WorldCat Identities

Hwang, Joo Ha

Works: 4 works in 9 publications in 1 language and 70 library holdings
Genres: Handbooks and manuals  Academic theses 
Roles: Author, Contributor
Publication Timeline
Most widely held works by Joo Ha Hwang
Yamada's handbook of gastroenterology by Tadataka Yamada( Book )

6 editions published in 2013 in English and held by 64 WorldCat member libraries worldwide

Portable, practical, and entirely clinical, this affordable guide to assessment and management of the entire range of gastroenterological complaints and conditions is ideally suited for use by GI fellows and specialists. The book is divided into two parts: symptom-focused and disease-focused. Features include key practice points, essentials of diagnosis, potential pitfalls, key web links, society guideline comparisons, case studies, and multiple choice questions. When you need answers in a hurry, turn to the most trusted name in gastroenterology: Yamada
Ultrasound-mediated vascular bioeffects : applications for hemostasis and sclerotherapy by Joo Ha Hwang( Book )

1 edition published in 2005 in English and held by 2 WorldCat member libraries worldwide

MRI-guided focused ultrasound application for targeted drug delivery by Navid Farr( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Pancreatic cancer is one of the most incurable and lethal human cancers in the United States. Mild hyperthermia (~ 41 °C) has been shown effective as an adjuvant for chemotherapy. An optimal mild hyperthermia treatment is targeted and non-invasive without tissue damage or vascular shutoff. High intensity focused ultrasound (HIFU) can non-invasively heat solid tumors without heating the surrounding organs. Magnetic resonance imaging (MRI) is suitable for therapy planning and monitoring of HIFU therapy due to its high spatial image resolution and ability to measure temperature changes in real time. Magnetic resonance-guided high intensity focused ultrasound (MR-g HIFU) is the novel approach for non-invasive mild hyperthermia applications. Temperature sensitive liposomes (TSL) release their drug cargo at the target temperature and in combination with mild hyperthermia may improve drug delivery to solid tumors. The objectives of this dissertation were to evaluate the ability of conventional and multi-parametric MRI techniques to characterize pancreas tumor in three different animal models. In addition, to develop and implement targeted drug delivery methods using mild hyperthermia induced by HIFU under guidance and monitoring of MRI in combination with TSL for pancreatic cancer. Moreover, to assess the short-term tumoricidal activity against tumor in response to MR-HIFU hyperthermia targeted drug delivery. The characterization of tumor models using conventional and multi-parametric MRI provided valuable information regarding tumor properties that can be use as in vivo markers for targeting and therapy monitoring. The combination of hyperthermia induced by MR-HIFU and TSL loaded with chemotherapy resulted in significantly higher tumor drug concentrations compared to TSL alone and free drug. Finally survival studies indicated combination of MR-HIFU and TSL for targeted drug delivery resulted in greater tumor response to the therapy. This technique has potential for clinical translation as an image guided method to deliver drug to pancreas tumor
Cavitation monitoring and spatial mapping for pulsed high-intensity focused ultrasound enhanced drug delivery by Tong Li( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

High intensity focused ultrasound (HIFU) is an emerging non-invasive ablation modality, in which high amplitude ultrasound waves are focused inside the human body to thermally ablate or mechanically disrupt the tissue at the focus. Ultrasound-enhanced drug delivery is an active and promising area of research. Enhanced drug diffusion and vascular permeability following HIFU is largely attributed to mechanical tissue disruption caused by ultrasound-induced bubble activity- cavitation. Although cavitation can be beneficial, the violent collapsing of bubbles may cause undesired tissue damage. Therefore, it is very important to monitor cavitation activity during pHIFU treatments and know the ultrasound pressure levels sufficient to reliably induce cavitation in a given tissue. Correlating the quantity and depth of drug penetration with the degree of cavitation is a significant challenge during in vivo treatment due to the highly complex dynamics of cavitation in different types of tissue. Furthermore, the current methods of cavitation detection are of either limited sensitivity or spatial mapping capability to monitor the site of occurrence and the extent of bubble activity in tissue. In this dissertation, three metrics of cavitation activity induced by pHIFU and evaluated by confocal passive cavitation detection were introduced: cavitation probability, cavitation persistence and the level of broadband acoustic emissions. These metrics were used to characterize cavitation activity in gel phantoms, ex vivo tissue and in vivo transgenic pancreatic tumors at varying peak-rarefactional focal pressures. Cavitation thresholds were also determined in various media. In order to find the ideal HIFU parameters for drug delivery, cavitation metrics were measured and correlated with the degree of chemotherapeutic drug uptake in in vivo tumors immediately after HIFU exposures and systematic administration of chemotherapeutic drug. The study demonstrated that reliable and intense cavitation activity induced by pHIFU is a sufficient and necessary condition for enhanced drug delivery. To spatially detect cavitation, a new ultrasound imaging method termed "Bubble Doppler" was developed to detect microbubbles using a modification of Doppler processing. This method was shown to provide sensitivity superior to that of existing cavitation detection methods, and has high spatial resolution inherent to conventional Doppler imaging
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.56 (from 0.55 for Yamada's h ... to 0.84 for Ultrasound ...)

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