WorldCat Identities

Can, Sinan 1977-

Overview
Works: 16 works in 21 publications in 3 languages and 177 library holdings
Genres: Personal narratives  History  Drama  Biographies 
Roles: Author, osp, Interviewer, Editor, Researcher
Classifications: DR432, 502.82
Publication Timeline
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Most widely held works about Sinan Can
 
Most widely held works by Sinan Can
Bloedbroeders : verscheurd door het verleden, herenigd in hun zoektocht by Sinan Can( Book )

3 editions published in 2015 in Dutch and held by 80 WorldCat member libraries worldwide

Verhalen en reportages over de Armeense genocide in de nadagen van het Ottomaanse rijk
De Arabische storm : vijf jaar na de lente by Sinan Can( Book )

3 editions published in 2016 in Dutch and held by 66 WorldCat member libraries worldwide

Journalistieke reportage over de ingrijpende politieke veranderingen in de Arabische wereld sedert 2011 aan de hand van gesprekken met 'gewone' Arabieren
Bloedbroeders( Visual )

1 edition published in 2015 in Dutch and held by 11 WorldCat member libraries worldwide

Een Nederlandse journalist van Turkse afkomst en een Nederlandse acteur van Armeense afkomst bespreken tijdens een reis door de regio het Armeense standpunt dat '1915' een genocide betrof en de Turkse ontkenning daarvan
Sonsuz( Visual )

1 edition published in 2010 in Turkish and held by 3 WorldCat member libraries worldwide

13 yaşında töre cinayeti yüzünden hapise girmiş olan Serhan, kanser hastalığı nedeniyle yattığı hastanede Volkan'la tanışır. Volkan, dj'lik yapmakta olduğu barda çalışan Tuğçe'ye yakınlık duyunca, bar sahibi Cihan ile çatışır. Cihan, sert karakterli birisi olmasına rağmen sanatın her türüne tutkun bir adamdır. Hayatındaki en büyük hayali bir kitabı olmasıdır. Volkan, Serhan'a son günlerini güzel yaşatmaya çalışırken Cihan'ın gölgesi üzerlerinde olacaktır
Directionality of dynein is controlled by the angle and length of its stalk by Sinan Can( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Uitgezet( Visual )

1 edition published in 2013 in Dutch and held by 2 WorldCat member libraries worldwide

Vierdelige documentaireserie over het lot van uitgezette asielkinderen: hoe is het kinderen uit Irak, Afghanistan, Angola, Armenië en Kosovo vergaan na hun uitzetting, is het goed met hen gekomen zoals politiek verantwoordelijke bestuurders veronderstelden?
Macht aan de beveiligers( Visual )

1 edition published in 2011 in Dutch and held by 1 WorldCat member library worldwide

Vanuit de samenleving komt er een steeds grotere roep om onze straten en wijken veiliger te krijgen, maar de politie kan het niet aan. Daarom surveilleren er steeds vaker particuliere beveiligers door woonwijken, ze houden toezicht in winkels en ze worden ingehuurd om grote evenementen te beveiligen. Inmiddels is het aantal beveiligers uitgegroeid tot 30.000, evenveel als er politieagenten op straat lopen. Minister Opstelten en staatssecretaris Teeven van Veiligheid en Justitie, willen de samenwerking met de beveiligingsbedrijven verder uitbreiden
Bilgelerin yolunda by Sadık K Tural( Book )

1 edition published in 2000 in English and held by 1 WorldCat member library worldwide

Directionality of dynein is controlled by the angle and length of its stalk by Sinan Can( )

1 edition published in 2019 in Undetermined and held by 1 WorldCat member library worldwide

The ability of cytoskeletal motors to move unidirectionally along filamentous tracks is central to their role in cargo transport, motility and cell division. Kinesin and myosin motor families have a subclass that moves towards the opposite end of the microtubule or actin filament with respect to the rest of the motor family1,2, whereas all dynein motors that have been studied so far exclusively move towards the minus end of the microtubule3. Guided by cryo-electron microscopy and molecular dynamics simulations, we sought to understand the mechanism that underpins the directionality of dynein by engineering a Saccharomyces cerevisiae dynein that is directed towards the plus end of the microtubule. Here, using single-molecule assays, we show that elongation or shortening of the coiled-coil stalk that connects the motor to the microtubule controls the helical directionality of dynein around microtubules. By changing the length and angle of the stalk, we successfully reversed the motility towards the plus end of the microtubule. These modifications act by altering the direction in which the dynein linker swings relative to the microtubule, rather than by reversing the asymmetric unbinding of the motor from the microtubule. Because the length and angle of the dynein stalk are fully conserved among species, our findings provide an explanation for why all dyneins move towards the minus end of the microtubule
De Arabische storm : vijf jaar na de lente( Visual )

1 edition published in 2016 in Dutch and held by 1 WorldCat member library worldwide

Vijf jaar na de Arabische Lente onderzoekt journalist Sinan Can hoe de revolutie van hoop tot chaos en strijd heeft geleid. Van de zelfontbranding van Mohammed Bouazizi in Tunesië naar de frontlinie van Syrië. In 3 delen reist Can naar het hart van het conflict om de gevolgen van de opstanden bloot te leggen
Onderduiken met illegalen( Visual )

1 edition published in 2012 in Dutch and held by 1 WorldCat member library worldwide

Nederland voert al jaren een keihard vreemdelingenbeleid. Iedere dag worden er tientallen vreemdelingen door de Nederlandse overheid op straat gezet. Ze zijn uitgeprocedeerd en moeten het land uit, terug naar hun eigen land. Eenmaal op straat zijn ze illegaal. Vaak kunnen ze ook niet terug naar het herkomst land. Hun land is niet veilig of laat ze niet meer toe. Met als gevolg dat ze weer worden opgepakt en soms voor langere tijd worden opgesloten zonder dat ze veroordeeld zijn voor strafbare feiten. Nederland moet namelijk zo onaangenaam worden zodat vreemdelingen het wel uit hun hoofd laten om hier te blijven
Gameverslaafd( Visual )

1 edition published in 2008 in Dutch and held by 1 WorldCat member library worldwide

Door de stormachtige opmars van online computergames groeit het aantal mensen dat bijna niks anders doet dan gamen. Voor de meesten is gamen een leuke hobby, maar voor sommigen is het geen spelletje meer. Ze eten, slapen en drinken te weinig, verwaarlozen school en werk en hebben weinig sociale contacten. Van elke tien gamers is er één gameverslaafd. In deze uitzending komen spelers en ex-spelers aan het woord over een door de gezondheidszorg nog niet officieel erkende vorm van verslaving
Directionality of dynein is controlled by the angle and length of its stalk by Sinan Can( )

1 edition published in 2019 in Undetermined and held by 1 WorldCat member library worldwide

The ability of cytoskeletal motors to move unidirectionally along filamentous tracks is central to their role in cargo transport, motility and cell division. Kinesin and myosin motor families have a subclass that moves towards the opposite end of the microtubule or actin filament with respect to the rest of the motor family1,2, whereas all dynein motors that have been studied so far exclusively move towards the minus end of the microtubule3. Guided by cryo-electron microscopy and molecular dynamics simulations, we sought to understand the mechanism that underpins the directionality of dynein by engineering a Saccharomyces cerevisiaedynein that is directed towards the plus end of the microtubule. Here, using single-molecule assays, we show that elongation or shortening of the coiled-coil stalk that connects the motor to the microtubule controls the helical directionality of dynein around microtubules. By changing the length and angle of the stalk, we successfully reversed the motility towards the plus end of the microtubule. These modifications act by altering the direction in which the dynein linker swings relative to the microtubule, rather than by reversing the asymmetric unbinding of the motor from the microtubule. Because the length and angle of the dynein stalk are fully conserved among species, our findings provide an explanation for why all dyneins move towards the minus end of the microtubule
THE MECHANICS OF DYNEIN STEPPING AND DIRECTIONALITY by Sinan Can( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

The ability of cytoskeletal motors to move unidirectionally along linear tracks is central to their cellular roles. While kinesin and myosin motor families have members that move in opposite directions, all dyneins studied to date exclusively move towards the microtubule minus-end. The source of dynein’s directionality remains as the central unresolved question about the mechanism of its motility. In my doctoral work, I focused on understanding the underlying mechanism of dynein’s directional motility along the microtubules in three dimensions. I used a protein engineering approach, guided by all-atom molecular dynamics simulations and high-resolution cryoEM imaging, along with the tools of single-molecule biophysics to dissect the elements of dynein motility. We successfully engineered a plus-end-directed dynein for the first time and revealed the mechanism of its directionality. This work has three major outcomes. First, by altering the length of the coiled-coil stalk that connects the dynein motor domain to the microtubule, we controlled the handedness of the helical motility of dynein around the circumference of the microtubule. This experiment showed that the stalk length of native dynein is critical for restricting sideways movement and directing dynein motility along the microtubule axis. Second, we altered the angle and length of dynein’s stalk. Remarkably, these modifications reversed the direction by which the linker swings relative to the microtubule and directed the motility towards the plus-end. Finally, similar to native dynein, the plus-end directed mutant maintains its preference to release from the microtubule when pulled towards the minus-end by an optical trap. Our results provide direct evidence for the linker swing model in which the direction the linker swings determines the direction of dynein motility. Our results also rule out the asymmetric release model that the directionality is proposed to be determined by the direction dynein favors for
Bidirectional helical motility of cytoplasmic dynein around microtubules by Sinan Can( )

1 edition published in 2014 in Undetermined and held by 1 WorldCat member library worldwide

Cytoplasmic dynein is a molecular motor responsible for minus-end-directed cargo transport along microtubules (MTs). Dynein motility has previously been studied on surface-immobilized MTs in vitro, which constrains the motors to move in two dimensions. In this study, we explored dynein motility in three dimensions using an MT bridge assay. We found that dynein moves in a helical trajectory around the MT, demonstrating that it generates torque during cargo transport. Unlike other cytoskeletal motors that produce torque in a specific direction, dynein generates torque in either direction, resulting in bidirectional helical motility. Dynein has a net preference to move along a right-handed helical path, suggesting that the heads tend to bind to the closest tubulin binding site in the forward direction when taking sideways steps. This bidirectional helical motility may allow dynein to avoid roadblocks in dense cytoplasmic environments during cargo transport
Bidirectional helical motility of cytoplasmic dynein around microtubules by Sinan Can( )

1 edition published in 2014 in Undetermined and held by 1 WorldCat member library worldwide

Cytoplasmic dynein is a molecular motor responsible for minus-end-directed cargo transport along microtubules (MTs). Dynein motility has previously been studied on surface-immobilized MTs in vitro, which constrains the motors to move in two dimensions. In this study, we explored dynein motility in three dimensions using an MT bridge assay. We found that dynein moves in a helical trajectory around the MT, demonstrating that it generates torque during cargo transport. Unlike other cytoskeletal motors that produce torque in a specific direction, dynein generates torque in either direction, resulting in bidirectional helical motility. Dynein has a net preference to move along a right-handed helical path, suggesting that the heads tend to bind to the closest tubulin binding site in the forward direction when taking sideways steps. This bidirectional helical motility may allow dynein to avoid roadblocks in dense cytoplasmic environments during cargo transport
 
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Alternative Names
Sinan Can Dutch journalist

Sinan Can giornalista neerlandese

Sinan Can jornalista neerlandês

Sinan Can journaliste néerlandais

Sinan Can periodista neerlandés

Սինան Ջան թուրքական ծագմամբ հոլանդացի լրագրող և կինոռեժիսոր

Languages
Dutch (13)

English (3)

Turkish (1)