Itzstein, Mark von
Overview
| Works: | 26 works in 87 publications in 2 languages and 2,502 library holdings |
|---|---|
| Genres: | Field guides |
| Roles: | Editor, Author, wpr, Publishing director, Contributor, htt, Other |
Publication Timeline
.
Most widely held works by
Mark von Itzstein
Microbial glycobiology : structures, relevance and applications by
Anthony P Moran(
)
15 editions published in 2009 in English and held by 1,456 WorldCat member libraries worldwide
This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. Key Features and Benefits * Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews. - Provides researchers with an overview and synthesis of the latest research * Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed. - Allows researchers to see at a glance what each chapter will cover * Each chapter includes a Research Focus Box - Identifies important problems that still need to be solved and areas that require further investigation
15 editions published in 2009 in English and held by 1,456 WorldCat member libraries worldwide
This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. Key Features and Benefits * Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews. - Provides researchers with an overview and synthesis of the latest research * Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed. - Allows researchers to see at a glance what each chapter will cover * Each chapter includes a Research Focus Box - Identifies important problems that still need to be solved and areas that require further investigation
Sialoglyco chemistry and biology by
Rita Gerardy-Schahn(
)
23 editions published in 2015 in English and held by 550 WorldCat member libraries worldwide
The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students
23 editions published in 2015 in English and held by 550 WorldCat member libraries worldwide
The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students
Influenza virus sialidase : a drug discovery target by
Mark von Itzstein(
)
18 editions published between 2011 and 2014 in English and held by 424 WorldCat member libraries worldwide
Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic
18 editions published between 2011 and 2014 in English and held by 424 WorldCat member libraries worldwide
Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic
SialoGlyco chemistry and biology(
)
9 editions published in 2015 in English and held by 30 WorldCat member libraries worldwide
The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students
9 editions published in 2015 in English and held by 30 WorldCat member libraries worldwide
The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students
SialoGlyco chemistry an biology(
Book
)
1 edition published in 2015 in English and held by 9 WorldCat member libraries worldwide
1 edition published in 2015 in English and held by 9 WorldCat member libraries worldwide
Praxishandbuch Influenza verstehen, vorbeugen, erkennen und behandeln ; 7 Tabellen by
Georg E Vogel(
Book
)
1 edition published in 2011 in German and held by 9 WorldCat member libraries worldwide
1 edition published in 2011 in German and held by 9 WorldCat member libraries worldwide
A New Facile Synthesis of C-4 Nitrogen-Containing Derivatives of KDN2en and KDO2en(
)
1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide
Glycointeractions in bacterial pathogenesis by Jessica Poole(
)
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
Unravelling the Role of O-glycans in Influenza A Virus Infection by Juliane Mayr(
)
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone by Tina S Skinner-Adams(
)
1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide
Synthesis of C-4 Halogen-Substituted Derivatives of Neu5Ac2en and KDN2en(
)
1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide
Rational design of potent sialidase-based inhibitors of influenza virus replication by
Mark von Itzstein(
)
1 edition published in 1993 in Undetermined and held by 1 WorldCat member library worldwide
Yes
1 edition published in 1993 in Undetermined and held by 1 WorldCat member library worldwide
Yes
Rapid access to uronic acid-based mimetics of Kdn2en from D-glucurono-6,3-lactone by
Mark von Itzstein(
)
1 edition published in 2000 in Undetermined and held by 1 WorldCat member library worldwide
In order to prepare 3-aminopropyl glycosides of Neu5Ac-"-(2 62)-lactosamine trisaccharide 1, and its N-glycolyl containing analogue Neu5Gc-"-(2 62)-lactosamine 2, a series of lactosamine acceptors with two, three, and four free OH groups in the galactose residue was studied in glycosylations with a conventional sialyl donor phenyl [methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio--glycero-"--And ²--galacto-2-nonulopyranosid]onates (3) and a new donor phenyl [methyl 4,7,8,9-tetra-O-acetyl-5-(N-tert-butoxycarbonylacetamido)-3,5-dideoxy-2-thio--glycero-"--and ²--galacto-2-nonulopyranosid]onates (4), respectively. The lactosamine 42,62-diol acceptor was found to be the most efficient in glycosylation with both 3 and 4, while imide-type donor 4 gave slightly higher yields with all acceptors, and isolation of the reaction products was more convenient. In the trisaccharides, obtained by glycosylation with donor 4, the 5-(N-tert-butoxycarbonylacetamido) moiety in the neuraminic acid could be efficiently transformed into the desired N-glycolyl fragment, indicating that such protected oligosaccharide derivatives are valuable precursors of sialo-oligosaccharides containing N-modified analogues of Neu5Ac
1 edition published in 2000 in Undetermined and held by 1 WorldCat member library worldwide
In order to prepare 3-aminopropyl glycosides of Neu5Ac-"-(2 62)-lactosamine trisaccharide 1, and its N-glycolyl containing analogue Neu5Gc-"-(2 62)-lactosamine 2, a series of lactosamine acceptors with two, three, and four free OH groups in the galactose residue was studied in glycosylations with a conventional sialyl donor phenyl [methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio--glycero-"--And ²--galacto-2-nonulopyranosid]onates (3) and a new donor phenyl [methyl 4,7,8,9-tetra-O-acetyl-5-(N-tert-butoxycarbonylacetamido)-3,5-dideoxy-2-thio--glycero-"--and ²--galacto-2-nonulopyranosid]onates (4), respectively. The lactosamine 42,62-diol acceptor was found to be the most efficient in glycosylation with both 3 and 4, while imide-type donor 4 gave slightly higher yields with all acceptors, and isolation of the reaction products was more convenient. In the trisaccharides, obtained by glycosylation with donor 4, the 5-(N-tert-butoxycarbonylacetamido) moiety in the neuraminic acid could be efficiently transformed into the desired N-glycolyl fragment, indicating that such protected oligosaccharide derivatives are valuable precursors of sialo-oligosaccharides containing N-modified analogues of Neu5Ac
Disease-associated carbohydrate-recognising proteins and structure-based inhibitor design by
Mark von Itzstein(
)
1 edition published in 2008 in Undetermined and held by 1 WorldCat member library worldwide
Yes
1 edition published in 2008 in Undetermined and held by 1 WorldCat member library worldwide
Yes
Future potential of glycomics in microbiology and infectious diseases by
Mark von Itzstein(
)
1 edition published in 2009 in Undetermined and held by 1 WorldCat member library worldwide
Yes
1 edition published in 2009 in Undetermined and held by 1 WorldCat member library worldwide
Yes
Anti-influenza Drugs: The development of sialidase inhibitors by
Mark von Itzstein(
)
1 edition published in 2009 in Undetermined and held by 1 WorldCat member library worldwide
Yes
1 edition published in 2009 in Undetermined and held by 1 WorldCat member library worldwide
Yes
A one-pot synthesis of novel N, N-dialkyl-S-glycosylsulfenamides by
Mark von Itzstein(
)
1 edition published in 2000 in Undetermined and held by 1 WorldCat member library worldwide
Yes
1 edition published in 2000 in Undetermined and held by 1 WorldCat member library worldwide
Yes
The war against influenza: discovery and development of sialidase inhibitors by
Mark von Itzstein(
)
1 edition published in 2007 in Undetermined and held by 1 WorldCat member library worldwide
The threat of a major human influenza pandemic, in particular from highly aggressive strains such as avian H5N1, has emphasized the need for therapeutic strategies to combat these pathogens. At present, two inhibitors of sialidase (also known as neuraminidase), a viral enzyme that has a key role in the life cycle of influenza viruses, would be the mainstay of pharmacological strategies in the event of such a pandemic. This article provides a historical perspective on the discovery and development of these drugs -- zanamivir and oseltamivir -- and highlights the value of structure-based drug design in this process
1 edition published in 2007 in Undetermined and held by 1 WorldCat member library worldwide
The threat of a major human influenza pandemic, in particular from highly aggressive strains such as avian H5N1, has emphasized the need for therapeutic strategies to combat these pathogens. At present, two inhibitors of sialidase (also known as neuraminidase), a viral enzyme that has a key role in the life cycle of influenza viruses, would be the mainstay of pharmacological strategies in the event of such a pandemic. This article provides a historical perspective on the discovery and development of these drugs -- zanamivir and oseltamivir -- and highlights the value of structure-based drug design in this process
Avian influenza virus, a very sticky situation by
Mark von Itzstein(
)
1 edition published in 2008 in Undetermined and held by 1 WorldCat member library worldwide
Yes
1 edition published in 2008 in Undetermined and held by 1 WorldCat member library worldwide
Yes
Bromohydroxylation of glycals - an investigation into the reaction of some 4-N-acylated derivatives of methyl 5-acetamido-7,
8, 9 tri-O acetyl-2, 6-anhydro-3, 4, 5-trideoxy-D-glycero-D-galacto-non-2-enonate and its 4-epimer by
Mark von Itzstein(
)
1 edition published in 2001 in Undetermined and held by 1 WorldCat member library worldwide
Yes
1 edition published in 2001 in Undetermined and held by 1 WorldCat member library worldwide
Yes
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Audience Level
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Related Identities
- Moran, Anthony P. Author Editor
- Holst, Otto Editor
- Brennan, Patrick J. Ph. D. Editor
- Delannoy, Philippe (Philippe Robert) 1956- Publishing director Editor
- Gerardy-Schahn, Rita Publishing director Author Editor
- Gerardy-Schahn, Rita Editor
- Bazhenov, A. (Alexey)
- Ernst, Beat
- Delannoy, Philippe Editor
- Manych, Matthias Contributor
Useful Links
Associated Subjects
Biochemistry Biomedical materials Bioorganic chemistry Chemistry Cytology Drugs--Design Drug targeting Emerging infectious diseases Glycomics Glycosylation Immunology Influenza vaccines Influenza viruses Medical virology Medicine Pathogenic microorganisms Pathogenic microorganisms--Identification Pharmaceutical chemistry Pharmacology Sialic acids Sialic acids--Physiological effect Toxicology Virology
