WorldCat Identities

Selkoe, Dennis J.

Overview
Works: 39 works in 103 publications in 2 languages and 1,371 library holdings
Genres: Conference papers and proceedings 
Roles: Author, Editor, Other, Contributor, htt
Publication Timeline
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Most widely held works about Dennis J Selkoe
 
Most widely held works by Dennis J Selkoe
Synaptic plasticity and the mechanism of Alzheimer's disease by Dennis J Selkoe( )

25 editions published in 2008 in English and held by 483 WorldCat member libraries worldwide

"Remarkable progress has been made in Alzheimer's research over the last decade. Our understanding of which molecular mechanisms are involved in the cascade of events characteristic of the disease is growing. However, the mechanisms by which they induce deleterious effect are still not clear. Many recent studies have confirmed that the synapse is a key target in the pathogenesis of Alzheimer's disease. Not only does synaptic loss occur at an early stage of the disease, but it seems that [Beta]-amyloid peptide deposits or microtubular disorders affect synaptic function. This may explain the memory deficits that are so characteristic of the disease. It is therefore logical to investigate therapeutic approaches targeting the deleterious mechanisms that affect the synapse. This area of research promises to be all the more productive because synaptic dysfunction is involved in various other neurodegenerative diseases or, more generally speaking, central nervous system disorders."--Jacket
Immunization against Alzheimer's disease and other neurodegenerative disorders by Dennis J Selkoe( )

10 editions published in 2003 in English and German and held by 183 WorldCat member libraries worldwide

"The promising effects of [beta]-amyloid immunization in mice, reported in a recent study, stimulated substantial research and raised high hopes in the field. In retrospect, this study seems both logical, being consistent with the amyloid theory central to the study of Alzheimer's disease today, and paradoxical, because it used the toxic substance itself for a treatment benefit. The ensuing research opened up multiple perspectives for experimentation and treatment, but clinical trails that were subsequently started had to be discontinued in January 2002 due to the serious side effects of the therapy. The aim of this book is not to arouse false hopes for a therapeutic project that remains to be proven, but to discuss the available information and the questions raised."--BOOK JACKET
Alzheimer's disease : lessons from cell biology by K. S Kosik( Book )

8 editions published in 1995 in English and held by 177 WorldCat member libraries worldwide

This book brings together recent developments in Alzheimer's disease research with related discoveries in the field of cell biology. The book moves between basic cell biological concepts that form the underpinnings of modern Alzheimer's disease research, and current findings about proteins and cellular processes affected by the disease. Divided into three topics, the book addresses (1) protein trafficking, a problem that has become germane to the study of the amyloid precursor protein; (2) phosphorylation, a problem that underlies studies of the pathological transformation of tau to paired helical filaments; and (3) cell death, a pervasive problem in neurodegeneration
The biology of Alzheimer disease( Book )

8 editions published between 2011 and 2012 in English and held by 144 WorldCat member libraries worldwide

Alzheimer Disease represents an important area of research in neurobiology, cell biology, developmental biology and pathology. Understanding the nature of the changes that occur in neurons as the disease progresses accumulation of amyloid beta and neurofibrillary tangles is obviously important as we try to develop therapeutic approaches. Moreover, the normal physiological roles of proteins such as APP and tau, whose processing appears to be altered in Alzheimer, is also an intense area of research
Protein homeostasis by Richard I Morimoto( Book )

6 editions published in 2012 in English and held by 129 WorldCat member libraries worldwide

Molecular biology and genetics of Alzheimer's disease : proceedings of the International Symposium on Dementia--Molecular Biology and Genetics of Alzheimer's Disease, Niigata, Japan, 11-14 November 1989 by International Symposium on Dementia: Molecular Biology and Genetics of Alzheimer's Disease( Book )

6 editions published in 1990 in English and held by 123 WorldCat member libraries worldwide

Frontiers of Alzheimer research : proceedings of the 5th International Symposium of the Psychiatric Research Institute of Tokyo (PRIT), Tokyo, 10-12 September 1990 by Tōkyō-to Seishin Igaku Sōgō Kenkyūjo( Book )

8 editions published in 1991 in English and held by 92 WorldCat member libraries worldwide

Alzheimer's Disease by Ken S Kosik( )

1 edition published in 1995 in English and held by 8 WorldCat member libraries worldwide

The science of aging : [lectures presented at] Nobel Conference XL, October 5 & 6, 2004 by Nobel Conference( Recording )

1 edition published in 2004 in English and held by 2 WorldCat member libraries worldwide

Annual conference of scientists, with an exchange of ideas addressing the challenges, philosophical and moral concerns, economic implications, and the latest research relative to aging
<> by Ting Yang( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

<> by Shaomin Li( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation by Richard C Davis( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

The Alzheimer's Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum by Jochen Walter( )

1 edition published in 1996 in English and held by 2 WorldCat member libraries worldwide

<> by Ming Jin( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways by Rachid El Fatimy( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Preventing Alzheimer's Disease by Dennis J Selkoe( )

1 edition published in 2012 in Undetermined and held by 1 WorldCat member library worldwide

The impact of novel treatments on A[beta] burden in Alzheimer's Disease : insights from a mathematical model by David Lee Craft( Book )

1 edition published in 2001 in English and held by 1 WorldCat member library worldwide

A mathematical model of the impact of novel treatments on the A[beta] burden in the Alzheimer's brain, CSF and plasma by Lawrence M Wein( Book )

1 edition published in 2001 in English and held by 1 WorldCat member library worldwide

With the advent of novel therapies for AD, there is a pressing need for biomarkers that are easy to monitor, such as the amyloid-beta levels in the cerebrospinal fluid (CSF) and plasma. To gain a better understanding of the explanatory power of these biomarkers, we formulate and analyze a compaxtmental mathematical model for the amyloid-beta accumulation in the brain, CSF and plasma throughout the course of Alzheimer's treatment. Our analysis reveals that the total amyloid-beta burden in the brain is dictated by a unitless quantity called the polymerization ratio, which is the product of the production and elongation rates divided by the product of the fragmentation and loss rates. In this ratio, the production rate and loss rate include a source and sink term, respectively, related to the intercompaxtmental transport. Our results suggest that production inhibitors are likely to reduce the amyloid-beta levels in all three compartments. In contrast, agents that ingest monomers off of polymers, or that increase fragmentation or block elongation, may also reduce amyloid-beta burden in the brain, but may produce little change in or even transiently increase CSF and plasma amyloid-beta levels. Hence, great care must be taken when interpreting these biomarkers. Keywords: amyloid beta, mathematical model
Preventing Alzheimer's Disease by Dennis J Selkoe( )

1 edition published in 2012 in Undetermined and held by 1 WorldCat member library worldwide

A mathematical model of the impact of novel treatments on the A\03B2 burden in the Alzheimer's brain, CSF and plasma by Lawrence M Wein( )

1 edition published in 2001 in English and held by 1 WorldCat member library worldwide

With the advent of novel therapies for AD, there is a pressing need for biomarkers that are easy to monitor, such as the amyloid-beta levels in the cerebrospinal fluid (CSF) and plasma. To gain a better understanding of the explanatory power of these biomarkers, we formulate and analyze a compartmental mathematical model for the amyloid-beta accumulation in the brain, CSF and plasma throughout the course of Alzheimer's treatment. Our analysis reveals that the total amyloid-beta burden in the brain is dictated by a unitless quantity called the polymerization ratio, which is the product of the production and elongation rates divided by the product of the fragmentation and loss rates. In this ratio, the production rate and loss rate include a source and sink term, respectively, related to the intercompaxtmental transport. Our results suggest that production inhibitors are likely to reduce the amyloid-beta levels in all three compartments. In contrast, agents that ingest monomers off of polymers, or that increase fragmentation or block elongation, may also reduce amyloid-beta burden in the brain, but may produce little change in or even transiently increase CSF and plasma amyloid-beta levels. Hence, great care must be taken when interpreting these biomarkers. Keywords: amyloid beta, mathematical model
 
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Synaptic plasticity and the mechanism of Alzheimer's disease
Covers
Immunization against Alzheimer's disease and other neurodegenerative disordersAlzheimer's disease : lessons from cell biologyThe biology of Alzheimer diseaseProtein homeostasis
Alternative Names
Dennis J. Selkoe néareolaí Meiriceánach

Dennis J. Selkoe United States of America karimba ŋun nyɛ doo

Dennis J. Selkoe US-amerikanischer Neurologe

Dennis Selkoe

Dennis Selkoe Amerikaans arts

Dennis Selkoe médecin américain

Dennis Selkoe médico estadounidense

Dennis Selkoe metge estatunidenc

Selkoe, D. J.

Selkoe, D. J. 1943-

Selkoe, D. J. (Dennis J.)

Selkoe, D. J. (Dennis J.), 1943-

دينيس جيه سيلكو دكتور من امريكا

Languages
English (82)

German (1)