WorldCat Identities

Duffy, Michael J. IV

Overview
Works: 23 works in 36 publications in 4 languages and 816 library holdings
Genres: Commentaries  Live sound recordings  Case studies  Academic theses  Catechisms  Overtures  Preludes (Music)  Chamber music  Folk songs  Handbooks and manuals 
Roles: Author, Instrumentalist
Classifications: ML111, 025.527678
Publication Timeline
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Most widely held works about Michael J Duffy
 
Most widely held works by Michael J Duffy
Basic music reference : a guide for non-specialist librarians, library assistants, and student employees by Alan Green( )

13 editions published between 2012 and 2013 in English and held by 634 WorldCat member libraries worldwide

Commentary on Saint Paul's First letter to the Thessalonians and the letter to the Philippians by Thomas( Book )

2 editions published between 1969 and 1993 in English and held by 161 WorldCat member libraries worldwide

Basic music reference : a guide for nonspecialist librarians, library assistants, and student employees by Alan Green( Book )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Llagas groundwater basin nitrate study( Book )

1 edition published in 1996 in English and held by 2 WorldCat member libraries worldwide

Katekizmas mažiems vaikams : anglų ir lietuvių kalbose by Michael J Duffy( Book )

1 edition published in 1932 in Lithuanian and held by 1 WorldCat member library worldwide

37th annual Concerto concert by Western Michigan University( Recording )

1 edition published in 1996 and held by 1 WorldCat member library worldwide

Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients( )

1 edition published in 2002 in English and held by 1 WorldCat member library worldwide

BACKGROUND: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients. To confirm the prognostic value of uPA and PAI-1 in primary breast cancer, we reanalyzed individual patient data provided by members of the European Organization for Research and Treatment of Cancer-Receptor and Biomarker Group (EORTC-RBG). METHODS: The study included 18 datasets involving8377 breast cancer patients. During follow-up (median 79 months), 35%of the patients relapsed and 27% died. Levels of uPA and PAI-1 in tumor tissue extracts were determined by different immunoassays; values were ranked within each dataset and divided by the number of patients in that dataset to produce fractional ranks that could be compared directly across datasets. Associations of ranks of uPA and PAI-1 levels with relapse-free survival (RFS)and overall survival (OS) were analyzed by Cox multivariable regression analysis stratified by dataset, including the following traditional prognosticvariables: age, menopausal status, lymph node status, tumor size, histologic grade, and steroid hormone-receptor status. All P values were two-sided. RESULTS: Apart from lymph node status, high levels of uPA and PAI-1were the strongest predictors of both poor RFS and poor OS in the analyses of all patients. Moreover, in both lymph node-positive and lymph node-negative patients, higher uPA and PAI-1 values were independently associated with poor RFS and poor OS. For (untreated) lymph node-negative patients in particular, uPA and PAI-1 included together showed strong prognostic ability (all P<.001). CONCLUSIONS: This pooled analysis of the EORTC-RBG datasets confirmed the strong and independent prognostic value of uPA and PAI-1 in primary breast cancer. (Abstract truncated at 2000 characters)
Neighborhood change in older suburbs : a case study of suburban neighborhoods in southern Westchester county by Michael Duffy( Book )

1 edition published in 1985 in Undetermined and held by 1 WorldCat member library worldwide

Blood-based biomarkers in breast cancer: From proteins to circulating tumor cells to circulating tumor DNA( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Biomarkers are the key to personalized treatment in patients with breast cancer. While tissue biomarkers are most useful in determining prognosis and upfront predicting response to therapy, circulating protein biomarkers such as CA 15-3 and carcinoembryonic antigen are mainly used in monitoring response to endocrine or chemotherapy in patients with advanced disease. Although several centers measure biomarkers in asymptomatic patients following curative surgery for primary breast cancer, the clinical utility of this practice is unclear. Promising new biomarkers for breast cancer include circulating tumor DNA and circulating tumor cells. In contrast to circulating protein biomarkers, measurement of circulating tumor DNA–based biomarkers is potentially useful in identifying mechanisms of resistance to ongoing therapies as well as identifying new targets for further treatment. To increase clinical utility, both the established and emerging circulating biomarkers should where possible be incorporated into randomized trials evaluating new therapies in patients with breast cancer
WMUsic showcase spectacular, 2017, 01/27( Recording )

1 edition published in 2017 in Multiple languages and held by 1 WorldCat member library worldwide

Katechism Christianskoj jauki, dl'a prihotovleniia d'itej ... k pervomu sv. pricasceniju by Michael J Duffy( Book )

in Slavic and held by 1 WorldCat member library worldwide

Predicting success in geography from pre-admission data by Michael J Duffy( Book )

1 edition published in 1974 in English and held by 1 WorldCat member library worldwide

A choral Christmas festival, 1995, 12/04( Recording )

1 edition published in 1995 in Multiple languages and held by 1 WorldCat member library worldwide

A Catechism of Christian doctrine suited to children of primary and grammar school grades( Book )

1 edition published in 1922 in English and held by 1 WorldCat member library worldwide

Tumor Markers : which ones are clinically useful by Michael J Duffy( )

1 edition published in 2003 in English and held by 1 WorldCat member library worldwide

Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer by Patrick C O'Leary( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Background: Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as their prohibitive cost. However, the limited availability of antibodies is a key barrier to the development of a lower cost alternative, namely a discrete collection of immunohistochemistry (IHC)-based biomarkers. The aim of this study was to use a systematic approach to generate and screen affinity-purified, mono-specific antibodies targeting progression-related biomarkers, with a view towards developing a clinically applicable IHC-based prognostic biomarker panel for breast cancer. Methods: We examined both in-house and publicly available breast cancer DNA microarray datasets relating to invasion and metastasis, thus identifying a cohort of candidate progression-associated biomarkers. Of these, 18 antibodies were released for extended analysis. Validated antibodies were screened against a tissue microarray (TMA) constructed from a cohort of consecutive breast cancer cases (n = 512) to test the immunohistochemical surrogate signature. Results: Antibody screening revealed 3 candidate prognostic markers: the cell cycle regulator, Anillin (ANLN); the mitogen-activated protein kinase, PDZ-Binding Kinase (PBK); and the estrogen response gene, PDZ-Domain Containing 1 (PDZK1). Increased expression of ANLN and PBK was associated with poor prognosis, whilst increased expression of PDZK1 was associated with good prognosis. A 3-marker signature comprised of high PBK, high ANLN and low PDZK1 expression was associated with decreased recurrence-free survival (p <0.001) and breast cancer-specific survival (BCSS) (p <0.001). This novel signature was associated with high tumour grade (p <0.001), positive nodal status (p = 0.029), ER-negativity (p = 0.006), Her2-positivity (p = 0.036) and high Ki67 status (p <0.001). However, multivariate Cox regression demonstrated that the signature was not a significant predictor of BCSS (HR = 6.38; 95% CI = 0.79-51.26, p = 0.082). Conclusions: We have developed a comprehensive biomarker pathway that extends from discovery through to validation on a TMA platform. This proof-of-concept study has resulted in the identification of a novel 3-protein prognostic panel. Additional biochemical markers, interrogated using this high-throughput platform, may further augment the prognostic accuracy of this panel to a point that may allow implementation into routine clinical practice
Patristic catechetics by Michael J Duffy( )

1 edition published in 1963 in English and held by 1 WorldCat member library worldwide

Academic advising handbook by University of New Orleans( Book )

1 edition published in 1981 in English and held by 1 WorldCat member library worldwide

Western String Chamber Orchestra, 1995, 04/02 by Western String Chamber Orchestra( Recording )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

Collegium Musicum, 2016, 11/10 : "a cavalcade of early classics"( Recording )

1 edition published in 2016 in Multiple languages and held by 1 WorldCat member library worldwide

 
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