WorldCat Identities

Honn, Kenneth V.

Overview
Works: 52 works in 198 publications in 2 languages and 2,907 library holdings
Genres: Conference papers and proceedings 
Roles: Editor, Author, Other, Contributor, htt, Publishing director
Classifications: QP752.E53, 616.994071
Publication Timeline
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Most widely held works by Kenneth V Honn
Prostate cancer : new horizons in research and treatment by Michael L Cher( )

21 editions published between 2002 and 2003 in English and held by 709 WorldCat member libraries worldwide

In recent years the pace of research in prostate cancer has increased dramatically. Creative ideas in combination with new and emerging technologies have led to an explosion of discovery. These types of advances in prostate cancer research presage an era of new treatment strategies based on an understanding of the cellular and molecular mechanisms of disease. In creating this book, we aimed to cover a broad "bench to bedside" research spectrum ranging from: genetic, molecular and cellular analyses to epidemiological studies, refinements in local treatment strategies and new biologically based non-hormonal treatments for systemic disease. Researchers and clinicians will find in this book a group of timely and clinically relevant chapters on prostate cancer research and treatment
Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury 2 by S. K Nigam( Book )

21 editions published between 1992 and 1998 in English and held by 345 WorldCat member libraries worldwide

In recent decades eicosanoids have been attracting an increasing amount of attention as a result of their important physiological roles in many areas of biology and medicine. The eicosanoids comprise the prostaglandins, thromboxanes and leukotrienes and are products of arachidonic acid, an essential polyunsaturated fatty acid stored in tissue phospholipids. Disturbances of eicosanoids and their metabolic products play a regulatory role in many types of cell injuries and diseases. One of the most exciting areas of eicosanoid research pinpoints their participation in the control of cell proliferation and differentiation. Eicosanoids form a link between different fields of research into such areas as cancer, inflammation and radiation-induced injury. This link provided the impetus for the development of the conference series of which the present volume represents the proceedings of the Second International Conference, held in Berlin in October 1991
Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury 4 by Kenneth V Honn( Book )

14 editions published between 1999 and 2013 in English and held by 274 WorldCat member libraries worldwide

Since their discovery over sixty years ago, eicosanoids have come to represent a diverse family of bioactive lipid modulators, including prostaglandins, thromboxanes, leukotrienes, lipoxins, isoprostanes, hepoxilins, hydroxy acids, epoxy and hydroxy fatty acids. This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. In addition, recent evidence over the last seven years has led to the identification of a number of receptors for these bioactive lipids. The new field of isoprostanes is also represented. It has become increasingly evident that eicosanoids play a critical role in signal transduction, both in normal cells and in pathological processes. These aspects are discussed in relation to cellular events, such as apoptosis, angiogenesis, and cancer prevention and treatment
The oncobiology of the prostate by David P Wood( )

11 editions published between 1999 and 2005 in English and held by 259 WorldCat member libraries worldwide

Prostate cancer (PCa) is the most common newly diagnosed cancer among men in the United States today. With the advent of the prostate-specific antigen (PSA) test, the number of newly diagnosed cases has increased tremendously. The rates of PCa have increased so dramatically over the last decade that the age-adjusted incidence rate of PCa is no greater than that for any other cancer among men in the United States. Although PCa rates have risen steadily since 1973, there has been a dramatic acceleration in the late 1980s which has been associated with the introduction and use of PSA for screening and early detection. There is now some evidence that the rates may be levelling off and even decreasing in some areas. After lung cancer, PCa is the leading cause of death due to cancer in men in the United States. Although PCa can occur in younger men, it is essentially a cancer of elderly men. The highest rates of PCa in the world occur among African-American men in the United States. African-Americans have higher rates than Caucasians at all age levels in the United States, and adjusting for social-economic status does not appear to account for this difference to any appreciable extent. There is no clear reason why PCa rates are so much greater among African-Americans compared with Caucasians in the United States. The reported rates in Africans are substantially lower than those of an African-American, suggesting that environmental factors have an influence on PCa. In spite of this substantial impact on our society. PCa remains a relatively understudied disease, with an essentially unknown etiology. The reviews contained in this book are by no means exhaustive. We have, however, attempted to provide information regarding the pathology of prostate cancer, the status of diagnostic and prognostic markers, as well as a discussion of our understanding of the molecular basis for the disease. The biology of prostate cancer is covered with a discussion on the role of apoptosis in prostate cancer and the suggestion of it being the target for new therapeutic development, as well as the role played by integrins and angiogenesis. The status of current therapies, both hormonal and chemotherapy, are also discussed. This volume should provide a useful background for individuals wishing to commence an in-depth understanding of prostate cancer
Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury, 5 by Kenneth V Honn( Book )

15 editions published between 2002 and 2003 in English and held by 256 WorldCat member libraries worldwide

Text presents a collection of contributions from the 6th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases held in Boston, September 12-15, 1999. For researchers
The role of bioactive lipids in cancer, inflammation and related diseases( )

9 editions published in 2019 in English and held by 220 WorldCat member libraries worldwide

This book examines the role of bioactive lipids as pro- and anti-inflammatory mediators in the diagnosis of and as novel therapies for cardiovascular disease, cancer, ocular and neurologic diseases, and inflammatory conditions. The major pathways of arachidonic acid and omega-3 fatty acid metabolism are represented, including cyclooxygenases, lipoxygenases, cytochrome P450 monooxygenases, specialized pro-resolving mediators, endocannabinoids, and ceramide and other sphingolipids. This book would be of great interest to basic and translational researchers, as well as physician-scientists working on selected topics (e.g., cancer, cardiovascular disease, stroke, diabetes, inflammation, etc.) in which the underlying role of lipid mediators in the pathophysiology is known or suspected. This compilation of peer-reviewed manuscripts represents reviews of timely topics presented at the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases. Authors selected are outstanding junior investigators representative of future leaders in the field of bioactive lipids
Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury 3 by Kenneth V Honn( Book )

12 editions published between 1996 and 2013 in English and held by 210 WorldCat member libraries worldwide

The 85 symposium speakers and poster contributions report recent research on the group of prostaglandin-like substances, especially in light of the discovery of the structure of genes that encode several key enzymes and receptors of the Eicosanoid cascade. They cover lipoxygenase, prostaglandin endoperoxide synthase, phospholipidases, the alteration of gene expression, receptors, inflammation, signal transduction, anandamide, plate-activating factor, and cell growth and apoptosis. Clinical studies include reports on activity during human spaceflight and curing murine AIDS by low-dosage, total-body irradiation. Among the poster papers are treatments of fatty acids hydroxamic derivatives as inhibitors of 5-lipoxygenase, mechanisms of cyclooxygenase-2 inhibition by indanone derivatives, and a novel method for prostaglandin endoperoxide H synthase activity in individual intact cells
Mechanisms of cancer metastasis : potential therapeutic implications by Kenneth V Honn( Book )

14 editions published between 1985 and 1987 in English and held by 192 WorldCat member libraries worldwide

The past twenty years have witnessed significant advances in the treatment of cancer by surgery and radiation therapy. Gains with cytotoxic chemotherapy have been much more modest. Of the approximately 900,000 newly diagnosed cases of cancer each year, 50010 result in death of the patient. The primary cause of these deaths is metastasis. Although the term metastasis was first coined by Recamier in 1829, only in the past ten years have there been intensive scientific investigations into the mechanisms by which tumor cells metastasize. What has emerged is a complex process of host-tumor cell interactions which has been termed the metastatic cascade. Due to the complexity of the metastatic process, the study of metastasis is multifaceted and involves elements of such areas as differentiation, en zymology, genetics, hematology, immunology, membrane biochemistry and molecular biology. The major objectives of this book were to present the most recent advances in our understanding of how tumor cells metastasize to secondary sites by the leading experts in the biology of tumor invasion and metastasis. We hope that this book will lead to new concepts for the treatment of subclinical metastatic cancer. The chapters in this book address both the basic science of metastasis and potential clinical therapies directed toward interruption of the metastatic cascade or toward eradication of subclinical metastases. Many relevant topics have been omitted due to space considerations and thus the topics included reflect the prej udices of the editors
Hemostatic mechanisms and metastasis by Kenneth V Honn( Book )

8 editions published in 1984 in English and held by 183 WorldCat member libraries worldwide

Eicosanoids and other bioactive lipids in cancer and radiation injury : proceedings of the 1st international conference, October 11-14, 1989, Detroit, Michigan, USA by Kenneth V Honn( Book )

11 editions published in 1991 in English and German and held by 148 WorldCat member libraries worldwide

This volume contains the proceedings of the First International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury held in Detroit, Michigan on October 11-14, 1989. The program consisted of 83 oral and 29 poster presentations, 74 of which are included in these proceedings. The major sponsors of the conference were the Armed Forces Radiobiology Research Institute, located in Bethesda, Maryland, the Radiation Oncology Research and Development Center of the Gershenson Radiation Oncology Center, Harper Hospital in Detroit, Michigan, and Schering AG of West Germany. Eighteen other organizations provided additional support. The conference was unique in its attempt to link the eicosanoid and lipid researchers in the radiobiology and cancer disciplines. The diverse roles that eicosanoids and other bioactive lipids play in these biological phenomena including the participation of lipid oxidation in conversion of procarcinogens, positive and negative modulation of tumor growth, immunomodulation, tissue injury, and yet protection and enhancement of cancer therapy, necessitated scientific interaction to sort out and understand these complex and sometimes contradictory observations. The success of this effort is reflected not only through these proceedings, but also through the decision to continue the conference series with a second meeting to be held in Berlin between September 17-21, 1991
Thromboxane Synthase and Prostate Cancer Progression( Book )

8 editions published between 2002 and 2005 in English and held by 8 WorldCat member libraries worldwide

The initiation and progression of prostate cancer remain not well understood to enable development of interventional therapy. Thromboxane synthase is an enzyme downstream of cyclooxygenase, utilizing prostaglandin H to form thromboxane A(sub 2). Using immunohistochemistry analysis, we found that 25% of clinical prostate tumor specimens had strong expression of thromboxane synthase; 33% of cases had medium expression and 42% of cases had weak expression of thromboxane synthase. Prostate cancer cells isolated from lymph node metastasis had higher levels of thromboxane synthase expression and activity than those isolated from the primary tumor sites in an animal model. We cloned and sequenced full-length thromboxane synthase cDNA from PC-3 cells and constructed an expression vector. Increased expression of thromboxane synthase in DU145 cells was found to stimulate cell migration. Inhibition of thromboxane synthase or blockade of thromboxane A(SUB 2) function inhibited prostate cancer cell migration. Further we found that PCa cells express receptors for TXA2 and stimulation with TXA2 mimetic led to the activation of RhoA and cell retraction. Our study suggest that thomboxane synthase and its eicosanoid product play a contributory role in prostate cancer progression
Biochemistry of arachidonic acid metabolism by William E. M Lands( Book )

1 edition published in 1985 in English and held by 8 WorldCat member libraries worldwide

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E, (POE,), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids
Carcinogenesis and Dietary Fat by Kenneth V Honn( Book )

1 edition published in 1989 in English and held by 7 WorldCat member libraries worldwide

Eicosanoids and Radiation by Kenneth V Honn( Book )

1 edition published in 1988 in English and held by 7 WorldCat member libraries worldwide

Bioactive Lipids: Role in Prostate Cancer Angiogenesis( Book )

6 editions published between 1999 and 2003 in English and held by 6 WorldCat member libraries worldwide

The hypothesis to be tested was that an increase in 12-lipoxygenase activity in prostate cancer cells would increase their angiogenic potential, either directly through the direct metabolite 12(S)-HETE or indirectly, through stimulation of angiogenic factors. The preliminary data regarding increased vascularization by 12-LOX transfectant PC-3 cells was confirmed in two additional PC-3 transfectants. In addition, we were able to demonstrate that 12(S)-HETE does stimulate endothelial cell migration. This stimulated migration occurred through activation of MAP kinase. We also determined that 12-LOX transfected cells secreted increased amounts of VEGF but not hFGF or IL8. Further studies demonstrated that 12(S)-HETE activated the VEGF promoter activity and we also confirmed increased VECF mRNA in 12-LOX transfectants by Northern blot. The role of increased VEGF production in 12-LOX transfectants was confirmed using a neutralizing antibody. The first four technical objectives have been met and work continues on technical objective five and six
Arachidonic acid metabolism and tumor promotion by Susan M Fischer( Book )

1 edition published in 1985 in English and held by 6 WorldCat member libraries worldwide

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respec arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids
Eicosanoid Regulation of Prostate Cancer Progression: Disruption of Hemidesmosomes and Collaboration in Tumor Invasive Growth( Book )

6 editions published between 2004 and 2006 in English and held by 6 WorldCat member libraries worldwide

A significant achievement in the current reporting period is our ability to immunostain both the 12-LOX protein and Beta4 integrin in paraffin- embedded prostate tumor tissues circumventing the problems described in the previous report. With the new protocol we have stained about 20 cases so far and the remaining cases are in progress. We have generated several stable transfectants of PC-3 cells expressing mutant forms of the Beta4 integrin and studied their interaction with 12-LOX. During this study we have identified that the peptide spanning between amino acids 1126 and 1315 of the cytoplasmic tail of the Beta4 integrin shows strong interaction with 12-LOX. An important observation is that the full-length cytoplasmic tail of Beta4 integrin when expressed ectopically disrupts the interaction with 12-LOX with Beta4 integrin in a dominant negative manner. This interaction also resulted in a decrease in the biosynthesis of the enzymatic product 12-HETE as well as reduction in the tumor growth rate from subcutaneously injected PC-3 cells in athymic nu/nu mice
Arachidonic acid metabolism and tumor initiation by Lawrence J Marnett( Book )

1 edition published in 1985 in English and held by 6 WorldCat member libraries worldwide

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengl Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids
Prostaglandins and immunity by James S Goodwin( Book )

1 edition published in 1985 in English and held by 5 WorldCat member libraries worldwide

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (PGE2), prostacyclin (PGI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di-and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids
Bioactive lipids in cancer progression and metastasis( Book )

1 edition published in 1994 in English and held by 3 WorldCat member libraries worldwide

 
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WorldCat IdentitiesRelated Identities
Covers
Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury 2Eicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury 4The oncobiology of the prostateEicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury, 5The role of bioactive lipids in cancer, inflammation and related diseasesEicosanoids and other bioactive lipids in cancer, inflammation, and radiation injury 3Mechanisms of cancer metastasis : potential therapeutic implicationsHemostatic mechanisms and metastasisEicosanoids and other bioactive lipids in cancer and radiation injury : proceedings of the 1st international conference, October 11-14, 1989, Detroit, Michigan, USA
Alternative Names
Honn, K. V.

Honn, K. V. (Kenneth V.)

Languages
English (161)

German (2)