WorldCat Identities

United States Army Medical Research and Materiel Command

Overview
Works: 140 works in 170 publications in 1 language and 2,679 library holdings
Genres: History  Periodicals  Conference papers and proceedings 
Roles: Funder
Classifications: UH223, 355.345072073
Publication Timeline
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Most widely held works about United States
 
Most widely held works by United States
USAMRMC : 50 years of dedication to the warfighter, 1958-2008( Book )

3 editions published in 2008 in English and held by 268 WorldCat member libraries worldwide

From the Preface: This book marks the first 50 years of the U.S. Army Medical Research and Materiel Command (USAMRMC). It documents a chronology highlighting some of the Command's many contributions to ensuring that world-class medical technologies are available to our service men and women. Our organizations and programs have evolved to support the needs of the warfighter in training, pre-deployment operations, deployment to nonhostile and hostile operations, post-deployment recovery and reconstitution, and into retirement
Proceedings of the National Forum: Military Telemedicine On-Line Today Research, Practice, and Opportunities, March 27-29, 1995, Mclean, Virginia by Practice, and Opportunities National Forum: Military Telemedicine On-Line Today Research( )

3 editions published in 1996 in English and held by 243 WorldCat member libraries worldwide

Battlemind training II : continuing the transition home( )

2 editions published in 2006 in English and held by 225 WorldCat member libraries worldwide

Blast injury : translating research into operational medicine by James H Stuhmiller( )

1 edition published in 2008 in English and held by 217 WorldCat member libraries worldwide

PDHRA battlemind training : continuing the transition home( )

1 edition published in 2006 in English and held by 211 WorldCat member libraries worldwide

Battlemind training II : continuing the transition home( )

1 edition published in 2005 in English and held by 208 WorldCat member libraries worldwide

CDMRP annual report by Congressionally Directed Medical Research Programs (U.S.)( )

in English and held by 205 WorldCat member libraries worldwide

USAMRMC products portfolio( )

2 editions published in 2011 in English and held by 201 WorldCat member libraries worldwide

U.S. Army Medical Research and Materiel Command : medical research technology & materiel for the 21st century soldier, sailor, airman, marine( Book )

2 editions published in 2003 in English and held by 149 WorldCat member libraries worldwide

Medical imaging 2001. 18-20 February 2001, San Diego, USA( )

4 editions published in 2001 in English and held by 130 WorldCat member libraries worldwide

U.S. Army Medical Research and Materiel Command : --research and materiel for the soldier--( Book )

2 editions published in 1995 in English and held by 122 WorldCat member libraries worldwide

A Novel DNA-Based Vaccine Methodology for AIDS by Joel R Haynes( )

1 edition published in 1996 in English and held by 55 WorldCat member libraries worldwide

Gene gun-based DNA immunization studies in mice using an HIV-l gp120 expression vector demonstrated that modest effects on the strength and quality of gpl2O-specific immune responses could be elicited via the codelivery of vectors encoding murine IL-2, IL-7, or IL. 12. However, much more dramatic effects on gp 120-specific immune responses could be elicited by administering fewer immunizations over a longer time frame. In the nonhuman primate model, synergistic effects on the induction of HIV or SIV gpI2O-specific antibody titers were observed when gene gun immunizations were boosted with either recombinant subunit or recombinant vaccinia virus vaccines, In addition, a measurable vaccine effect was observed in rhesus macaques, in that lower virus loads and higher CD4 counts were observed in gene gun-vaccinated animals relative to naive controls following a heterologous challenge with SIVB67O. Protection was not correlated with the strength of gp120- specific antibody titers. In the swine model, very strong humoral responses were observed in a three dose regimen using as little as 0.5 ug of DNA per immunization. These responses were equivalent to those elicited following administration of a commercial adjuvanted recombinant subunit vaccine
Human Immunodeficiency Virus (HIV) Research (AIDS) by John Lowe( )

1 edition published in 1994 in English and held by 55 WorldCat member libraries worldwide

A comprehensive HIV Research Program conducted studies in the areas or Vaccines and Immunotherapy/Immunoprophylaxis, Epidemiology/Natural History, Behavioral Medicine, Chemotherapy/Chemoprophylaxis, Retroviral Biology, Animal models, Diagnostics and opportunistic Infections. Research was directed towards ameliorating the effects of HIV infections within the US Armed Forces. Program priorities were early stage disease over late stage disease; interventions over descriptive studies; and primary anti-retroviral therapy over treatment/ prophylaxis of opportunistic infection or symptomatic therapy of late stage disease. Research involved clinical trials, natural history studies, and laboratory and animal model studies. Significant outcomes of this research included (but not limited) to: Volunteers, EA I, Therapeutic trials, HIV, Retrovirus clinical facility, WRAMC, Biotechnology
Selection and characterization of drug-resistant variants of human immunodeficiency virus (AIDS) : [final report] by John Mellors( )

1 edition published in 1995 in English and held by 55 WorldCat member libraries worldwide

The original aims of this 5 year project were (i) to complete the molecular characterization of variants HW-1 that are resistant to the pyrophosphate analog foscarnet, (ii) to identify by in vitro selection variants of HIV-1 that are resistant to new reverse transcriptase (RT) and protease inhibitors that are in preclinical or early clinical stages of evaluation, and (iii) to construct a panel of drug-resistant infectious proviral clones for use as standards in HW-1 drug susceptibility assays. During the 14 month period of funding, major progress has been made on each of these aims. First, we have completed a comprehensive analysis of the genetic basis for HW-1 resistance to foscarnet. Six novel mutations in HIV-1 RT have been identified in foscarnet resistant laboratory and clinical isolates. In addition, important interactions between foscarnet and azidothymidine resistance have been identified. Second, we have isolated a variant of HIV-1 that is resistant to the novel RT inhibitor dioxolane guanosine and encodes a K65R mutation in the IKKK motif of HIV-1 RT. Third, we have engineered an HlV-1 proviral clone to encode unique silent restriction sites that allow rapid cloning of mutant protease or RT genes into the provirus. Using this novel vector we have produced stocks of recombinant mutant viruses that are highly resistant to foscarnet, nonnucleoside RT inhibitors, azidothymidine, or oxathiolane cytosine nucleosides (e.g. 3TC). In summary, new discoveries and several products of importance to HW research have arisen from this project during the short period of funding
Retrospective Study of HIV Infection in Human Tissues by Armed Forces Institute of Pathology (U.S.)( )

1 edition published in 1997 in English and held by 55 WorldCat member libraries worldwide

To seek, review identify, and retrieve repository materials (slides, blocks, wet tissues, and information) of cases fulfilling the CDC definition of AIDS in the absence of demonstrable HIV infection Identify cases for potential use in basic research on the chronology of HIV retroviral infection in human tissues
Mechanism of Cytotoxicity of the Aids Virus, HTLV-III/LAV by Lee Ratner( )

1 edition published in 1994 in English and held by 55 WorldCat member libraries worldwide

The study was undertaken in order to devise a quantitative assay of human immunodeficiency virus type 1 (HIV-1) load in patients' tissues. No methods are currently available which are both sensitive and specific for this purpose. Our method utilizes blood mononuclear cell or tissue DNA. HIV-1 sequences are amplified by the primer chain amplification reaction (PCR) technique. The reaction products are detected and quantitated by polyacrylamide gel electrophoresis, ethidium bromide stain, and Southern blot hybridization. This method has proven successful using a single set of primers in detection of HIV-1 DNA sequences from 10 of 12 HIV-1 infected individuals, and 0 of 10 uninfected individuals. Methods of quantitation of using standard curves with defined amounts of HIV-1 DNA sequences and internal controls are under investigation. In addition, we have developed a sensitive and specific assay from HTLV-1 and HTLV-II DNA sequences using the same methodology and we have successfully applied it to the evaluation of blood samples from asymptomatic HTVL-1 infected individuals and individuals with adult T cell leukemia-lymphoma. Keywords: Immunosuppression; Diagnosis medicine. (aw)
Interactions of HIV-1 and HIV-2 in West Africa by Phyllis J Kanki( )

1 edition published in 1999 in English and held by 54 WorldCat member libraries worldwide

Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are genetically and antigenically related viruses with distinct epidemiologic and biologic properties. Since its discovery in West Africa in 1985, various studies have suggested differences between HIV-2 and HIV-1 in geographic distribution, distinct temporal trends in the epidemic spread, and dramatic differences in perinatal and sexual transmission. Studies of HIV-2 infected individuals have shown a significantly slower progression to AIDS. This dramatic difference in pathogenicity provides a unique opportunity to identify viral and host immune mechanisms involved in a closely related virus system that is predicted to have an attenuated phenotype in vivo. This view gave rise to the hypothesis that infection with HIV-2 might provide protection against subsequent infection with the more pathogenic HIV-1. The striking conclusion was that HIV-2 did provide approx. 60% protection against subsequent infection with HIV-1, now evaluated for over 13 years of study. The "natural experiment" of HIV-2's observed protection against HIV-1 infection represents an invaluable model in which important correlates of HIV-1 protection can be identified and characterized. We are hopeful that further comparative studies of these related immunodeficiency viruses will yield important information on the pathogenic mechanisms employed by HIV viruses and lead the way to the development of effective interventions for the prevention and control of the AIDS pandemic
Sustaining soldier health and performance in Somalia : guidance for small unit leaders( Book )

1 edition published in 1992 in English and held by 7 WorldCat member libraries worldwide

1996 Medical Defense Bioscience Review : proceedings ... 12-16 May by Medical Defense Bioscience Review( Book )

1 edition published in 1996 in English and held by 4 WorldCat member libraries worldwide

Proteolytic Mechanisms of Cell Death Following Traumatic Brain Injury by Ronald L Hayes( Book )

4 editions published between 2000 and 2004 in English and held by 4 WorldCat member libraries worldwide

We have examined the pathological significance of calcium accumulation in the central nervous system (CNS) following a variety of insults including cerebral ischemia, spinal cord and traumatic brain injury (TBI). This research has been motivated by recognition that disturbances in neuronal calcium homeostasis can result in activation of several calcium sensitive enzymes including lipases, kinases, phosphatases and, importantly, proteases. Recent studies have provided strong evidence that activation of the calpains, calcium activated intracellular proteases, is a major pathological event in a number of acute CNS injuries including TBI. In addition to calpains, other data have implicated another important family of cysteine proteases, caspases. Caspase-3 is an effector caspase especially important to caspase mediated pathology. Western blot immunoassays of calpain and caspase-3 specific breakdown products proposed in SOW 1 provided an efficient means of determining which brain regions and time points were most usefully incorporated into studies of SOW 2 which provided more detailed information on mechanisms of calpain activation. SOW 3 focused on endogenous modulation of protelytic activity, including the enzyme calpastatin. SOW 4 addressed the task of providing more direct evidence of the pathological significance of activation of calpains and caspases
 
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Alternative Names

controlled identityUnited States. Army Research, Development, Acquisition, and Logistics Command

AMRMC

MRMC

U.S.A.M.R.M.C.

U.S. Army Medical Research and Materiel Command

United States. Army Medical Command. Army Medical Research and Materiel Command

United States Army Medical Research and Materiel Command

USAMRMC

美國陸軍醫療研究司令部

Languages
English (37)