WorldCat Identities

Perlis, Roy H.

Overview
Works: 22 works in 27 publications in 1 language and 39 library holdings
Roles: Other, Author
Classifications: R1, 616.89
Publication Timeline
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Most widely held works by Roy H Perlis
The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment by Thomas G Schulze( )

2 editions published between 2010 and 2014 in English and held by 3 WorldCat member libraries worldwide

Current controversies in the management of insomnia( Visual )

1 edition published in 2006 in English and held by 3 WorldCat member libraries worldwide

Describes the risks, benefits and clinical indications for the new sleep agents and older non-hypnotic agents in the treatment of insomnia; outlines the evidence regarding abnormal sleep-related behaviors and the newer sedative-hypnotic medications
Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records by Jiayan Chen( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma by Jessica E Sagers( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Publisher Correction: Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma by Jessica E Sagers( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression by EQTLGen( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls by Carl M Sellgren( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia by Zhicheng Shao( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report by Mirko Manchia( )

2 editions published in 2016 in English and held by 2 WorldCat member libraries worldwide

Efficient Genome-wide Association in Biobanks Using Topic Modeling Identifies Multiple Novel Disease Loci by Thomas H McCoy( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning by Carl M Sellgren( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders by Hannah E Brown( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Diagnosis, neurobiology and treatment approaches to ADHD( Visual )

2 editions published in 2006 in English and held by 2 WorldCat member libraries worldwide

Discusses emerging data on the underlying neural networks, comorbidity and functional impairments; reviews the evidence base for the pharmacotherapy of ADHD
Bipolar disorder beyond episodes : the challenge of sustained wellness( Visual )

2 editions published in 2006 in English and held by 2 WorldCat member libraries worldwide

Explains the complexities of the interepisodic course of patients with bipolar disorder and the impact of comorbid disorders on the course of bipolar disorder; discusses psychotherapies
Can electronic health records revive central nervous system clinical trials? by Roy H Perlis( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8 by Thomas H McCoy( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Lessons learned from STAR*D( Visual )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

Describes the results of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study and the remission rates obtained with various antidepressant treatment strategies across all four STAR*D treatment levels. Explains the importance of specific predictors of antidepressant response in the STAR*D population and how this will impact real-world practice
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Background: Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified. Methods: Here, we report the results of a genome-wide association study of lithium response in 2563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen). Data from common single nucleotide polymorphisms (SNPs) were tested for association with categorical and continuous ratings of lithium response. Lithium response was measured using a well established scale (Alda scale). Genotyped SNPs were used to generate data at more than 6 million sites, using standard genomic imputation methods. Traits were regressed against genotype dosage. Results were combined across two batches by meta-analysis. Findings: A single locus of four linked SNPs on chromosome 21 met genome-wide significance criteria for association with lithium response (rs79663003, p=1·37 × 10 −8 ; rs78015114, p=1·31 × 10 −8 ; rs74795342, p=3·31 × 10 −9 ; and rs75222709, p=3·50 × 10 −9 ). In an independent, prospective study of 73 patients treated with lithium monotherapy for a period of up to 2 years, carriers of the response-associated alleles had a significantly lower rate of relapse than carriers of the alternate alleles (p=0·03268, hazard ratio 3·8, 95% CI 1·1-13·0). Interpretation: The response-associated region contains two genes for long, non-coding RNAs (lncRNAs), AL157359.3 and AL157359.4 . LncRNAs are increasingly appreciated as important regulators of gene expression, particularly in the CNS. Confirmed biomarkers of lithium response would constitute an important step forward in the clinical management of bipolar disorder. Further studies are needed to establish the biological context and potential clinical utility of these findings. Funding: Deutsche Forschungsgemeinschaft, National Institute of Mental Health Intramural Research Program
Child and adolescent psychiatry : current concepts in the diagnosis, neurobiology, and treatment of adult ADHD( Visual )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

Explains how to identify the symptoms of ADHD in adulthood and utilize screening tools and diagnostic criteria to accurately diagnose ADHD; outlines the appropriate management of ADHD in adulthood
Use of large data sets and the future of personalized treatment( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

 
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Languages
English (24)