WorldCat Identities


Works: 11 works in 11 publications in 1 language and 11 library holdings
Genres: Academic theses 
Publication Timeline
Most widely held works by IMPERIAL COLL LONDON (Great Britain)
Identification of Molecular Receptors for Therapeutic Targeting in Prostate Cancer( Book )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

Prostate cancer is a difficult disease to treat due to its molecular heterogeneity and diverse clinical outcomes. Current therapies for treating and diagnosing prostate cancer are unsatisfactory, suggesting that new strategies and molecular markers are greatly needed. Tumor cells express specific cell surface receptor complexes for rapid growth and survival. Specific receptor-ligand complexes have profound biological functions such as cell signaling and growth. For example, androgen receptor complex plays a critical role in prostate tumor growth and response to hormone therapy. We propose to identify new receptor-ligand pairs for prostate cancer. We have developed a sophisticated targeting system to probe the tumor vasculature in vivo by phage display technology. We plan to inject phage peptides libraries into prostate tumor-bearing mice to identify specific peptides targeting to the tumor and not to the normal tissues. The tumor-specific peptides will be recovered and analyzed by molecular and biochemical methods. The tumor-specific peptides will be used as a bait to identify and clone the binding receptors by affinity chromatography and biochemical cell fractionation approaches. If we are successful, we will identify new biologically relevant receptor-ligand pairs that may be developed for therapeutic applications for prostate cancer

1 edition published in 1966 in English and held by 1 WorldCat member library worldwide

This report consists of two sections: Section A. The Interaction of Perfluorobutadiene with Iron and Cobalt Carbonyls and Section B. Complexes Derived from Perfluorobut-2-ene and tetrakistrifluoromethylcyclopentadienone ("dione")
Predicting the Effect of Defect Distributions in the Bulk and on Surfaces of Ceramic Materials( )

1 edition published in 2003 in English and held by 1 WorldCat member library worldwide

This report results from a contract tasking Imperial College, London as follows: The contractor will investigate and ultimately develop ways to select optimum compositions for materials using atomic scale computer simulation. The particular material systems to be studied are: pyrochiores and fluorites (important in fuel cell and oxygen generator applications and as thermal barrier coatings on turbine blades in jet engines), and the perovskites, important electronic ceramics that also act as catalysts. The work proposed here falls into two categories: those associated with the behavior of defects within the bulk or interior, and those associated with surface structures. The contractor shall: Investigate solution of aliovalent dopant ions in pyrochlore oxides. Predict the extent of disorder in pyrochlore oxides.-Identify compositions that exhibit complex defect behavior in perovskite oxides. Predict surface hydroxylation of yttria stabilized ZrO2. Investigate how surface tension is changed by hydroxylation of ZrO2 surfaces
Detailed and simplified chemical kinetics of aviation fuels and surrogates by Valentini Markaki( )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

This report results from a contract tasking Imperial College London as follows: 1.0 Introduction and Overview Current fuel quality regulations for aviation kerosene provide significant scope for large regional and source differences. The chemistry of high-performance fuels aimed at specific applications and devices show less variation but their chemistries remain complex. There is now arguably a well-established need to incorporate accurate chemical mechanisms into calculation procedures. Flow timescales associated with high performance propulsion devices also increasingly lead to difficulties associated with the burning characteristics of the current generation of propulsion fuels. In particular, chemical time-scale restrictions pose a particular challenge in terms of combustion initiation and/or flame stability. The current development of alternative combustor designs based premixed or partially premixed lean burn technologies further emphasises the need to consider finite rate chemistry effects. Critical steps in the derivation of realistic chemical mechanisms include the definition of a surrogate (or model) fuel and validation of the performance of the surrogate against practical fuel samples. The required practical parameter space typically leads to a need to determine heat release characteristics, burning velocities, effects of strain, ignition delay times, the dynamics of the fuel breakdown process and quantification of key intermediate species. The latter is often essential in understanding the propensity of a device to form pollutants, such as soot, that may affect signatures and combustor life. Furthermore, current indications suggest that fuel sources will become significantly more diverse in the future and may, for example, encompass Fischer-Tropsch and/or bio-derived components
Bypass Transition in Turbomachinery Flows: Turbulent Spots and the Calming Effect( Book )

1 edition published in 2010 in English and held by 1 WorldCat member library worldwide

Direct numerical simulations (DNS) were carried out of bypass transition in favorable, zero, and adverse pressure gradient boundary layers in the presence of free-stream turbulence. A time sequence from the ZPG simulations was stored in order to obtain a number of spots for the study of the calming effect. Since the previous report on the research, additional spots have been obtained, in order to increase the number of available events to forty two (42) spots. Various flow visualization techniques were used to analyze the evolution of the spots. It was observed that the location of spot inception is difficult to identify. In the previous report, the investigator analyzed the instability of the streaky boundary layer. The investigator herein report the use of the Lyapunov Exponent in order to determine the Lagrangian Coherent Structures (LCS), which form the spot. Additionally, work was done to determine the average spot inception location, spreading rate, and speed of propagation
Nano-Composites: Relationships Between Nano-Structure and Mechanical Properties: Phase II( )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

This work aims to understand and model the structure/property relationships of polymer nanocomposites, based upon thermosetting epoxy polymers that are widely used as adhesives and matrices for fibre-reinforced composites. The work concentrates on investigating the mechanical and fracture properties of multiphase materials (both bulk materials and reinforced fibre-composites), and on modelling the structure/property relationships of nanocomposites. The present work shows that a substantial increase in toughness may be achieved when nano- SiO2 particles are well dispersed in a hot-cured single-part epoxy polymer. Most importantly, the synergistic effect of having a multiphase structure based upon both nano-SiO2 particles and rubbery particles is clearly demonstrated. The use of nano-SiO2 particles and rubbery particles to give?hybrid-toughened? epoxy polymers is shown to give a range of novel matrices which lead to an increased delamination toughness of the resulting carbon-fibre reinforced-plastic (CFRP) composites. Also, it is noteworthy, that the presence of even a relatively high concentration of the nano-SiO2 particles does not lead to a decrease in the modulus of the composite. Nor does it lead to a significant increase in the viscosity of the epoxy resin, which would preclude the use of low-cost manufacturing routes, such as a vacuum-assisted resin-transfer moulding (VARTM) process
Distributed Compression in Camera Sensor Networks( )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

This report results from a contract tasking Imperial College London as follows: This effort will address a distributed compression problem using information theoretic methods originating in the work of Slepian and Wolf for lossless compression and extended by Wyner and Ziv to the case of lossy compression of continuous-valued sources. The theories developed in these papers are non-constructive and rely on asymptotic random coding arguments. Constructive designs of encoders for the distributed compression problem based on channel codes have been subsequently proposed with applicability to sensor networks. However, in a realistic context the statistics of the source are not known a-priori and channels codes such as turbo or trellis codes might be too complicated in this context. This effort will make use of the correlation structure of the data given by the plenoptic function in the case of multi-camera systems. In many cases the structure of the plenoptic function can be estimated without requiring inter-sensor communications, but by using some a-priori global geometrical information. Once the structure of the plenoptic function has been predicted, it is possible to develop specific distributed compression algorithms that do not require the use of complicated channel codes. This effort will develop techniques to predict the structure of the plenoptic function and develop very simple and efficient distributed compression algorithms derived from a design of a new fully distributed image compression scheme for multi-view images. The algorithm will be implemented in Matlab or C and will operate on some sets of pre-selected multi-view images. Commented MatLab psuedo-code and or C code will be provided with any executables demonstrating the algorithms
Oxygen Ion Conduction in Pyrochlores( )

1 edition published in 2001 in English and held by 1 WorldCat member library worldwide

This report results from a contract tasking Imperial College London as follows: The contractor will investigate use of cellular automata (CA) algorithms to predict the growth of surface structures and the effects of the underlying substrate on the surface morphology. Structure/property maps will be generated using atomistic simulation calculations. Three systems will be investigated First the activation energy for oxygen ion conduction in pyrochlore oxides. Second the stability of the perovskite structure with particular reference to stoichiometry Third the structure type exhibited by AB2O4 compounds. The results of the research will be presented at the 102nd American Ceramic Society meeting at a Materials Directorate organized meeting and will be a published in the open literature
Laser Initiated Ignition of Liquid Propellant( Book )

1 edition published in 1989 in English and held by 1 WorldCat member library worldwide

The 4th Interim Report included the first high speed movie sequence, albeit of rather optical quality, of the interaction between laser generated plasma and a droplet. This was a first step in a more extensive series of studies. Figure 1 shows three sequences illustrating the various parameters under investigations. These include the energy of the laser beam and the distance between the position of the laser focus and the droplet. Moreover, double firing the laser can be used to inject a second plasma kernel into the environment of a drop that is already disintegrating. The records show interaction with the propellant droplet of a rapidly expanding shock wave as well as the more slowly developing plasma kernel and illustrate the wide variation in the rate and completeness of the burning of the droplet that can be achieved. The provisional interpretation is that the shock wave emanating from the laser-generated plasma shatters the droplet and the fine filaments of liquid propellant which result are ignited when they become engulfed by the plasma. This makes the intensity of burning very dependent on the relative positioning of the droplet and laser focus. A second laser pulse (e.g. 200us, 3rd sequence) interacting with the disintegrating and burning fragments from the first in an additional means of promoting rapid decomposition. Comparative experiments with water droplets show shattering without combustion. Keywords: Propellants; Laser ignition
Planar Magneto-Inductive Waveguide Devices( )

1 edition published in 2005 in English and held by 1 WorldCat member library worldwide

This report results from a contract tasking Imperial College London as follows: The Grantee will perform theoretical analysis and experimental investigations of simple planar magneto-inductive wave circuits based on closely coupled LC resonators and formed using low cost flexible PCB techniques. The aim will be to establish propagation characteristics, investigate coupling to electromagnetic radiation in straight sections and bends and demonstrate magnetic field concentration
Online Tracking of the Degree of Nonlinearity Within Complex Signals( )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

A novel method for online tracking of the changes in the nonlinearity within complex-valued signals is introduced. This is achieved by a collaborative adaptive signal processing approach by means of a hybrid filter. By tracking the dynamics of the adaptive mixing parameter within the employed hybrid filtering architecture, we show that it is possible to quantify the degree of nonlinearity within complex-valued data. Simulations on both benchmark and real world data support the approach
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English (11)