WorldCat Identities

Pickard, John B.

Overview
Works: 9 works in 18 publications in 1 language and 336 library holdings
Genres: Biography  History  Pictorial works  Guidebooks 
Roles: Editor
Classifications: PS3281, 811.3
Publication Timeline
Key
Publications about  John B Pickard Publications about John B Pickard
Publications by  John B Pickard Publications by John B Pickard
Most widely held works by John B Pickard
Memorabilia of John Greenleaf Whittier ( Book )
4 editions published in 1968 in English and Undetermined and held by 250 WorldCat member libraries worldwide
Florida's Eden : an illustrated history of Alachua County by John B Pickard ( Book )
1 edition published in 1994 in English and held by 43 WorldCat member libraries worldwide
Historic Alachua County and old Gainesville : a tour guide to the past by John B Pickard ( Book )
4 editions published between 1990 and 2001 in English and held by 18 WorldCat member libraries worldwide
Celebrating Whittier : New England's Quaker poet and abolitionist : America's 1907 centennial by Pamela J Fenner ( Book )
4 editions published between 2007 and 2008 in English and held by 12 WorldCat member libraries worldwide
The Samuel Kipnis film collection ( Book )
1 edition published in 1982 in English and held by 6 WorldCat member libraries worldwide
Dudley Farm : a history of Florida farm life by John B Pickard ( Book )
1 edition published in 2003 in English and held by 4 WorldCat member libraries worldwide
Candidate gene studies in psychiatric illness by Helen Miranda Knight ( )
1 edition published in 2009 in English and held by 1 WorldCat member library worldwide
Schizophrenia, bipolar disorder and major depression are common, heritable neuropsychiatric conditions and yet the source of the inherited risk remains largely unknown. This thesis focuses on two complementary strategies for identifying and characterising the genetic component of these illnesses: homozygosity mapping in consanguineous pedigrees, and genetic and neurobiological investigations of candidate genes identified by the analysis of structural chromosomal abnormalities carried by patients with psychiatric diagnoses. In a family of a cousin marriage, five of six offspring presented with a rare combination of schizophrenia, sensori-neural hearing impairment and epilepsy. Two loci were located on chromosomes 22q13 and 2p24-25 where a series of markers were homozygous by descent (HBD). Five further HBD loci were identified in a second, related family where four of five offspring had hearing loss. However, there was no overlap of the HBD intervals in the two families, and sequencing coding regions of candidate genes failed to identify causative mutations. A second study investigated the candidate gene ABCA13 identified at a breakpoint region on chromosome 7 in a patient with schizophrenia who carried a complex chromosomal rearrangement. Re-sequencing exons encoding the highly conserved functional domains identified eight potentially pathogenic, rare coding variants. Case control association studies involving cohorts of schizophrenia, bipolar disorder and major depression revealed significant associations of these variants with all three clinical phenotypes, and follow-up in relatives displayed familial inheritance patterns. Disruption of ABCA13, expressed in human hippocampus and frontal cortex, implicates aberrant lipid biology as a pathological pathway in mental illness. A third study focused on GRIK4, a candidate gene previously reported disrupted in a patient with schizophrenia who carried a chromosome abnormality. A deletion in the 3'UTR of GRIK4, encoding the kainate receptor subunit KA1, was identified as a protective factor for bipolar disorder. Using post mortem human brain tissue from control subjects, KA1 protein expression patterns were characterized in the hippocampal formation, amygdala, frontal cortex and cerebellum. KA1 expression was found significantly increased in subjects with the protective allele, supporting the hypothesis that reduced glutamatergic neurotransmission is a risk factor in major psychiatric illnesses. Together, these novel discoveries define aspects of the genetic contribution to mental illness, implicate specific dysfunctional processes and suggest new directions for research in the quest to find rationally based treatments and preventative strategies for some of the most common and disabling psychiatric disorders
Transcriptional regulation of neurodevelopmental and metabolic pathways by the psychiatric illness candidate gene NPAS3 by Li Sha ( )
1 edition published in 2011 in English and held by 1 WorldCat member library worldwide
The basic helix-loop-helix PAS domain transcription factor gene NPAS3 is a risk factor for psychiatric disorders. A knockout mouse model also exhibits behavioural and adult neurogenesis deficits consistent with human illness. To define the location and mechanism of NPAS3 aetiopathology immunofluorescent and transcriptomic approaches were used. Npas3 was co-localised with Dcx, but not other neurogenesis markers, in the hippocampal subgranular zone - the site of adult neurogenesis. This implied that NPAS3 might be involved in maturing, rather than proliferating, neuronal precursor cells. Microarray analysis revealed that the transcriptional activities of NPAS3 and its truncated form (C-terminal deletion) in the HEK293 cell line are sensitive to circadian rhythm context. The most highly up-regulated NPAS3 target gene, VGF, encodes secretory peptides with established roles in neurogenesis, depression and schizophrenia. VGF was one of many NPAS3 target genes also shown to be regulated by the SOX family of transcription factors, suggesting an overlap in neurodevelopmental pathways. The transcriptional repression of multiple glycolytic genes indicated that NPAS3 has a second role in metabolic regulation. This finding was also confirmed by collaboration with a metabolomics research group at the University of Strathclyde. SOX11, a transcription factor known to play a role in neuronal and glial cell differentiation, was shown to be down-regulated by NPAS3. The set of genes targeted by SOX11 and their ontologies were deduced by a microarray analysis in a SOX11 overexpressing HEK293 cell line. Regulated genes include a previously established SOX11 target, known markers of neurogenesis as well as genes implicated in neuropsychiatric disorders. Multiple histone and zinc finger genes are regulated by SOX11, many of which were located in two clusters on chromosomes 6 and 19. The chromosome 6 cluster lies within a region of the genome showing the strongest genetic association with schizophrenia. SOX11 may alter localised expression competence and its targets induce a complex programme of chromatin remodelling and downstream gene expression changes to achieve the mature neuronal phenotype. This thesis details how transcription factors are involved in biological processes linked to psychiatric illness. The dual neurodevelopmental and metabolic aspects of NPAS3 activity described here increase our understanding of aspects of neurogenesis relevant to mental illness and may explain the innate and medication-induced susceptibility to diabetes reported in psychiatric patients
Austistic spectrum disorder in prehistory by Catriona Pickard ( )
1 edition published in 2011 in English and held by 1 WorldCat member library worldwide
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.70 (from 0.00 for Transcript ... to 1.00 for Austistic ...)
Alternative Names
Pickard, Ben
Pickard, Benedict L.
Languages
English (17)