WorldCat Identities

睿桓

Overview
Works: 6 works in 9 publications in 2 languages and 15 library holdings
Classifications: JQ1508, 320.53230951
Publication Timeline
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Most widely held works by 睿桓
Zheng zhi ti zhi gai ge jiang hua( Book )

2 editions published in 1987 in Chinese and held by 6 WorldCat member libraries worldwide

Ben shu nei rong bao kuo:zheng zhi ti zhi gai ge shi wo guo she hui zhu yi zhi du de zi wo wan shan he fa zhan;Zheng zhi ti zhi gai ge qu de chu bu cheng xiao;Jing jian ji gou, Zeng qiang huo li, Ti gao xiao lü deng 6 zhang
Bu lun da xiao jie yi zong by Kelisibin( Book )

2 editions published in 1987 in Chinese and held by 3 WorldCat member libraries worldwide

Hai nei cun zhi ji : Zhong wai ming ren you shu jian shang by Yin Lü( Book )

1 edition published in 1999 in Chinese and held by 3 WorldCat member libraries worldwide

Guang dong sheng gun jing zhou by Kun Rong( Book )

2 editions published in 1999 in Chinese and held by 2 WorldCat member libraries worldwide

Conformational Transitions and Alternating-Access Mechanism in the Sarcoplasmic Reticulum Calcium Pump( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract: Ion pumps are integral membrane proteins responsible for transporting ions against concentration gradients across biological membranes. Sarco/endoplasmic reticulum Ca 2 + -ATPase (SERCA), a member of the P-type ATPases family, transports two calcium ions per hydrolyzed ATP molecule via an "alternating-access" mechanism. High-resolution crystallographic structures provide invaluable insight on the structural mechanism of the ion pumping process. However, to understand the molecular details of how ATP hydrolysis is coupled to calcium transport, it is necessary to gain knowledge about the conformational transition pathways connecting the crystallographically resolved conformations. Large-scale transitions in SERCA occur at time-scales beyond the current reach of unbiased molecular dynamics simulations. Here, we overcome this challenge by employing the string method, which represents a transition pathway as a chainofstates linking two conformational endpoints. Using a multiscale methodology, we have determined all-atom transition pathways for three main conformational transitions responsible for the alternating-access mechanism. The present pathways provide a clear chronology and ordering of the key events underlying the active transport of calcium ions by SERCA. Important conclusions are that the conformational transition that leads to occlusion with bound ATP and calcium is highly concerted and cooperative, the phosphorylation of Asp351 causes areorganization of the cytoplasmic domains that subsequently drives the opening of the luminal gate, and thereclosing of luminal gate induces a shift in the cytoplasmic domains that subsequently enables the dephosphorylation of Asp351-P. Formation of transient residue–residue contacts along the conformational transitions predicted by the computations provide an experimental route to test the general validity of the computational pathways. Graphical Abstract: Highlights: All-atom computational pathways of three main conformational transitions in SERCA Phosphoryl transfer reaction cannot take place without the binding of two calcium ions. The transition responsible for binding and occlusion of calcium ions is cooperative. Luminal opening is driven by the cytoplasmic domains and is a two-step process. Closing of the luminal gate drives dephosphorylation in the catalytic site. The results elucidate the coupling between ATPhydrolysis and calcium transport
Guang Dong sheng gun liang zhou by Kun Rong( Book )

1 edition published in 1999 in Chinese and held by 0 WorldCat member libraries worldwide

 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.87 (from 0.80 for Hai nei cu ... to 1.00 for Guang Dong ...)

Alternative Names
Jui, Huan

睿桓

瑞桓

Languages