WorldCat Identities

Sigel, Astrid

Works: 131 works in 631 publications in 1 language and 11,651 library holdings
Roles: Editor, Author, Contributor, Other
Classifications: QP532, 574.19214 S
Publication Timeline
Most widely held works by Astrid Sigel
Handbook on toxicity of inorganic compounds by Hans G Seiler( Book )

7 editions published between 1987 and 1988 in English and held by 329 WorldCat member libraries worldwide

Metal ions in biological systems( )

in English and held by 264 WorldCat member libraries worldwide

Calcium and its role in biology( Book )

7 editions published in 1984 in English and held by 253 WorldCat member libraries worldwide

Circulation of metals in the environment( Book )

9 editions published in 1984 in English and held by 220 WorldCat member libraries worldwide

Zinc and its role in biology and nutrition( Book )

7 editions published in 1983 in English and held by 219 WorldCat member libraries worldwide

Neurodegenerative diseases and metal ions by Astrid Sigel( Book )

15 editions published in 2006 in English and held by 179 WorldCat member libraries worldwide

Over the years substantial evidence has accumulated implicating that metal ions play a role in the pathophysiology and pathogenesis of neurodegenerative disorders. This is emphasized in Chapter 1, which sets the scene for this volume and provides an organizational frame for metal-related disorders, namely (i) those caused by a defect in metal ion transport or homeostasis, (ii) those caused by toxicological exposure to metals, and (iii) those caused or associated with metalloprotein aggregation and/or misfolding. Indeed, misfolded proteins are implicated in a rapidly growing list of debilitating illnesses like Alzheimer's, Parkinson's, and Creutzfeldt-Jakob diseases. Therefore Chapter 2 deals with protein folding and misfolding; structures, energetics, and dynamics of transient species are considered in detail because their characterization is an essential step in understanding the benign and malignant pathways of protein folding. The three chapters following these general considerations are devoted to metal ion interactions, mainly of copper, with mammalian prion proteins and their fragments, to transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases) as well as to the amyloid precursor protein (Alzheimer's disease). Chapters 6 and 7 consider in particular the role of iron in Parkinson's and Huntington's diseases, respectively, whereas Chapter 8 details the interrelation between copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis. The malfunctioning of copper transport in Wilson and Menkes diseases, where copper accumulates or is not absorbed, respectively, is dealt with in Chapter 9
Manganese and its role in biological processes( Book )

11 editions published between 1999 and 2000 in English and held by 156 WorldCat member libraries worldwide

Nickel and its surprising impact in nature( Book )

13 editions published between 2006 and 2007 in English and held by 156 WorldCat member libraries worldwide

Volume 2 focuses on the vibrant research area concerning nickel as well as its complexes and their role in Nature. With more than 2800 references and over 130 illustrations, it is an essential resource for scientists working in the wide range from inorganic biochemistry all the way through to medicine. In 17 stimulating chapters, written by 47 internationally recognized experts, Nickel and Its Surprising Impact in Nature highlights critically the biogeochemistry of nickel, its role in the environment, in plants and cyanobacteria, as well as for the gastric pathogen Helicobacter pylori, for gene expression and carcinogenensis. In addition, it covers the complex-forming properties of nickel with amino acids, peptides, phosphates, nucleotides, and nucleic acids. The volume also provides sophisticated insights in the recent progress made in understanding the role of nickel in enzymes such as ureases, hydrogenases, superoxide dismutases, acireductone dioxygenases, acetyl-coenzyme A synthases, carbon monoxide dehydrogenases, methyl-coenzyme M reductases ... and it reveals the chaperones of nickel metabolism. The book opens with the biogeochemistry of this element and its release into the environment, which occurs from both natural and anthropogenic sources, whereby atmospheric distribution plays an important role. In the second chapter the impact of nickel on the metabolism of cyanobacteria and eukaryotic plants including deficiency and toxicity is considered, as is the application of nickel hyperaccumulator plants for phytomining and phytoremediation. Complex formation of nickel(II/III) with amino acids and peptides as well as of nickel(II) with sugar residues, nucleobases, phosphates, nucleosides, and nucleic acids is summarized in Chapters 3 and 4, respectively, by also taking into account intramolecular equilibria and comparisons with related metal ions
The ubiquitous roles of cytochrome P450 proteins( Book )

13 editions published in 2007 in English and held by 145 WorldCat member libraries worldwide

Looking across the tree of life, it is amazing to find cytochrome P450 proteins represented in all life forms. Volume 3, devoted solely to the vital and still expanding research area concerning P450s, offers in 17 stimulating chapters written by 36 internationally recognized experts an authoritative and timely account of this fascinating subject. The Ubiquitous Roles of Cytochrome P450 Proteins highlights, supported by nearly 2700 references, more than 20 tables and 190 illustrations, the function of these versatile catalysts which act as monooxygenases and insert an oxygen atom from dioxygen into a substrate molecule oxidizing it. P450s are important in the biosynthesis of hormones and signaling molecules as well as in xenobiotic metabolism and detoxification ranging from pharmaceuticals in humans to toxic substances in insects and plants. Mechanistic aspects and the design and engineering of P450 systems for biotechnological applications are also covered. MILS-3 is essential for scientists working in the wide range from bioinorganic chemistry all the way through to medicine including the clinic. This volume encompasses the breadth of research efforts focused on P450s from structure to function including an appreciation of the diversity and complexity of the biotransformations they catalyze. The introductory Chapter 1, setting the scene, explores the many different levels at which these P450 enzymes (and their respective genes) have diverged in the process of evolution to yield the plethora of enzymes that are now termed "P450 monooxygenases". This broad and unprecedented reactivity of P450 enzymes which contain a heme iron center (most commonly iron(III)protoporphyrin IX) with a deprotonated cysteine side chain providing the fifth ligand to iron, has challenged the "biomimetic community". Indeed, much has been accomplished over the past five decades, e.g., regarding the understanding of the unusual activation of paramagnetic dioxygen by reductive oxygen clea
Biogeochemical cycles of elements( Book )

11 editions published in 2005 in English and held by 139 WorldCat member libraries worldwide

(Publisher-supplied data) In 10 stimulating chapters, Volume 43 of Metal Ions in Biological Systems focuses on the vibrant research area related to the cycling of elements, metals, and nonmetals in biology and geology. It critically highlights the biogeochemistry of hydrogen, oxygen, nitrogen, sulfur, and phosphorus, examines the interrelations between the availability of iron, phytoplankton growth, and the carbon cycle, considers the biogeochemical cycling of mercury and lead, and includes a chapter devoted to cadmium, a highly toxic element that is also a micronutrient for phytoplankton. This volume contains more than 50 illustrations along with more than 1300 references for further research on the subject
Metal-carbon bonds in enzymes and cofactors by Astrid Sigel( Book )

18 editions published between 2009 and 2015 in English and Undetermined and held by 132 WorldCat member libraries worldwide

This volume is the 50th book in the two Sigels' series (44 in MIBS and 6 in MILS) and this is celebrated with a comprehensive Author Index given at the end of this Volume 6. Supported by nearly 1700 references and about 160 illustrations (many in color), Metal-Carbon Bonds in Enzymes and Cofactors highlights the function of these metal-carbon bonds in life, but also their importance in research. Written by 20 internationally recognized experts, 12 stimulating chapters provide an authoritative and timely resource for scientists working in the wide range from physical and inorganic biochemistry all the way through to physiology and medicine. This volume is devoted to naturally occurring metal-carbon bonds, a topic recently obtaining (again) significant momentum, largely - but not only - due to new insights gained with hydrogenases. The field started out about 50 years ago when coenzyme B12 was identified as organometallic derivative of vitamin B12. This moved the cobalt-carbon bond into the center of interest and consequently, the first two chapters of this book are devoted to the organometallic chemistry of B12 coenzymes and to the biochemistry of cobalamin- and corrinoid-dependent enzymes. B12 coenzymes are required in the metabolism of a broad range of organisms including humans; however, only microorganisms have the ability to biosynthesize B12 and other natural corrinoids. This fact alone, together with new metabolic insights (e.g., riboswitches), guarantees a continued fascination - not only for the B12 community
Biomineralization : from nature to application by Astrid Sigel( Book )

17 editions published between 2008 and 2010 in English and held by 128 WorldCat member libraries worldwide

Biomineralization is a hot topic in the area of materials, and this volume in the Metals Ions in Life Sciences series takes a systematic approach, dealing with all aspects from the fundamentals to applications. Key biological features of biomineralization, such as gene directed growth and the role of enzymes are covered, as are new areas, including copper/zinc in the jaws of invertebrates or magnetic biomaterials that help birds with navigation
Organometallics in environment and toxicology by Astrid Sigel( Book )

15 editions published between 2010 and 2015 in English and Undetermined and held by 111 WorldCat member libraries worldwide

"Organometallic compounds contain per definition a metal-carbon bond. Therefore, the present Volume 7 is related to the preceding Volume 6, Metal-Carbon Bonds in Enzymes and Cofactors, which, as follows from its title, focused on living organisms. Now the focus is on the role that organometal(loid)s play in the environment and in toxicology; naturally, here again living systems are involved in the synthesis, transformation, remediation, detoxification, etc."--Preface
Metallothioneins and related chelators( Book )

14 editions published in 2009 in English and held by 100 WorldCat member libraries worldwide

Chapters 3 to 5 give an account of bacterial MTs, MTs in yeast and fungi, and MTs in plants. Most astonishingly, the MTs of bacteria and plants contain next to cysteine also histidine residues and thus, metal ions are not only sulfur- but also imidazole-coordinated which gives rise to zinc finger-like structures. Remarkably, yeast and fungal MTs are Cu(I) rather than Zn(II) or Cd(II) binding proteins. Next, Chapters 6 through 9 discuss the MTs of dipteran insects, including the model organism Drosophila melanogaster, earthworms and nematodes, as well as echinoderms, crustaceans, molluscs, and fish. Actually, aquatic animals, both vertebrates and invertebrates, have the potential to be used for monitoring metal contamination in aquatic ecosystems. Interestingly, in Chapter 9 the remarkable speculation is presented that under chronic natural exposure conditions the animals establish a trade-off between the "cost" of detoxifying non-essential metals and the "cost" of allowing some of these metals to spill over onto metal-sensitive sites. This contrasts with laboratory experiments involving aquatic animals, where the toxicity of non-essential metals normally exhibits a threshold response: at low exposure concentrations the organisms can detoxify the incoming metal and thus, tolerate the exposure, whereas at concentrations above the threshold, the detoxification mechanism is no longer able to protect the organism completely
Metal ions in toxicology : effects, interactions, interdependencies by Roland K. O Sigel( Book )

16 editions published between 2010 and 2015 in English and Undetermined and held by 85 WorldCat member libraries worldwide

It is an old wisdom that metals are indispensable for life. Indeed, severalof them, like sodium, potassium, and calcium, are easily discovered in livingmatter. However, the role of metals and their impact on life remainedlargely hidden until inorganic chemistry and coordination chemistryexperienced a pronounced revival in the 1950s. The experimental and theoreticaltools created in this period and their application to biochemicalproblems led to the development of the field or discipline now known asBioinorganic Chemistry, Inorganic Biochemistry, or more recently alsooften addressed as Biological Inorganic Chemistry.By 1970 Bioinorganic Chemistry was established and further promoted bythe book series Metal Ions in Biological Systems founded in 1973 (edited byH.S., who was soon joined by A.S.) and published by Marcel Dekker, Inc.,New York, for more than 30 years. After this company ceased to be a familyendeavor and its acquisition by another company, we decided, after havingedited 44 volumes of the MIBS series (the last two together with R.K.O.S.)to launch a new and broader minded series to cover today's needs in the LifeSciences. Therefore, the Sigels new series is entitledMetal Ions in Life Sciences.After publication of the first four volumes (2006-2008) with John Wiley &Sons, Ltd., Chichester, UK, we are happy to join forces now in this still newendeavor with the Royal Society of Chemistry, Cambridge, UK; a mostexperienced Publisher in the Sciences
Interplay between metal ions and nucleic acids by Astrid Sigel( Book )

14 editions published between 2011 and 2014 in English and Undetermined and held by 75 WorldCat member libraries worldwide

Structural and catalytic roles of metal ions in RNA( Book )

10 editions published between 2011 and 2015 in English and held by 66 WorldCat member libraries worldwide

The discovery of ribozymes triggered a huge interest in the chemistry and biology of RNAs. Much of the recently made progress focusing on metal ions is addressed in Volume 9. This book, written by 28 internationally recognized experts, provides a most up-to-date view and it is thus of special relevance for colleagues teaching courses in biological inorganic chemistry and for researchers dealing, e.g., with nucleic acids, gene expression, and enzymology, but also for those in analytical and bioinorganic chemistry or biophysics. Structural and Catalytic Roles of Metal Ions in RNA describes metal ion-binding motives, methods to detect and characterize metal ion binding sites, and the role of metal ions in folding and catalysis. It deals with diffuse metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial ribozymes. The ribosome, ribozymes and redox cofactors, as well as the binding of kinetically inert metal ions to RNA are also considered
Cadmium : from toxicity to essentiality by Astrid Sigel( Book )

10 editions published between 2012 and 2013 in English and held by 40 WorldCat member libraries worldwide

Cadmium: From Toxicity to Essentiality, MILS-11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted. The book terminates with a fascinating report on the use of Cd(II) in carbonic anhydrase of certain marine phytoplankton species.Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems
Interrelations between essential metal ions and human diseases by Astrid Sigel( Book )

8 editions published in 2013 in English and held by 34 WorldCat member libraries worldwide

MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems
Metal ions in biological systems( Book )

6 editions published in 1997 in English and held by 9 WorldCat member libraries worldwide

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Audience level: 0.60 (from 0.03 for Metal ions ... to 0.69 for Biomineral ...)

Calcium and its role in biologyCirculation of metals in the environment
English (233)

Circulation of metals in the environmentNeurodegenerative diseases and metal ionsManganese and its role in biological processesNickel and its surprising impact in natureThe ubiquitous roles of cytochrome P450 proteinsBiogeochemical cycles of elementsMetal-carbon bonds in enzymes and cofactorsBiomineralization : from nature to application