WorldCat Identities

Kriete, Andres

Works: 40 works in 99 publications in 2 languages and 1,677 library holdings
Genres: Academic theses 
Roles: Author, Editor, Thesis advisor, Contributor, Other, Publishing director, Creator
Classifications: QH324.2, 570.113
Publication Timeline
Most widely held works by Andres Kriete
Computational systems biology by Andres Kriete( )

32 editions published between 2005 and 2014 in English and Undetermined and held by 1,300 WorldCat member libraries worldwide

Computational systems biology is a field that aims to develop a systems level understanding of biological processes using computational techniques. This book presents a compendium of the state-of-the-art in this new era of biological understanding. The contributors review bioinformation engineering and data integration technologies along with biomedical applications. Different computational approaches to model and simulate biological systems are discussed. Current computational research efforts, comprehensively covered in this volume, are focused on regulatory, signaling and metabolic networks. New concepts for computer representations on multi-scales predicting emergent properties of biological systems are introduced
Form and function of mammalian lung : analysis by scientific computing by Andres Kriete( Book )

7 editions published in 1998 in English and German and held by 160 WorldCat member libraries worldwide

The study approaches the investigations of airway morphology of the lung with a new set of imaging and cmputer graphical methods, including confocal imaging, computer-guided image acquisition, visualization and fractal graphics. The key result is that, in contrast to the belief that the design of the conductive part of the lung of smaller mammals can be decribed with a trumpet model, the findings reported here document a strongly monopodial branching pattern with the functional consequence of a variation of dead space between the trachea and the acini. This non-dichotomic structural design finds its continuation within the respiratory units as the necessary requirement for an optimal space filling and dense packing which cannot be achieved by a dichotomic branching only. Based on a computer model, computational physics tightly coupled with computer visualistics enables functional simulation of the lung model regarding gas transport. The predicted variance in the ventilation of acini gives rise to an explanation of the well-known difference between the morphologically predicted and physiologically required diffusion capacity
Visualization in biomedical microscopies : 3-D imaging and computer applications( Book )

10 editions published between 1992 and 1994 in English and German and held by 118 WorldCat member libraries worldwide

On-line Bildanalyse am Transmissionselektronenmikroskop zur Abschätzung struktureller und elementarer Eigenschaften biologischer Dünnschnitte by Andres Kriete( Book )

2 editions published in 1985 in German and held by 36 WorldCat member libraries worldwide

Scientific image computing in lung research from form to function = Wissenschaftliche Bildbearbeitung in der Lungenforschung by Andres Kriete( Book )

6 editions published between 1996 and 1997 in German and English and held by 13 WorldCat member libraries worldwide

Confocal microscopy( Book )

4 editions published in 1993 in English and held by 6 WorldCat member libraries worldwide

Computational systems biology( )

3 editions published in 2013 in English and held by 6 WorldCat member libraries worldwide

Visualization in biomedical microscipics : 3-D imaging and computer applications( Book )

1 edition published in 1992 in English and held by 3 WorldCat member libraries worldwide

Selecting age-related functional characteristics in the human gut microbiome by Yemin Lan( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Intraoperative Three-Dimensional Ultrasonography: An Approach to Register Brain Shift using Multidimensional Image Processing( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Automated Tissue Analysis - a Bioinformatics Perspective( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Sicheres Verhandeln mit Banken Basiswissen "Strategie & Umsetzung" und praxiserprobte, offensive Gesprächsvarianten für den erfolgreichen Umgang mit Banken( )

2 editions published between 1999 and 2018 in German and held by 2 WorldCat member libraries worldwide

Der Computer, der Unkraut erkennen kann Automatische Bildanalyse in der Landtechnik by Franz-Josef Bockisch( )

1 edition published in 2008 in German and held by 2 WorldCat member libraries worldwide

Combined histomorphometric and gene-expression profiling applied to toxicology by Andres Kriete( )

1 edition published in 2003 in English and held by 2 WorldCat member libraries worldwide

Eine neue Dimension der Anschaulichkeit Dreidimensionale Rekonstruktions- und Meßverfahren in der Mikroskopie by Hans-Rainer Duncker( )

1 edition published in 2008 in German and held by 2 WorldCat member libraries worldwide

Morphometrie mit Hilfe der Bildanalyse Die Leistungsfähigkeit von Organsystemen ist anatomisch meßbar by Hans-Rainer Duncker( )

1 edition published in 2008 in German and held by 2 WorldCat member libraries worldwide

Characterization and Modeling of Metabolic Stress Responses in Cellular Aging by David J Alfego( Book )

2 editions published in 2017 in English and held by 2 WorldCat member libraries worldwide

Cellular aging describes the buildup of changes over time that affect normal mechanisms of cells, tissues and organisms throughout their lifespan, which can lead to any number of potential health risks, diseases or other disorders. One of the major causes of these changes is declining mitochondrial function, though the cause of this energy stress is still debated. The prevailing experimental model for aging studies examines cells in a senescent state as the hallmark of aging. Yet this permanent, post-mitotic phase is more commonly observed in vitro. Aged cells in vivo often retain their mitotic potential, indicative of a paused, quiescent state. This thesis proposes a new platform to study aging through perturbations of mitochondrial function via an experimental energy restriction in quiescence (ERiQ) model that may be more relevant to aging in tissues. This model causes adaptive changes in major stress response pathways for AKT, NF-[kappa]B, p53 and mTOR as a reaction to reduced ATP, NAD+ and NADP levels. The construction of a theoretical computational model, complementary to the experimental model, is based on feedback motifs that investigate the interplay between those key stress response pathways. The in silico model demonstrates adaptations to sudden energetic perturbations, promoting pro-survival phenotypes and recovery. This thesis hypothesizes that the very same survival mechanisms are chronically activated during aging, but also cause conflicting responses that actively suppress mitochondrial function to contribute to a lockstep progression of decline. The model makes predictions consistent with inhibitory and gain-of-function experiments in aging. The relevance of ERiQ as a model to study aging is further emphasized by a transcription factor (TF) meta-analysis of gene expression datasets accrued from 18 tissues from individuals at different biological ages, which were compared to 7 different experimental platforms. Experimental datasets included replicative senescence and ERiQ, in which ATP was transiently reduced. TF motifs in promoter regions of trimmed sets of target genes were scanned using JASPAR and TRANSFAC motifs and TF signatures established a global mapping of agglomerating motifs with distinct clusters when ranked hierarchically. Remarkably, the majority of in vivo aged tissues correlated with the ERiQ profile instead of senescence, confirming its relevance as a new experimental model. Fitting motifs in a minimalistic protein-protein interaction (PPI) network model allowed us to probe for connectivity to distinct stress sensors, as well as identify novel targets of study in transcription factors that significantly switch enrichment between ERiQ and senescence. In the PPI, DNA damage sensors ATM and ATR linked to one subnetwork associated with senescence. By contrast, energy sensors PTEN and AMPK connected to the nodes in the ERiQ subnetwork. These data suggest that energy deprivation may be linked to transcriptional patterns characteristic of many aged tissues distinct from cumulative DNA damage associated with senescence. Finally, this thesis exemplifies the combined use of the predictive power of the computational model with experimental investigation in vitro. Preliminary experiments show how the model can be refined to reflect how certain conditions may alter metabolic output and offer intriguing insights into the future of cellular aging studies
Regulation of NF-kappaB in response to age-related energy stress in human skin fibroblasts by Nirupama Yalamanchili( Book )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Aging is associated with cumulative damage to nuclear and mitochondrial genomes, misfolding and oxidization of proteins, and organelle dysfunction. It encompasses not only the accumulation of damage over time, but also protective/adaptive responses regulated by complex signaling processes. Whereas the loss of molecular fidelity and cellular damage has been, in large part, deciphered and quantified, no clear picture has emerged on the relative importance, interconnectivity and sequence of events that characterize the adaptive response to cellular aging. Our previous work has implicated activation of inflammatory pathways as an adaptive mechanism to cellular aging. Specifically, we observed that fibroblasts from donors at advanced age exhibit a gene expression signature in vitro reflective of an inflammatory cell stress response. We found that these age-associated changes in transcriptional patterns were cell autonomous and accompanied by an enhanced kappaB DNA binding activity (Kriete, Mayo et al. 2008). The central objective of this thesis project was to identify pathways and mechanisms involved in NF-kappaB activation of aging fibroblasts. Since mitochondrial dysfunction has been implicated in aging we first investigated the basal levels of ROS and intracellular ATP in pre-senescent fibroblasts from young and old donors (22 to 92 years old). Though there was no noticeable change in the intracellular ROS levels, we found an overall decrease in the total basal ATP levels with aging. Based on this observation, we explored a potential link between cellular energy levels and increased NF-kappaB p65 DNA binding activity in fibroblasts. In our approach we subjected 'young' fibroblasts to experimental conditions (glycolysis reduction, disruption of oxidative phosphorylation) that mimicked reduced basal ATP levels in 'old' fibroblasts. These treatments triggered increased NF-kappaB p65 DNA binding activity. Activation of NF-kappaB under these conditions occurred through the canonical NF-kappaB pathway and was independent of PI3K/Akt and p53 pathways. Further analysis revealed autophagy induction in parallel to energy deprivation-triggered NF-kappaB. Autophagy, a fundamental cellular 'housekeeping' process and usually pro-survival in response to metabolic stress, might be induced presumably as an adaptive response. Pharmacological inhibition of autophagy reduced energy deprivation-triggered NF-kappaB indicating its crucial role as a mediator of NF-kappaB activation in response to reduced cellular energy levels in 'young' fibroblasts. These findings motivated us to probe for autophagy in pre-senescent fibroblasts aged in vivo. In doing so, we found evidence that supports the involvement of autophagy. However, further studies are required to elucidate additional intracellular signal transduction pathways that may contribute to NF-kappaB regulation in aging. While the aging process is inherently driven by damage accumulation and multiple pathways in response to various cell stressors over time, our studies establish a new mechanism of whereby 'chronic inflammation' as evidenced by enhanced NF-kappaB activity may be induced in response to energy stress increasing during the normal aging process
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Audience level: 0.45 (from 0.26 for Characteri ... to 0.97 for Visualizat ...)

WorldCat IdentitiesRelated Identities
Computational systems biology
Form and function of mammalian lung : analysis by scientific computing
Alternative Names
Kriete, A.

Kriete, A. (Andres)

English (64)

German (14)