Polano, Machiel K.
Overview
| Works: | 41 works in 111 publications in 7 languages and 708 library holdings |
|---|---|
| Genres: | Scientific atlases Atlases Conference papers and proceedings Academic theses |
| Roles: | Author, Editor |
| Classifications: | RL81, 616.5 |
Publication Timeline
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Most widely held works by
Machiel K Polano
Color atlas and synopsis of clinical dermatology : common and serious diseases by
Thomas B Fitzpatrick(
Book
)
11 editions published between 1983 and 1997 in English and held by 232 WorldCat member libraries worldwide
Full color dermatology atlas with full text and 595 illustrations allows users to review therapy, get advice, check out laboratory tests and see the skin signs of serious disorders. Allows cutting, pasting, and search customization
11 editions published between 1983 and 1997 in English and held by 232 WorldCat member libraries worldwide
Full color dermatology atlas with full text and 595 illustrations allows users to review therapy, get advice, check out laboratory tests and see the skin signs of serious disorders. Allows cutting, pasting, and search customization
Topical skin therapeutics by
Machiel K Polano(
Book
)
6 editions published in 1984 in English and held by 110 WorldCat member libraries worldwide
6 editions published in 1984 in English and held by 110 WorldCat member libraries worldwide
Skin therapeutics, prescription and preparation; materia medica dermatologica by
Machiel K Polano(
Book
)
14 editions published in 1952 in 4 languages and held by 99 WorldCat member libraries worldwide
14 editions published in 1952 in 4 languages and held by 99 WorldCat member libraries worldwide
Dermatologie clinique : atlas commenté en couleur by
Thomas B Fitzpatrick(
Book
)
5 editions published between 1986 and 1995 in French and held by 65 WorldCat member libraries worldwide
5 editions published between 1986 and 1995 in French and held by 65 WorldCat member libraries worldwide
Retinoids, advances in basic research and therapy : proceedings of the International Dermatology Symposion [i.e. Symposium]
(IDS), Berlin, October 13-15, 1980 by
C. E Orfanos(
)
1 edition published in 1981 in English and held by 48 WorldCat member libraries worldwide
With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels of both unchanged drug and main metabolite (corre sponding carboxylic acid) were observed up to 140 days after cessation of the therapy. An apparent half-life of elimination of 80-100 days can be calculated. The drug appears to be stored at some yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are excreted in the bile in high amounts (60-80% of dose). No drug appeared unchanged in the excreta after i. v. administration to rats. References 1. Bollag W (1971) Effects of vitamin A acid (NSC-122758) on transplantable and chemically-induced tumors. Cancer Chemother Rep 55:53-58 2
1 edition published in 1981 in English and held by 48 WorldCat member libraries worldwide
With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels of both unchanged drug and main metabolite (corre sponding carboxylic acid) were observed up to 140 days after cessation of the therapy. An apparent half-life of elimination of 80-100 days can be calculated. The drug appears to be stored at some yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are excreted in the bile in high amounts (60-80% of dose). No drug appeared unchanged in the excreta after i. v. administration to rats. References 1. Bollag W (1971) Effects of vitamin A acid (NSC-122758) on transplantable and chemically-induced tumors. Cancer Chemother Rep 55:53-58 2
Advances in topical corticosteriod therapy : proceedings of an international symposium held in Amsterdam, Sept. 18-19, 1975 by
Machiel K Polano(
Book
)
8 editions published between 1975 and 1976 in English and Japanese and held by 25 WorldCat member libraries worldwide
8 editions published between 1975 and 1976 in English and Japanese and held by 25 WorldCat member libraries worldwide
Dermatologie in beeld : 151 foto's uit het archief van de dermatologische kliniek van de Rijksuniversiteit Leiden by
Machiel K Polano(
Book
)
8 editions published between 1974 and 1992 in Dutch and held by 15 WorldCat member libraries worldwide
8 editions published between 1974 and 1992 in Dutch and held by 15 WorldCat member libraries worldwide
Atlas de dermatología clínica by
Thomas B Fitzpatrick(
Book
)
11 editions published between 1985 and 1991 in Spanish and Italian and held by 15 WorldCat member libraries worldwide
11 editions published between 1985 and 1991 in Spanish and Italian and held by 15 WorldCat member libraries worldwide
Het quotient cholesterol/ phosphorlipoid bij dermatosen by
Machiel K Polano(
Book
)
5 editions published in 1934 in Dutch and Undetermined and held by 14 WorldCat member libraries worldwide
5 editions published in 1934 in Dutch and Undetermined and held by 14 WorldCat member libraries worldwide
Dermatologische Arzneimittel : Verschreibung und Anfertigung : (Materia medica dermatologica) by
Machiel K Polano(
Book
)
4 editions published in 1956 in German and Undetermined and held by 11 WorldCat member libraries worldwide
4 editions published in 1956 in German and Undetermined and held by 11 WorldCat member libraries worldwide
Dermatologie en venereologie voor den medicus practicus by
Machiel K Polano(
Book
)
1 edition published in 1946 in Dutch and held by 8 WorldCat member libraries worldwide
1 edition published in 1946 in Dutch and held by 8 WorldCat member libraries worldwide
Dermatologie en venereologie voor den medicus practicus by
Machiel Eduard Polano(
Book
)
2 editions published in 1938 in Dutch and held by 7 WorldCat member libraries worldwide
2 editions published in 1938 in Dutch and held by 7 WorldCat member libraries worldwide
Huidziekten : een populaire verhandeling over hun oorzaken, behandeling en voorkoming by
Machiel K Polano(
Book
)
3 editions published between 1940 and 2020 in Dutch and held by 7 WorldCat member libraries worldwide
3 editions published between 1940 and 2020 in Dutch and held by 7 WorldCat member libraries worldwide
De wisselwerking tussen de dermatologie en andere wetenschappen by
Machiel K Polano(
Book
)
1 edition published in 1962 in Dutch and held by 6 WorldCat member libraries worldwide
1 edition published in 1962 in Dutch and held by 6 WorldCat member libraries worldwide
Huidverzorging & huidziekten by
Machiel K Polano(
Book
)
1 edition published in 1984 in Dutch and held by 4 WorldCat member libraries worldwide
1 edition published in 1984 in Dutch and held by 4 WorldCat member libraries worldwide
Petit guide dermatologique illustré by
Machiel K Polano(
Book
)
2 editions published between 1979 and 1980 in French and held by 4 WorldCat member libraries worldwide
2 editions published between 1979 and 1980 in French and held by 4 WorldCat member libraries worldwide
Dermatologie in beeld : 151 foto's uit het archief van de afdeling dermatologie, Academisch ziekenhuis Leiden(
Book
)
in Dutch and held by 3 WorldCat member libraries worldwide
in Dutch and held by 3 WorldCat member libraries worldwide
A pictorial guide to selected skin diseases by
Machiel K Polano(
Book
)
2 editions published in 1980 in English and held by 3 WorldCat member libraries worldwide
2 editions published in 1980 in English and held by 3 WorldCat member libraries worldwide
Retinoids advances in basic research and therapy ; proceedings(
Book
)
1 edition published in 1981 in English and held by 3 WorldCat member libraries worldwide
1 edition published in 1981 in English and held by 3 WorldCat member libraries worldwide
Dermatologie im Bild by
Machiel K Polano(
Book
)
2 editions published between 1979 and 1985 in German and held by 3 WorldCat member libraries worldwide
Haut / Krankheiten / Abbildung
2 editions published between 1979 and 1985 in German and held by 3 WorldCat member libraries worldwide
Haut / Krankheiten / Abbildung
more
fewer
Audience Level
| 0 |
 |
1 | ||
| Kids | General | Special | ||
Related Identities
- Suurmond, Dick
- Fitzpatrick, Thomas B. (Thomas Bernard) 1919-2003 Author
- August, P. J. Editor
- Schuppli, R.
- Grupper, Ch
- Orfanos, C. E. Author
- Braun-Falco, O.
- Farber, E. M.
- Hagenouw, J. R. B. Editor
- Richter, J. R. Author Editor
Associated Subjects
Acne Acne--Chemotherapy Adrenocortical hormones--Physiological effect Adrenocortical hormones--Therapeutic use Blood--Examination Cholesterol Cutaneous manifestations of general diseases Dermatologic agents Dermatology Dermatopharmacology Drugs Lipids Lupus erythematosus Materia medica Medicine Psoriasis Psoriasis--Chemotherapy Retinoids--Physiological effect Skin Skin--Diseases Skin--Diseases--Chemotherapy Skin--Diseases--Diagnosis Skin--Inflammation--Diagnosis Vitamin A Vitamin A--Physiological effect Vitamin A--Testing