WorldCat Identities

Kadomatsu, Kenji

Overview
Works: 19 works in 24 publications in 2 languages and 226 library holdings
Roles: Other, Contributor, Editor, htt
Classifications: R1, 616.6
Publication Timeline
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Most widely held works by Kenji Kadomatsu
Glycoscience : basic science to applications : insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG)( )

6 editions published in 2019 in English and held by 194 WorldCat member libraries worldwide

This book presents the state of the art in glycoscience and proposes a road map for the coming decade, focusing on the potential of glycoscience research to shed light on important basic science issues and give rise to exciting new applications, especially in the field of diagnosis and therapeutics. Individual sections offer in-depth coverage of various topics relating to glycans and biopharmaceuticals, glycans in medical science and medicine, glycan technologies, glycans in food and nutrients, and glycan-related materials and their uses. In addition, the book presents an exemplary training course on glycomics and highlights educational and analytical web resources, and also includes glossaries and boxes summarizing key facts to ensure ease of understanding for non-expert readers and students. Written by more than 150 active participants in the Japan Consortium for Glycobiology and Glycotechnology (JCGG), whose goal is to promote the development of interdisciplinary glycoscience and establish a global network in the field, it is a valuable resource for students, postdocs, and researchers in the life sciences as well as for stakeholders and professionals in government, funding agencies and industry
Tosa seibutsugaku : Seimei gensho to tosa joho( Book )

1 edition published in 2020 in Japanese and held by 4 WorldCat member libraries worldwide

Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin by Kiyonari Katō( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Compositional analysis of the glycosaminoglycan family in velvet antlers of Sika deer (Cervus nippon) at different growing stages by Naoko Takeda-Okuda( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma by Wan-Ling Ho( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Efficacy of urinary midkine as a biomarker in patients with acute kidney injury by Hiroki Hayashi( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases by Yoshiko Mori( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain by Narentuya( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Keratan Sulfate Regulates the Switch from Motor Neuron to Oligodendrocyte Generation During Development of the Mouse Spinal Cord by Hirokazu Hashimoto( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury by Yoshio Funahashi( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury by Ryoji Tauchi( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

<> by Kazuma Sakamoto( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Origin and initiation mechanisms of neuroblastoma by Shoma Tsubota( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

CD147/Basigin Limits Lupus Nephritis and Th17 Cell Differentiation in Mice by Inhibiting the Interleukin-6/STAT-3 Pathway( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract Objective Interleukin-17 (IL-17)-producing T cells (Th17 cells) play critical roles in the pathogenesis of immune-related diseases, including systemic lupus erythematosus. However, the fundamental mechanism regulating Th17 cell differentiation is not fully understood. Recently, we demonstrated that plasma levels of CD147/basigin (Bsg) in patients with lupus nephritis (LN) were closely associated with disease activity. but the molecular mechanism involving Bsg has been elusive. Here, we addressed the role of Bsg in the pathogenesis of LN. Methods Injections of pristane (2, 6, 10, 14-tetramethylpentadecane [TMPD]) were administered to Bsg−/− or Bsg+/+ mice to induce LN. The mice were killed 6 months after being injected, for histologic and biochemical analyses of the kidneys and spleens. Results Pristane induced LN more strikingly in Bsg−/− mice than in Bsg+/+ mice, even though humoral autoimmunity was similarly increased in both genotypes. The increased number of Th17, but not Th1, Treg cells, was augmented in Bsg−/− mice. The expression of IL-17 was also increased in the kidneys of Bsg−/− mice, in proportion to LN disease activity. Furthermore, treatment with anti-IL-17 antibody reduced LN disease activity in Bsg−/− mice. Complementary to these phenotypes of Bsg−/− mice, Bsg expression was enhanced in activated CD4+ T cells in vivo and in vitro. Bsg deficiency selectively augmented in vitro differentiation of naive CD4+ T cells to Th17 cells and STAT-3 phosphorylation during this differentiation. Moreover, STAT-3 phosphorylation was suppressed by crosslinking of Bsg with its antibody. Conclusion Bsg plays an indispensable role in Th17 cell differentiation as a negative regulator by suppressing the IL-6/STAT-3 pathway
Involvement of midkine in the development of pulmonary fibrosis( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Dual inhibition of P-glycoprotein and midkine may increase therapeutic effects of anticancer drugs( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract: Multidrug resistance (MDR) to chemotherapy may significantly affect the outcome of cancer treatment. ATP-dependent drug efflux pumps, including P-glycoprotein (P-gp), contribute to the resistance of various chemotherapeutic agents. Overexpression of P-gp in tumor cells induces chemoresistance via pumping the anticancer drugs out of the cells. In addition to taking part in many biological processes such as development, reproduction and repair, midkine (MK) also plays important roles in the pathogenesis of malignant diseases as well as in the regulation of MDR. Although, the mechanisms of action of P-gp and MK are different, overexpression of both proteins prevents the accumulation of many chemotherapeutics in tumor cells, leading to decreased therapeutic effects of anticancer drugs. Therefore, identification of the result of dual inhibition of P-gp and MK in overcoming chemoresistance may enhance the likelihood for a more efficient chemotherapy
A combination of keratan sulfate digestion and rehabilitation promotes anatomical plasticity after rat spinal cord injury( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Highlights: KS-digestion plus rehabilitation was evaluated in a spinal cord injury model. KS-digestion/rehabilitation tended to improve functional plasticity. KS-digestion and rehabilitation synergistically improved anatomical plasticity. This effect was comparable with that of CS-digestion/rehabilitation. KS-digestion/rehabilitation might widen the therapeutic window of neuronal injury. Abstract: Functional recovery after neuronal injuries relies on neuronal network reconstruction which involves many repair processes, such as sealing of injured axon ends, axon regeneration/sprouting, and construction and refinement of synaptic connections. Chondroitin sulfate (CS) is a major inhibitor of axon regeneration/sprouting. It has been reported that the combination of task-specific rehabilitation and CS-digestion is much more effective than either treatment alone with regard to the promotion of functional and anatomical plasticity for dexterity in acute and chronic spinal cord injury models. We previously reported that keratan sulfate (KS) is another inhibitor and has a potency equal to CS. Here, we compared the effects of KS- or CS-digestion plus rehabilitation on recovery from spinal cord injury. Keratanase II or chondroitinase ABC was locally administered at the lesion after spinal cord injury at C3/4. Task-specific rehabilitation training, i.e., a single pellet reaching task using a Whishaw apparatus, was done for 3 weeks before injury, and then again at 1-6 weeks after injury. The combination of KS-digestion and rehabilitation yielded a better rate of pellet removal than either KS-digestion alone or rehabilitation alone, although these differences were not statistically significant. The combination of CS-digestion and rehabilitation showed similar results. Strikingly, both KS-digestion/rehabilitation and CS-digestion/rehabilitation showed significant increases in neurite growth in vivo as estimated by 5-hydroxytryptamine and GAP43 staining. Thus, KS-digestion and rehabilitation exerted a synergistic effect on anatomical plasticity, and this effect was comparable with that of CS-digestion/rehabilitation. KS-digestion might widen the therapeutic window of spinal cord injury if combined with rehabilitation
Tōsa seibutsugaku : seimei genshō to tōsa jōhō( Book )

1 edition published in 2020 in Japanese and held by 1 WorldCat member library worldwide

 
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Audience level: 0.57 (from 0.51 for Glycoscien ... to 0.99 for Glycoscien ...)

Alternative Names
Kadomatsu, Kenji

カドマツ, ケンジ

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