WorldCat Identities

Browne, John Symonds Lyon 1904-1984

Overview
Works: 18 works in 31 publications in 1 language and 58 library holdings
Genres: Archives  Radio panel discussions  Nonfiction radio programs 
Roles: Author
Publication Timeline
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Most widely held works by John Symonds Lyon Browne
The metabolism of the hormone of the adrenal cortex by Paul G Weil( )

2 editions published in 1939 in English and held by 4 WorldCat member libraries worldwide

"The importance to clinical medicine and surgery of the metabolism of the hormone of the adrenal cortex is becoming increasingly more evident from the recent work of many investigators. It has long been known that in the human, destructive lesions of the adrenal cortex are responsible for the fatal disease described by Addison in 1855 and which bears his name. In Addison's disease, the symptoms and signs are pigmentation of skin and mucous membrane, gastro-intestinal disturbances, asthenia, low blood pressure, dehydration and hamoconcentration (increased sodium excretion, low blood sodium), high blood potassium and hypoglycemia in the terminal stages. ... Adrenal cortical extracts or synthetic cortical substances administered to patients with Addison's disease will restore them to health and prolong life. Adrenalectomized animals can be maintained in good health indefinitely on cortical substances. Hyperfunction of the adrenal cortex occurs in cases of adrenal cortical hyperplasia, adrenal cortical tumors, and in Cushing's Syndrome. The clinical features of Cushing's syndrome are hypertension, localized obesity, osteoporosis, hyperglycemia, polycythemia and skin changes. The clinical features of the adrenogenital syndrome are sex-reversal or precocious maturity. While the features mentioned are the main characteristics of the respective syndromes, there are cases which show manifestations of both types of condition. ..."--
Some aspects of the metabolism of the steroid hormones by Martin M Hoffman( )

2 editions published in 1943 in English and held by 4 WorldCat member libraries worldwide

"Until very recently interest in the steroid hormones has centered round the problem of their exact chemical structure and their main physiological actions in the organism. Now that the chemical structure and the physiological role of many of these hormones are known interest is being manifested in their intermediary metabolism. An understanding of the changes undergone by the hormones in the course of their inactivation and excretion by the animal body, will, it is hoped, provide information regarding the chemical mechanisms involved when these hormones produce their physiological effects in the organs and tissues upon which they act." --
Study of Water Balance in the "Alarm Reaction" by John G Howlett( )

2 editions published in 1937 in English and held by 4 WorldCat member libraries worldwide

"The effect of the "Alarm Reaction" upon the excretion of the intravenously injected 0.85;6 sodium chloride solution has been studied in the rat. The "Alarming" stimuli used have been surgical trauma and intraperitoneal histamine injections. The results of Selye have been confirmed in that there has been a marked tendency to develop oedema under the conditions of alarm. The degree of water retention is less prolonged in the case of single injections of histamine than in the case of surgical operations, but parallels the severity of the damage. No clear effect of cortin in affecting the rate of excretion of water and salt has been demonstrated in the intact "alarmed" animal. In the adrenalectomized animal cortin does not affect the rate of water excretion in the 'non-alarmed' animal. Cortin markedly increases the rate of excretion of injected water and salt in adrenelectomized "alarmed" animals. After pretreatment with histamine the effect of this substance in producing water retention in adrenalectomized animals is much lessened. Theories of the mechanism of action of the "Alarm Reaction" in producing water and salt retention and Cortin in discharging it are discussed."--
The bio-assay of DCA-like substances by Nathan Heller( )

2 editions published in 1944 in English and held by 4 WorldCat member libraries worldwide

"When the organism is exposed to a stress, the adrenal cortices would then respond by producing corticoids which have a more rapid, more pronounced, and briefer action as is the case with the corticoids of the corticosterone type. Under the conditions standardized in the experimental section, both DCA and cortical extract will cause the deposition of liver glycogen, but DCA is negative in this respect when the regular 7-hour assay method is used. Thus, a combination of these two methods might enable one to differentiate between these two types of corticoids."--
The determination of histamine in blood and tissues under various conditions by B Rose( )

2 editions published in 1937 in English and held by 4 WorldCat member libraries worldwide

"1. The histamine content of the normal and adrenalectomised male rat is lower than that of the female. 2. Evidence is presented to show that there is an increase in the histamine content of the portal blood of the adrenalectomised rat after injury to the gastro-intestinal tract, which appears within two minutes and disappears after five minutes. 3. There is an increase in the histamine content of lung and lymphatic tissue in the normal rat which has been subjected to the action of muscular exercise, and surgical trauma. 4. There is a decrease in the histamine content of the lung tissue and an increase of the histamine content of the lymphatic tissue in the adrenalectomised animal after surgical trauma and the intraperitoneal injection of histamine. This change is modified by the action of Cortin."--
The chemical and physiological properties of crystalline oestrogenic hormones by John Symonds Lyon Browne( )

3 editions published between 1932 and 1933 in English and held by 4 WorldCat member libraries worldwide

"A crystalline oestrogenic hormone has been isolated from human placenta. This substance shows a melting point ot 274 c. (uncorrected). The carbon-hydrogen analysis gives carbon 74.8 per cent, hydrogen 8.8 per cent. The mixed melting point with theelol shows no lowering. The substance differs physiologically from previously isolated female sex hormones. It is relatively inactive on the adult ovariectomized albino rat. The dose required is 16y, as compared to 1.5y for theelol. It is however, effective on the immature intact rat, 21 days old, in a dose of 1.2y. This is the same as theelol. [...]" --
Experimental study of blood fats in health and disease by Eleanor M Venning( )

2 editions published in 1933 in English and held by 4 WorldCat member libraries worldwide

"Although our knowledge of protein and carbohydrate metabolism has advanced with great strides in recent years, relatively little interest has been focussed on fat metabolism. A true understanding of the factors that determine the level of the various constituents in the blood is still lacking. Even the intermediary products of metabolism have not yet been isolated. The great obstacle to the advancement of knowledge in this case has been a lack of aocurate methods. A particular attempt has been made in this present work to investigate the reliability of the methods employed and considerable time has been spent in this direction. ..."--
The metabolism of histamine by B Rose( )

2 editions published in 1939 in English and held by 4 WorldCat member libraries worldwide

"Up to the end of the last century, the only mode of functional co-ordination in the organism which was understood was that of reflex nervous mechanism. With the discovery however of specific hormones, the concept that there might be a humoral co-ordinating mechanism began to be entertained. ... It is now generally accepted that the specific hormones are produced in especially developed glandular organs, the glands of internal secretion, and are transported by the blood stream to distant organs where they exert their effect. ... In contra-distinction to these, there are substances not only produced in any one organ but which are formed in many tissues as well as tissue juices, which do not require any specific type or cell. These 'tissue-hormones' are found under physiological conditions in the body, and they are supposed to act at the site of production or liberation, thus differing markedly from the specific or hormones of internal secretion. ... Of all the tissue hormones only three are of known chemical constitution. These are histamine, acetylcholine and adenylic acid and its derivatives. ... This thesis is concerned mainly with the metabolism of histamine, and in particular with certain aspects of the mechanism of its detoxification in the animal organism. There now follows a general review of the subject, the detailed headings of which will be found in the index. ..."--
Metabolism of glucuronic acid by Diane Croll( )

2 editions published in 1942 in English and held by 4 WorldCat member libraries worldwide

"Glucuronic acid is a hexose uronic acid, discovered by Wiedemann in 1876 in dog's urine and later identified by Schmiedeberg in 1879. It is conjugated in vivo with various exogenous and endogenous substances and excreted entirely in this combined form. It does not represent the only conjugating mechanism nor even the most common conjugating mechanism, but special interest has been aroused in its metabolism with the recent finding that many of the sex hormones are excreted in conjugation with glucuronic acid."--
The adrenal cortex and its role in resistance by Paul G Weil( )

2 editions published in 1941 in English and held by 4 WorldCat member libraries worldwide

"The historical development of the knowledge of the metabolism of the hormones of the adrenal cortex reflects the development of the advances made in the whole field of endocrinology. Clinical observations of deranged function have been followed by experimentation in attempts to produce in the laboratory animal signs of hypo- or hyperfunction of a particular gland. The usual order of experimentation has been first ablation of the gland to determine it the findings following its removal are similar to those occurring in man as a result of destruction of the analogous gland. ..."--
The metabolism of histidine and histamine by W. M Shaw( )

1 edition published in 1952 in English and held by 3 WorldCat member libraries worldwide

"Although histamine since its discovery in 1910 has been courted with enthusiasm by workers in the fields of allergy and of endocrinology, many of the secrets of its physiological and pathological roles lurk evasively in the future. The work recorded here details the findings of some investigations done in an effort to determine the origin of histamine in the tissues."--
Experiences in the Measurement of Various Body Fluid Compartments by Lionel E McLeod( )

1 edition published in 1957 in English and held by 3 WorldCat member libraries worldwide

"Water constitutes an integral part of all living matter. It is important in transport, chemical reactions, maintenance of osmotic pressure. It affects the swelling and solubility of colloids, the viscosity of protein solutions and inhibits or activates enzyme-catalyzed reactions. The body economy has been pictured as designed to maintain the body volume of water by equalizing the input and output mechanisms. The ability of the body to conserve water under severe circumstances has been noted. ..."--
Nitrogen metabolism in damage and convalescence by Victor Schenker( )

1 edition published in 1944 in English and held by 3 WorldCat member libraries worldwide

"The living organism are constantly undergoing processes of destruction and of growth. These processes involve physico-chemical reactions whose end-products are either simpler compounds derived from more complex molecules, or conversely, higher compounds from lower ones: in short, the processes of catabolism and anabolism. The sum total of these reactions, from which derives the energy necessary to maintain life, constitutes metabolism. Under this term are included all the mechanisms tending to regulate the rate of these reactions; the enzyme systems, the hormones and vitamins (and these may be synonymous) 9 the nervous stimuli, and a host of other 'factors, most of them unknown, all functioning towards the common end of homeostasis. ..."--
The histamine content of allergic and non-allergic human nasal mucous membrane with simultaneous observations on the eosinophils by J. D Baxter( )

1 edition published in 1952 in English and held by 3 WorldCat member libraries worldwide

"This investigation was undertaken at the suggestion of Dr. Bram Rose in order to assess what happens to the histamine content of human nasal mucous membrane during allergic raction. In previous work carried out by Rose, Entin and Baxter (1951) on the histamine content of various human tissues, several high values (101 and 140 Y per gram) were obtained on antral mucous membrane from allergic individuals. The exact significance of such findings was not clear."--
ACTH and cortisone: a new era in medicine. An NBC radio discussion by John Symonds Lyon Browne( Book )

2 editions published in 1949 in English and held by 2 WorldCat member libraries worldwide

ACTH and cortisone : a new era in medicine by Alan T Kenyon( Recording )

2 editions published in 1949 in English and held by 2 WorldCat member libraries worldwide

Alan T. Kenyon, Edward C. Kendall, and John S. L. Browne discuss the breakthrough in the treatment rheumatoid arthritis with the drugs ACTH and Cortisone. Part of the University of Chicago Roundtable, program number 611
The interdependence of gastric secretion and the CO2 content of the blood by J. S. L Browne( Book )

1 edition published in 1932 in English and held by 1 WorldCat member library worldwide

John Symonds Lyon Browne fonds : P158( )

in English and held by 1 WorldCat member library worldwide

 
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Audience Level
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Audience level: 0.74 (from 0.56 for The chemic ... to 0.76 for The metabo ...)

Alternative Names
Browne, John S. L. (John Symonds Lyon), 1904-

Browne, John Symonds Lyon, 1904-

Languages
English (31)