WorldCat Identities

Czeisler, Charles A.

Overview
Works: 32 works in 53 publications in 2 languages and 347 library holdings
Genres: Television mini-series  Documentary television programs  Science television programs  Internet videos  Filmed dance  Conference papers and proceedings  Slides  Biography  Interviews 
Roles: Author, Other, Editor
Publication Timeline
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Most widely held works by Charles A Czeisler
Mathematical models of the circadian sleep-wake cycle( Book )

8 editions published between 1983 and 1984 in English and Polish and held by 224 WorldCat member libraries worldwide

This contract funded a Satellite Symposium on the Mathematical Modeling of Circadian Systems which was held on June 21, 1981 in conjunction with the Annual Meeting of the Association for the Psychophysiological Study of Sleep (APSS) from June 17-21, 1981, at Dunfey's Hyannis Hotel on Cape Cod, Massachusetts. The Satellite Symposium brought together the leading investigators concerned with modeling the circadian system to ensure that the various proposed models were critically reviewed and their strengths and weaknesses in predicting periodic biological phenomena were fully understood. The papers of each participant and an edited transcription of the discussion were published as a book entitled 'Mathematical Models of the Circadian Sleep-Wake Cycle' by Raven Press in 1984. The published volume serves as an important source of all those who are concerned about the temporal organization of human and animal behavior and physiology. (Author)
REM sleep : its temporal distribution( Book )

2 editions published in 1980 in English and held by 59 WorldCat member libraries worldwide

Application of sleep science and circadian biology to clinical medicine by Charles A Czeisler( Visual )

1 edition published in 2007 in English and held by 14 WorldCat member libraries worldwide

(CIT): Growing evidence indicates that chronic sleep loss aversely affects human health. Inadequate daily sleep, such as that experienced by shiftworkers and individuals with sleep disorders (i.e., insomnia or apnea) is associated with a higher risk of developing obesity, heart disease, and cancer. Furthermore, acute sleep loss profoundly impairs alertness, cognitive performance, and judgment, resulting in an increased risk of automobile- and work-related accidents. Defining the neural pathways and genetic basis of sleep-wake regulation is of critical importance for identifying individuals who are at risk of developing sleep and circadian disorders, as well for the development of countermeasures to treat the adverse consequences of sleep loss. In humans, the daily pattern of consolidated sleep and wake is determined by the interaction of two processes; the homeostatic buildup and dissipation of sleep pressure, and the circadian rhythm of sleep/wake propensity. The circadian period of sleep-wake behavior is genetically encoded by a transcriptional/translational negative feedback loop in neurons in the suprachiasmatic nucleus (SCN) in the anterior hypothalamus, which determines the timing of the sleep-wake cycle relative to the solar day and morning vs. evening preference. The SCN temporally coordinates daily changes in behavior, physiology, and gene expression by synchronizing autonomous circadian oscillators in peripheral tissues. Determining the pathways and mechanisms by which the SCN resets the phase of peripheral clocks will provide insight into how the circadian timing system establishes the timing of diverse physiologic functions. Tissues such as the heart, lung and liver show circadian expression of thousands of genes, many of which are tissue specific and non-overlapping. Characterizing the specific functional role of sleep- and circadian-regulated genes in multiple organ systems will be critical for understanding the temporal dynamics and function of these tissues, and represents a significant opportunity for application of these findings to most, if not all, clinical specialties
Human circadian physiology : internal organization of temperature sleep-wake and neuroendocrine rhythms monitored in an environment free of time cues by Charles A Czeisler( )

3 editions published between 1978 and 1979 in English and held by 7 WorldCat member libraries worldwide

Melatonin, sleep, and circadian rhythms : current progress and controversies( Book )

3 editions published in 1997 in English and held by 4 WorldCat member libraries worldwide

Sleep by Horst Günter Koch( Visual )

3 editions published between 1977 and 1990 in English and held by 3 WorldCat member libraries worldwide

Explores elements of sleep such as what it is, why we require it, the brain's activity while asleep, normal and abnormal sleep patterns, and the different levels and stages of sleep. Narcolepsy, cataplexy, sleepwalking and nightmares are discussed
REM sleeep: its temporal distribution( Book )

1 edition published in 1980 in English and held by 3 WorldCat member libraries worldwide

Proceedings of the Workshop on Biomathematical Models of Circadian Rhythmicity, Sleep Regulations, and Neurobehavioral Function in Humans by Sleep Regulations, and Neurobehavioral Function in Humans Workshop on Biomathematical Models of Circadian Rhythmicity( Book )

2 editions published between 1995 and 1999 in English and held by 3 WorldCat member libraries worldwide

AFOSR PRET: Homeostatic & Circadian Regulation of Wakefulness During Jet Lag and Sleep Deprivation: Effect of Wake-Promoting Countermeasures( Book )

2 editions published in 2005 in English and held by 2 WorldCat member libraries worldwide

The Center was part of the academic-industry Partners for Research Excellence and Transition (PRET) program of AFOSR. Its focus was on basic science discoveries of countermeasures that could be transitioned to Air Force to prevent cognitive and neurobehavioral performance impairments during transmeridian deployment, sustained operations and night operations. Basic clinical research undertaken in laboratories at the University of Pennsylvania School of Medicine and Brigham & Women's Hospita/Harvard Medical School, resulted in extensive new data on the performance- enhancing effects of the novel wake-promoting drug modafinil. The information acquired on modafinil were transitioned to and implemented by AF operations. These two laboratories also used study results and their mathematical modeling expertise to advance predictive modeling of human performance relative to sleep and circadian dynamics, including collaboration with AFRL and other laboratories engaged in computational modeling. The Center successfully achieved the PRET goal of transitioning basic science on development of wake-promoting drugs through creation and involvement of Hypnion Inc., a sleep-wake biotechnology company. As part of the Center, Hypnion conducted screening of a range of drugs for sleep-wake effects and conducted a forward genetics-based novel drug target discovery program
Clinical Trial of Exercise on Circadian Clock Resetting( Book )

2 editions published in 2001 in English and held by 2 WorldCat member libraries worldwide

Specific Aim 1: test the hypothesis that a 9-hr phase delay shift of the duty-rest schedule, such as that required for either transmeridian travel or night operations, will induce physiologic maladaptation in the endogenous circadian rhythms of core body temperature, plasma melatonin, reaction time, alertness and performance; Specific Aim 2: test the hypothesis that multiple nightly bouts of exercise will induce significant delays in the endogenous circadian rhythms of core body temperature, plasma melatonin, reaction time, alertness and performance relative to the control group, even in- the absence of properly timed exposure to photic cues; Specific Aim 3: test the hypothesis that exercise-induced phase delay shifts of will facilitate adaptation of these rhythms to an imposed duty-rest schedule, thereby improving sleep efficiency during daytime sleep and improve reaction time, alertness and performance during scheduled waketime at night relative to control group
Clinical Trial of the Effect of Exercise on Endogenous Circadian Period, Sleep and Performance( Book )

2 editions published in 1997 in English and held by 2 WorldCat member libraries worldwide

In summary, the addition of the research studies conducted in year three of the project solidifies the notion that regular bouts of aerobic exercise affect the physiology of the thermoregulatory system in a phase-dependent manner. Preliminary results from the reaction time data continue to be extremely promising. These data suggest that aerobic exercise may have the potential to enhance neurobehavioral performance, as reflected by simple visual reaction time, particularly at the nadir of the temperature cycle where neurobehavioral deficits are known to be the greatest
Clinical Trial of the Effect of Exercise on Resetting of the Endogenous Circadian Pacemaker( Book )

2 editions published in 2000 in English and held by 2 WorldCat member libraries worldwide

The objectives of the research effort have not changed; they remain as follows: Specific Aim 1: test the hypothesis that a 9-hr phase delay shift of the duty-rest schedule, such as that required for either transmeridian travel or night operations, will induce physiologic maladaptation in the endogenous circadian rhythms of core body temperature, plasma melatonin, reaction time, alertness and performance; Specific Aim 2: test the hypothesis that multiple nightly bouts of exercise will induce significant delays in the endogenous circadian rhythms of core body temperature, plasma - melatonin, reaction time, alertness and performance relative to the control group, even in the absence of properly timed exposure to photic cues; Specific Aim 3: test the hypothesis that exercise-induced phase delay shifts of will facilitate adaptation of these rhythms to an imposed duty-rest schedule, thereby improving sleep efficiency during daytime sleep and improve reaction time, alertness and performance during scheduled waketime at night relative to control group
Catastrophes, sleep, and public policy: consensus report by Merrill Morris Mitler( Book )

2 editions published in 1988 in English and held by 2 WorldCat member libraries worldwide

[Tom Bearden reports on the launch of the space shuttle Discovery] by Tom Bearden( Recording )

1 edition published in 1998 in English and held by 2 WorldCat member libraries worldwide

Tom Bearden reports on the launch of the space shuttle Discovery. Former astronaut Scott Carpenter wishes the crew good luck in a pre-recorded message. Crew-member John Glenn talks about how his age of 77 will be used as point of research on how aging is affected while in space. Dr. Charles Czeisler examines how normal human sleep cycles are disrupted in space. On "NewsHour."
Activity Monitoring Equipment( Book )

2 editions published in 2001 in English and held by 2 WorldCat member libraries worldwide

To evaluate the impact of sleep and waking alertness on the operational success of Air Force personnel, a system of individual monitoring is required. Monitoring is essential for evaluating the operational readiness of critical personnel, predicting individual differences in performance during sustained operations and jet-lag/shift work operations, and for use as a selection tool to identify individuals who may be better suited for particular missions. The current research was designed to implement the use of an unobtrusive ambulatory monitor (Actiwatch-L, Mini-Mitter Corporation, Bend, Oregon) to record ambient light level and wrist actigraphy of all subjects prior to the sleep deprivation jet-lag protocol; and to develop and conduct near-real-time analysis of these sleep and light exposure data. Data collected from these individuals will be analyzed using our most recent mathematical model that predicts waking alertness and neurobehavioral performance as well as circadian phase from activity (sleep-wake) and light history
Sleep and alertness in a 12-hour rotating shift work environment by Theodore L Baker( )

1 edition published in 1994 in English and held by 1 WorldCat member library worldwide

Circadian rhythmicity and its disorders by Charles A Czeisler( Visual )

1 edition published in 1986 in English and held by 1 WorldCat member library worldwide

Charlie Rose. a conversation with Mitt Romney ; a discussion on sleep( Visual )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

Judy Woodruff interviews Governor Mitt Romney of Massachusetts about his programs and plans. Paul Nurse discusses sleep disorders with two experts
Implementing a Sleep Health Education and Sleep Disorders Screening Program in Fire Departments( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract : Objective: The objective of this study is to compare three methods of administering a sleep health program (SHP) in fire departments. Methods: An SHP, comprising sleep health education and screening for common sleep disorders, was implemented in eight fire departments using three approaches: expert-led, train-the-trainer, and online. Participation rates, knowledge assessments, surveys, and focus group interviews were analyzed to assess the reach and effectiveness of the methodologies. Results: The Expert-led SHP had the highest participation rate, greatest improvement in knowledge scores, and prompted more firefighters to seek clinical sleep disorder evaluations (41%) than the other approaches (20 to 25%). Forty-two percent of focus group participants reported changing their sleep behaviors. Conclusion: All approaches yielded reasonable participation rates, but expert-led programs had the greatest reach and effectiveness in educating and screening firefighters for sleep disorders
Effects of extended work hours on intern health and safety( Book )

1 edition published in 2010 in English and held by 1 WorldCat member library worldwide

"The Challenge: The current work hour guidelines of the Accreditation Council for Graduate Medical Education (ACGME) recently limited work hours for U.S. medical residents to less than 320 hours in a four-week period, but still allow interns in the United States to work 30 consecutive hours every other shift. Although sleep deprivation, inherent in these schedules, has been shown to impair neurobehavioral performance and negatively affect health, these long work hours and extended duration work shifts remain a hallmark of medical education in the United States. Approach: In the nationwide Web-based survey, interns received e-mails directing them to complete a baseline survey at the beginning of their internship, monthly surveys throughout the year and a year-end survey. In order to validate reported work hours, a randomized subset of participants completed a daily diary, and we sought documentation for all reported motor vehicle crashes. In the smaller intervention study, subjects worked two rotations in the ICU: one using the traditional schedule (three interns working on a three-day cycle, with every other shift of extended duration) and one using the intervention rotation (four interns working a four-day schedule, with a maximal scheduled shift duration of 16 hours). Interns recorded work and sleep hours in a daily log and underwent continuous ambulatory polysomnographic monitoring. Attentional failures were identified by means of continuous electrooculography and direct observation by physicians was the principal means of detecting serious medical errors. Results: We found that the odds that interns will have a motor vehicle crash on the commute following an extended work shift were more than double the odds after a nonextended shift [OR=2.3 (1.6,3.3)]. Near-miss incidents were more than five times as likely to occur after an extended work shift as they were after a nonextended shift [OR=.5.9 (5.4,6.3)]. In a prospective analysis, every extended work shift that was scheduled in a month increased the monthly risk of any motor vehicle crash by 9.1% (3.4,14.7%). In the intervention study, interns worked 19.5 hours/week less (p<0.001), slept 5.8 hours/week more (p<0.001), and had less than half the rate of attentional failures while working during on-call nights (p=.0.02) on the intervention schedule as compared with the traditional schedule. Additionally, we found interns made 5.6 times as many serious diagnostic errors during the traditional schedule as during the intervention schedule (p<0.001). Impact: Extended-duration work shifts, currently sanctioned by the ACGME, pose safety hazards for interns. These results have important implications for medical residency programs, which routinely schedule physicians to work more than 24 consecutive hours. Eliminating interns' extended work shifts in an ICU significantly increased intern sleep, decreased attentional failures during night work hours, and reduced serious medical errors. Moreover, our data indicate that scheduling physicians to work such extended shifts poses a serious and preventable safety hazard for them and other motorists. Further modifications of ACGME standards, particularly with respect to shift duration, are clearly indicated to improve the safety of interns. Our findings in interns will likely have broader implications for all medical residents and others working long work weeks and shifts of extended duration. This research should be expanded to identify if these safety risks exist in the later years of medical residency and throughout medical practice."--NIOSHTIC-2
 
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Alternative Names
Charles Czeisler American sleep researcher

Czeisler, Charles

Languages
English (40)

Polish (1)