WorldCat Identities

Wheatley, Ed

Overview
Works: 3 works in 3 publications in 1 language and 23 library holdings
Genres: History  Pictorial works  Juvenile works  Biography 
Roles: Author
Publication Timeline
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Most widely held works by Ed Wheatley
St. Louis Browns : the story of a beloved team by Bill Borst( Book )

1 edition published in 2017 in English and held by 17 WorldCat member libraries worldwide

As we all know, St. Louis is the best baseball town in America, but the city's major league history is not confined to the Cardinals. For several decades, until the middle of the twentieth century, St. Louis fielded a second professional team. True, it was mostly a losing team, but it once featured a first baseman who hit .400, a legendary Negro League star, and a pitcher who would go on to throw a perfect game in the World Series. They were the St. Louis Browns--the forerunners of the current Baltimore Orioles and a part of St. Louis's rich baseball history
Incredible Cardinals by Ed Wheatley( Book )

1 edition published in 2018 in English and held by 5 WorldCat member libraries worldwide

"Deep in Busch Stadium's left field, you'll find a wall of heroes. The greatest Cardinals of all time are painted there, reminding us that dreams do come true. On this wall, Dizzy Dean still throws his flaming fastball. Lou Brock flashes his supersonic speed around the bases. Ozzie Smith puts on a show with his fielding magic. Just like players today, young Cardinal fans dream of joining their heroes on the wall. Will you join them one day too?"--Publisher's website
A High-Throughput Screening Triage Workflow to Authenticate a Novel Series of PFKFB3 Inhibitors( )

in English and held by 1 WorldCat member library worldwide

A high-throughput screen (HTS) of human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) resulted in several series of compounds with the potential for further optimization. Informatics was used to identify active chemotypes with lead-like profiles and remove compounds that commonly occurred as actives in other HTS screens. The activities were confirmed with IC50 measurements from two orthogonal assay technologies, and further analysis of the Hill slopes and comparison of the ratio of IC50 values at 10 times the enzyme concentration were used to identify artifact compounds. Several series of compounds were rejected as they had both high slopes and poor ratios. A small number of compounds representing the different leading series were assessed using isothermal titration calorimetry, and the X-ray crystal structure of the complex with PFKFB3 was solved. The orthogonal assay technology and isothermal calorimetry were demonstrated to be unreliable in identifying false-positive compounds in this case. Presented here is the discovery of the dihydropyrrolopyrimidinone series of compounds as active and novel inhibitors of PFKFB3, shown by X-ray crystallography to bind to the adenosine triphosphate site. The crystal structures of this series also reveal it is possible to flip the binding mode of the compounds, and the alternative orientation can be driven by a sigma-hole interaction between an aromatic chlorine atom and a backbone carbonyl oxygen. These novel inhibitors will enable studies to explore the role of PFKFB3 in driving the glycolytic phenotype of tumors
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.32 (from 0.22 for Incredible ... to 0.88 for A High-Thr ...)

Alternative Names
Wheatley, Edward (Author)

Languages