WorldCat Identities

Lewis, Russell J.

Overview
Works: 26 works in 64 publications in 1 language and 2,728 library holdings
Roles: Author
Classifications: RC1054.U5,
Publication Timeline
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Most widely held works by Russell J Lewis
A novel method for the determination of sildenafil (Viagra) and its metabolite (UK-103,320) in postmortem specimens using LC/MS/MS and LC/MS/MS/MS : final report by Russell J Lewis( Book )

3 editions published in 2000 in English and held by 193 WorldCat member libraries worldwide

Formation of an interfering substance, 3,4-dimethyl-5-phenyl-1,3-oxazolidine, during a pseudoephedrine urinalysis( Book )

5 editions published in 1999 in English and held by 192 WorldCat member libraries worldwide

During fatal aviation accident investigations, bio-samples from the victims are submitted to the FAA Civil Aeromedical Institute for drug analysis. In the process of one such analysis, an unknown substance was found in a urine sample. Its initial analyses by thin layer chromatography and by liquid-liquid extraction/gas chromatography (GC) disclosed the presence of pseudoephedrine. Subsequent analyses of the reaccessioned sample by solid phase separation/GC Fourier transform infrared/GC mass spectrometry indicated that the retention times of the unknown substance matched with those of pseudoephedrine. However, its infrared and mass spectra were different-the -OH and -NH- groups were missing, a C-O-C group was present, and the molar mass was 12 atomic mass units (amu) more than that of pseudoephedrine. A subsequent literature search suggested that ephedrine-like amines react with aldehydes to form oxazolidines. Therefore, the 12-amu increase could be accounted for by condensation of pseudoephedrine with formaldehyde. Since this aldehyde is present in various grades of methanol, and methanol was used during the solid phase separation, 3,4-dimethyl-5-phenyl-1,3-oxazolidine was synthesized by using (+)-pseudoephedrine-HCl and formaldehyde. The analytical and spectral findings of the synthesized compound were consistent with those of the unknown interfering substance, confirming that it was the oxazolidine. Aldehyde contaminants can transform the drug of interest and may result in misidentification of a compound not originally present in specimens. Therefore, chemicals used in analyses should be of the highest available purity, and a multianalytical approach should be adopted to maintain a high degree of quality assurance
Postmortem concentrations of Tramadol and O-Desmethyltramadol in 11 aviation accident fatalities( Book )

3 editions published in 2010 in English and held by 35 WorldCat member libraries worldwide

"Tramadol is a centrally acting analgesic used to treat moderate-to-severe pain. Side effects of this medication include dizziness, confusion, drowsiness, seizures, and respiratory depression. Any of these side effects could negatively affect a pilot's performance and become a factor in an aviation accident. Due to the severity of aviation accidents, blood samples are often not available, and frequently, only tissue specimens are available for analysis. Therefore, understanding the distribution of a drug throughout all fluids and tissues of the body is important when trying to interpret drug impairment and/or intoxication. Our laboratory has determined the distribution of tramadol and its main active metabolite, O-desmethyltramadol, in various postmortem tissues and fluids obtained from 11 fatal aviation accident cases. Whole blood tramadol concentrations obtained from these 11 cases ranged from 81-2720 ng/mL. When available, 10 specimen types were analyzed for each case, including blood, urine, vitreous humor, liver, lung, kidney, spleen, muscle, heart, and brain. Distribution, expressed as specimen/blood ratio, for tramadol was 69 ± 74 in urine, 2.58 ± 3.26 in vitreous humor, 4.90 ± 3.32 in liver, 3.43 ± 2.31 in lung, 3.05 ± 1.49 in kidney, 5.15 ± 2.66 in spleen, 1.18 ± 0.85 in muscle, 2.33 ± 1.21 in brain, and 1.89 ± 1.01 in heart. Distribution coefficients obtained had coefficient of variations (CV) ranging from 49-126%. With such large CV's, the distribution coefficients have little use in predicting blood concentrations from the analysis of a tissue specimen. This study indicates that tramadol concentrations undergo significant postmortem changes."--Report documentation page
Distribution of oxycodone in postmortem fluids and tissues by Sabra R Botch( Book )

2 editions published in 2010 in English and held by 35 WorldCat member libraries worldwide

Oxycodone is a heavily used and abused analgesic agent. Its pharmacological effects, including euphoria, respiratory depression, nausea, and drowsiness, have the potential to adversely affect performance. The postmortem distribution of oxycodone has not been well characterized, particularly at sub-lethal levels. Therefore, an attempt was made to evaluate the distribution of oxycodone in postmortem specimens collected from aviation accidents. Methods: A search of our database identified 4 oxycodone-positive fatalities from separate civil aviation accidents that occurred during a period of 6 years that had numerous biological tissues and fluids available (blood, urine, vitreous humor, liver, kidney, skeletal muscle, lung, spleen, heart muscle, and brain). These specimens were extracted using solid-phase extraction and were analyzed for oxycodone by GC/MS. Results: Oxycodone concentration ranges (g/mL, g/g) found in the different tissues and fluids were: blood 0.027-0.742, urine 2.20 - 12.5, vitreous humor 0.048 - 0.118, liver 0.103-3.35, lung 0.047-1.35, kidney 0.045-3.12, spleen 0.115-2.43, muscle 0.017-0.400, brain 0.032-1.36, and heart 0.038-3.19. Conclusion: The blood concentrations found indicate that the oxycodone in these cases ranged from therapeutic to above therapeutic, but all were below lethal levels. Tissue/fluid to blood distribution coefficients were found to have large coefficients of variation (ranging from 26-128%), thereby rendering them unreliable for estimating a blood oxycodone concentration from a tissue value when no blood is available for analysis
Distribution of butalbital in biological fluids and tissues by Russell J Lewis( Book )

3 editions published in 2000 in English and held by 34 WorldCat member libraries worldwide

An accurate method for the determination of carbon monoxide in postmortem blood using GC/TCD by Russell J Lewis( Book )

4 editions published in 2002 in English and held by 34 WorldCat member libraries worldwide

During the investigation of aviation accidents, postmortem samples from accident victims are submitted to the FAA's Civil Aerospace Medical Institute for toxicological analysis. To determine if the accident victim was exposed to an in-flight/post crash fire or faulry heating/exhaust system, the analysis of carbon monoxide (CO) is conducted. While our laboratory predominantly uses a spectrophotometric method for the determination of carboxyhemoglobin (COHb), we consider it essential to confirm with a second technique based on a different analytical principle. Our laboratory encountered difficulties with many of our postmortem samples while employing a commonly used CC method. We believed these problems were due to elevated methemoglobin (MetHb) concentration in our specimens. MetHb does not bind CO, thus elevated MetHb levels will result in a loss of CO binding capacity. Since most commonly employed CC methods determine %COHb from a ratio of unsaturated blood to CO-saturated blood, a loss of CO binding capacity will result in an erroneously high %COHb value. Our laboratory has developed a new CC method for the determination of %COHb that incorporates sodium dithionite, which will reduce any MetHb present to Hb. Using numerous fresh human blood controls ranging from 1% to 67% COHb, we found no statistically significant differences between %COHb results from our new CC method and our spectrophotometric method. We then applied our new CC method to putrefied and non-putrefied postmortem samples. To validate the new CC method, postmortem samples were analyzed with our existing spectrophotometric method, a CC method commonly used without reducing agent, and our new CC method with the addition of sodium dithionite. As expected, we saw errors up to and exceeding 50% when comparing the unreduced CC results with our spectrophotometric method. With our new CC procedure, which incorporates a reducing agent, the error was virtually eliminated
The distribution of fluoxetine and norfluoxetine in postmortem fluids and tissues by Russell J Lewis( Book )

4 editions published in 2007 in English and held by 33 WorldCat member libraries worldwide

During aviation accident investigations, postmortem specimens from the flight crews are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute for toxicological analysis. Our laboratory has determined the distribution of fluoxetine and its desmethyl metabolite, norfluoxetine, in various postmortem tissues and fluids from 10 fatal aviation accident cases. Most cases fell within the expected therapeutic range for patients that regularly take this drug
Identification of Sildenafil (Viagra®) and its metabolite (UK-103,320) in six aviation fatalities by Robert D Johnson( Book )

4 editions published in 2006 in English and held by 33 WorldCat member libraries worldwide

This report presents a rapid and reliable method for the identification and quantitation of sildenafil and its active metabolite UK-103,320 in postmortem fluid and tissue specimens collected from 6 fatal aviation accident victims. The FAA is responsible for investigating "general aviation and air carrier accidents and search for biomedical and clinical causes of the accidents, including evidence of ... chemical [use]."
Poppy seed consumption or opiate use : the determination of thebaine and opiates of abuse in postmortem fluids and tissues by Robert D Johnson( Book )

5 editions published in 2005 in English and held by 32 WorldCat member libraries worldwide

Opiates are some of the most widely prescribed drugs in America. Some opiate compounds are highly addictive and are often abused. Opiate abuse transcends all social, racial, and economic boundaries. Demonstrating the presence or absence of opiate compounds in postmortem fluids and/or tissues derived from fatal civil aviation accidents can have serious legal consequences and may help determine the cause of impairment and/or death. However, the consumption of poppy seed products can result in a positive opiate drug test. Therefore, the interpretation of positive opiate results must be viewed with caution. We have developed a simple method for the simultaneous determination of 8 opiate compounds from one extraction. These compounds are hydrocodone, dihydrocodeine, codeine, oxycodone, hydromorphone, 6-monoacetylmorphine, morphine, and thebaine. The inclusion of thebaine is notable as it is an indicator of poppy seed consumption and may help explain morphine/codeine positives in cases where no opiate use was indicated. This method incorporates a Zymark RapidTrace automated solid-phase extraction system, gas chromatography/mass spectrometry, and trimethyl silane (TMS) and oxime-TMS derivitives. The limits of detection ranged from 0.78-12.5 ng/mL. The linear dynamic range for most analytes was 6.25-1600 ng/mL. The extraction efficiencies ranged from 70-103%. We applied this method to 8 separate aviation fatalities where opiate compounds had previously been detected. The specimens analyzed for the determination of these 8 opiate compounds were blood, urine, liver, kidney, and skeletal muscle. This method has proven to be simple, robust, and accurate for the simultaneous determination of 8 opiate compounds in postmortem fluids and tissues
Aeromedical aspects of findings from aircraft-assisted pilot suicides in the United States, 1993-2002( Book )

2 editions published in 2006 in English and held by 32 WorldCat member libraries worldwide

This report details the findings of the FAA Civil Aerospace Medical Institute's evaluation of the epidemiological, toxicological, and aeromedical findings from pilots involved in aircraft-assisted suicides. Case histories, accident information, and the declaration of suicide as the probable cause in the aviation accidents were obtained from the National Transportation Safety Board (NTSB). Toxicological information was obtained from the Civil Aerospace Medical Institute's Bioaeronautical Sciences Research Laboratory. Other relevant information was obtained from medical certification data systems
False carbamazepine positives due to 10,11-dihydro-10-hydroxycarbamazepine breakdown in the GC/MS injector port by Robert D Johnson( Book )

3 editions published in 2010 in English and held by 32 WorldCat member libraries worldwide

"During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. A case recently received by CAMI screened positive for the anticonvulsant medication carbamazepine (Tegretol) by gas chromatography/mass spectrometry (GC/MS). The carbamazepine found during the routine screening procedure was subsequently confirmed using a carbamazepine-specific GC/MS procedure. Concurrently, it was discovered that the accident victim had been prescribed oxcarbazepine (Trileptal). Oxcarbazepine is nearly structurally identical to carbamazepine and is metabolized by cytosolic enzymes in the liver to the active compound 10,11-dihydro-10-hydroxycarbamazepine. The carbamazepine initially found in this case was present due to the breakdown of the active oxcarbazepine metabolite in the GC/MS injector port. In the current study this conversion is investigated, the percentage of carbamazepine formed at various injector port temperatures is determined, and these three compounds are quantified in nine fluid and tissue specimens from the case in question. Lastly, liquid chromatography/mass spectrometry (LC/MS) was used to demonstrate the absence of carbamazepine, and its formation, in the same specimens."--Report documentation page
Determination of etomidate in human postmortem fluids and tissues by Robert D Johnson( Book )

3 editions published in 2009 in English and held by 29 WorldCat member libraries worldwide

"Following an aviation accident, biological specimens from the operator of the aircraft are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute for toxicological analysis. During the course of medical treatment following an aviation accident, pilots who later died as a result of their injuries may have been administered etomidate as an intravenous anesthetic. Our laboratory has developed a sensitive method for the identification and quantitation of etomidate in the biological specimens received from these pilots. Furthermore, we have evaluated the distribution of this compound in various postmortem tissues and fluids from 3 fatal aviation accident cases."--Report documentation page
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS by Robert D Johnson( Book )

4 editions published in 2005 in English and held by 28 WorldCat member libraries worldwide

Hypertension is a growing medical concern in the United States. With an increasing number of Americans suffering from hypertension every year, the use of antihypertensive medications such as beta-blockers has increased as well. Three beta-blocker medications--atenolol, metoprolol, and propranolol--were among the 200 most prescribed drugs in the United States in 2003, ranked 4, 14, and 165, respectively. Pilots that successfully manage their hypertension either with diet, exercise, and/or medication may remain medically certified to operate an aircraft. However, these pilots are closely monitored to ensure that their hypertension is properly controlled. The FAA classifies approximately 8% of all active civil aviation pilots as "hypertensive with medication." Toxicological evaluation of postmortem samples obtained from pilots is an important part of the investigation of fatal civil aviation accidents. During this evaluation it is not uncommon to detect beta-blocker compounds such as atenolol, metoprolol, or propranolol in the submitted biological samples. In forensic toxicology laboratories, these compounds are most commonly confirmed and/or quantitated by gas chromatography with mass spectrometric detection (GC/MS). Liquid chromatography coupled with mass spectrometric detection (LC/MS), however, is becoming increasingly more prevalent in the field of forensic toxicology and is considered a superior alternative to GC/MS for the analysis of many compounds. There are very few analytical LC/MS methods published for the determination of beta-blockers from biological specimens. Furthermore, we were unable to find any citation for the toxicological determination of beta-blockers in postmortem fluid and tissue specimens using LC/MS; in particular, atmospheric pressure chemical ionization (APCI) in conjunction with ion trap MS. This manuscript describes the validation and application of such a method
Analysis of cocaine, its metabolites, prolysis products, and ethanol adducts in postmortem fluids and tissues using Zymark [superscript registered trademark symbol] automated solid-phase extractions and gas chromatography-mass spectrometry( Book )

2 editions published in 2003 in English and held by 28 WorldCat member libraries worldwide

Cocaine (COC) is one of the most widely abused illicit drugs in America. COC abuse transcends all social, racial, and economic boundaries. Following the introduction in the mid-1980s of a new form of cocaine called crack, cocaine use has been on the rise. Because of its intense high, crack smoking has become very popular. Despite its popularity, crack smoking is a particularly dangerous form of COC use. Additionally, COC and ethanol are frequently used together, resulting in the formation of a biologically active molecule that is nearly as psycoactive as COC but produces a longer lasting and toxic effect. Demonstrating the presence or absence of COC and COC-related molecules in postmortem fluids and/or tissues can have serious legal consequences and may help determine the cause of impairment and/or death. We have developed a simple method for the simultaneous determination of COC and the COC metabolites benzoylecgonine, norbenzoylecgonine, ecgonine methyl ester, ecgonine, and norcocaine, as well as anhydroecgonine methyl ester (a unique byproduct of COC smoking), cocaethylene (a molecule formed by the concurrent use of COC and ethanol) and their related metabolites, anhydroecgonine, norcocaethylene, and ecgonine ethyl ester. This method incorporates a Zymark RapidTrace automated solid-phase extraction system, gas chromatography/mass spectrometry, and PFP/PFPA derivatives. The lower limits of detection ranged from 0.78 - 12.5 ng/mL, and the linear dynamic range for most analytes was 0.78 3200 ng/mL. The extraction efficiencies were from 26 - 84%, with the exception of anhydroecgonine and ecgonine, which were from 1 - 4%. We applied this method to 5 aviation fatalities. This method has proven to be simple, robust, and accurate for the simultaneous determination of COC and 11 COC metabolites in postmortem fluids and tissues
The LC/MS quantitation of vardenafil (Levitra®) in postmortem biological specimens : final report by Robert D Johnson( Book )

5 editions published in 2006 in English and held by 22 WorldCat member libraries worldwide

During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. As new medications are introduced to the market and are subsequently used by aviation accident victims, CAMI's forensic toxicology laboratory is tasked with developing analytical methods for the determination of these compounds. This report presents a rapid and reliable method for the identification and quantitation of vardenafil (Levitra®) in biological specimens. This procedure utilizes sildenafil-d8, which structurally is closely related to vardenafil, as an internal standard for more accurate and reliable quantitation. The method incorporates solid phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization ion trap mass spectrometer in the positive chemical ionization mode. Solid-phase extraction proved to be exceptionally efficient providing recoveries that ranged from 94-97%. The limit of detection for vardenafil was determined to be 0.19 ng/mL. The linear dynamic range for this compound was 0.39-200 ng/mL. This method was successfully applied to postmortem fluid and tissue specimens obtained from an aviation accident victim. This novel analytical procedure proved to be simple, accurate, and robust for the identification and quantitation of vardenafil in postmortem specimens
Comparison of pilot medical history and medications found in postmortem specimens by Dennis V Canfield( Book )

2 editions published in 2006 in English and held by 21 WorldCat member libraries worldwide

Following a fatal aviation accident, specimens from deceased pilots are collected by local pathologists and sent to the Bioaeronautical Sciences Research Laboratory for toxicological analysis, to identify all pilots found positive for medications used to treat cardiovascular, psychological, or neurological conditions
Gas chromatographic/mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol by Mike K Angier( Book )

1 edition published in 2004 in English and held by 2 WorldCat member libraries worldwide

"Pilots who successfully control their hypertension with medications, diet, and/or exercise can be medically certified to fly an aircraft. At the present time, approximately 8% of active pilots are designated as "hypertensive with medication" by the Federal Aviation Administration (FAA). One of the groups of antihypertensives is the beta-blocker. Of this group, atenolol, metoprolol, and propranolol are commonly prescribed, and they also have chemical and structural similarities. The FAA's Civil Aerospace Medical Institute (CAMI) toxicologically evaluates postmortem biological samples collected from pilots involved in fatal civil aviation accidents. Over the 10-year period, 1993-2002, CAMI has identified 50 pilot fatalities wherein atenolol was found in 24 pilots, metoprolol in 19 pilots, and propranolol in 7 pilots, which is consistent with the fact that these drugs have been in the lists of the top 200 most-prescribed drugs in the United States. [snip] By using the unique mass fragments, none of the re-examined pilot fatality cases were found to contain more than 1 beta-blocker. Several unique mass fragments reported in this study can be used for the positive identification of the 3 commonly used and chemically/structurally similar beta-blockers and a co-eluting interfering metabolite product of metoprolol. Therefore, these mass ions can be used for differentiating and simultaneously analyzing these beta-blockers in biological samples."--Page i
A study of chemical and clay mineralogical properties of soils of the Memphis catena by Russell J Lewis( )

1 edition published in 1957 in English and held by 1 WorldCat member library worldwide

The formation of ethanol in postmortem tissues( )

1 edition published in 2004 in English and held by 0 WorldCat member libraries worldwide

During the investigation of aviation accidents, postmortem samples obtained from fatal accident victims are submitted to the FAA's Civil Aerospace Medical Institute for toxicological analysis. During toxicological evaluations, ethanol analysis is performed on all cases. Many species of bacteria, yeast and fungi have the ability to produce ethanol and other volatile organic compounds in postmortem specimens. The potential for postmortem ethanol formation complicates the interpretation of ethanol-positive results from accident victims. Therefore, the prevention of ethanol formation at all steps following specimen collection is a priority. Sodium fluoride is the most commonly used preservative for postmortem specimens. Several studies have been published detailing the effectiveness of sodium fluoride for the prevention of ethanol formation in blood and urine specimens; however, our laboratory receives blood or urine in approximately 70% of cases. Thus, we frequently rely on tissue specimens for ethanol analysis. The postmortem tissue specimens received by our laboratory have generally been subjected to severe trauma and may have been exposed to numerous microbial species capable of ethanol production. With this in mind, we designed an experiment utilizing unadulterated tissue specimens obtained from a aviation accident victims to determine the effectiveness of sodium fluoride at various storage temperatures for the prevention of microbial ethanol formation. We found that without preservative, specimens stored at 4 deg C for 96 h showed an average increase in ethanol concentration of 1470%. At 25 deg C, these same specimens showed an average ethanol increase of 1432% after 48 h. With the addition of 1.00% sodium fluoride, there was no significant increase in ethanol concentration at either temperature
Sublimation rate of dry ice packaged in commonly used quantities by the air cargo industry : final report by Douglas C Caldwell( )

1 edition published in 2006 in English and held by 0 WorldCat member libraries worldwide

Dry ice is used as a refrigerant for the shipment of perishable goods in the aviation industry. The sublimation of dry ice can, however, lead to incapacitating levels of carbon dioxide in the aircraft cabin environment, as exemplified by the National Transportation Safety Board's (NTSB's) probable cause determination in a 1998 Brownsville, Texas, incapacitation incident. This incident prompted the NTSB to request that the Federal Aviation Administration (FAA) revisit the dry ice sublimation rate published in FAA Advisory Circular AC 103-4. The sublimation rate used in AC 103-4 to calculate permissible dry ice loads was based on a study where a single, large piece of dry ice (100 lb block) was used. Today, the majority of dry ice shipments contain smaller amounts of dry ice obtained in pellet form (<5 lb). This study focuses on the sublimation rate of dry ice packed in such commonly encountered amounts. In this study, approximately 5 lb of dry ice, in pellet form, was added to each of 20 pre-weighed TheromoSafe shipping containers. The boxes were then weighed to obtain "preflight" weights and placed in an altitude chamber located at the FAA's Civil Aerospace Medical Institute. The chamber was depressurized to an altitude of 8000 ft at a rate of 1000 ft/min. The total "flight" time was 6 h. The containers were then removed and immediately weighed to obtain "post-flight" measurements. Using the differences in weight as well as the total flight time, an average sublimation rate of 2.0 +/- 0.3%/h was determined. Results indicate that the sublimation rate is greater when dry ice is packaged in pellet form in small quantities. These results contrast the Pan American Airlines study that employed one solid 100-lb block of dry ice. The current study improves air cargo safety by providing a sublimation rate for dry ice shipped in small, more representative quantities. The updated sublimation rate can be used to calculate safe dry ice loads for containers commonly used today
 
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Alternative Names
Lewis, R. J.

Lewis, R. J. (Russell J.)

Languages
English (58)