon heavy metal load, metallothionein gene transcription is strongly induced. Indeed, all organisms use elaborate systems to regulate the levels of bioavailable zinc, copper, and other essential metals. Thus, MTs play pivotal roles in metal homeostasis as well as in detoxification reactions. Their high cysteine content enables MTs to avidly bind toxic metals and also to influence the cellular redox balance and radical scavenging. In fact, these points are further highlighted throughout the volume
Metal ions in toxicology : effects, interactions, interdependencies by Roland K. O Sigel( Book )

15 editions published between 2010 and 2015 in English and Undetermined and held by 79 WorldCat member libraries worldwide

Volume 8, solely devoted to the toxicology of metals and metalloids as well as their compounds, focuses on human health. Not surprisingly, all related research areas are rapidly developing due to the role of metals and metalloids in the environment, for the work place, for food and water supply, etc. Written by 40 internationally recognized experts, the 14 stimulating chapters provide an authoritative and timely resource for scientists working in the wide range from analytical, physical, inorganic, and environmental biochemistry all the way through to toxicology, physiology, and medicine. Volu
Structural and catalytic roles of metal ions in RNA( Book )

10 editions published between 2011 and 2015 in English and held by 68 WorldCat member libraries worldwide

The discovery of ribozymes triggered a huge interest in the chemistry and biology of RNAs. Much of the recently made progress focusing on metal ions is addressed in Volume 9. This book, written by 28 internationally recognized experts, provides a most up-to-date view and it is thus of special relevance for colleagues teaching courses in biological inorganic chemistry and for researchers dealing, e.g., with nucleic acids, gene expression, and enzymology, but also for those in analytical and bioinorganic chemistry or biophysics. Structural and Catalytic Roles of Metal Ions in RNA describes metal ion-binding motives, methods to detect and characterize metal ion binding sites, and the role of metal ions in folding and catalysis. It deals with diffuse metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial ribozymes. The ribosome, ribozymes and redox cofactors, as well as the binding of kinetically inert metal ions to RNA are also considered
Interplay between metal ions and nucleic acids by Astrid Sigel( Book )

13 editions published between 2011 and 2014 in English and Undetermined and held by 66 WorldCat member libraries worldwide

Annotation
Cadmium : from toxicity to essentiality by Astrid Sigel( Book )

11 editions published between 2012 and 2013 in English and held by 43 WorldCat member libraries worldwide

Cadmium: From Toxicity to Essentiality, MILS-11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted. The book terminates with a fascinating report on the use of Cd(II) in carbonic anhydrase of certain marine phytoplankton species.Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems
Interrelations between essential metal ions and human diseases by Astrid Sigel( Book )

7 editions published in 2013 in English and held by 34 WorldCat member libraries worldwide

"MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between essential metal ions and human diseases"--Publisher's description
Metal ions in biological systems( Book )

6 editions published in 1997 in English and held by 9 WorldCat member libraries worldwide

 
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Calcium and its role in biologyCirculation of metals in the environment
Languages
English (225)

Covers
Circulation of metals in the environmentNeurodegenerative diseases and metal ionsNickel and its surprising impact in natureThe ubiquitous roles of cytochrome P450 proteinsManganese and its role in biological processesBiogeochemical cycles of elementsMetal-carbon bonds in enzymes and cofactorsBiomineralization : from nature to application