Perlis, Roy H.
Overview
| Works: | 22 works in 27 publications in 1 language and 39 library holdings |
|---|---|
| Roles: | Other, Author |
| Classifications: | R1, 616.89 |
Publication Timeline
.
Most widely held works by
Roy H Perlis
The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis
of Response to Lithium Treatment by
Thomas G Schulze(
)
2 editions published between 2010 and 2014 in English and held by 3 WorldCat member libraries worldwide
2 editions published between 2010 and 2014 in English and held by 3 WorldCat member libraries worldwide
Current controversies in the management of insomnia(
Visual
)
1 edition published in 2006 in English and held by 3 WorldCat member libraries worldwide
Describes the risks, benefits and clinical indications for the new sleep agents and older non-hypnotic agents in the treatment of insomnia; outlines the evidence regarding abnormal sleep-related behaviors and the newer sedative-hypnotic medications
1 edition published in 2006 in English and held by 3 WorldCat member libraries worldwide
Describes the risks, benefits and clinical indications for the new sleep agents and older non-hypnotic agents in the treatment of insomnia; outlines the evidence regarding abnormal sleep-related behaviors and the newer sedative-hypnotic medications
Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records by
Jiayan Chen(
)
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma by Jessica E Sagers(
)
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
Publisher Correction: Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma by Jessica E Sagers(
)
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression by EQTLGen(
)
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls by Carl M Sellgren(
)
1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons
from subjects with schizophrenia by Zhicheng Shao(
)
1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide
Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report by Mirko Manchia(
)
2 editions published in 2016 in English and held by 2 WorldCat member libraries worldwide
2 editions published in 2016 in English and held by 2 WorldCat member libraries worldwide
Efficient Genome-wide Association in Biobanks Using Topic Modeling Identifies Multiple Novel Disease Loci by Thomas H McCoy(
)
1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning by Carl M Sellgren(
)
1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide
Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders by Hannah E Brown(
)
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
Diagnosis, neurobiology and treatment approaches to ADHD(
Visual
)
2 editions published in 2006 in English and held by 2 WorldCat member libraries worldwide
Discusses emerging data on the underlying neural networks, comorbidity and functional impairments; reviews the evidence base for the pharmacotherapy of ADHD
2 editions published in 2006 in English and held by 2 WorldCat member libraries worldwide
Discusses emerging data on the underlying neural networks, comorbidity and functional impairments; reviews the evidence base for the pharmacotherapy of ADHD
Bipolar disorder beyond episodes : the challenge of sustained wellness(
Visual
)
2 editions published in 2006 in English and held by 2 WorldCat member libraries worldwide
Explains the complexities of the interepisodic course of patients with bipolar disorder and the impact of comorbid disorders on the course of bipolar disorder; discusses psychotherapies
2 editions published in 2006 in English and held by 2 WorldCat member libraries worldwide
Explains the complexities of the interepisodic course of patients with bipolar disorder and the impact of comorbid disorders on the course of bipolar disorder; discusses psychotherapies
Can electronic health records revive central nervous system clinical trials? by
Roy H Perlis(
)
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide
Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8 by Thomas H McCoy(
)
1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide
1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide
Lessons learned from STAR*D(
Visual
)
1 edition published in 2006 in English and held by 1 WorldCat member library worldwide
Describes the results of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study and the remission rates obtained with various antidepressant treatment strategies across all four STAR*D treatment levels. Explains the importance of specific predictors of antidepressant response in the STAR*D population and how this will impact real-world practice
1 edition published in 2006 in English and held by 1 WorldCat member library worldwide
Describes the results of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study and the remission rates obtained with various antidepressant treatment strategies across all four STAR*D treatment levels. Explains the importance of specific predictors of antidepressant response in the STAR*D population and how this will impact real-world practice
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study(
)
1 edition published in 2016 in English and held by 1 WorldCat member library worldwide
Background: Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified. Methods: Here, we report the results of a genome-wide association study of lithium response in 2563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen). Data from common single nucleotide polymorphisms (SNPs) were tested for association with categorical and continuous ratings of lithium response. Lithium response was measured using a well established scale (Alda scale). Genotyped SNPs were used to generate data at more than 6 million sites, using standard genomic imputation methods. Traits were regressed against genotype dosage. Results were combined across two batches by meta-analysis. Findings: A single locus of four linked SNPs on chromosome 21 met genome-wide significance criteria for association with lithium response (rs79663003, p=1·37 × 10 −8 ; rs78015114, p=1·31 × 10 −8 ; rs74795342, p=3·31 × 10 −9 ; and rs75222709, p=3·50 × 10 −9 ). In an independent, prospective study of 73 patients treated with lithium monotherapy for a period of up to 2 years, carriers of the response-associated alleles had a significantly lower rate of relapse than carriers of the alternate alleles (p=0·03268, hazard ratio 3·8, 95% CI 1·1-13·0). Interpretation: The response-associated region contains two genes for long, non-coding RNAs (lncRNAs), AL157359.3 and AL157359.4 . LncRNAs are increasingly appreciated as important regulators of gene expression, particularly in the CNS. Confirmed biomarkers of lithium response would constitute an important step forward in the clinical management of bipolar disorder. Further studies are needed to establish the biological context and potential clinical utility of these findings. Funding: Deutsche Forschungsgemeinschaft, National Institute of Mental Health Intramural Research Program
1 edition published in 2016 in English and held by 1 WorldCat member library worldwide
Background: Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified. Methods: Here, we report the results of a genome-wide association study of lithium response in 2563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen). Data from common single nucleotide polymorphisms (SNPs) were tested for association with categorical and continuous ratings of lithium response. Lithium response was measured using a well established scale (Alda scale). Genotyped SNPs were used to generate data at more than 6 million sites, using standard genomic imputation methods. Traits were regressed against genotype dosage. Results were combined across two batches by meta-analysis. Findings: A single locus of four linked SNPs on chromosome 21 met genome-wide significance criteria for association with lithium response (rs79663003, p=1·37 × 10 −8 ; rs78015114, p=1·31 × 10 −8 ; rs74795342, p=3·31 × 10 −9 ; and rs75222709, p=3·50 × 10 −9 ). In an independent, prospective study of 73 patients treated with lithium monotherapy for a period of up to 2 years, carriers of the response-associated alleles had a significantly lower rate of relapse than carriers of the alternate alleles (p=0·03268, hazard ratio 3·8, 95% CI 1·1-13·0). Interpretation: The response-associated region contains two genes for long, non-coding RNAs (lncRNAs), AL157359.3 and AL157359.4 . LncRNAs are increasingly appreciated as important regulators of gene expression, particularly in the CNS. Confirmed biomarkers of lithium response would constitute an important step forward in the clinical management of bipolar disorder. Further studies are needed to establish the biological context and potential clinical utility of these findings. Funding: Deutsche Forschungsgemeinschaft, National Institute of Mental Health Intramural Research Program
Child and adolescent psychiatry : current concepts in the diagnosis, neurobiology, and treatment of adult ADHD(
Visual
)
1 edition published in 2006 in English and held by 1 WorldCat member library worldwide
Explains how to identify the symptoms of ADHD in adulthood and utilize screening tools and diagnostic criteria to accurately diagnose ADHD; outlines the appropriate management of ADHD in adulthood
1 edition published in 2006 in English and held by 1 WorldCat member library worldwide
Explains how to identify the symptoms of ADHD in adulthood and utilize screening tools and diagnostic criteria to accurately diagnose ADHD; outlines the appropriate management of ADHD in adulthood
Use of large data sets and the future of personalized treatment(
)
1 edition published in 2014 in English and held by 1 WorldCat member library worldwide
1 edition published in 2014 in English and held by 1 WorldCat member library worldwide
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