WorldCat Identities

Balligand, J.-L (Jean-Luc)

Overview
Works: 15 works in 23 publications in 3 languages and 185 library holdings
Roles: Contributor, Other, Opponent, Collector
Classifications: QP535.N1, 572.54
Publication Timeline
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Most widely held works by J.-L Balligand
Nitric oxide by B Mayer( Book )

8 editions published in 2000 in English and German and held by 160 WorldCat member libraries worldwide

"This book describes various aspects of nitric oxide biology, physiology and pharmacology. It is divided into three sections. The first part deals with the basic chemistry and enzymology of NO, thus laying a molecular basis for what follows. The middle part surveys the physiological roles of NO under normal conditions. The concluding part explores the relevance of NO to disease, both as a pathogenic factor and a therapeutic target. The book thus provides detailed information on NO biology to the reader unfamiliar with the field and represents a reference work for scientists working in an NO-related field of biomedical research. Each chapter, written by experts in their fields, gives a broad introduction followed by a comprehensive review of the current knowledge and a detailed reference list."--BOOK JACKET
Conséquences d'une obésité nutritionnelle sur les fonctions cardiovasculaires et neurovégétatives chez le chien : approches physiologiques et pharmacologiques by Michel Pelat( Book )

2 editions published in 2000 in French and held by 4 WorldCat member libraries worldwide

L'obésité s'associe fréquemment à une hypertension artérielle (HTA), à une insulinorésistance et à une hyperlipidémie. Les mécanismes physiopathologiques concourant à la morbidité de cette association restent mal compris. En utilisant un modèle d'obésité nutritionnelle développé chez le chien, nous avons étudié les conséquences de l'obésité sur les fonctions cardiovasculaires et neurovégétatives. Lors de l'installation de l'obésité et de I'HTA, nous observons une hyperadradrénergie transitoire ainsi qu'une diminution durable de la variabilité haute fréquence de la fréquence cardiaque reflétant la modulation vagale du rythme cardiaque. Nous montrons que la phase d'état du triptyque morbide, obésité-HTA-insulino-résistance, s'accompagne d'anomalies des réceptivités13- et a2-adrénergiques cardio-vasculaires pouvant résulter de cette hyperadrénergie. Parallèlement, nous avons montré que la réponse pressive à une activation cholinergique centrale, attribuée aux récepteurs muscariniques M1, s'avère amoindrie mais plus durable chez les chiens obèses-hypertendus. Ces observations soulignent l'existence d'altérations fonctionnelles du système nerveux autonome qui peuvent participer à la mise en place et/ou au. maintien de I'HTA secondaire à l 'obésité. De plus nous montrons que les altérations de la variabilité à court et long terme de la fréquence cardiaque observées dans ce modèle s'expliquent en partie par des modifications de la réceptivité muscarinique cardiaque. Ainsi, nous avons attribué l'atténuation de la réponse chronotrope à la méthylscopolamine, à un effondrement du nombre et de l'affinité des récepteurs muscariniques auriculaires chez les chiens obèses hypertendus. L'étude de la transduction du signal muscarinique cardiaque révèle que les protéines Gi et l'adénylyl cyclase ne sont pas modifiées (ni dans leur expression, ni dans leur fonctionnalité propre). Par contre dans l'oreillette droite, nous montrons une modification de la voie de transduction NO-dépendante (surexpression de la nitric oxide synthase endothéliale (eNOS)) qui concourt à son hyperfonctionnalité. Cette surexpression de la eNOS ne concerne ni l'aorte, ni le ventricule gauche. Cette spécificité tissulaire illustre l'existence de particularités physiopathologiques de I'HTA associée à l'obésité
Intra-observer, inter-experiment and inter-observer variability of left ventricular volumes and mass measurements in mice using an 11.7 Tesla MRI by Laetitia Vanhoutte( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Erratum to: High field magnetic resonance imaging of rodents in cardiovascular research by Laetitia Vanhoutte( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Statins and Hypertension( )

1 edition published in 2005 in English and held by 2 WorldCat member libraries worldwide

Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart by Anne Van Steenbergen( )

1 edition published in 2021 in English and held by 2 WorldCat member libraries worldwide

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation by Roselle Gélinas( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

High field magnetic resonance imaging of rodents in cardiovascular research by Laetitia Vanhoutte( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Nitric oxide( Book )

1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide

<> by Michael Horckmans( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Living Donor Liver Transplantation in Children( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract : Objectives: To evaluate the outcome of pediatric living donor liver transplantation (LDLT) regarding portal vein (PV) reconstruction, ABO compatibility, and impact of maternal donation on graft acceptance. Background: LDLT and ABO-mismatched transplantation constitute feasible options to alleviate organ shortage in children. Vascular complications of portal hypoplasia in biliary atresia (BA) and acute rejection (AR) are still major concerns in this field. Methods: Data from 250 pediatric LDLT recipients, performed at Cliniques Universitaires Saint-Luc between July 1993 and June 2012, were collected retrospectively. Results were analyzed according to ABO matching and PV complications. Uni- and multivariate analyses were performed to study the impact of immunosuppression, sex matching, and maternal donation on AR rate. Results: Overall, the 10-year patient survival rate was 93.2%. Neither patient or graft loss nor vascular rejection, nor hemolysis, was encountered in the ABO nonidentical patients (n = 58), provided pretransplant levels of relevant isoagglutinins were below 1/16. In BA recipients, the rate of PV complications was lower after portoplasty (4.6%) than after truncal PV anastomosis (9.8%) and to jump graft interposition (26.9%; P = 0.027). In parental donation, maternal grafts were associated with higher 1-year AR-free survival (55.2%) than paternal grafts (39.8%; P = 0.041), but only in BA patients. Conclusions: LDLT, including ABO-mismatched transplantation, constitutes a safe and efficient therapy for liver failure in children. In BA patients with PV hypoplasia, portoplasty seems to constitute the best technique for PV reconstruction. Maternal donation might be a protective factor for AR
Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease by Melanie Ricke-Hoch( )

1 edition published in 2021 in English and held by 1 WorldCat member library worldwide

The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglan-din-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses
Can stress make you relax?( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Handbook of experimental pharmacology( Book )

1 edition published in 2000 in English and held by 1 WorldCat member library worldwide

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract : Activation of the immune system in heart failure (HF) has been recognized for over 20 years. Initially, experimental studies demonstrated a maladaptive role of the immune system. However, several phase III trials failed to show beneficial effects in HF with therapies directed against an immune activation. Preclinical studies today describe positive and negative effects of immune activation in HF. These different effects depend on timing and aetiology of HF. Therefore, herein we give a detailed review on immune mechanisms and their importance for the development of HF with a special focus on commonalities and differences between different forms of cardiomyopathies. The role of the immune system in ischaemic, hypertensive, diabetic, toxic, viral, genetic, peripartum, and autoimmune cardiomyopathy is discussed in depth. Overall, initial damage to the heart leads to disease specific activation of the immune system whereas in the chronic phase of HF overlapping mechanisms occur in different aetiologies
 
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Nitric oxide Nitric oxide Handbook of experimental pharmacology
Covers
Nitric oxideHandbook of experimental pharmacology
Alternative Names
Jean-Luc Balligand onderzoeker

Languages
English (20)

French (2)

German (1)