WorldCat Identities

Peuchmaur, Michel

Overview
Works: 15 works in 20 publications in 2 languages and 72 library holdings
Genres: Laboratory manuals 
Roles: Other, Author, Opponent
Classifications: QH452.8, 574.87
Publication Timeline
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Most widely held works by Michel Peuchmaur
Hybridation in situ by O Devergne( Book )

4 editions published in 1991 in French and held by 42 WorldCat member libraries worldwide

Rôle physiologique des chimiokines : l'exemple de SDF-1 et de la fractalkine by Aurore Coulomb L'Hermine( )

2 editions published in 1999 in French and held by 4 WorldCat member libraries worldwide

L'expression et le rôle des chimiokines dans l'organisation et le développement du système immunitaire à l'état basal sont très peu connus. Pour aborder cette question, l'expression tissulaire des chimiokines dans différents organes à l'état normal a été étudiée. Tout d'abord, l'expression de la chimiokine SDF-1 au cours du développement embryonnaire et fœtal chez l'homme a été analysée. SDF-1 est exprimé par les cellules du mésoderme de la splahchnopleure intraembryonnaire et par toutes les cellules mésothéliales chez le foetus. Dans les tissus périphériques foetaux, SDF-1 est fortement exprimé par la plupart des cellules épithéliales. Dans le foie fœtal, les hépatocytes n'expriment pas SDF-1 alors qu'il est fortement exprimé par les cellules épithéliales biliaires des plaques ductales et des canaux biliaires intrahépatiques. Les précurseurs B, exprimant VpréB, sont essentiellement localisés autour des espaces portes en contact étroit avec les cellules épithéliales de la plaque ductale. Ces résultats suggèrent que SDF1 est impliqué dans le développement de la lymphopoïèse B précoce chez l 'embryon et que les cellules épithéliales de la plaque ductale jouent pour la lymphopoïèse B du foie fœtal un rôle comparable à celui des cellules épithéliales de la bourse de Fabricius chez les oiseaux pour la lymphopoïèse B, ou à celui des cellules épithéliales thymiques pour la lymphopoïèse T. Nous avons ensuite étudié l'expression de la chimiokine fractalkine dans les tissus périphériques et les organes lymphoïdes des sujets adultes ainsi que l'expression et la fonction de son récepteur CX3CR1 par les différentes populations lymphocytaires T. Nous avons montré que CX3CR1 est exprimé par les cellules CD4+ mémoires activées et qu'il est fonctionnel sur ces cellules. Dans les tissus périphériques, la chimiokine fractalkine est exprimée par les cellules endothéliales. Dans les ganglions, la fractalkine est exprimée par les cellules endothéliales des veinules post-capillaire (HEV), par les cellules dendritiques, par les cellules folliculaires dendritiques et par de lymphocytes des follicules lymphoïdes. Dans le thymus, la fractalkine est exprimée par le cellules endothéliales sous capsulaires. Ces résultats suggèrent que les lymphocytes T CD4+ qui ont été activés dans les zones T, expriment CX3CR1 et migrent sous l'effet de la fractalkine soit dans les tissus périphériques, soit dans les centres germinatifs. Dans ce dernier site, l'interaction entre la fractalkine et son récepteur pourrait favoriser les contacts entre les cellules folliculaires dendritiques, les lymphocytes B et les lymphocytes T activés. Ainsi, il apparaît que certaines chimiokines sont exprimées constitutivement dans de nombreux tissus. Au cours du développement, ces chimiokines peuvent jouer un rôle dans la migration et la maturation de certaines populations cellulaires. Chez l'adulte, ces chimiokines contribuent à la surveillance immunologique exercée par les lymphocytes « sentinelles », et à l'organisation fonctionnelle des tissus lymphoïdes
ETUDE DE L'EXPRESSION IN SITU DES GENES DES CYTOKINES DANS LES TISSUS LYMPHOIDES EN PATHOLOGIE HUMAINE by M Peuchmaur( Book )

2 editions published in 1992 in French and held by 3 WorldCat member libraries worldwide

LES METHODES D'INVESTIGATION IN SITU TELLES QUE L'IMMUNOHISTOCHIMIE ET L'HYBRIDATION IN SITU SUR COUPES TISSULAIRES PERMETTENT DE DETERMINER UNE CARTOGRAPHIE DE L'EXPRESSION DES GENES DES CYTOKINES. ELLES CONCOURENT A DEMONTRER DES DYSREGULATIONS DANS LE RESEAU DES CYTOKINES AVEC EXPRESSION DIFFERENTIELLE DE CERTAINS GENES PAR RAPPORT A D'AUTRES. CES ANOMALIES D'EXPRESSION PEUVENT ETRE CORRELEES A LA PATHOLOGIE, RENDENT COMPTE DES LESIONS MORPHOLOGIQUES CONSTATEES ET CONTRIBUENT A LA COMPREHENSION DE CERTAINES MALADIES VIRALES, IMMUNES ET TUMORALES
L'Endobrachyoesophage : une lésion acquise pré-cancéreuse, étude anatomo-clinique by M Peuchmaur( Book )

1 edition published in 1983 in French and held by 3 WorldCat member libraries worldwide

Nephrotic-range proteinuria and brown urine in an 8-year-old girl: Questions by Emilie Saucier( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Nephrotic-range proteinuria and brown urine in an 8-year-old girl: Answers by Emilie Saucier( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis by Lucille Lopez-Delisle( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Cytomegalovirus infection can mimic genetic nephrotic syndrome: a case report by Julien Hogan( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Further delineation of the congenital form of X-linked dyskeratosis congenita (Hoyeraal-Hreidarsson syndrome) by Yves Sznajer( )

1 edition published in 2003 in English and held by 2 WorldCat member libraries worldwide

Acute renal failure in a 3-year-old child as part of the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome following hepatitis A by Arnaud Garnier( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

Histological prognostic factors in children with Henoch-Schönlein purpura nephritis by Jean-Daniel Delbet( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Fatal pulmonary fibrosis after rituximab administration by Marie-Camille Chaumais( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

Cinacalcet in hyperparathyroidism management after pediatric renal transplantation by Olivier Niel( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Role of the mutated ALK oncogene in neuroblastoma oncogenesis and in development by Lucille Delisle( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Neuroblastoma (NB) is a pediatric tumor arising from the sympathetic nervous system. Activating mutations of the ALK gene have been observed in around 8 % of sporadic neuroblastoma as well as in familial cases. The ALK gene encodes a tyrosine kinase receptor of the insulin receptor super-family. It is mainly expressed in the central and peripheral nervous system. The ALK receptor represents a therapeutic target in this cancer. De novo ALK mutations have also been reported in a syndrome associating congenital NB and severe encephalopathy with abnormal shape of the brainstem, suggesting a developmental role for the ALK gene in addition to its implication in oncogenesis.In this context, my PhD project was to determine the role of the mutated ALK receptor in NB oncogenesis and in development, mainly with original mouse models obtained in the laboratory. I extensively characterized two knock-in (KI) Alk mouse lines with the two mutations that are most frequently observed in NB: F1174L and R1275Q in human and F1178L and R1279Q in mouse.A detailed analysis of these two mouse lines showed that the KI AlkR179Q heterozygous and homozygous mice as well as the KI AlkF1178L heterozygous mice do not show striking clinical signs. On the contrary, we documented a high postnatal lethality for KI AlkF1178L homozygous mice and showed that these pups presented with a dramatic reduced milk intake. Thus, the KI AlkF1178L homozygous mice partially phenocopy the human patients with encephalopathy. The difference of phenotype between the heterozygous and the homozygous KI AlkF1178L mice highly suggest a threshold of activity of the Alk receptor compatible with survival.We then explored the role of the mutated ALK receptor in the sympathetic nervous system of the KI Alkmut mice. This analysis showed that the activation of the receptor induces an excess of proliferation in sympathetic neurons from E14.5 to birth. However, we could not observe NB in these animals. We next bread these mice with the transgenic TH-MYCN line. We documented cooperation between Alk mutations and the MYCN oncogene to induce NB. Comparison of transcriptomic profiles of MYCN vs MYCN/Alkmut tumors revealed that the expression of the Ret oncogene (encoding a tyrosine kinase receptor) was strongly induced by the activation of the Alk receptor. Besides, the induction of the expression of the RET gene by the mutated ALK receptor in NB was confirmed in human cell lines and tumors.In order to determine the mechanism by which the activation of the ALK receptor regulates RET gene expression, experiments were done on human NB cell lines in which the ALK receptor can be activated or inactivated. This work showed that RET gene expression is dependent of the ALK-ERK-ETV5 axis. Indeed, the modulation of the ALK receptor activity affects gene expression of ETV5 and RET. This effect is dependent of the activation of the MEK/ERK pathway. Besides, ETV5 increases RET gene expression. In order to confirm the role of the Ret receptor in oncogenesis driven by the mutated Alk receptor, we bread mice bearing an activating mutation of the Ret gene with the TH-MYCN mice. We showed that the activated Ret receptor cooperates with the MYCN oncogene in tumor formation and that these tumors are NB presenting with characteristics very close to MYCN/Alkmut tumors. Thus, the Ret gene appears to be an essential target of the mutated Alk receptor in NB oncogenesis
GEPELIN : genomics of pediatric liver neoplasms by Guillaume Morcrette( )

1 edition published in 2018 in French and held by 1 WorldCat member library worldwide

 
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WorldCat IdentitiesRelated Identities
Alternative Names
Peuchmaur, Michel

Languages
French (10)

English (10)