WorldCat Identities

Carlton, Jane M.

Overview
Works: 20 works in 30 publications in 1 language and 692 library holdings
Genres: Academic theses 
Roles: Author, Contributor, Other, Editor
Classifications: QR201.M3, 616.936201
Publication Timeline
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Most widely held works by Jane M Carlton
Malaria parasites : comparative genomics, evolution, and molecular biology by Jane M Carlton( )

9 editions published in 2013 in English and held by 662 WorldCat member libraries worldwide

falciparum epigenetic modification and transcriptional regulation; Plasmodium invasion of host red blood cells; protein export and trafficking by malaria parasites; Plasmodium-mosquito vector interactions; and a practical guide to many of the revolutionary new techniques and molecular tools for Plasmodium research
Trhomonas vaginalis: Population structure, pathogenicity and the vaginal microbiome by Melissa D Conrad( )

1 edition published in 2012 in English and held by 3 WorldCat member libraries worldwide

Trichomonas vaginalis, the causative agent of human trichomoniasis, is the most prevalent non-viral sexually transmitted infection world-wide. Although associated with increased risk of HIV transmission, making its detection and treatment a global health priority, little is known about its diversity or population structure. We developed a panel of T. vaginalis genetic markers, including 21 microsatellites and six single-copy genes, to evaluate the population genetics of: 18 clinical isolates collected from female patients attending New York City STD clinics in 2008; 177 isolates from ten global regions; 174 samples from 123 HIV-infected female patients in the U.S.A; and 32 strains associated with vaginal microbiome data. We find the species to be genetically diverse with a striking, globally-distributed population structure consisting of two 'types' (type 1 and type 2). We find that parasite types are associated with certain clinical traits; for example, when compared to type 2 parasites, type 1 parasites have a higher in vitro growth rate, more frequently harbor a dsRNA virus, are more sensitive to metronidazole in vitro, cause more disruption to the vaginal microbiota, and are associated with higher viral loads in HIV-positive women. In addition, we uncover evidence of genetic exchange, suggesting a sexual life-cycle of the parasite despite an absence of morphologically-distinct sexual stages and indicating that recombination has played an important role in evolution of the T. vaginalis genome. Together our findings are important for understanding the spread and mechanisms of drug resistance, for characterizing virulence factors, and in understanding why many individuals remain asymptomatic while others have severe manifestations of disease
Evolution of human malaria by Jane M Carlton( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

A review of malaria transmission dynamics in forest ecosystems by Narayani Prasad Kar( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Chloroquine efficacy studies confirm drug susceptibility of Plasmodium vivax in Chennai, India by Sneh Shalini( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

An 18S rRNA Workflow for Characterizing Protists in Sewage, with a Focus on Zoonotic Trichomonads by Julia M Maritz( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites by Tobias J Sargeant( )

1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India by Pavitra N Rao( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

IDEA: Interactive Display for Evolutionary Analyses by Amy Egan( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses( Book )

2 editions published in 2005 in English and held by 2 WorldCat member libraries worldwide

Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500 Plasmodium genes in the central regions of the 14 chromosomes and highlighted genes evolving rapidly because of stage-specific selective pressures. Four strategies for gene expression are apparent during the parasites life cycle: (i) housekeeping; (ii) host-related; (iii) strategy-specific related to invasion, asexual replication, and sexual development; and (iv) stage-specific. We observed post transcriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3 untranslated region motif is implicated in this process
Novel Antigen Identification Method for Discovery of Protective Malaria Antigens by Rapid Testing of DNA Vaccines Encoding Exons from the Parasite Genome( Book )

2 editions published in 2004 in English and held by 2 WorldCat member libraries worldwide

We describe a novel approach for identifying target antigens for preerythrocytic malaria vaccines. Our strategy is to rapidly test hundreds of DNA vaccines encoding exons from the Plasmodium yoelii yoelii genomic sequence. In this antigen identification method, we measure reduction in parasite burden in the liver after sporozoite challenge in mice. Orthologs of protective P. y. yoelii genes can then be identified in the genomic databases of Plasmodium falciparum and Plasmodium vivax and investigated as candidate antigens for a human vaccine. A pilot study to develop the antigen identification method approach used 192 P. y. yoelii exons from genes expressed during the sporozoite stage of the life cycle. A total of 182 (94%) exons were successfully cloned into a DNA immunization vector with the Gateway cloning technology. To assess immunization strategies, mice were vaccinated with 19 of the new DNA plasmids in addition to the well-characterized protective plasmid encoding P. y. yoelii circumsporozoite protein. Single plasmid immunization by gene gun identified a novel vaccine target antigen which decreased liver parasite burden by 95% and which has orthologs in P. vivax and P. knowlesi but not P. falciparum. Intramuscular injection of DNA plasmids produced a different pattern of protective responses from those seen with gene gun immunization. Intramuscular immunization with plasmid pools could reduce liver parasite burden in mice despite the fact that none of the plasmids was protective when given individually. We conclude that high-throughput cloning of exons into DNA vaccines and their screening is feasible and can rapidly identify new malaria vaccine candidate antigens
The use of mosquito repellents at three sites in India with declining malaria transmission: surveys in the community and clinic by Anna Maria van Eijk( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

The repertoire diversity of the Plasmodium falciparum stevor multigene family in complicated and uncomplicated malaria in India by Surendra K Prajapati( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

The complexities of malaria disease manifestations with a focus on asymptomatic malaria by Dolie D Laishram( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Antibody responses within two leading Plasmodium vivax vaccine candidate antigens in three geographically diverse malaria-endemic regions of India by Sonal Kale( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

The developmental role of the intestinal microbiota in shaping adult body composition by Laura Michelle Cox( Book )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

This work begins to identify candidate biomarker organisms that influence host metabolism and identifies a critical window of host microbiome interaction
Genome sequence and comparative analysis of rthe model rodent malaria parasite plasmodium yoelii yoelii by Jane M Carlton( )

1 edition published in 2002 in English and held by 0 WorldCat member libraries worldwide

What is the value of reactive case detection in malaria control? A case-study in India and a systematic review by Anna Maria van Eijk( )

1 edition published in 2016 in English and held by 0 WorldCat member libraries worldwide

Malaria in Meghalaya: a systematic literature review and analysis of data from the National Vector-Borne Disease Control Programme by Anne Kessler( )

1 edition published in 2018 in English and held by 0 WorldCat member libraries worldwide

Publisher Correction: Evolution of human malaria by Jane M Carlton( )

1 edition published in 2018 in English and held by 0 WorldCat member libraries worldwide

 
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English (30)