WorldCat Identities

Hemler, Martin E.

Overview
Works: 4 works in 12 publications in 1 language and 182 library holdings
Genres: Conference papers and proceedings 
Roles: Author, Editor, htt
Publication Timeline
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Most widely held works by Martin E Hemler
Cell adhesion molecules : cellular recognition mechanisms by Martin E Hemler( Book )

8 editions published in 1993 in English and held by 175 WorldCat member libraries worldwide

The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression
Targeting of CD151 in Breast Cancer and in Breast Cancer Stem Cells( Book )

2 editions published in 2007 in English and held by 2 WorldCat member libraries worldwide

A mouse model for spontaneous breast cancer has been set up to analyze the role of CD151 during breast cancer progression. Using this model, which involves amplification of the ErbB2 oncogene, preliminary data was then obtained indicating that the absence of CD151 causes a substantial delay in the appearance of mouse mammary tumors. To confirm these preliminary results, we next set up a larger scale experiment to evaluate the role of CD151 during mammary tumor progression. Results from this larger scale experiment are pending further growth of the mice. In another experiment, a subpopulation of human MCF7 cells was isolated that has 'stem-cell' like properties. Removal of CD151 from this 'stem cell'-like population dramatically diminished cell invasion and responsiveness to EGF. In addition, the CD151 gene was successfully ablated from several different human mammary carcinoma cell lines, by using an siRNA strategy. As a consequence of CD151 removal, human mammary epithelial cells show diminished invasion, migration, signaling, adhesion, and EGFR collaboration. Together these results establish that CD151 plays a major role in the progression of breast cancer
Cell adhesion molecules : Cellular reconition mechanisms : 4th Annual Pezcoller symposium on "Adhesion molecules" : Papers( Book )

1 edition published in 1993 in English and held by 1 WorldCat member library worldwide

 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.64 (from 0.63 for Cell adhes ... to 0.94 for Targeting ...)

Languages
English (12)