WorldCat Identities

Bhattarai, Dinesh

Overview
Works: 6 works in 11 publications in 1 language and 45 library holdings
Roles: Author, Editor
Classifications: DS494.8.I4, 327.5405496
Publication Timeline
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Most widely held works by Dinesh Bhattarai
Nepal India : democracy in the making of mutual trust by Dinesh Bhattarai( Book )

5 editions published in 1993 in English and held by 38 WorldCat member libraries worldwide

Nepal's foreign policy : from expediency to pragmatism by Sushil Koirala( Book )

2 editions published in 2017 in English and held by 3 WorldCat member libraries worldwide

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1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Hot Spots: Nepal( Recording )

1 edition published in 2001 and held by 1 WorldCat member library worldwide

The Himalayas. Kathmandu. Maybe Shangri-La. That's what most people think of when you say "Nepal." But according to many, a revolution is brewing, and soon "guerrilla warfare" may replace those earlier tranquil images. Our Hot Spots series continues with a look at the Maoist insurgency challenging Nepal's fragile democracy
Prevalence of campylobacter isolated from water by Dinesh Bhattarai( Book )

1 edition published in 2011 in English and held by 1 WorldCat member library worldwide

Role and mechanism of AMH in the regulation of Sertoli cells in mice( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Highlights: AMH causes apoptosis of primary Sertoli cells in a concentration-dependent manner. At low concentrations, AMH promotes proliferation via a non-traditional pathway. AMH also promotes the expression of spermatogenesis-regulating factors. Abstract: Sertoli cells produce anti-Müllerian hormone (AMH), a glycoprotein belonging to the transforming growth factor-beta family. AMH mediates the regression of Müllerian ducts in the developing male fetus. However, the role of AMH in the regulation of primary Sertoli cells remains unclear. The present study was designed to investigate the effect of AMH on the viability and proliferation of Sertoli cells, with an additional focus on stem cell factor (SCF). Treatment of Sertoli cells with increasing concentrations of rh-AMH (0, 10, 50, 100, and 800 ng/ml) for two days revealed that AMH, at high concentrations, increased apoptosis. These results were confirmed by a significant increase in Caspase-3 and Bax and a decrease in Bcl-2 protein and mRNA expression (P < 0.01). Paradoxically, treatment with a low concentration of rh-AMH (10 ng/ml), but not higher concentrations (50–800 ng/ml), promoted Sertoli cell proliferation, which was verified by an increase in PCNA mRNA (P < 0.05). Furthermore, only low concentrations of rh-AMH activated the non-canonical ERK signaling pathway. Similarly, low concentrations of rh-AMH (10–50 ng/ml) significantly increased (P < 0.05) SCF mRNA and SCF protein levels. These findings indicate that AMH differentially regulates the fate of Sertoli cells in vitro by promoting proliferation at low concentrations and apoptosis at high concentrations. In addition, AMH increased the expression of SCF, an important regulator of Sertoli cell development. Therefore, AMH may play a role in Sertoli cell development
 
Audience Level
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Audience Level
1
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Audience level: 0.79 (from 0.38 for Hot Spots: ... to 0.94 for Nepal's fo ...)

Alternative Names
Dinesh Bhattarai

Languages
English (10)