Williams, Gordon H.

Clinical and translational science : principles of human research by David Robertson( )

28 editions published between 2008 and 2017 in English and Spanish and held by 1,336 WorldCat member libraries worldwide

Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. This book is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science

Textbook of nephro-endocrinology by Ajay Singh( )

22 editions published between 2008 and 2018 in English and Spanish and held by 1,240 WorldCat member libraries worldwide

Annotation

Quality of life under antihypertensive treatment : satellite symposium of the eleventh scientific meeting of the International Society of Hypertension, 6 September 1986, Heidelberg, Federal Republic of Germany( Book )

2 editions published in 1987 in English and held by 10 WorldCat member libraries worldwide

Clinical and Translational Science: Principles of Human Research, Second Edition( Book )

1 edition published in 2017 in English and held by 5 WorldCat member libraries worldwide

The evolving role of angiotensin-II receptor blockers in cardiovascular risk reduction( Book )

2 editions published in 1998 in English and held by 5 WorldCat member libraries worldwide

The evolving role of angiotensin-II receptor blockers in cardiovascular risk reduction [these issues formed the focus of an interactive clinical case study Conference Titled "The Evolving Role of A-II Receptor Blockers in Cardiovascular Risk Reduction" held November 8, 1997, in Orlando, Florida]( Book )

1 edition published in 1998 in English and held by 2 WorldCat member libraries worldwide

Aldosterone: The Missing Cardiorenal Link by Gordon H Williams( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

A genome-wide association search for type 2 diabetes genes in African Americans by Nicholette D Palmer( )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10( -8)). SNP rs7560163 (P = 7.0×10( -9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10( -5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations

Adrenal cortex( Book )

1 edition published in 1998 in English and held by 1 WorldCat member library worldwide

Lin chuang yu zhuan hua yi xue : yan jiu ji ben yuan ze = Clinical and translation science : principles of human research( Book )

1 edition published in 2015 in Chinese and held by 1 WorldCat member library worldwide