WorldCat Identities

Fondation IPSEN pour la recherche thérapeutique

Overview
Works: 147 works in 288 publications in 2 languages and 6,226 library holdings
Genres: Conference papers and proceedings 
Roles: isb, Editor, Organizer of meeting, Other, Collector, Publishing director
Classifications: RC523, 616.8047
Publication Timeline
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Most widely held works by Fondation IPSEN pour la recherche thérapeutique
Genotype-proteotype-phenotype relationships in neurodegenerative diseases by Fondation IPSEN( )

7 editions published in 2005 in English and held by 480 WorldCat member libraries worldwide

Neurodegenerative Disorders as Proteinopathies: Phenotypic Relationships.- Towards a Molecular Classification of Neurodegenerative Disease.- Racial and Ethnic Influences on the Expression of the Genotype in Neurodegenerative Diseases.- Causes and Consequences of Oxidative Stress in Neurodegenerative Diseases.- Early Onset Familial Alzheimer's Disease: Is a Mutation Predictive of Pathology?.- Identification of Genes that Modify the Age of Onset in a Large Familial Alzheimer's Disease Kindred.- Variable Phenotype of Alzheimer's Disease with Spastic Paraparesis.- Presenilin Mutations: Variations in the Behavioral Phenotype with an Emphasis on the Frontotemporal Dementia Phenoytpe.- Frontotemporal Dementias: Genotypes and Phenotypes.- Chromosome 17-Linked Frontotemporal Dementia with Ubiquitin-Positive, tau-Negative Inclusions.- Variations of the Phenotype in Frontotemporal Dementias.- Phenotype/Genotype Correlations in Parkinson's Disease.- Subject Index
Memories : molecules and circuits by B Bontempi( )

5 editions published in 2007 in English and held by 479 WorldCat member libraries worldwide

Provides an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. This book also discusses the state-of-the-art and future avenues, along with an overview of the underlying neurobiology of cognitive processes from a basic science standpoint
Hormonal control of cell cycle by Shlomo Melmed( )

10 editions published between 2007 and 2008 in English and held by 475 WorldCat member libraries worldwide

"The book contains the proceedings of a meeting organized by the Fondation Ipsen. The topics delivered by internationally renowned experts in the field, provide an in depth view of basic hormonal mechanisms subserving both normal and abnormal cell replicative controls. The impact of basic mechanisms is underscored for further understanding tumor pathogenesis and offering novel subcellular approaches to therapy for endocrine tumors, including those of the breast, prostate and pituitary. This book thus provides a strong link between pre-mammalian cell cycle genetics through mammalian cells, animal models and ultimately preclinical application by anchoring and expounding current knowledge of mechanisms for hormones to determine mitotic activity of the cell. This integration of endocrine and oncologic principles will serve as the highest standard for inter-disciplinary sharing of cutting edge information."--Jacket
Longevity and frailty by James R Carey( )

8 editions published in 2005 in English and held by 464 WorldCat member libraries worldwide

"Understanding the relationship between frailty and longevity becomes increasingly important as the world continues to age and life expectancy in most countries continues to increase. The articles contained in this book are the outcome of a colloquium sponsored by Fondation IPSEN in which interdisciplinary perspectives were brought to bear on conceptual, empirical and clinical aspects of this relationship. The result is a blend of papers on topics ranging from frailty concepts in animal models and early Homo sapiens, to documentation of progress in morbidity compression, on the relationships between frailty and impairments and inflammation, and perspectives on long-term health care needs in an aging world."--Jacket
Synaptic plasticity and the mechanism of Alzheimer's disease by Dennis J Selkoe( )

7 editions published in 2008 in English and held by 437 WorldCat member libraries worldwide

"Remarkable progress has been made in Alzheimer's research over the last decade. Our understanding of which molecular mechanisms are involved in the cascade of events characteristic of the disease is growing. However, the mechanisms by which they induce deleterious effect are still not clear. Many recent studies have confirmed that the synapse is a key target in the pathogenesis of Alzheimer's disease. Not only does synaptic loss occur at an early stage of the disease, but it seems that [Beta]-amyloid peptide deposits or microtubular disorders affect synaptic function. This may explain the memory deficits that are so characteristic of the disease. It is therefore logical to investigate therapeutic approaches targeting the deleterious mechanisms that affect the synapse. This area of research promises to be all the more productive because synaptic dysfunction is involved in various other neurodegenerative diseases or, more generally speaking, central nervous system disorders."--Jacket
Micro-, meso- and macro-dynamics of the brain by Yves Christen( )

1 edition published in 2016 in English and held by 407 WorldCat member libraries worldwide

How does the brain orchestrate perceptions, thoughts, and actions from the activity of its neurons? Addressing these challenging issues requires methods with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks as well as theories to advance understanding how different levels of brain dynamics interact. This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The topics cover the most fascinating facets of neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory and mental illness, brain controlled robots, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Overall, this volume offers an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease
A time for metabolism and hormones by Paolo Sassone-Corsi( )

2 editions published in 2016 in English and held by 398 WorldCat member libraries worldwide

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies
Genetic approaches in the prevention of mental disorders : proceedings of the joint meeting organized by the World Health Organization and the Foundation Ipsen in Paris, May 29-30, 1989 by V Bulyzhenkov( Book )

8 editions published in 1990 in English and held by 156 WorldCat member libraries worldwide

This review will be useful to those interested in the problems of medical genetics, mental disorders and their control. The book reviews the problems which exist in the field of genetics and psychiatry, including the role of gene defects, from the development of the disease to ethical issues in the application of genetic knowledge. It considers the possibilities offered by molecular genetic approaches to the prevention and control of mental disorders. The application of molecular genetic techniques has already led to the recognition of genes or chromosomal aberrations associated with selected mental disorders and this will continue in the future. Many DNA markers are known today, and some show a linkage with several of the more common mental illnesses, such as manic depression, schizophrenia, Alzheimer's disease
Ethical issues of molecular genetics in psychiatry by R. J Srám( Book )

5 editions published in 1991 in English and held by 153 WorldCat member libraries worldwide

Over the past few years, genetics research has been in a phase of remarkably sustained and continuous revolution. The advent of "new genetics" of recombinant DNA has resulted in new discoveries occurring at a breath­ taking pace, many of which have important clinical implications, for example, in new approaches to the diagnosis and treatment of hemoglobinopathies, cystic fibrosis and some forms of muscular dystrophies. Recent findings of psychiatric relevance have included the localization of the genes for Huntington's chorea and the use of DNA probes in predictive testing. Advances have been achieved in the understanding of the molecular biology of Alzheimer's disease, and at least some familiar forms of the condition appear to be linked to a gene of chromosome 21. Taking into account current achievements in molecular genetics as well as future findings, it can be predicted that the application of new genetic technologies is likely to lead to ethical problems in practical psychiatry. In order to initiate discussions aiming to generate ideas and develop the background for future consensus in the complex area of ethics relating to the application of molecular approaches in the study of psychiatric disorders, the World Health Organization, in collaboration with the IPSEN Foundation, organized in Brno, Czechoslovakia, June 11-12, 1990, an international conference to review knowledge related to molecular genetic studies in psychiatry, with particular reference to ethical problems
Growth factors and Alzheimer's disease by Franz Hefti( Book )

8 editions published in 1991 in English and German and held by 126 WorldCat member libraries worldwide

The study of the relationships between neurotrophic factors (NGF, FGF, amyloid) and neurodegenerative disorders (especially Alzheimer's disease) is of major importance not only for understanding the pathogenesis of the latter, but also for the pharmacological approach to this disease. Information on the subject stemming from the symposium in Strasbourg in April, 1990, organized by the Fondation IPSEN is presented in this book. It provides stimulating hypotheses about the possible role of growth factors in the generation of senile plaques, the process of degeneration and regeneration in Alzheimer's disease, the expression of the gene of NGF and the possible use of NGF in treatment
Immunology and Alzheimer's disease by A Pouplard-Barthelaix( Book )

4 editions published in 1988 in English and held by 115 WorldCat member libraries worldwide

Alzheimer's disease is one of the major scientific, medical and social challenges of our time. This book, the first in the new series Research and Perspectives in Alzheimer's Disease, presents a particularly up-to-date approach of immunological and biochemical aspects. It is written by the most outstanding scientists and contains recent data. The following are among the most interesting ideas contained in this book: - Alzheimer's disease is a cerebral form of amyloidosis. - some data are in accordance with an immunological hypothesis of this disease. - degeneration of microvessels - including amyloid angiopathy - could be very important in the changes in the brain with Alzheimer's disease. - the molecular study of A4 protein and its precursor is important for the understanding of the disease. This synthesis by prominent scientists provides a stimulating hypothesis about the determinism of the disease
Neurobiology of human values by Jean-Pierre Changeux( Book )

3 editions published in 2005 in English and held by 109 WorldCat member libraries worldwide

Man has been pondering for centuries over the basis of his own ethical and aesthetic values. Until recent times, such issues were primarily fed by the thinking of philosophers, moralists and theologists, or by the findings of historians or sociologists relating to universality or variations in these values within various populations. Science has avoided this field of investigation within the confines of philosophy. Beyond the temptation to stay away from the field of knowledge science may also have felt itself unconcerned by the study of human values for a simple heuristic reason, namely the lack of tools allowing objective study. For the same reason, researchers tended to avoid the study of feelings or consciousness until, over the past two decades, this became a focus of interest for many neuroscientists. It is apparent that many questions linked to research in the field of neuroscience are now arising. The hope is that this book will help to formulate them more clearly rather than skirting them. The authors do not wish to launch a new moral philosophy, but simply to gather objective knowledge for reflection
Biological markers of Alzheimer's disease by François Boller( Book )

4 editions published in 1989 in English and held by 107 WorldCat member libraries worldwide

This volume presents the proceedings of the symposium held in Toulouse on April 24, 1989, on the topic "Biological Markers of Alzheimer's Disease. " This sym­ posium was the fourth of a continuing and successful series of Colloques Medecine et Recherche organized by the Fondation IPSEN pour la Recherche Therapeutique, addressing various aspects of contemporary research in the field of Alzheimer's disease (AD). The series started in September 1987 with "Im­ munology and Alzheimer's Disease," followed 6 months later in Paris by "Gene­ tics and Alzheimer's Disease" and in September 1988 in Montpellier by "Neuronal Grafting and Alzheimer's Disease. " The present symposium was organized for the purpose of gathering the most current ideas concerning biological markers of AD. The papers presented at this symposium may be roughly subdivided into three groups. The first deals with the markers of AD at the level of the brain itself. These markers are studied either through the cerebrospinal fluid or through techniques such as nuclear magnetic resonance (NMR) - approaches which respectively aim at demonstrating the cerebral changes indicated by the debris resulting from the disease, or studying the possible neurochemical abnormalities that occur in the earlier stages of AD
Normal and abnormal development of the cortex( Book )

1 edition published in 1997 in English and held by 104 WorldCat member libraries worldwide

This is an examination of the normal and abnormal development of cortex. Issues covered include the nature and nurture of cortical development, mechanisms of neuronal migration, intra- and extra-cellular control of neuronal migration and genetic insights into cerebral cortical development
Imaging, cerebral topography, and Alzheimer's disease by Stanley I Rapoport( Book )

6 editions published in 1990 in English and German and held by 104 WorldCat member libraries worldwide

This volume contains the proceedings of the symposium organized by the Fondation IPSEN in Lille on October 16, 1989. It includes new data on imaging techniques (computed tomography, photon emission computed tomography, nuclear magnetic resonance), neuropathology, neurochemistry, and molecular biology. It provides a consistent interpretation of Alzheimer`s disease with respect to cerebral topography and its implications
Stem cells in the nervous system : functional and clinical implications by F Gage( Book )

1 edition published in 2004 in English and held by 102 WorldCat member libraries worldwide

After 40 years of research, scientists have confirmed that persistent neurogenesis occurs in the adult mammalian brain. The obvious next question is: "Are the newly generated neurons functional?" If so, "What are the functions of these new neurons?" This volume intends to clarify both questions by providing the latest data available
Neuronal grafting and Alzheimer's disease by F Gage( Book )

4 editions published in 1989 in English and German and held by 101 WorldCat member libraries worldwide

Alzheimer's disease is one of the major scientific, medical and social challenges of our time. This book (the third volume of proceedings of the Colloques Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique) is dedicated to neuronal grafting and Alzheimer's disease. The wealth of basic information presented testifies to the progress that has been achieved in intracerebral grafting and to the utility of intracerebral grafting as a tool for the understanding of brain development, adult neuronal plasticity and age-related pathology. An answer to the question, whether neuronal grafting will be useful as a therapy for Alzheimer's disease, must wait for a better understanding of the disease and the identification of animal models that can be used to test potential therapies. Meanwhile, the tool of intracerebral grafting may, in the future, be used to address the pathophysiology of Alzheimer's disease
Free radicals in the brain : aging, neurological, and mental disorders by Lester Packer( Book )

4 editions published in 1992 in English and held by 99 WorldCat member libraries worldwide

There is an increasing body of literature suggesting that at some stage during the development of most human diseases free radicals may be involved, and therefore retarded by antioxidants. Although in some cases this evidenceis only circumstantial, it is becoming overwhelming. In particular, certain brain disorders and aging itself appear to involve free radicals and free radical reactions in generating damage associated with chronic degenerative disorders. With respect to the brain, examples are epilepsy, Alzheimer's disease, Parkinson's disease, tardive dyskinesia, aging of the brain, and others. Thus, the idea that antioxidant intervention may help to prevent or retard brain disorders is an area of increasing interest. As a result, this book should find wide interest in the biomedical field and is of particular importance for the neurosciences
Genes and resistance to disease by V Boulyjenkov( Book )

2 editions published in 2000 in English and held by 96 WorldCat member libraries worldwide

The advances in human genetics that have ocurred during the past 20 years have revolutionized our knowledge of the role played by inheritance in health and disase. It is clear that our DNA determines not only the emergence of catastrophic single-gene disorders, which affect millions of persons worldwide, but also interacts with environments to predispose individuals to cancer, allergy, hypertension, heart disease, diabetes, psychiatric disorders and even to some infectious diseases. Overall, the study of longevity and the demonstration of genes favouring a long lifespan suggest that such protective systems exist. In recent years, the study of genetic polymorphisms has made clear that some alleles have beneficial effects. These discoveries can substantially improve our understanding of the interactions between genetics and the environment, between pathogenetic mechanisms and new treatments
Neuronal plasticity : building a bridge from the laboratory of the clinic by Jordan Grafman( Book )

2 editions published in 1999 in English and held by 94 WorldCat member libraries worldwide

Neuronal Plasticity: Building a bridge from the laboratory to the clinic arrives at an opportune time in the history of the neurological sciences. Over the last twenty years there has been an explosive growth in our understanding of the molecular, cellular, and anatomical changes that occur in the days and weeks following brain injury. It is now clear that training and exposure to certain environments can modify and shape neuronal plasticity in lower animals and humans. In humans, in particular, there are new ways of charting neuronal plasticity at the ensemble or regional level using functional neuroimaging techniques such as positron emission tomography and functional magnetic resonance imaging. Transcranial magnetic stimulation is a technique that can be used to both chart and facilitate/inhibit neuronal plasticity and has been used with much recent success. The design of neuroplasticity experiments and the methods used to interpret findings have also become more sophisticated. Thus, the time seems right for transporting the laboratory results to the clinic so that experimental findings can be tested in the "field". In general, there has been a rather slow absorption of the experimental findings in rehabilitation medicine. This volume provides some impetus to moving the field of cognitive neuroscience a little further among in its efforts to improve the lives of patients who have suffered a debilitating brain injury
 
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Genotype-proteotype-phenotype relationships in neurodegenerative diseases
Covers
Memories : molecules and circuitsHormonal control of cell cycleLongevity and frailtySynaptic plasticity and the mechanism of Alzheimer's diseaseNeurobiology of human valuesNormal and abnormal development of the cortexStem cells in the nervous system : functional and clinical implicationsGenes and resistance to diseaseNeuronal plasticity : building a bridge from the laboratory of the clinic
Alternative Names
Fondation I.P.S.E.N. pour la recherche thérapeutique

Fondation IPSEN

Fondation Ipsen other organization in Paris, France

Foundation for the Therapeutic Research

I.P.S.E.N. Foundation for the Therapeutic Research

Institut de produits de synthèse et d'extraction naturelle (Paris, France). Fondation IPSEN pour la recherche thérapeutique

Institut de produits de synthèse et d'extraction naturelle (Paris, France). IPSEN Foundation for the Therapeutic Research

IPSEN Foundation

IPSEN Foundation for the Therapeutic Research

IPSEN Foundation for Therapeutic Research

IPSEN (Institute) Fondation IPSEN pour la recherche thérapeutique

IPSEN (Institute) IPSEN Foundation for the Therapeutic Research

Languages
English (88)

German (4)