WorldCat Identities

Shugart, Lee R.

Overview
Works: 12 works in 22 publications in 1 language and 507 library holdings
Genres: Conference proceedings 
Roles: Editor
Classifications: QH541.15.I5, 363.7363
Publication Timeline
Key
Publications about  Lee R Shugart Publications about Lee R Shugart
Publications by  Lee R Shugart Publications by Lee R Shugart
Most widely held works by Lee R Shugart
Biomarkers of environmental contamination by John F McCarthy ( Book )
6 editions published in 1990 in English and held by 347 WorldCat member libraries worldwide
Overview. Anatomical and cytological endpoints. Detoxication, adaptive and immunological responses. Genotoxic responses. Metal metabolism. Application of biomakers in field evaluation
Biomarkers : research and application in the assessment of environmental health by David B Peakall ( Book )
5 editions published in 1993 in English and held by 142 WorldCat member libraries worldwide
Biological markers used to assess the effects of environmental pollution have attracted considerable attention from regulatory agencies and are currently under evaluation at a number of research facilities throughout the world. However promising a biomarker-based biomonitoring approach may be, the development of this concept is complicated by a range of technical issues. This book provides a conceptional framework for research and application of biomarkers. International experts on biomonitoring have formulated a unified strategy for the development and validation of biomarkers in assessing environmental health as well as appropriate protocols for their implementation and interpretation in a biological monitoring program
Napa Conference on Genetic and Molecular Ecotoxicology : October 12-15, 1993, Yountville, California by Napa Conference on Genetic and Molecular Ecotoxicology ( Book )
2 editions published in 1994 in English and held by 8 WorldCat member libraries worldwide
Ecotoxicology, chemistry and risk assessment of nanoparticles ( Book )
1 edition published in 2008 in English and held by 3 WorldCat member libraries worldwide
Biomarker-based biomonitoring for evaluating health and ecological effects of environmental contamination by John F McCarthy ( Book )
1 edition published in 1991 in English and held by 2 WorldCat member libraries worldwide
Genetic and molecular ecotoxicology ( Book )
1 edition published in 1994 in English and held by 1 WorldCat member library worldwide
Biological (Molecular and Cellular) Markers of Toxicity ( )
1 edition published in 1991 in English and held by 1 WorldCat member library worldwide
Several molecular and cellular markers of genotoxicity were adapted for measurement in the Medaka (Oryzias latipes), and were used to describe the effects of treatment of the organism with diethylnitrosamine (DEN). A discontinuous DEN treatment inhibited the activity of a detoxication enzyme activity (ethoxyresorufin-O-deethylase) 65 percent and the activity of glutathione-S-transferase transferase 35 percent No 01-ethyl guanine adducts were detected, and a slight, but statistically significant, in DNA strand breaks was observed. These results are consistent with the hypothesis that prolonged exposure to high levels of DEN induced alkyltransferase activity which enzymatically removes any 01-ethyl guanine adducts but does not result in strand breaks or hypomethylation of the DNA such as might be expected from excision repair of chemically modified DNA. Following a five week continuous DEN exposure with 100 percent renewal of DEN-water every third day, the F values (DNA double strandedness) increased considerably and to a similar extent in fish exposed to 25, 50, and 100 ppm DEN. This has been observed also in medaka exposed to BaP. Flow cytometric analysis of DEN exposed liver tissue showed that cell killing and stimulation of replacement cell production occurred during exposure. An increased rate of cell division and fixation of DEN induced mutation may be an important early component of liver carcinogenesis. Following a series of exposures to BaP (I ug/L), there was an increase in fecundity and in the number of ovarian vitellogenic oocytes. Japanese Kodak and; Chemical carcinogensis; DNA damage; Diethylnitrosamine; Benzo(a)pyrene; Detoxification; Developmental abnormalities; RA3
Conceptual strategy for design, implementation, and validation of a biomarker-based biomonitoring capability by John F McCarthy ( Book )
1 edition published in 1991 in English and held by 1 WorldCat member library worldwide
This document describes a strategy for defining specific objectives for biomarker studies and for designing and implementing a biomonitoring study that focuses on these objectives. In researching this subject, it became clear to the authors that the subject of biomarkers created a great deal of interest among scientists and regulators but that general acceptance of biomarkers as a tool for environmental protection was hampered by lack of a clear notion of how to develop and apply this approach. We intend this document to be a user's guide'' that lays out a logical scheme for applying biomarkers in environmental monitoring. In addition, laboratory and field research components needed to develop and validate fundamental understanding and interpretation of biomarker responses are also described, as is a strategy for evolution of a biomarker-based biomonitoring capability. The document is divided into sections intended to lead the reader to an understanding of how biomarkers can be developed and applied
TNT Metabolites in Animal Tissues ( )
1 edition published in 1991 in English and held by 1 WorldCat member library worldwide
Analyses for TNT and nine potential metabolites (TNT-related compounds) were made in deer, rabbit, and quail tissues (muscle and liver) taken from the Alabama Army Ammunition Plant, Childersburg, Alabama. The listed TNT- related compounds are 2,4,6-trinitrotoluene (parent compound); 2,4-diamino-6- nitrotoluene; 2,6-diamino-4-nitrotoluene;2-amino-4,6-dinitrotoluene;4-amino-2,6- dinitrotoluene;2,4,6-trinitrobenzyl alcohol;2,4,6-trinitrobenzoic acid; 1,3,5- trinitrobenzene; 4-hydroxylamino-2,6-dinitrotoluene; and 2,6,2',6'-tetranitro-4, 4'-azoxytoluene. The procedure for extraction of these compounds from animal tissue required homogenization in acetonitrile, and subsequent partitioning into chloroform. Quantitative analysis of extracted compounds was obtained by chromatographic separation. The main objective of the work was to determine whether TNT and the metabolites were present in the tissues of deer and other game animals at concentrations that would be unsuitable for human consumption
Dinitrotoluene in deer tissues final report by Lee R Shugart ( Book )
1 edition published in 1991 in English and held by 1 WorldCat member library worldwide
A study of ashing and colorimetric procedures in the determination of protein-bound iodine by Lee R Shugart ( Book )
1 edition published in 1962 in English and held by 0 WorldCat member libraries worldwide
A study of the proteinase of streptococcus faecalis var liquefaciens by Lee R Shugart ( Book )
1 edition published in 1965 in English and held by 0 WorldCat member libraries worldwide
 
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Audience Level
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Audience level: 0.80 (from 0.00 for Ecotoxicol ... to 1.00 for Biomarker- ...)
Alternative Names
Shugart, Lee R.
Languages
English (22)