WorldCat Identities

Scott, David W. 1943-

Overview
Works: 11 works in 26 publications in 1 language and 548 library holdings
Genres: Conference papers and proceedings  Outlines and syllabi 
Roles: Author, Other, Editor
Classifications: QR188.4, 616.079
Publication Timeline
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Most widely held works by David W Scott
Immunological tolerance to self and non-self( Book )

8 editions published in 1982 in English and held by 329 WorldCat member libraries worldwide

Key facts in immunology by David W Scott( Book )

6 editions published in 1985 in English and Undetermined and held by 104 WorldCat member libraries worldwide

The nature of immunologic tolerance by David W Scott( Book )

4 editions published in 1994 in English and held by 103 WorldCat member libraries worldwide

Reproducibility of histologic prognostic parameters for mantle cell lymphoma: cytology, Ki67, p53 and SOX11 by Giorgio A Croci( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Rapid, real time pathology review for ECOG/ACRIN 1412: a novel and successful paradigm for future lymphoma clinical trials in the precision medicine era by Rebecca L King( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

High-dose Benda-EAM versus BEAM in patients with relapsed/refractory classical Hodgkin lymphoma undergoing autologous stem cell transplantation by Erica S Tsang( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis by Matt Teater( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Violence by David W Scott( Book )

1 edition published in 1991 in English and held by 1 WorldCat member library worldwide

Driving CARs to BARs : the road to engineered specific human T regulatory cells( Visual )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

(CIT): David W. Scott, Ph.D. is Vice Chair for Research in the Department of Medicine at the Uniformed Services School of Health Sciences, Bethesda, MD. An alumnus of Antioch College, he received his M.S. degree from the University of Chicago and Ph.D. from Yale University in 1969. Following a post-doctoral fellowship at Oxford University, he has held tenured faculty positions at Duke University, the University of Rochester, and the University of Maryland Medical School. He assumed his current position in September 2010. Dr. Scott has contributed to over 200 research papers on several subjects on immunologic tolerance, and its application in autoimmune diseases, hemophilia and gene therapy. He is the author of two textbooks, including The Nature of Immunologic Tolerance, and recipient of a number of awards, e.g. Distinguished Service Award from the American Association of Immunologists, a Boarhaave Professorship at Leiden University in Holland, and the 2009 Scientific Achievement Award from AAPS. Abstract: Clinical application of expanded T regulatory cells (Tregs) offers great promise for the treatment of undesirable immune responses. However, treatment with polyclonal Tregs, which are not specific for a single epitope, could potentially lead to global immunosuppression. We have engineered human T cells to express chimeric antigen receptors (CARs) using either T-cell receptors from MS or hemophilia patients or specific single chain Fv"s. Thus, we adapted the CAR approach utilized successfully for leukemia therapy (e.g. CD19 CAR CD8's) to create specific T regulatory cells recognizing myelin basic protein (for MS) or FVIII, in the case of hemophilia. Such cells can actively suppress effector T cell proliferation and cytokine formation, as well as antibody formation in vitro. Further development with B-cell targeting strategies have also been successful by expressing antigen domains in CD8 T cells that kill B cells specific for FVIII, for example. Application of these engineered T cells to modulate adverse antibody responses in hemophilia and pathogenic responses to CNS proteins will be presented, and the mechanisms further discussed
Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma by Sarah E Arthur( )

1 edition published in 2018 in English and held by 0 WorldCat member libraries worldwide

 
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Audience level: 0.63 (from 0.60 for Immunologi ... to 1.00 for Genome-wid ...)

Alternative Names
Scott, David W.

Languages
English (25)