WorldCat Identities

California Univ., Riverside

Overview
Works: 73 works in 95 publications in 1 language and 127 library holdings
Genres: Academic theses 
Classifications: LB15, 428.4
Publication Timeline
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Most widely held works by Riverside California Univ.
Stimulation of p53-dependent Transcription by the Growth Suppressor, c-Abl( )

5 editions published between 1997 and 2001 in English and held by 5 WorldCat member libraries worldwide

Since this grant was awarded (7/1/96), we have constructed a set of deletion mutants and showed that deletion of last 30 amino acids in p53 severely disrupted its ability to bind to c-Abl and deletion of the tetramerization domain also greatly reduced the binding to c-Abl. Based on these results, we proposed a model in which c-Abl interacts with the regulatory domain (aa 363 to 393) on p53 to diminish its negative regulatory effect and thereby to enhance the DNA binding activity of p53. This interaction, however, requires the tetrameric conformation of the protein To test this, we first investigated the ability of a mutant p53 (341K344E348E355K, tetramerization impair) to interact with c-Abl and showed that this mutant is defective in c-Abl interaction. Second, we proposed to obtain the purified c-Abl protein via a baculovirus expression system to assay its ability to enhance p53,s DNA binding. Unfortunately, we have not been able to do so using c-Abl virus we have. We are currently in a process to construct a new virus which expresses His-tag c-Abl. We hope that we will be able to obtain a large amount of purified protein to enable us to perform EMSA experiments as we proposed
Spatial Relationships between Drug Binding Sites on the Surface of the Acetylcholine Receptor( Book )

4 editions published between 1985 and 1989 in English and held by 4 WorldCat member libraries worldwide

This report is divided into three sections dealing with the development of fluorescent probes of the nicotinic acetylcholine receptor (AChR). Section I summarizes our characterization of the interaction of ethidium with the noncompetitive inhibitory (NCI) site identified by phencycliding (PCP) binding. Due to an incomplete understanding of the interrelation ship between the agonist/antagonist and NCI sites on the AChR, ethidium was originally thought only to interact with the agonist/antagonist sites. However, we show that ethidium, indeed, binds selectively to the NCI site when the AChR is in the desensitized state. Section II deals with our efforts to convert the a-toxin-bound AChR to the desensitized state with butanol. Our hope was that, if the a-toxin bound could be converted to the desensitized state, ethidium could be utilized in conjunction with specifically labelled a-toxins to measure the distances between agonist/antagonist and NCI site. Keywords: Acetylcholine receptor, Cobra a-toxin, Fluorescein isothiocyanate, Ethidium, Anesthetics, Fluorescence. (JES)
The electrical properties of semipermeable membranes( Book )

4 editions published between 1964 and 1967 in English and held by 4 WorldCat member libraries worldwide

The first paper of this series presented a general formulation of the problem of stationary ion flow through membranes. The second treated in detail the special case of unipolar flow across membranes separating symmetric electrolytes. This, the third paper of the series, deals with another special case, that of bipolar flow between symmetric electrolytes. It is assumed that the total current is carried by both positive and negative permeant ions. The restriction to symmetric electrolytes implies that all ions present in the membrane and surrounding solutions have valences of identical absolute magnitude. The author begins by extracting from the general development of his first paper a set of equations appropriate to the special case being considered. A procedure for the numerical solution of the conductance problem for this case is then outlined. Numerical results are, however, presented as part of a discussion of approximate analytic methods of solution. The utility of these methods is thereby established. (Author)
Characterization of a p53 Regulatory Domain( )

4 editions published between 1998 and 2001 in English and held by 4 WorldCat member libraries worldwide

We purposed to characterize a regulatory domain on p53 and identify kinase(s) that may be involved in the regulation. Since 7/1/97, we constructed a set of deletions to disrupt the potential regulatory domains of p53 on Gal4-p53(1-160) and on full-length p53. Using these mutants we have obtained the following results: 1. Mutants Gal4-p53N(Delta92- 109), Gal4-p53N (Al17-128) and Gal4-p53N (Ser117/l27Ala) had little effect on the putative inhibitory effect. 2. TPA stimulation inhibited the transcriptional activities of Gal4-p53N (DELTA92-109) and (Ga14-p53N (Delta117-128), but did not affect Gal4-p53(1-92). 3. Mutants p53(DELTA92-109), p53(Deltas117-128), p53(Sl17/127A) and p53(S117/127D) significantly lost their ability to activate transcription in vivo. 4. Mutants p53(DELTA92-109), p53(DELTA117-128) and p53(S117/127A) retained their abilities to bind to DNA, but p53(S1 17/127D) not. 5. MAP-kinase is involved in the degradation of mutant p53 protein. In conclusion, we have shown that two serine residues 117 and 127 may play a role in stabilization of p53 protein levels. Further experiments will be conducted to confirm these results. We have also showed that MAP-kinase is involved in the degradation of mutant p53 protein. Our findings suggest a role for MAPK in the degradation of mutated form of p53 protein and in cell differentiation. These% results were published as a JBC paper
Graduate Education : Turning Graduate Students into Professors. Final Report by Darold D Holten( Book )

1 edition published in 1990 in English and held by 3 WorldCat member libraries worldwide

In response to the need for better trained teaching assistants to serve a growing undergraduate population, this project established a campus-wide Teaching Assistant Development Program (TADP) at the University of California Riverside. Project efforts included inviting departmental participation in shaping teaching assistant (TA) seminar content; focusing seminars on "practical" instructional, testing and grading techniques; developing three "disciplinary cluster" seminars; fostering cooperative TA-faculty relations in the seminar's content; and inviting departments to develop their own TA training programs. In addition the project actively promoted TADP services and benefits in meetings with departments, in publications and memos, as well as successfully courting the campus press for favorable coverage of its events and services. Project results included public accolades from top administrators, funding for additional equipment for the next fiscal year, heightened campus commitment to teaching, reduced numbers of low-evaluated (problematic) TAs by 33 percent, and improved student ratings of first- and second-year TAs. In addition the project compiled a book of readings from other TA handbooks and newsletters and published an original TA handbook and a quarterly TA newsletter. Extensive appendixes contain correspondence and memos from the project, event announcements, evaluation forms, student evaluations, three issues of a TA newsletter, the Tadpole, and a quarter report for fall 1989. (JB)
Administration of Additional Phosphorylated Prolactin During Pregnancy Inhibits Mammary Ductal Branching and Promotes Premare Lobuloalveolus Development( )

3 editions published between 2001 and 2003 in English and held by 3 WorldCat member libraries worldwide

Prolactin (PRL) is a hormone recognized as having both proliferative and differentiative activities in the mammary gland. Current theory proposes that it is the coexisting steroidal environment which dictates whether PRL is proliferative or differentiative. Preliminary data, presented as part of the initial proposal and established during year 1, however, suggested that it was the form of PRL released that dictated whether proliferation or differentiation would occur. By form of PRL we mean whether the PRL is released from the pituitary as an unmodified polypeptide or whether it is phosphorylated. To study this issue, we have produced recombinant, unmodified PRL (U-PRL) and a recombinant, molecular mimic of phosphorylated PRL, S179D PRL In the studies conducted during the first and second year, we have demonstrated that U-PRL promotes mammary growth, while Sl79D PRL inhibits growth and promotes differentiation. Further, we have demonstrated that these effects of U-PRL and S179D PRL are produced directly on the mammary gland. In addition, we have been able to show that U-PRL and S179D PRL exert these very different effects by changing the balance of signaling between the two major pathways in mammary epithelium. Thus U-PRL primarily uses the Jak 2-Stat 5a pathway, while Sl%9D PRL increases use of the MAP kinase pathway
Early Experience and Spatial Functioning in the Blind by Terry Lyndell Schmitt( Book )

1 edition published in 1978 in English and held by 3 WorldCat member libraries worldwide

A review of the literature on the spatial functioning of the blind, the results of a questionnaire of 75 sighted college students and their parents, and results of a study of 87 blind and seeing adults' performance on three spatial tasks are presented. The review suggested that adventitiously blind individuals perform better than congenitally blind individuals on tasks where the stimuli were complex, familiar and/or appended within arm's length of the body. Results of the questionnaire were used to predict several performance measures from the three spatial tasks. The findings indicated that tactual pattern discrimination performance and tactual path learning performance were primarily predicted by the degree of early visual experience, whereas locomotor path performance was primarily predicted by the degree of perceptual motor experience. The preliminary and final questionnaires and a table of correlations between all dependent variables are appended. (Author/PHR)
Three-Dimensional Structure Determination of Botulinum Toxin( Book )

2 editions published in 1998 in English and held by 3 WorldCat member libraries worldwide

The immediate goals of the contract on the structure and function relationship of botulinum neurotoxin are: 1) Determine the three-dimensional structure of botulinum neurotoxin at atomic resolution by x-ray crystallography. 2) Based on the structure of the neurotoxin, understand the toxins mechanism of action. We have accomplished the first goal of determining the three-dimensional structure of the 150 kD botulinum neurotoxin serotype A. The toxin is Y-shaped, with a very long alpha-helical translocation domain forming the backbone of the structure. The translocation domain is composed almost entirely of helices, 2 of which are 95 A in length and form a pseudo-coiled coil. The binding domain and catalytic domain are more globular in shape, located at two different ends of the translocation domain. The overall dimensions of the protein are 120 A x 80 A x 40 A.A complete description of the three- dimensional structure is described in the report (the manuscript will he published in the September issue of Nature Structural Biology). We have recently collected data on an inhibitor complex and a receptor - complex. Refinement and analysis of the toxin with bound molecules will be completed within the next 12 months
A Study of Minimum Competency Tests and Their Impact. Final Report by Donald L MacMillan( Book )

1 edition published in 1990 in English and held by 3 WorldCat member libraries worldwide

This project studied the impact of Minimum Competency Tests (MCT) on the educational careers of secondary students. The educational experiences of those students passing the MCT were compared with the experiences of those students not passing the MCT. The study compared three categories of students (learning handicapped, educationally marginal, and controls) on such outcomes as types of courses taken, transferring out of the district (to a district with an "easier" test), early school dropout, school attendance, disciplinary problems, self-concept, and attitudes toward school. Results indicated that performance on the MCT greatly impacts the types of courses selected, with students passing the MCT enrolling in more elective courses and fewer remedial courses. Students failing the MCT transferred up to 10 times more frequently than those passing the MCT. Students failing the MCT were up to 10 times more likely to drop out of school than passing students. Students failing the MCT were absent more often and had lower self-concept in the areas of academics in general, math, honesty, and same-sex relations. Appendixes include a sample data collection sheet, a self-description questionnaire, and a school attitude survey. References accompany each chapter. (JDD)
Factors contributing to adjustment and achievement [in racially desegregated public schools] : progress report by Harold B Gerard( Book )

1 edition published in 1968 in English and held by 2 WorldCat member libraries worldwide

A longitudinal study to determine the conditions surrounding successful or unsuccessful integration of Negroes, Mexican Americans, and Anglos in the Riverside Unified School District in Riverside, California, began in school year 1965-66, and included kindergarten through grade 6. Test batteries placed emphasis on achievement "related attitudes. It was found that, on a delay-of-gratification test, racial differences were not significant, and age seemed to be the primary source of difference between the 3 ethnic groups. It was also found that there was a marked change in dialect tending toward standardization of dialect as measured by Standard California English (sce). An experiment is planned to determine the effects of changes in comparison referents caused by desegregation of the public school. (Da)
Molecular Mechanisms of Biosynthesis of Metal-Binding PCs( Book )

2 editions published in 1997 in English and held by 2 WorldCat member libraries worldwide

Our research during the project period was directed towards three fundamental aspects of PCs: (1) metal-chelation by PCs, (2) sulfide complexes of PCs and (3) biosynthesis of PCs. We have made thorough investigations of the metal-binding properties of PCs and published data that provides benchmark information on the Ag(1), Cu(1), Cd(2), Hg(2) and Pb(2)-binding characteristics of these plant metal binding peptides. We have carried out detailed investigations on the sulfide complexes of PCs (PCs) that profoundly influence the metal-binding capacity of these peptides. In addition, these complexes have the potential to be very useful reagents for the detoxification of a variety of organic contaminants. Using a complementation cloning strategy, we have isolated a gene that is required for Cd tolerance and PC production. Although this gene did not turn out to be PC synthase, it provides us a good picture of the role of heme biosynthesis in PC production
BEHAVIOR OF SOLIDS UNDER PRESSURE( Book )

2 editions published between 1963 and 1964 in English and held by 2 WorldCat member libraries worldwide

The pressure dependence of the electrical conductivity of Ag2HgI4 was investigated. The resistance of VO2 through the semiconductor-to-metal transition was measured as a function of hydrostatic pressure. The transition was studied in pure and partially hydrated single crystals of VO2 and in powdered VO2. Finally, a high pressure microwave cavity for use in magnetic resonance was investigated. A sapphire cone terminated at the large end with a metallic sample served simultaneously as a pressure seal and the resonant structure for a 1 cm magnetic resonance spectrometer
A Study of Desegregation in the Public Schools, Riverside, California. Riverside School Study, Progress Report 1968-1969. Project No. M8-14 by Mabel C Purl( Book )

1 edition published in 1969 in English and held by 2 WorldCat member libraries worldwide

This progress report of the Riverside Unified School District comprises a summary of the effect of integration on the achievement of elementary pupils. Little change is considered to have occurred in the achievement of these students following integration. However, the achievement of many minority pupils, it is held, may eventually improve through the cumulative effects of the receiving pupils' home backgrounds and through the influence of favorable classroom atmospheres. It is noted that desegregation must be accompanied by intense efforts to provide instruction which will help compensate for earlier disadvantages. The report also includes a description of a project that emphasizes the areas of physical development of children, their cognitive development, and strengthening of their social identities. The project includes concentrated inservice teacher education in the field of cognitive development according to the theories of Piaget. Appended are papers on comparative data on Raven's Progressive Matrices Test and the Peabody Picture Vocabulary Test and on the effect of integration on the achievement of elementary pupils. (Author/JW)
Substrata-factor reorganization accompanying development in speed and power of reading at the elementary school level by Harry Singer( Book )

1 edition published in 1965 in English and held by 2 WorldCat member libraries worldwide

Several developmental hypotheses drawn from the substrata-factor theory of reading were tested at the elementary school level. To elaborate on theoretical assertions that reading ability is an audiovisual processing skill of symbolic reasoning, the substrata factors accompanying development of speed and power of reading were depicted in diagrammatic models. The experimental design consisted of (1) selection of a battery of tests for predicting speed and power of reading, (2) administration of this battery to representative pupils in grades three through six, and (3) statistical tests of hypotheses by means of multiple correlation, significance of differences between means of known groups, and factor analysis. The sample contained 927 pupils in grades three through six in six elementary schools in an average socioeconomic district. Developmental hypotheses of the substrata-factor theory were confirmed. Specific findings indicated that (1) sequential development of a hierarchical organization of substrata-factors did accompany improvement in speed and power of reading, (2) visual processes were dominant for speed of reading, but both visual and auditory processes continued to operate in power of reading throughout the intermediate grades, (3) shift in instructional emphasis during these grade towards word meaning and reasoning-in-context abilities and processes was to some degree consistent with developmental changes, (4) the average reader developed more or less at an even rate in all of his subabilities and in speed and power of reading throughout the intermediate grades, and (5) during grades three through six, the slowest and least powerful readers were approximately three grades behind the development of the fastest and most powerful readers. (Jm)
Academic abbreviations and acronyms by John Alexander Moore( Book )

1 edition published in 1981 in English and held by 2 WorldCat member libraries worldwide

This list of over 2,500 acronyms and abbreviations likely to be encountered in academe, together with their definitions, is arranged in alphabetical order by acronym. U.S. government agencies and international organizations of academic interest are included. Cross references, multiple definitions, and brief scope notes are provided where required, as well as the addresses of a few organizations. The publication begins with a list of four other acronym dictionaries and concludes with listings of U.S. airport abbreviations and the official two-letter abbreviations for states and U.S. territories. (Author/ESR)
Preparation of reading content specialists for the junior high school : teaching reading in the content areas at the junior high school level, strategies for meeting a wide range of individual differences in reading achievement by Harry Singer( Book )

1 edition published in 1973 in English and held by 2 WorldCat member libraries worldwide

This project investigated whether teachers, committed and trained to teach reading in the content areas at the junior high school level, could improve the reading performance of all their students, particularly Mexican-Americans and blacks. The chapters are organized to reflect the accomplishments in all the objectives of the program. The first chapter summarizes the program and reports on the research conducted. The second chapter reviews the research made prior to the investigation. The third chapter describes the teaching materials found to be beneficial and how they were used. The fourth chapter discusses instructional processes and strategies for teaching reading in the content area. The fifth chapter contains information on the consulting role of the specialists and the dissemination objective of the project. The sixth chapter contains the content reading specialists' evaluation, a report on the project to the Board of Education of Riverside Unified School District, and a summary of an on-site evaluation made by an outside evaluator. The appendixes contain consultant reports, tests used in the project, project literacy reports, lists of references and trade books, and statistical analysis of data. (WR)
Tables on non-relativistic electron trajectories for field emission cathodes by Allan Melvin Russell( Book )

2 editions published between 1962 and 1964 in English and held by 2 WorldCat member libraries worldwide

Schemas in Memory? Increasing the Usefulness of an Unconfirmable Hypothesis by Eliot R Smith( Book )

1 edition published in 1980 in English and held by 2 WorldCat member libraries worldwide

There are several problems associated with research using the schema concept. One problem is that there seems to be a lack of cumulative development, with the research being horizontal in quality, spreading out to new areas. Another problem with schema research is that a person not already convinced of the merit of the schema notion can remain unconvinced by the entire body of evidence relating to schema. What appears to be lacking is a formal theory of schemas that not only describes their own nature but also shows how they fit into overall cognitive processing. A theory that gives an adequate account of schemas as structural entities must give an account of processing as well, because in general one cannot test a structural hypothesis without an auxiliary set of assumptions about processing, and vice versa. A theoretical effort at defining schema processing as well as structural issues would have a number of beneficial effects, including the following: (1) schema research would acquire a vertical, cumulative quality; (2) the research might go a long way toward answering the objections of the unconvinced; (3) research efforts could be coordinated; (4) there would be a clear test for what is and what is not part of the schema hypothesis; and (5) negative evidence (failed replications and different findings) could be applied usefully to the advancement of schema theory. (RL)
Approaches to Desegregation The Superintendent's Perspective; A Dialogue on April 27-29, 1969, University of California Conference Center, Lake Arrowhead by Riverside California Univ.( Book )

1 edition published in 1969 in English and held by 2 WorldCat member libraries worldwide

A conference for educators on the subject of school desegregation was sponsored by the University of California, Riverside, in the spring of 1969. Concerned school superintendents, authorities in behavioral science research, government officials, political leaders, and school board members discussed the rationale for attempting to solve racial problems in education and ways in which integration might be accomplished. The dialogue centered around research support, legal requirements, and social, political strategies. This account of the proceedings is presented in the form of representative excerpts from the comments and papers given at the conference. In addition, the superintendents agreed upon a number of recommendations which cover topics in need of research, preservice education, and inservice education of teachers. (Author/JW)
Competency-based training in education : a conceptual view by Howard S Adelman( Book )

1 edition published in 1973 in English and held by 2 WorldCat member libraries worldwide

This document is one in a series of monographs that present concepts and practices reflecting an analysis of programs to prepare general and special education personnel. This monograph presents a conceptual model of the seven major phases and tasks involved in planning, implementing, and evaluating personnel preparation programs in the field of education, including a) the formulation of the program rationale, b) curricular planning, c) evaluational planning, d) administrative planning, e) instructional planning, f) program implementation, and g) program evaluation. Also presented are some views on how prototype programs might be developed, disseminated, installed, and maintained. Six appendixes include information concerning recruiting and maintaining education professionals, implications for the preparation of teachers, and criteria for admission to preparation programs and accredited professional standing. Bibliographic references follow each chapter and tables are presented throughout the document. (PD)
 
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