WorldCat Identities

Mazabraud, André

Overview
Works: 26 works in 43 publications in 3 languages and 215 library holdings
Roles: Author, Thesis advisor, Publishing director, Contributor, htt, Other, 958
Classifications: RC280.B6, 616.9927107
Publication Timeline
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Most widely held works by André Mazabraud
Pathology of bone tumours : personal experience by André Mazabraud( )

9 editions published between 1997 and 1998 in English and German and held by 121 WorldCat member libraries worldwide

This book deals with the pathologic diagnosis of malignant and benign bone tumors. The final chapters are devoted to extra-skeletal skeletogenic tumors and pseudo-tumoral lesions that may be confused with true tumors. To emphasis the indissoluble nature of the anatomic and clinical relations, the discussions are preceded by one or two clinical cases. The author imparts his personal experience without ignoring the material in the literature on the subject. Over 1100 radiographic and histologic illustrations. The references mention recent studies but also review the classical studies leading to definition of the various disease entities. The chief differential diagnoses and the pitfalls to be avoided are reviewed in an insert at the end of each chapter
Anatomie pathologique osseuse tumorale : expérience personnelle by André Mazabraud( Book )

3 editions published in 1994 in French and German and held by 44 WorldCat member libraries worldwide

Pathology of Bone Tumours Personal Experience by M Postel( )

1 edition published in 1997 in English and held by 9 WorldCat member libraries worldwide

Etude des mécanismes moléculaires conduisant à la mort cellulaire programmée au cours de la métamorphose du xénope by David Du Pasquier( Book )

2 editions published in 2003 in French and held by 4 WorldCat member libraries worldwide

LES GENES SPECIFIANT LES FACTEURS D'ELONGATION EF-1 ALPHA CHEZ LE XENOPE. EXPRESSION DANS LES LIGNEES GERMINALES ET TUMORALES. STRUCTURE DU GENE EF-1 ALPHA OOCYTAIRE by BASSIMA ABDALLAH( Book )

2 editions published in 1993 in French and held by 4 WorldCat member libraries worldwide

NOUS AVONS ETUDIE L'EXPRESSION DES GENES SPECIFIANT PLUSIEURS ELEMENTS DU SYSTEME DE SYNTHESE PROTEIQUE PENDANT LA GAMETOGENESE ET L'EMBRYOGENESE DE XENOPUS LAEVIS. LES GENES ETUDIES SONT CEUX QUI CODENT POUR LE FACTEUR D'ELONGATION 1 ALPHA (EF-1 ALPHA), LA THESAURINE A ET LA THESAURINE B. CES DEUX DERNIERES PROTEINES SONT IMPLIQUEES DANS LE STOCKAGE A LONG TERME DU RNA 5S ET DU TRNA DANS LES OOCYTES. ELLES NE SONT PAS DETECTABLES DANS LES CELLULES SOMATIQUES. EF-1 ALPHA EXISTE SOUS DEUX FORMES: UNE FORME SOMATIQUE (EF-1 ALPHAS) ET UNE FORME OOCYTAIRE (EF-1 ALPHAO). ON DEMONTRE ICI QUE LE RNA MESSAGER DE EF-1 ALPHAS EST INDETECTABLE DANS LES OOCYTES ET LES SPERMATOCYTES, MAIS QU'IL EST PRESENT DANS LES CELLULES EMBRYONNAIRES A PARTIR DU STADE NEURULA. LE RNA MESSAGER DE EF-1 ALPHAO EST PRESENT NON SEULEMENT DANS LES OOGONIES ET LES OOCYTES DE TOUS LES STADES, MAIS AUSSI DANS LES SPERMATOGONIES ET LES SPERMATOCYTES PRIMAIRES. LES RNA MESSAGERS CODANT POUR LA THESAURINE A ET LA THESAURINE B SONT EGALEMENT SPECIFIQUES DES CELLULES GERMINALES. ILS SONT TRADUITS EN PROTEINES DANS LE TESTICULE COMME ILS LE SONT DANS L'OVAIRE. CETTE ETUDE REVELE UNE SIMILITUDE FRAPPANTE DANS LE PROGRAMME D'EXPRESSION DES GENES DURANT L'OOGENESE ET LA SPERMATOGENESE. LES PRODUITS DES GENES EF-1 ALPHAO, THESAURINE A ET LA THESAURINE B PEUVENT ETRE CONSIDERES COMME DES MARQUEURS DE LA DIFFERENCIATION DES CELLULES GERMINALES
Recherche de nouveaux antipaludiques actifs sur les souches sauvages et résistantes de Plasmodium vivax et Plasmodium falciparum by Liselotte Yimga Djapa( Book )

2 editions published in 2005 in French and held by 3 WorldCat member libraries worldwide

La culture in vitro de P. vivax étant difficile à réaliser, les gènes dhfr de P. vivax sensible à la pyriméthamine (Ser58Ser117), le double mutant (Ser58Arg+Ser117Asn) et le triple mutant résistant à la pyriméthamine (Ser58Arg+Ser117Asn+Ile173Leu) ont été exprimés dans la levure mutée Saccharomyces cerevisiae pour l'expression de son gène dhfr chromosomique. Les gènes dhfr humain et de levure ont aussi été testés à titre de contrôle de l'activité inhibitrice spécifique des antifoliniques sur les DHFRs de P. vivax. La levure mutante ainsi transformée a permis de sélectionner 6 antifoliniques parmi les 25 inhibant spécifiquement les transformants exprimant les gènes dhfr de P. vivax en se référant à la pyriméthamine et au MTX. La concentration inhibitrice à 50% (CI50) des 6 drogues a été déterminée sur des isolats de P. falciparum. Le séquençage des gènes dhfr des isolats confirme la corrélation qui existe entre le génotype dhfr des isolats et la réponse in vitro au test de chimiosensibilité.Au cours de ce travail, le sulfanilamide, utilisé pour augmenter la pénétration des drogues dans la levure, a montré une inhibition sélective des transformants exprimant les gènes de dhfr de Plasmodium. Cette inhibition confirmait le fait suggéré par d'autres laboratoires que les sulfamides, famille à laquelle appartient le sulfanilamide, ont une deuxième cible qui la DHFR. Ainsi, la découverte de cette nouvelle action du sulfanilamide ou de son dérivé le sulfa-DHP pourrait permettre le développement et l'exploitation d'une nouvelle classe d'antifoliniques utiles pour le traitement des maladies parasitaires tel le paludisme
Xenopus tropicalis, nouveau modèle d'étude de maladies génétiques humaines by Qods Ymlahi Ouazzani( Book )

2 editions published in 2008 in French and held by 3 WorldCat member libraries worldwide

This thesis aims to validate the use of Xenopus tropicalis as a model to study human genetic diseases. We first looked for orthologs of 264 humans "morbid" genes, then defined by in situ hybridization the expression profiles of 73 of them. We then decided to create a model of amphibian spinal muscular atrophy (SMA). The cause of the disease is reducing amount of SMN protein (Survival of motoneuron) in the body, due to loss of function of the smn1 gene in man. We have obtained a phenocopy of this disease in Xenopus using morpholinos oligonucleotides anti-SMN. By immunostaining with acetylated tubuline, we see that the motorneurons of anti-SMN morpholinos injected embryos show defects in growth and branching probably leading to a muscle denervation. These embryos have a stronger signal of parvalbumin than those who received a control morpholino. This increase in parvalbumin caused a strong release of Ca + + by the muscle, reflecting the state of embryonic muscle denervation. By staining acetylcholine receptors with bungarotoxin we can analyze the topology of neuromuscular junctions. In treated embryos, this topology is normal, suggesting that muscle cells are not directly affected, but motorneurons would be primary affected by the decrease in the SMN. We have obtained an amphibian model of spinal muscular atrophy which will broaden our knowledge of the pathophysiology of this disease
Cahiers de pathologie osseuse by Stanislas de Sèze( )

in French and held by 2 WorldCat member libraries worldwide

Coxarthrose by Centre de rhumatologie Viggo Petersen (Paris)( Book )

1 edition published in 1964 in French and held by 2 WorldCat member libraries worldwide

Origin of several abundant proteins of amphibian oocytes by André Mazabraud( )

1 edition published in 1992 in English and held by 2 WorldCat member libraries worldwide

The mariner Transposons Belonging to the irritans Subfamily Were Maintained in Chordate Genomes by Vertical Transmission by Ludivine Sinzelle( )

1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

Évaluation de la chimiorésistance de Plasmodium falciparum à différents antipaludiques (chloroquine, sulfadoxine-pyriméthamine, quinine) et profil génétique des isolats correspondants by Allico Joseph Djaman( Book )

2 editions published in 2003 in French and held by 2 WorldCat member libraries worldwide

Since the notification in 1986 of the first cases of P. falciparum resistance in Côte d'Ivoire, relatively few studies have been devoted to the assessment of chemio-resistance in the country. It appeared necessary to us to set up a monitoring system of the resistance of P. falciparum to antimalarial drugs by means of the tests of therapeutic efficacy to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP), in vitro to chloroquine, pyrimethamine and quinine. A more fundamental approach based on the PCR, the RFLP using specific endonucleases and the sequencing of DNA fragments of dhfr, dhps, pfmdr-1 genes of P. falciparum isolates have been achieved. The results of the therapeutic efficacy revealed 21.7% of early therapeutic failures (ETF), 3.6% of late clinical failures (LCF) and 19.3% of late parasitological failures (LPF) against 55.4% of adequate clinical and parasitological responses (ACPR) to chloroquine. 36.2% of the isolates were chloroquino-resistant (CQ-R). As for the sulfadoxine-pyriméthamine, 23.6% of therapeutic failures (TF) and 76.4% of adequate clinical and parasitological responses were observed. 39% of the isolates tested in vitro were highly resistant to pyrimethamine (PYR). On the other hand, no quinino-resistant isolate was highlighted in this study. The analysis of the polymorphism of size of P. falciparum DNA fragments revealed 100% of isolates K76T in the children having therapeutic failures to chloroquine and 71.4% of isolates K76T within the CQ-R isolates. However, 11.8% of the children having ACPR carried pfcrt mutant isolates. The changes affecting the dhfr and dhps genes concerned respectively 26.4% and 93.4% of the studied isolates. If the mutant dhfr isolates were carried by 85.7% of the children having ETF, the mutants dhps were present at 100% of these children. Moreover, 85.4% of these dhfr mutant isolates were highly resistant to the PYR. Ultimately, these results rest the problem of the use of the chloroquine and the sulfadoxine-pyrimethamine as first and second line drug in Côte.d'Ivoire in general and in Abidjan in particular. These results can also be used as a basis of data for the National Program of Fight against Malaria in the country for a better use and a rationalization of usual antimalarial drugs
Deletion and dosage modulation of the eEF1A gene inPodospora anserina: effect on the life cycle by Philippe Silar( )

1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide

Etude des fonctions du facteur suppresseur de métastases Nm23/NDPK au cours du développement embryonnaire de Xenopus laevis by Myriam Sélo( Book )

2 editions published in 2002 in French and held by 2 WorldCat member libraries worldwide

Nucleoside diphosphate kinases (NDPK), also referred to as Nm23 proteins, form a small multigenic family. These factors seem to be implicated in numerous biological processes, such as the suppression of metastasis and regulation of gene expression. Nevertheless, their exact functions and the underlying molecular mechanisms in the organism are still poorly understood. The goal of our work was to obtain further information on the in vivo Nm23 activities by using a vertebrate organism, Xenopus laevis.In our initial approach, we examined the consequences of the overexpression of Xenopus NDPK X1 and X3 proteins on early embryonic development. Overabundant proteins cause a high lethality, associated with severe defects of the invagination of endodermal cells and closure of blastopore during gastrulation. Based on these abnormalities, we postulate that Nm23 proteins interfere with the epithelium-mesenchyme transition, a mechanism of acquisition of cell motility that takes place during both gastrulation and metastatic progression. Secondly, we proceeded to injections of wild-type or mutant human Nm23 proteins into Xenopus embryos. Our results, which have been validated by statistical methods, suggest that the NDPK enzymatic activity is not implicated in the inhibition of cell migration by Nm23-Hl protein during gastrulation. Nm23-H2 protein inhibits cell division during segmentation; this effect is mainly due to its capacity to bind nucleic acids. Finally, we characterised the cDNA encoding four new X. laevis Nm23 proteins. We determined the expression patterns of all members of Xenopus nm23 family during embryogenesis and metamorphosis as well as in several adult tissues. These data suggest different biological functions of each Nm23 protein
Caractérisation des transposons à ADN Tc1-mariner chez le xénope et utilisation du transposon Sleeping Beauty comme vecteur de transgenèse germinale by Ludivine Sinzelle( Book )

2 editions published in 2005 in French and held by 2 WorldCat member libraries worldwide

LES ELEMENTS DE TYPE TC1 (TLES) ET LES ÉLÉMENTS DE TYPE MARINER APPARTIENNENT A LA SUPERFAMILLE DES TRANSPOSONS À ADN TC1-MARINER QUI SONT TRÈS LARGEMENT RÉPANDUS DANS LE RÈGNE VIVANT. GRÂCE AUX DONNÉES DE RESSOURCES GÉNOMIQUES COMBINÉES À UNE STRATÉGIE DE PCR DÉGÉNÉRÉE, NOUS AVONS IDENTIFIÉ SIX LIGNÉES DE TLES PRÉSENTS DANS LE GÉNOME DE L'AMPHIBIEN XENOPUS TROPICALIS. LA PLUPART DE CES LIGNÉES APPELÉES EAGLE, FROGGY, XEMINOS, XTTXR ET JUMPY PRÉSENTE DES CARACTÉRISTIQUES TYPIQUES DES ÉLÉMENTS TLES: UN CADRE DE LECTURE CODANT UNE TRANSPOSASE DE 340-350 ACIDES AMINÉS, ENCADRÉ PAR DES SÉQUENCES RÉPÉTÉES INVERSÉES. POUR CHACUNE DE CES LIGNÉES, NOUS AVONS IDENTIFIÉ DES COPIES CONTENANT UN CADRE DE LECTURE DE LA TRANSPOSASE INTACT SUGGÉRANT QUE CES ÉLÉMENTS POURRAIENT ÊTRE ENCORE ACTIFS. L'ANALYSE PHYLOGÉNÉTIQUE MONTRE QUE CES TLES SONT RELIÉS À DES TLES D'ACTINOPTERIGIENS ET D'AMPHIBIENS DANS UN DEUXIÈME TEMPS, NOUS AVONS IDENTIFIÉ LE PREMIER MLE, XTMAR1, ISOLÉ D'UN GÉNOME DE VERTÉBRÉ À SANG-FROID XENOPUS TROPICALIS. L'ANALYSE PHYLOGÉNÉTIQUE INCLUANT DES REPRÉSENTANTS DES DIFFÉRENTES SOUS-FAMILLES DE MLES RÉVÈLE QUE XTMAR1 EST RELIÉ AU MLE HUMAIN HSMAR2, DANS UNE DEUXIÈME LIGNÉE DE LA SOUS-FAMILLE IRRITANS. EN DERNIÈRE PARTIE, NOUS AVONS UTILISÉ LE TARNSPOSON TC1-MARINER SLEEPING BEAUTY (SB) COMME VECTEUR DE TRANSGENÈSE GERMINALE CHEZ LE XÉNOPE. CETTE TECHNIQUE REPOSE SUR LA MICROINJECTION. DANS UN EMBRYON DE XÉNOPE AU STADE UNE CELLULE, DE LA TRANSPOSASE SB ET D'UN PSEUDO-TRANSPOSON CONTENANT LE MARQUEUR FLUORESCENT GFP. DANS DES CONDITIONS OPTIMISÉES, NOUS OBTENONS UN NOMBRE IMPORTANT D'INDIVIDUS DEMI-TRANSGÉNIQUES
Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis by Ana C Fierro( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

Reduced levels of survival motor neuron protein leads to aberrant motoneuron growth in a Xenopus model of muscular atrophy by Qods Ymlahi-Ouazzani( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

Tuberculose ostéo-articulaire by Centre de rhumatologie Viggo Petersen (Paris)( Book )

1 edition published in 1961 in French and held by 1 WorldCat member library worldwide

Évaluation de la chimiorésistance de Plasmodium falciparum à différents antipaludiques (chloroquine, sulfadoxine-pyriméthamine, quinine) et profil génétique des isolats correspondants by Allico Joseph Djaman( )

1 edition published in 2003 in French and held by 1 WorldCat member library worldwide

Since the notification in 1986 of the first cases of P. falciparum resistance in Côte d'Ivoire, relatively few studies have been devoted to the assessment of chemio-resistance in the country. It appeared necessary to us to set up a monitoring system of the resistance of P. falciparum to antimalarial drugs by means of the tests of therapeutic efficacy to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP), in vitro to chloroquine, pyrimethamine and quinine. A more fundamental approach based on the PCR, the RFLP using specific endonucleases and the sequencing of DNA fragments of dhfr, dhps, pfmdr-1 genes of P. falciparum isolates have been achieved. The results of the therapeutic efficacy revealed 21.7% of early therapeutic failures (ETF), 3.6% of late clinical failures (LCF) and 19.3% of late parasitological failures (LPF) against 55.4% of adequate clinical and parasitological responses (ACPR) to chloroquine. 36.2% of the isolates were chloroquino-resistant (CQ-R). As for the sulfadoxine-pyriméthamine, 23.6% of therapeutic failures (TF) and 76.4% of adequate clinical and parasitological responses were observed. 39% of the isolates tested in vitro were highly resistant to pyrimethamine (PYR). On the other hand, no quinino-resistant isolate was highlighted in this study. The analysis of the polymorphism of size of P. falciparum DNA fragments revealed 100% of isolates K76T in the children having therapeutic failures to chloroquine and 71.4% of isolates K76T within the CQ-R isolates. However, 11.8% of the children having ACPR carried pfcrt mutant isolates. The changes affecting the dhfr and dhps genes concerned respectively 26.4% and 93.4% of the studied isolates. If the mutant dhfr isolates were carried by 85.7% of the children having ETF, the mutants dhps were present at 100% of these children. Moreover, 85.4% of these dhfr mutant isolates were highly resistant to the PYR. Ultimately, these results rest the problem of the use of the chloroquine and the sulfadoxine-pyrimethamine as first and second line drug in Côte.d'Ivoire in general and in Abidjan in particular. These results can also be used as a basis of data for the National Program of Fight against Malaria in the country for a better use and a rationalization of usual antimalarial drugs
Analyse biochimique et moléculaire d'une zinc-aminopeptidase du Plasmodium falciparum, agent du paludisme by Zakia Derhy( Book )

in French and held by 1 WorldCat member library worldwide

L'identification de nouvelles potentielles, impliquées dans des étapes clés du cycle biologique de P. Falciparum est devenue essentielle pour concevoir de nouvelles molécules inhibitrices du développement du parasite. Un gène en copie unique a été identifie par immunocriblage d'une banque génomique d'expression de la souche FcB1 de P. Falciparum. Sa séquence présente une phase ouverte de lecture unique et sans intron de 3171 pb, elle possède les caractéristiques (richesse en A+T et usages des codons) de P. Falciparum. Ce gène est exprimé dans les stades érythrocytaires (ARN de 4 kb). Il code pour une protéine de 122 kDa, présentant des similitudes importantes avec les aminopeptidases n d'escherichia coli et haemophilius influenza et significatives avec plusieurs autres aminopeptidases procaryotes et eucaryotes. Elle contient la séquence canonique HExxHx18, caractéristique des zinc-metallopeptidases de la famille m1, et le motif gamen, caractéristique des aminopeptidases de cette famille. La proteine correspondant au produit du gene a été identifiée dans des extraits solubles des stades schizontes erythrocytaires de p. Falciparum, la leucyl-aminopeptidase. Elle correspond à une protéine de 120 kDa et une forme probablement maturée de 68 kDa. In vitro, des formes de maturation supplémentaire de 105 kda et 96 kda sont également mises en évidence. Toutes ces formes sont reconnues par l'anticorps ayant servi à immunocribler la banque ainsi qu'un anticorps dirige contre une séquence peptidique déduite de la séquence du gène. La leucyl-aminopeptidase possède un large spectre d'hydrolyse, clivant les substrats L-Leu> Arg-> Ala-AMC, avec un pH optimal d'activité neutre. Son profil d'inhibition avec différents inhibiteurs de protéases la caractérise comme metallo-aminopeptidase du type N, ce qui est en accord avec les prédictions réalisées à partir de l'analyse de la séquence du gène
 
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Pathology of bone tumours : personal experience
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French (21)

English (13)

German (3)